|
97
|
344
|
5bx0A |
An automated microscale thermophoresis screening approach for fragment-based lead discovery |
|
109
|
350
|
5bujA |
Erk2 complexed with a n-h tetrahydroazaindazole |
|
107
|
346
|
5byyA |
Erk5 in complex with small molecule |
|
109
|
348
|
5bueA |
Erk2 complexed with n-benzylpyridone tetrahydroazaindazole |
|
93
|
274
|
5c26A |
Crystal structure of syk in complex with compound 1 |
|
90
|
300
|
5b7vA |
Human fgfr1 kinase in complex with ch5183284 |
|
89
|
271
|
5bq0A |
Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with bms-824171 aka 6-[(3r)-3-(4-tert-bu tylbenzamido)piperidin-1-yl]-2-{[4-(morpholine-4-carbonyl) phenyl]amino}pyridine-3-carboxamide |
|
55
|
296
|
5b2mA |
A crucial role of cys218 in the stabilization of an unprecedented auto-inhibition form of map2k7 |
|
89
|
263
|
5bpyA |
Crystal structure of bruton agammaglobulinemia tyrosine kinase complexed with bms-824171 aka 6-[(3r)-3-(4-tert-bu tylbenzamido)piperidin-1-yl]-2-{[4-(morpholine-4-carbonyl) phenyl]amino}pyridine-3-carboxamide |
|
93
|
364
|
5bnjA |
Cdk8/cycc in complex with 8-{3-chloro-5-[4-(1-methyl-1h-pyrazol-4-yl)-phenyl]-pyridin- 4-yl}-2,8-diaza-spiro[4.5]decan-1-one |
|
92
|
291
|
5bmsA |
Crystal structure of p21-activated kinase 4 in complex with an inhibitor compound 29 |
|
93
|
300
|
5b2lA |
A crucial role of cys218 in the stabilization of an unprecedented auto-inhibition form of map2k7 |
|
75
|
262
|
5aadA |
Aurora a kinase bound to an imidazopyridine inhibitor (7a) |
|
99
|
292
|
5aepA |
Novel pyrrole carboxamide inhibitors of jak2 as potential treatment of myeloproliferative disorders |
|
89
|
276
|
5autA |
Crystal structure of dapk1 in complex with ans. |
|
97
|
309
|
5aa8A |
Structure of c1156y,l1198f mutant human anaplastic lymphoma kinase in complex with pf-06463922 ((10r)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile). |
|
88
|
276
|
5auuA |
Crystal structure of dapk1 in complex with luteolin. |
|
87
|
276
|
5av4A |
Crystal structure of dapk1-genistein complex in the presence of bromide ions. |
|
98
|
309
|
5a9uA |
Structure of c1156y mutant human anaplastic lymphoma kinase in complex with pf-06463922 ((10r)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile). |
|
82
|
270
|
5a6oA |
Crystal structure of the apo form of the unphosphorylated human death associated protein kinase 3 (dapk3) |
|
100
|
309
|
5aa9A |
Structure of l1198f mutant human anaplastic lymphoma kinase in complex with pf-06463922 ((10r)-7-amino-12-fluoro-2,10,16-trimethyl- 15-oxo-10,15,16,17-tetrahydro-2h-8,4-(metheno)pyrazolo(4,3-h)(2,5,11) benzoxadiazacyclotetradecine-3-carbonitrile). |
|
71
|
263
|
5aaeA |
Aurora a kinase bound to an imidazopyridine inhibitor (14d) |
|
72
|
262
|
5aagA |
Aurora a kinase bound to an imidazopyridine inhibitor (14b) |
|
86
|
302
|
5a46A |
Fgfr1 in complex with dovitinib |
|
112
|
347
|
5a54A |
Dyrk1a in complex with nitro benzothiazole fragment |
|
85
|
293
|
4zy4A |
Crystal structure of p21 activated kinase 1 in complex with an inhibitor compound 4 |
|
114
|
345
|
4zznA |
Human erk2 in complex with an inhibitor |
|
88
|
302
|
5a4cA |
Fgfr1 ligand complex |
|
120
|
347
|
5a4qA |
Dyrk1a in complex with chloro benzothiazole fragment |
|
111
|
345
|
4zzoA |
Human erk2 in complex with an irreversible inhibitor |
|
84
|
271
|
5a6nA |
Crystal structure of human death associated protein kinase 3 (dapk3) in complex with compound 2 |
|
80
|
292
|
4zy5A |
Crystal structure of p21-activated kinase 1 in complex with an inhibitor compound 17 |
|
109
|
347
|
5a4tA |
Dyrk1a in complex with nitrile benzothiazole fragment |
|
111
|
347
|
5a4lA |
Dyrk1a in complex with fluoro benzothiazole fragment |
|
109
|
347
|
5a4eA |
Dyrk1a in complex with methoxy benzothiazole fragment |
|
81
|
296
|
5a14A |
Human cdk2 with type ii inhibitor |
|
86
|
290
|
4hvgA |
Jak3 kinase domain in complex with 2-cyclopropyl-5h-pyrrolo[2,3-b]pyrazine-7-carboxylic acid ((s)-2-hydroxy-1,2-dimethyl-propyl)-amide |
|
94
|
301
|
4zsaA |
Crystal structure of fgfr1 kinase domain in complex with 7n |
|
98
|
298
|
4ztmA |
Irak4-inhibitor co-structure |
|
86
|
283
|
4zjvA |
Crystal structure of egfr kinase domain in complex with mitogen-inducible gene 6 protein |
|
77
|
294
|
4zloA |
Serine/threonine-protein kinase pak1 complexed with a dibenzodiazepine: identification of an allosteric site on pak1 |
|
104
|
402
|
4z7gA |
Crystal structure of human ire1 cytoplasmic kinase-rnase region - apo |
|
89
|
270
|
4zlyA |
Crystal structure of bruton's tyrosine kinase bound to a cinnoline fragment |
|
81
|
320
|
4zauA |
Azd9291 complex with wild type egfr |
|
90
|
270
|
4zlzA |
Crystal structure of bruton's tyrosine kinase in complex with a substituted cinnoline |
|
113
|
402
|
4z7hA |
Crystal structure of human ire1 cytoplasmic kinase-rnase region - complex with imidazopyridine compound 3 |
|
102
|
307
|
4z55A |
Anaplastic lymphoma kinase catalytic domain complexed with pyrazolopyrimidine derivative of ldk378 |
|
100
|
355
|
4yr8A |
Crystal structure of jnk in complex with a regulator protein |
|
98
|
289
|
4ytcA |
Discovery of vx-509 (decernotinib): a potent and selective janus kinase (jak) 3 inhibitor for the treatment of autoimmune disease |
|
99
|
289
|
4ytfA |
Discovery of vx-509 (decernotinib): a potent and selective janus kinase (jak) 3 inhibitor for the treatment of autoimmune diseases |
