|
57
|
164
|
8jc5A |
Crystal structure of plekhm1 run domain in complex with gtp-bound arl8b(q75l) |
|
61
|
164
|
8jcaA |
Cyrstal structure of skip run domain in complex with gtp-bound arl8b(q75l) |
|
60
|
178
|
8gi6A |
Small gtpase mutant arg |
|
59
|
179
|
8gi3A |
Small gtpase rhoa mutant 2 |
|
65
|
170
|
8t4vA |
Crystal structure of compound 1 bound to k-ras(g12d) |
|
50
|
178
|
8q0nC |
Hace1 in complex with rac1 q61l |
|
61
|
168
|
8un3A |
Kras-g13d-gdp in complex with cpd5 (1-((s)-10-(6-amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl)-11-chloro-7-(((2s,4r)-4-fluoro-1-methylpyrrolidin-2-yl)methoxy)-3,4,13,13a-tetrahydropyrazino[2',1':3,4][1,4]oxazepino[5,6,7-de]quinazolin-2(1h)-yl)prop-2-en-1-one) |
|
62
|
170
|
8un4A |
Kras-g13d-gdp in complex with cpd36 ((e)-1-((3s)-4-(7-(6-amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl)-6-chloro-8-fluoro-2-(((s)-2-methylenetetrahydro-1h-pyrrolizin-7a(5h)-yl)methoxy)quinazolin-4-yl)-3-methylpiperazin-1-yl)-3-(4-((dimethylamino)methyl)-5-methylpyridin-2-yl)prop-2-en-1-one) |
|
65
|
169
|
8un5A |
Kras-g13d-gdp in complex with cpd38 ((e)-1-((3s)-4-(7-(6-amino-4-methyl-3-(trifluoromethyl)pyridin-2-yl)-6-chloro-8-fluoro-2-(((s)-2-methylenetetrahydro-1h-pyrrolizin-7a(5h)-yl)methoxy)quinazolin-4-yl)-3-methylpiperazin-1-yl)-3-(1,2,3,4-tetrahydroisoquinolin-8-yl)prop-2-en-1-one) |
|
63
|
168
|
7rpzA |
Kras g12d in complex with mrtx-1133 |
|
35
|
177
|
6tgcC |
Cryoem structure of the ternary dock2-elmo1-rac1 complex. |
|
65
|
169
|
7ewbA |
Gdp-bound kras g12d in complex with th-z835 |
|
57
|
163
|
7dn8B |
Crystal structure of salmonella effector sopf in complex with arf1 |
|
64
|
169
|
7rt5A |
Crystal structure of kras g12d with compound 36 (4-[(1r,5s)-3,8-diazabicyclo[3.2.1]octan-3-yl]-7-(8-ethynyl-7-fluoronaphthalen-1-yl)-8-fluoro-2-{[(4s,7as)-tetrahydro-1h-pyrrolizin-7a(5h)-yl]methoxy}pyrido[4,3-d]pyrimidine) bound |
|
66
|
169
|
7rt2A |
Crystal structure of kras g12d with compound 25 (4-(4-[(1r,5s)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2r,4r,7as)-2-fluorotetrahydro-1h-pyrrolizin-7a(5h)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)naphthalen-2-ol) bound |
|
65
|
170
|
7rt4A |
Kras g12d in complex with compound 5b (7-(8-chloronaphthalen-1-yl)-8-fluoro-2-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}-4-(piperazin-1-yl)pyrido[4,3-d]pyrimidine) |
|
64
|
168
|
7rt3A |
Crystal structure of kras g12d with compound 24 (4-(4-[(1r,5s)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2s,4s,7ar)-2-fluorotetrahydro-1h-pyrrolizin-7a(5h)-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)naphthalen-2-ol) bound |
|
62
|
169
|
7rt1A |
Crystal structure of kras g12d with compound 15 (4-(4-[(1r,5s)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-{[(2s)-1-methylpyrrolidin-2-yl]methoxy}pyrido[4,3-d]pyrimidin-7-yl)naphthalen-2-ol) bound |
|
68
|
169
|
7t47A |
Kras g12d (gppcp) with mrtx-1133 |
|
57
|
170
|
7rp2A |
Crystal structure of kas g12c in complex with 2h11 clamp |
|
67
|
168
|
7ew9A |
Gdp-bound kras g12d in complex with th-z816 |
|
68
|
169
|
7ewaA |
Gdp-bound kras g12d in complex with th-z827 |
|
65
|
167
|
7rp3A |
Crystal structure of gne-1952 alkylated kras g12c in complex with 2h11 clamp |
|
64
|
183
|
7q9uAAA |
Crystal structure of the high affinity kras mutant pde6d complex |
|
64
|
166
|
7og9A |
Gtpase hras under ambient pressure |
|
64
|
166
|
7ogaA |
Gtpase hras under 200 mpa pressure |
|
62
|
166
|
7ogcA |
Gtpase hras under 650 mpa pressure |
|
60
|
166
|
7ogeA |
Gtpase hras mutant d33k under 200 mpa pressure |
|
59
|
166
|
7ogdA |
Gtpase hras mutant d33k under ambient pressure |
|
63
|
166
|
7ogbA |
Gtpase hras under 500 mpa pressure |
|
66
|
166
|
7ogfA |
Gtpase hras mutant d33k under 900 mpa pressure |
|
65
|
169
|
7lz5A |
Crystal structure of oncogenic kras q61e gmppcp-bound |
|
62
|
170
|
6ws2A |
Crystal structure of kras-k104q mutant, gdp-bound |
|
61
|
169
|
6ws4A |
Crystal structure of kras-g12d/k104q mutant, gdp-bound |
|
61
|
167
|
7mdpA |
Kras g12c in complex with g-2897 |
|
61
|
171
|
7kmrA |
Crystal structure analysis of human kras mutant |
|
60
|
169
|
7rp4A |
Crystal structure of kras g12c in complex with gne-1952 |
|
51
|
167
|
8t09B |
Co-crystal structure of krit1 with a 1-hydroxy 2-naphthaldehyde derivative (6-ethynyl-2-hydroxy-1-naphthaldehyde) |
|
52
|
161
|
7dn9B |
Crystal structure of salmonella effector in complex with nad and host co-factor arf1 |
|
57
|
166
|
7jigA |
Hras a59t gppnhp crystal 2 |
|
60
|
166
|
7jiiA |
Hras a59e gdp |
|
61
|
166
|
7jifA |
Hras a59t gppnhp |
|
53
|
166
|
7jihA |
Hras a59e gppnhp |
|
58
|
171
|
7f6jA |
Crystal structure of the pdzd8 coiled-coil domain - rab7 complex |
|
52
|
167
|
8su8B |
Co-crystal structure of krit1 with a 1-hydroxy 2-naphthaldehyde derivative (6-(furan-2-yl)-2-hydroxy-1-naphthaldehyde). |
|
36
|
166
|
8qvuA |
Crystal structure of ligand acbi3 in complex with kras g12d c118s gdp and pvhl:elonginc:elonginb complex |
|
61
|
170
|
8fjhB |
Crystal structure of rala in a covalent complex with sof-531 |
|
42
|
166
|
8qw7A |
Crystal structure of compound 4 in complex with kras g12v c118s gdp and pvhl:elonginc:elonginb |
|
61
|
170
|
8qu8F |
Protac-mediated complex of kras with vhl/elongin-b/elongin-c/cullin-2/rbx1 |
|
60
|
170
|
8fjiB |
Crystal structure of rala in a covalent complex with sof-367 |
