|
47
|
157
|
5ecxA |
Klebsiella pneumoniae dfra1 complexed with nadph and 6-ethyl-5-(3-(6-(pyridin-4-yl)benzo[d][1,3]dioxol-4-yl)but-1-yn-1-yl)pyrimidine-2,4-diamine |
|
45
|
159
|
5eajA |
Crystal structure of dhfr in 0% isopropanol |
|
40
|
159
|
5dfrA |
Crystal structure of unliganded escherichia coli dihydrofolate reductase. ligand-induced conformational changes and cooperativity in binding |
|
40
|
157
|
4xe6X |
Staphylococcus aureus dihydrofolate reductase complexed with nadph and 6-ethyl-5-[(3r)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (ucp1061) |
|
40
|
157
|
4xecX |
Staphylococcus aureus dihydrofolate reductase complexed with nadph and 6-ethyl-5-[(3r)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (ucp1061) |
|
44
|
159
|
4x5fA |
Ecdhfr complexed with folate and nadp+ at 0.1 mpa |
|
38
|
159
|
4x5jA |
Ecdhfr complexed with folate and nadp+ at 750 mpa |
|
43
|
159
|
4x5iA |
Ecdhfr complexed with folate and nadp+ at 660 mpa |
|
42
|
159
|
4x5gA |
Ecdhfr complexed with folate and nadp+ at 270 mpa |
|
44
|
159
|
4x5hA |
Ecdhfr complexed with folate and nadp+ at 500 mpa |
|
41
|
157
|
4tu5X |
Staphylococcus aureus dihydrofolate reductase complexed with nadph and 6-ethyl-5-[(3s)-3-[3-methoxy-5-(pyridin-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (ucp1062) |
|
56
|
206
|
4qjzD |
Pneumocystis carinii dihydrofolate reductase ternary complex with nadph and the inhibitor 24, (n~6~-methyl-n~6~-(naphthalen-1-yl)pyrido[2,3-d]pyrimidine-2,4,6-triamine) |
|
54
|
186
|
4qhvA |
Crystal structure of human dihydrofolate reductase as complex with pyridopyrimidine 22 (n~6~-methyl-n~6~-[4-(propan-2-yl)phenyl]pyrido[2,3-d]pyrimidine-2,4,6-triamine) |
|
50
|
186
|
4qjcA |
Human dihydrofolate reductase ternary complex with nadph and inhibitor 26 (n~6~-methyl-n~6~-(3,4,5-trifluorophenyl)pyrido[2,3-d]pyrimidine-2,4,6-triamine) |
|
43
|
159
|
4p68A |
Electrostatics of active site microenvironments for e. coli dhfr |
|
45
|
159
|
4pdjA |
Neutron crystal structure of e.coli dihydrofolate reductase complexed with folate and nadp+ |
|
41
|
159
|
4p66A |
Electrostatics of active site microenvironments of e. coli dhfr |
|
44
|
159
|
4nx6A |
Single room temperature model of dhfr |
|
44
|
159
|
4nx7A |
Single cryogenic temperature model of dhfr |
|
49
|
168
|
4m7vA |
Dihydrofolate reductase from enterococcus faecalis complexed with nadp(h)and rab-propyl |
|
54
|
186
|
4m6kA |
Crystal structure of human dihydrofolate reductase (dhfr) bound to nadp+ and folate |
|
49
|
170
|
4m7uA |
Dihydrofolate reductase from enterococcus faecalis complexed with nadp(h) |
|
53
|
184
|
4m6jA |
Crystal structure of human dihydrofolate reductase (dhfr) bound to nadph |
|
42
|
159
|
4m2xA |
Mycobacterium tuberculosis dihydrofolate reductase complexed with trimetrexate (tmq) |
|
53
|
186
|
4m6lA |
Crystal structure of human dihydrofolate reductase (dhfr) bound to nadp+ and 5,10-dideazatetrahydrofolic acid |
|
43
|
157
|
4laeX |
Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines |
|
43
|
157
|
4lagX |
Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines |
|
43
|
159
|
4kneA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis in complex with cycloguanil |
|
50
|
159
|
4kjkA |
Room temperature wt dhfr |
|
143
|
608
|
4ky4A |
Crystal structure of non-classical ts inhibitor 2 in complex with toxoplasma gondii ts-dhfr |
|
42
|
160
|
4kl9A |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis in the space group c2 |
|
51
|
186
|
4kd7A |
Human dihydrofolate reductase complexed with nadph and 5-{3-[3-methoxy-5(pyridine-4-yl)phenyl]prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4-diamine |
|
41
|
157
|
4lahX |
Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines |
|
46
|
161
|
4km0A |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis in complex with pyrimethamine |
|
43
|
157
|
4lekX |
Structure-based design of new dihydrofolate reductase antibacterial agents: 7-(benzimidazol-1-yl)-2,4-diaminoquinazolines |
|
50
|
160
|
4kjlA |
Room temperature n23pps148a dhfr |
|
42
|
159
|
4km2A |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis in an open conformation in complex with trimethoprim |
|
53
|
186
|
4kfjA |
Human dihydrofolate reductase complexed with nadph and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]prop-1-yn-1-yl}6-ethylprimidine-2,4-diamine |
|
43
|
161
|
4klxA |
Crystal structure of dihydrofolate reductase from mycobacterium tuberculosis in an open conformation. |
|
54
|
186
|
4kebA |
Human dihydrofolate reductase complexed with nadph and 5-{3-[3-methoxy-5-(isoquin-5-yl)phenyl]but-1-yn-1-yl}6-ethylpyrimidine-2,4-diamine |
|
55
|
186
|
4kakA |
Crystal structure of human dihydrofolate reductase complexed with nadph and 6-ethyl-5-[(3s)-3-[3-methoxy-5-(pyridine-4-yl)phenyl]but-1-yn-1-yl]pyrimidine-2,4-diamine (ucp1006) |
|
50
|
159
|
4kjjA |
Cryogenic wt dhfr |
|
53
|
186
|
4kbnA |
Human dihydrofolate reductase complexed with nadph and 5-{3-[3-(3,5-pyrimidine)]-phenyl-prop-1-yn-1-yl}-6-ethyl-pyrimidine-2,4diamine |
|
56
|
206
|
4ixfX |
Pcdhfr-269 f69n variant |
|
47
|
159
|
4i1nA |
R104a-ca1697 nanobody binding to the binary dhfr.folate complex |
|
57
|
206
|
4ixgX |
Pcdhfr-268-k37s-n69f variant |
|
46
|
159
|
4i13A |
Nanobody ca1697 binding to the dhfr.folate binary complex |
|
60
|
206
|
4ixeD |
Pcdhfr-nadph-270 |
|
59
|
192
|
4hoeA |
Candida albicans dihydrofolate reductase complexed with nadph and 5-[3-(2,5-dimethoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (ucp111e) |
|
58
|
192
|
4hofA |
Candida albicans dihydrofolate reductase complexed with nadph and 5-[3-(2-methoxy-4-phenylphenyl)but-1-yn-1-yl]-6-methylpyrimidine-2,4-diamine (ucp111h) |
