5I2EA

Human histidine triad nucleotide binding protein 1 (hint1) with bound sulfamate inhibitor 3a:3-(5-o-{[3-(1h-indol-3-yl)propanoyl]sulfamoyl}-beta-d-ribofuranosyl)-3h-imidazo[2,1-i]purine
Total Genus 29
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
29
sequence length
115
structure length
115
Chain Sequence
RPGGDTIFGKIIRKEIPAKIIFEDDRCLAFHDISPQAPTHFLVIPKKHISQISVAEDDDESLLGHLMIVGKKCAADLGLNKGYRMVVNEGSDGGQSVYHVHLHVLGGRQMHWPPG
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Hydrolase/hydrolase inhibitor
molecule keywords Histidine triad nucleotide-binding protein 1
publication title Design, Synthesis, and Characterization of Sulfamide and Sulfamate Nucleotidomimetic Inhibitors of hHint1.
pubmed doi rcsb
source organism Homo sapiens
total genus 29
structure length 115
sequence length 115
chains with identical sequence B
ec nomenclature ec 3.-.-.-:
pdb deposition date 2016-02-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01230 HIT HIT domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.428.10 Alpha Beta 2-Layer Sandwich HIT family, subunit A HIT-like 5i2eA00
4NJZA 1ST4A 1ST0A 3L7XA 1HXPA 1XMLA 3LB5A 3OHEA 3O0MA 5IPBA 3SZQA 3O1XA 3WO5A 4EQHA 4NDFA 2FITA 5IPEA 3FITA 1FHIA 1XMMA 3OMFA 4FITA 4NJYA 4XBAA 3RHNA 5I2EA 5ED3A 4INIA 4ZKVA 4NJXA 2OIKA 4YKLB 1GUQA 4NDGA 3R6FA 4NDHA 1HXQA 3ANOA 1KPAA 2Q4LA 5IN3A 1Z84A 5CS2A 1KPFA 5RHNA 3P0TA 4ZKLA 2EO4A 1KPCA 4QEBA 1VLRA 4NDIA 3O1CA 1Y23A 3N1TA 6RHNA 3O1ZA 3BL9A 5IPCA 3KSVA 4INCA 1RZYA 4EQEA 4QDEA 6FITA 3BL7A 5ED6A 1KPBA 4QDVA 3OXKA 4RHNA 3QGZA 3N1SA 1FITA 4EGUA 2H39A 1EMSA 1AV5A 3I24A 3SPLA 3SPDA 3SP4A 1KPEA 2Q4HA 2FHIA 1GUPA 5FITA 5I2FA 5EMTA 4ZGLA 3TW2A 3I4SA 4NK0A 1ZWJA 3OJ7A 4EQGA 3NRDA 5BV3A 3BLAA 5IPDA 3IMIA
chains in the Genus database with same CATH superfamily
4NJZA 1ST4A 1ST0A 3L7XA 1HXPA 4I5TA 1XMLA 3LB5A 3OHEA 3O0MA 5IPBA 3SZQA 3O1XA 3WO5A 4EQHA 4NDFA 2FITA 5IPEA 3FITA 1FHIA 1L9VA 1XMMA 3OMFA 4FITA 4NJYA 4XBAA 3RHNA 5I2EA 5ED3A 4INIA 4ZKVA 4NJXA 2OIKA 4YKLB 1GUQA 4NDGA 2LJWA 3R6FA 4NDHA 1HXQA 3ANOA 1KPAA 2Q4LA 5IN3A 1Z84A 5CS2A 1KPFA 5RHNA 3P0TA 4I5VA 4ZKLA 2EO4A 1KPCA 4QEBA 1VLRA 4NDIA 2R7JA 1Y23A 3N1TA 3O1CA 6RHNA 3O1ZA 3BL9A 5IPCA 3KSVA 4INCA 1RZYA 4EQEA 4QDEA 6FITA 3BL7A 2GU0A 1KPBA 5ED6A 4QDVA 3OXKA 4RHNA 3QGZA 3N1SA 4G0AA 1FITA 4EGUA 2H39A 1EMSA 1AV5A 2R7CA 3I24A 3SPLA 2R8FA 3SPDA 3SP4A 1KPEA 2Q4HA 4G0JA 2FHIA 1GUPA 5FITA 5I2FA 5EMTA 4ZGLA 2POFA 3TW2A 2R7PA 3I4SA 4NK0A 1ZWJA 3OJ7A 4EQGA 3NRDA 4I5WA 5BV3A 3BLAA 5IPDA 3IMIA
chains in the Genus database with same CATH topology
4NJZA 1ST4A 1ST0A 3L7XA 1HXPA 1XMLA 3LB5A 3OHEA 3O0MA 5IPBA 3SZQA 3O1XA 3WO5A 4EQHA 4NDFA 2FITA 5IPEA 3FITA 1FHIA 1XMMA 3OMFA 4FITA 4NJYA 4XBAA 3RHNA 5I2EA 5ED3A 4INIA 4ZKVA 4NJXA 2OIKA 4YKLB 1GUQA 4NDGA 3R6FA 4NDHA 1HXQA 3ANOA 1KPAA 2Q4LA 5IN3A 1Z84A 5CS2A 1KPFA 5RHNA 3P0TA 4ZKLA 2EO4A 1KPCA 4QEBA 1VLRA 4NDIA 3O1CA 1Y23A 3N1TA 6RHNA 3O1ZA 3BL9A 5IPCA 3KSVA 4INCA 1RZYA 4EQEA 4QDEA 6FITA 3BL7A 5ED6A 1KPBA 4QDVA 3OXKA 4RHNA 3QGZA 3N1SA 1FITA 4EGUA 2H39A 1EMSA 1AV5A 3I24A 3SPLA 3SPDA 3SP4A 1KPEA 2Q4HA 2FHIA 1GUPA 5FITA 5I2FA 5EMTA 4ZGLA 3TW2A 3I4SA 4NK0A 1ZWJA 3OJ7A 4EQGA 3NRDA 5BV3A 3BLAA 5IPDA 3IMIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4NJZ A;  1ST4 A;  1ST0 A;  3L7X A;  1HXP A;  1XML A;  3LB5 A;  3OHE A;  3O0M A;  5IPB A;  3SZQ A;  3O1X A;  3WO5 A;  4EQH A;  4NDF A;  2FIT A;  5IPE A;  3FIT A;  1FHI A;  1XMM A;  3OMF A;  4FIT A;  4NJY A;  4XBA A;  3RHN A;  5I2E A;  5ED3 A;  4INI A;  4ZKV A;  4NJX A;  2OIK A;  4YKL B;  1GUQ A;  4NDG A;  3R6F A;  4NDH A;  1HXQ A;  3ANO A;  1KPA A;  2Q4L A;  5IN3 A;  1Z84 A;  5CS2 A;  1KPF A;  5RHN A;  3P0T A;  4ZKL A;  2EO4 A;  1KPC A;  4QEB A;  1VLR A;  4NDI A;  3O1C A;  1Y23 A;  3N1T A;  6RHN A;  3O1Z A;  3BL9 A;  5IPC A;  3KSV A;  4INC A;  1RZY A;  4EQE A;  4QDE A;  6FIT A;  3BL7 A;  5ED6 A;  1KPB A;  4QDV A;  3OXK A;  4RHN A;  3QGZ A;  3N1S A;  1FIT A;  4EGU A;  2H39 A;  1EMS A;  1AV5 A;  3I24 A;  3SPL A;  3SPD A;  3SP4 A;  1KPE A;  2Q4H A;  2FHI A;  1GUP A;  5FIT A;  5I2F A;  5EMT A;  4ZGL A;  3TW2 A;  3I4S A;  4NK0 A;  1ZWJ A;  3OJ7 A;  4EQG A;  3NRD A;  5BV3 A;  3BLA A;  5IPD A;  3IMI A; 
#chains in the Genus database with same CATH topology
 4NJZ A;  1ST4 A;  1ST0 A;  3L7X A;  1HXP A;  4I5T A;  1XML A;  3LB5 A;  3OHE A;  3O0M A;  5IPB A;  3SZQ A;  3O1X A;  3WO5 A;  4EQH A;  4NDF A;  2FIT A;  5IPE A;  3FIT A;  1FHI A;  1L9V A;  1XMM A;  3OMF A;  4FIT A;  4NJY A;  4XBA A;  3RHN A;  5I2E A;  5ED3 A;  4INI A;  4ZKV A;  4NJX A;  2OIK A;  4YKL B;  1GUQ A;  4NDG A;  2LJW A;  3R6F A;  4NDH A;  1HXQ A;  3ANO A;  1KPA A;  2Q4L A;  5IN3 A;  1Z84 A;  5CS2 A;  1KPF A;  5RHN A;  3P0T A;  4I5V A;  4ZKL A;  2EO4 A;  1KPC A;  4QEB A;  1VLR A;  4NDI A;  2R7J A;  1Y23 A;  3N1T A;  3O1C A;  6RHN A;  3O1Z A;  3BL9 A;  5IPC A;  3KSV A;  4INC A;  1RZY A;  4EQE A;  4QDE A;  6FIT A;  3BL7 A;  2GU0 A;  1KPB A;  5ED6 A;  4QDV A;  3OXK A;  4RHN A;  3QGZ A;  3N1S A;  4G0A A;  1FIT A;  4EGU A;  2H39 A;  1EMS A;  1AV5 A;  2R7C A;  3I24 A;  3SPL A;  2R8F A;  3SPD A;  3SP4 A;  1KPE A;  2Q4H A;  4G0J A;  2FHI A;  1GUP A;  5FIT A;  5I2F A;  5EMT A;  4ZGL A;  2POF A;  3TW2 A;  2R7P A;  3I4S A;  4NK0 A;  1ZWJ A;  3OJ7 A;  4EQG A;  3NRD A;  4I5W A;  5BV3 A;  3BLA A;  5IPD A;  3IMI A; 
#chains in the Genus database with same CATH homology
 4NJZ A;  1ST4 A;  1ST0 A;  3L7X A;  1HXP A;  1XML A;  3LB5 A;  3OHE A;  3O0M A;  5IPB A;  3SZQ A;  3O1X A;  3WO5 A;  4EQH A;  4NDF A;  2FIT A;  5IPE A;  3FIT A;  1FHI A;  1XMM A;  3OMF A;  4FIT A;  4NJY A;  4XBA A;  3RHN A;  5I2E A;  5ED3 A;  4INI A;  4ZKV A;  4NJX A;  2OIK A;  4YKL B;  1GUQ A;  4NDG A;  3R6F A;  4NDH A;  1HXQ A;  3ANO A;  1KPA A;  2Q4L A;  5IN3 A;  1Z84 A;  5CS2 A;  1KPF A;  5RHN A;  3P0T A;  4ZKL A;  2EO4 A;  1KPC A;  4QEB A;  1VLR A;  4NDI A;  3O1C A;  1Y23 A;  3N1T A;  6RHN A;  3O1Z A;  3BL9 A;  5IPC A;  3KSV A;  4INC A;  1RZY A;  4EQE A;  4QDE A;  6FIT A;  3BL7 A;  5ED6 A;  1KPB A;  4QDV A;  3OXK A;  4RHN A;  3QGZ A;  3N1S A;  1FIT A;  4EGU A;  2H39 A;  1EMS A;  1AV5 A;  3I24 A;  3SPL A;  3SPD A;  3SP4 A;  1KPE A;  2Q4H A;  2FHI A;  1GUP A;  5FIT A;  5I2F A;  5EMT A;  4ZGL A;  3TW2 A;  3I4S A;  4NK0 A;  1ZWJ A;  3OJ7 A;  4EQG A;  3NRD A;  5BV3 A;  3BLA A;  5IPD A;  3IMI A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...