4E45B

Crystal structure of the hmhf1/hmhf2 histone-fold tetramer in complex with fanconi anemia associated helicase hfancm
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
74
structure length
74
Chain Sequence
SGFRKELVSRLLHLHFKDDKTKVSGDALQLMVELLKVFVVEAAVRGVRQAQAEDALRVDVDQLEKVLPQLLLDF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Dna binding protein/hydrolase
molecule keywords Centromere protein S
publication title Crystal Structures Reveal that FANCM remodels the MHF Tetramer in favor of binding Branched DNA
rcsb
source organism Homo sapiens
total genus 25
structure length 74
sequence length 74
chains with identical sequence D, G, I, L, N
ec nomenclature
pdb deposition date 2012-03-12

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
B PF09415 CENP-X CENP-S associating Centromere protein X
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.286.100 Mainly Alpha Orthogonal Bundle GTP Cyclohydrolase I; Chain A, domain 1 GTP Cyclohydrolase I; Chain A, domain 1 4e45B02
4E45B 3B0BC 4NE6B 4DRBJ 4E44B 4NE5B 4NE3B 4DRAE
chains in the Genus database with same CATH superfamily
2WSEK 1TFEA 1WPLA 2WSFK 1A9CA 4E44B 4Q7JA 1EFUB 4NE5B 2WSCG 3LW5G 3BMBA 2P11A 4QPMA 1AIPC 1N3RA 2KR1A 1IS7A 1N3SA 4JA3A 3VEJA 5DMZA 2WSCK 3LW5K 1N3TA 3B0BC 1EL6A 4NE6B 2PN0A 1WUQA 1A8RA 4NE3B 2WSEG 2LO0A 2LNZA 1GTPA 2WSFG 4DRAE 4R8QA 1FBXA 1WM9A 1IS8A 4DU6A 1FB1A 2O01G 4DRBJ 4E45B 1WURA
chains in the Genus database with same CATH topology
1TFEA 1WPLA 1A9CA 4E44B 4Q7JA 1EFUB 4NE5B 3BMBA 2P11A 4QPMA 1AIPC 1N3RA 2KR1A 1IS7A 1N3SA 4JA3A 3VEJA 5DMZA 1N3TA 3B0BC 1EL6A 4NE6B 2PN0A 1WUQA 1A8RA 4NE3B 2LO0A 2LNZA 1GTPA 4DRAE 4R8QA 1FBXA 1WM9A 1IS8A 4DU6A 1FB1A 4DRBJ 4E45B 1WURA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4E45 B;  3B0B C;  4NE6 B;  4DRB J;  4E44 B;  4NE5 B;  4NE3 B;  4DRA E; 
#chains in the Genus database with same CATH topology
 2WSE K;  1TFE A;  1WPL A;  2WSF K;  1A9C A;  4E44 B;  4Q7J A;  1EFU B;  4NE5 B;  2WSC G;  3LW5 G;  3BMB A;  2P11 A;  4QPM A;  1AIP C;  1N3R A;  2KR1 A;  1IS7 A;  1N3S A;  4JA3 A;  3VEJ A;  5DMZ A;  2WSC K;  3LW5 K;  1N3T A;  3B0B C;  1EL6 A;  4NE6 B;  2PN0 A;  1WUQ A;  1A8R A;  4NE3 B;  2WSE G;  2LO0 A;  2LNZ A;  1GTP A;  2WSF G;  4DRA E;  4R8Q A;  1FBX A;  1WM9 A;  1IS8 A;  4DU6 A;  1FB1 A;  2O01 G;  4DRB J;  4E45 B;  1WUR A; 
#chains in the Genus database with same CATH homology
 1TFE A;  1WPL A;  1A9C A;  4E44 B;  4Q7J A;  1EFU B;  4NE5 B;  3BMB A;  2P11 A;  4QPM A;  1AIP C;  1N3R A;  2KR1 A;  1IS7 A;  1N3S A;  4JA3 A;  3VEJ A;  5DMZ A;  1N3T A;  3B0B C;  1EL6 A;  4NE6 B;  2PN0 A;  1WUQ A;  1A8R A;  4NE3 B;  2LO0 A;  2LNZ A;  1GTP A;  4DRA E;  4R8Q A;  1FBX A;  1WM9 A;  1IS8 A;  4DU6 A;  1FB1 A;  4DRB J;  4E45 B;  1WUR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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