|
32
|
163
|
4d8kA |
Crystal structure of a sh3-sh2 domains of a lymphocyte-specific protein tyrosine kinase (lck) from homo sapiens at 2.36 a resolution |
|
58
|
151
|
4a55B |
Crystal structure of p110alpha in complex with ish2 of p85alpha and the inhibitor pik-108 |
|
24
|
96
|
3wa4A |
Grb2 sh2 domain/cd28-derived peptide complex |
|
117
|
447
|
3vs6A |
Crystal structure of hck complexed with a pyrazolo-pyrimidine inhibitor tert-butyl {4-[4-amino-1-(propan-2-yl)-1h-pyrazolo[3,4-d]pyrimidin-3-yl]-2-methoxyphenyl}carbamate |
|
116
|
447
|
3vs2A |
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor 7-[cis-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine |
|
122
|
447
|
3vryA |
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor 4-amino-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-7-yl-cyclopentane |
|
110
|
447
|
3vs4A |
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor 5-(4-phenoxyphenyl)-7-(tetrahydro-2h-pyran-4-yl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine |
|
123
|
447
|
3vs3A |
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor 7-[trans-4-(4-methylpiperazin-1-yl)cyclohexyl]-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine |
|
106
|
447
|
3vs7A |
Crystal structure of hck complexed with a pyrazolo-pyrimidine inhibitor 1-cyclopentyl-3-(1h-pyrrolo[2,3-b]pyridin-5-yl)-1h-pyrazolo[3,4-d]pyrimidin-4-amine |
|
109
|
447
|
3vs0A |
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor n-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]benzamide |
|
112
|
447
|
3vs1A |
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-phenylurea |
|
117
|
447
|
3vrzA |
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor 1-[4-(4-amino-7-cyclopentyl-7h-pyrrolo[2,3-d]pyrimidin-5-yl)phenyl]-3-benzylurea |
|
116
|
447
|
3vs5A |
Crystal structure of hck complexed with a pyrrolo-pyrimidine inhibitor 7-(1-methylpiperidin-4-yl)-5-(4-phenoxyphenyl)-7h-pyrrolo[2,3-d]pyrimidin-4-amine |
|
27
|
114
|
3uyoA |
Crystal structure of monobody sh13/abl1 sh2 domain complex |
|
21
|
97
|
3us4A |
Crystal structure of a sh2 domain of a megakaryocyte-associated tyrosine kinase (matk) from homo sapiens at 1.50 a resolution |
|
39
|
160
|
3uf4A |
Crystal structure of a sh3 and sh2 domains of fyn protein (proto-concogene tyrosine-protein kinase fyn) from mus musculus at 1.98 a resolution |
|
132
|
523
|
4y5wA |
Transcription factor-dna complex |
|
25
|
99
|
3tl0A |
Structure of shp2 n-sh2 domain in complex with rlnpyaqlwhr peptide |
|
23
|
100
|
3tkzA |
Structure of the shp-2 n-sh2 domain in a 1:2 complex with rvipyfvplnr peptide |
|
31
|
98
|
3t04A |
Crystal structure of monobody 7c12/abl1 sh2 domain complex |
|
22
|
101
|
3s8lA |
Protein-ligand interactions: thermodynamic effects associated with increasing hydrophobic surface area |
|
140
|
534
|
5xzrA |
The atomic structure of shp2 e76a mutant in complex with allosteric inhibitor 9b |
|
97
|
277
|
5xgiB |
Crystal structure of pi3k complex with an inhibitor |
|
100
|
278
|
5xgjB |
Crystal structure of pi3k complex with an inhibitor |
|
27
|
105
|
1nrvA |
Crystal structure of the sh2 domain of grb10 |
|
46
|
218
|
5x7bA |
Crystal structure of shp2_sh2-caga epiya_c peptide complex |
|
25
|
114
|
5w3rA |
Sh2b1 sh2 domain |
|
66
|
202
|
5vklA |
Spt6 tsh2-rpb1 1476-1500 ps1493 |
|
96
|
265
|
5ukjB |
The co-structure of n,n-dimethyl-4-[(6r)-6-methyl-5-(1h-pyrrolo[2,3- b]pyridin-4-yl)-4,5,6,7-tetrahydropyrazolo[1,5- a]pyrazin-3-yl]benzenesulfonamide and a rationally designed pi3k-alpha mutant that mimics atr |
|
102
|
265
|
5ul1B |
The co-structure of 3-amino-6-(4-((1-(dimethylamino)propan-2-yl)sulfonyl)phenyl)-n-phenylpyrazine-2-carboxamide and a rationally designed pi3k-alpha mutant that mimics atr |
|
95
|
267
|
5uk8B |
The co-structure of (r)-4-(6-(1-(cyclopropylsulfonyl)cyclopropyl)-2-(1h-indol-4-yl)pyrimidin-4-yl)-3-methylmorpholine and a rationally designed pi3k-alpha mutant that mimics atr |
|
29
|
100
|
5u1qA |
Grb7-sh2 with bicyclic peptide inhibitor |
|
27
|
107
|
5u06A |
Grb7-sh2 with bicyclic peptide inhibitor containing a py mimetic |
|
25
|
105
|
5tyiA |
Grb7 sh2 with bicyclic peptide containing py mimetic |
|
24
|
101
|
5tqsA |
Phospholipase c gamma-1 c-terminal sh2 domain bound to a phosphopeptide derived from the receptor tyrosine kinase erbb2 |
|
24
|
100
|
5tnwA |
Phospholipase c gamma-1 c-terminal sh2 domain |
|
28
|
101
|
5tq1A |
Phospholipase c gamma-1 c-terminal sh2 domain bound to a phosphopeptide derived from the insulin receptor |
|
24
|
99
|
5to4A |
Phospholipase c gamma-1 c-terminal sh2 domain, spacegroup p212121 |
|
64
|
270
|
5sxcB |
Crystal structure of pi3kalpha in complex with fragment 8 |
|
66
|
269
|
5sxbB |
Crystal structure of pi3kalpha in complex with fragment 23 |
|
74
|
270
|
5sxiB |
Crystal structure of pi3kalpha in complex with fragment 13 |
|
79
|
272
|
5swpB |
Crystal structure of pi3kalpha in complex with fragments 6 and 24 |
|
76
|
272
|
5swtB |
Crystal structure of pi3kalpha in complex with fragments 17 and 27 |
|
75
|
272
|
5sxdB |
Crystal structure of pi3kalpha in complex with fragment 22 |
|
64
|
271
|
5sxjB |
Crystal structure of pi3kalpha in complex with fragment 29 |
|
71
|
271
|
5sxeB |
Crystal structure of pi3kalpha in complex with fragments 19 and 28 |
|
75
|
272
|
5swrB |
Crystal structure of pi3kalpha in complex with fragments 20 and 26 |
|
73
|
271
|
5sx9B |
Crystal structure of pi3kalpha in complex with fragment 14 |
|
69
|
258
|
5sxfB |
Crystal structure of pi3kalpha in complex with fragment 9 |
|
82
|
272
|
5swoB |
Crystal structure of pi3kalpha in complex with fragments 4 and 19 |
