1HCQA

The crystal structure of the estrogen receptor dna-binding domain bound to dna: how receptors discriminate between their response elements
Total Genus 15
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
15
sequence length
74
structure length
74
Chain Sequence
MKETRYCAVCNDYASGYHYGVWSCEGCKAFFKRSIQGHNDYMCPATNQCTIDKNRRKSCQACRLRKCYEVGMMK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The crystal structure of the estrogen receptor DNA-binding domain bound to DNA: how receptors discriminate between their response elements.
pubmed doi rcsb
molecule tags Transcription/dna
source organism Homo sapiens
molecule keywords DNA (5'-D(*CP*CP*AP*GP*GP*TP*CP*AP*CP*AP*GP*TP*GP*AP*CP*CP*T
total genus 15
structure length 74
sequence length 74
chains with identical sequence B, E, F
ec nomenclature
pdb deposition date 1995-01-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00105 zf-C4 Zinc finger, C4 type (two domains)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.50.10 Alpha Beta 2-Layer Sandwich Erythroid Transcription Factor GATA-1; Chain A Erythroid Transcription Factor GATA-1, subunit A 1hcqA00
4TNTA 1R4OA 6GATA 3DZYA 3M9EA 3DZYD 2EBLA 4OORA 3DFXA 1GNFA 5KRBB 5E69A 1LO1A 1HCQA 3G97A 5GATA 5E6BA 4AA6A 2KAEA 4HCAA 1R4IA 3DFVC 1LV3A 3G6RA 4HC7A 4HN5A 3DZUA 5E6AA 3DZUD 5CC1A 3G9IA 1R0NA 3E00A 3G6QA 1KB6A 3E00D 1GDCA 4CN5A 1YNWB 1HRAA 2HANA 4CN7A 2GATA 1RGDA 4NQAB 4OV7A 5CC0A 1RXRA 3VEKC 1KB2A 4OLNA 1DSZB 2NLLA 1R0OB 1A6YA 2M9WA 4IQRA 5EMPA 3G6PA 5L0MA 1GA5A 3G9OA 1LATA 2VUSI 1HLZA 5CBYA 3GATA 3FYLA 1BY4A 2C7AA 2A66A 4CN3A 4CN3D 1GAUA 2FF0A 1GLUA 1HCPA 5CBXA 3G8UA 3G6UA 4GATA 4ONDA 1CITA 1GATA 2ENVA 4TMAI 4HN6A 4CN2C 5E6CA 7GATA 2GDAA 1YNWA 2VUUI 1R0NB 3G9PA 3G6TA 1R4RA 4HC9A 2HANB 3G8XA 3G99A 5E6DA 3CBBA 5EMQA 3VD6C 2NLLB 1DSZA 1KB4A 3G9JA 2VUTI 1R0OA 5EMCA 5CBZA 3G9MA
chains in the Genus database with same CATH superfamily
4TNTA 1R4OA 6GATA 3DZYA 3M9EA 3DZYD 2EBLA 4OORA 3DFXA 1GNFA 5KRBB 5E69A 1LO1A 1HCQA 3G97A 5GATA 5E6BA 4AA6A 2KAEA 4HCAA 1R4IA 3DFVC 1LV3A 3G6RA 4HC7A 4HN5A 3DZUA 5E6AA 3DZUD 5CC1A 3G9IA 1R0NA 3E00A 3G6QA 1KB6A 3E00D 1GDCA 4CN5A 1YNWB 1HRAA 2HANA 4CN7A 2GATA 1RGDA 4NQAB 4OV7A 5CC0A 1RXRA 3VEKC 1KB2A 4OLNA 1DSZB 2NLLA 1R0OB 1A6YA 2M9WA 4IQRA 5EMPA 3G6PA 5L0MA 1GA5A 3G9OA 1LATA 2VUSI 1HLZA 5CBYA 3GATA 3FYLA 1BY4A 2C7AA 2A66A 4CN3A 4CN3D 1GAUA 2DS5A 2DS6A 1GLUA 2FF0A 1HCPA 5CBXA 3G8UA 3G6UA 4GATA 4ONDA 1CITA 1GATA 2ENVA 4TMAI 4HN6A 3G27A 4CN2C 5E6CA 7GATA 2GDAA 1YNWA 2VUUI 1R0NB 2DS8A 3G9PA 3G6TA 1R4RA 4HC9A 2HANB 3G8XA 3G99A 5E6DA 3CBBA 5EMQA 3VD6C 2NLLB 1DSZA 1KB4A 3G9JA 2VUTI 1R0OA 5EMCA 5CBZA 3G9MA
chains in the Genus database with same CATH topology
4TNTA 1R4OA 6GATA 3DZYA 3M9EA 3DZYD 2EBLA 4OORA 3DFXA 1GNFA 5KRBB 5E69A 1LO1A 1HCQA 3G97A 5GATA 5E6BA 4AA6A 2KAEA 4HCAA 1R4IA 3DFVC 1LV3A 3G6RA 4HC7A 4HN5A 3DZUA 5E6AA 3DZUD 5CC1A 3G9IA 1R0NA 3E00A 3G6QA 1KB6A 3E00D 1GDCA 4CN5A 1YNWB 1HRAA 2HANA 4CN7A 2GATA 1RGDA 4NQAB 4OV7A 5CC0A 1RXRA 3VEKC 1KB2A 4OLNA 1DSZB 2NLLA 1R0OB 1A6YA 2M9WA 4IQRA 5EMPA 3G6PA 5L0MA 1GA5A 3G9OA 1LATA 2VUSI 1HLZA 5CBYA 3GATA 3FYLA 1BY4A 2C7AA 2A66A 4CN3A 4CN3D 1GAUA 2FF0A 1GLUA 1HCPA 5CBXA 3G8UA 3G6UA 4GATA 4ONDA 1CITA 1GATA 2ENVA 4TMAI 4HN6A 4CN2C 5E6CA 7GATA 2GDAA 1YNWA 2VUUI 1R0NB 3G9PA 3G6TA 1R4RA 4HC9A 2HANB 3G8XA 3G99A 5E6DA 3CBBA 5EMQA 3VD6C 2NLLB 1DSZA 1KB4A 3G9JA 2VUTI 1R0OA 5EMCA 5CBZA 3G9MA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TNT A;  1R4O A;  6GAT A;  3DZY A;  3M9E A;  3DZY D;  2EBL A;  4OOR A;  3DFX A;  1GNF A;  5KRB B;  5E69 A;  1LO1 A;  1HCQ A;  3G97 A;  5GAT A;  5E6B A;  4AA6 A;  2KAE A;  4HCA A;  1R4I A;  3DFV C;  1LV3 A;  3G6R A;  4HC7 A;  4HN5 A;  3DZU A;  5E6A A;  3DZU D;  5CC1 A;  3G9I A;  1R0N A;  3E00 A;  3G6Q A;  1KB6 A;  3E00 D;  1GDC A;  4CN5 A;  1YNW B;  1HRA A;  2HAN A;  4CN7 A;  2GAT A;  1RGD A;  4NQA B;  4OV7 A;  5CC0 A;  1RXR A;  3VEK C;  1KB2 A;  4OLN A;  1DSZ B;  2NLL A;  1R0O B;  1A6Y A;  2M9W A;  4IQR A;  5EMP A;  3G6P A;  5L0M A;  1GA5 A;  3G9O A;  1LAT A;  2VUS I;  1HLZ A;  5CBY A;  3GAT A;  3FYL A;  1BY4 A;  2C7A A;  2A66 A;  4CN3 A;  4CN3 D;  1GAU A;  2FF0 A;  1GLU A;  1HCP A;  5CBX A;  3G8U A;  3G6U A;  4GAT A;  4OND A;  1CIT A;  1GAT A;  2ENV A;  4TMA I;  4HN6 A;  4CN2 C;  5E6C A;  7GAT A;  2GDA A;  1YNW A;  2VUU I;  1R0N B;  3G9P A;  3G6T A;  1R4R A;  4HC9 A;  2HAN B;  3G8X A;  3G99 A;  5E6D A;  3CBB A;  5EMQ A;  3VD6 C;  2NLL B;  1DSZ A;  1KB4 A;  3G9J A;  2VUT I;  1R0O A;  5EMC A;  5CBZ A;  3G9M A; 
#chains in the Genus database with same CATH topology
 4TNT A;  1R4O A;  6GAT A;  3DZY A;  3M9E A;  3DZY D;  2EBL A;  4OOR A;  3DFX A;  1GNF A;  5KRB B;  5E69 A;  1LO1 A;  1HCQ A;  3G97 A;  5GAT A;  5E6B A;  4AA6 A;  2KAE A;  4HCA A;  1R4I A;  3DFV C;  1LV3 A;  3G6R A;  4HC7 A;  4HN5 A;  3DZU A;  5E6A A;  3DZU D;  5CC1 A;  3G9I A;  1R0N A;  3E00 A;  3G6Q A;  1KB6 A;  3E00 D;  1GDC A;  4CN5 A;  1YNW B;  1HRA A;  2HAN A;  4CN7 A;  2GAT A;  1RGD A;  4NQA B;  4OV7 A;  5CC0 A;  1RXR A;  3VEK C;  1KB2 A;  4OLN A;  1DSZ B;  2NLL A;  1R0O B;  1A6Y A;  2M9W A;  4IQR A;  5EMP A;  3G6P A;  5L0M A;  1GA5 A;  3G9O A;  1LAT A;  2VUS I;  1HLZ A;  5CBY A;  3GAT A;  3FYL A;  1BY4 A;  2C7A A;  2A66 A;  4CN3 A;  4CN3 D;  1GAU A;  2DS5 A;  2DS6 A;  1GLU A;  2FF0 A;  1HCP A;  5CBX A;  3G8U A;  3G6U A;  4GAT A;  4OND A;  1CIT A;  1GAT A;  2ENV A;  4TMA I;  4HN6 A;  3G27 A;  4CN2 C;  5E6C A;  7GAT A;  2GDA A;  1YNW A;  2VUU I;  1R0N B;  2DS8 A;  3G9P A;  3G6T A;  1R4R A;  4HC9 A;  2HAN B;  3G8X A;  3G99 A;  5E6D A;  3CBB A;  5EMQ A;  3VD6 C;  2NLL B;  1DSZ A;  1KB4 A;  3G9J A;  2VUT I;  1R0O A;  5EMC A;  5CBZ A;  3G9M A; 
#chains in the Genus database with same CATH homology
 4TNT A;  1R4O A;  6GAT A;  3DZY A;  3M9E A;  3DZY D;  2EBL A;  4OOR A;  3DFX A;  1GNF A;  5KRB B;  5E69 A;  1LO1 A;  1HCQ A;  3G97 A;  5GAT A;  5E6B A;  4AA6 A;  2KAE A;  4HCA A;  1R4I A;  3DFV C;  1LV3 A;  3G6R A;  4HC7 A;  4HN5 A;  3DZU A;  5E6A A;  3DZU D;  5CC1 A;  3G9I A;  1R0N A;  3E00 A;  3G6Q A;  1KB6 A;  3E00 D;  1GDC A;  4CN5 A;  1YNW B;  1HRA A;  2HAN A;  4CN7 A;  2GAT A;  1RGD A;  4NQA B;  4OV7 A;  5CC0 A;  1RXR A;  3VEK C;  1KB2 A;  4OLN A;  1DSZ B;  2NLL A;  1R0O B;  1A6Y A;  2M9W A;  4IQR A;  5EMP A;  3G6P A;  5L0M A;  1GA5 A;  3G9O A;  1LAT A;  2VUS I;  1HLZ A;  5CBY A;  3GAT A;  3FYL A;  1BY4 A;  2C7A A;  2A66 A;  4CN3 A;  4CN3 D;  1GAU A;  2FF0 A;  1GLU A;  1HCP A;  5CBX A;  3G8U A;  3G6U A;  4GAT A;  4OND A;  1CIT A;  1GAT A;  2ENV A;  4TMA I;  4HN6 A;  4CN2 C;  5E6C A;  7GAT A;  2GDA A;  1YNW A;  2VUU I;  1R0N B;  3G9P A;  3G6T A;  1R4R A;  4HC9 A;  2HAN B;  3G8X A;  3G99 A;  5E6D A;  3CBB A;  5EMQ A;  3VD6 C;  2NLL B;  1DSZ A;  1KB4 A;  3G9J A;  2VUT I;  1R0O A;  5EMC A;  5CBZ A;  3G9M A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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