1YCQA

Xenopus laevis mdm2 bound to the transactivation domain of human p53
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
88
structure length
88
Chain Sequence
EKLVQPTPLLLSLLKSAGAQKETFTMKEVIYHLGQYIMAKQLYDEKQQHIVHCSNDPLGELFGVQEFSVKEPRRLYAMISRNLVSANV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of the MDM2 oncoprotein bound to the p53 tumor suppressor transactivation domain.
pubmed doi rcsb
molecule tags Complex (oncogene protein/peptide)
source organism Xenopus laevis
molecule keywords MDM2
total genus 30
structure length 88
sequence length 88
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 1996-09-30

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02201 SWIB SWIB/MDM2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.245.10 Mainly Alpha Orthogonal Bundle MDM2 SWIB/MDM2 domain 1ycqA00
5HMHA 4HG7A 2VYRA 4ODFA 4ZYCA 5LN2A 1V32A 4J3EA 4OGNA 4ZYFA 3W69A 2LZGA 1YCRA 2MPSA 3FEAA 4IPFA 4ZFIA 3TPXA 4JRGA 3DACA 4JV7A 3G03A 3JZKA 1RV1A 1Z1MA 4JWRA 4UMNA 4UE1A 4ZYIA 5LAZA 4LWTA 3U15A 3FDOA 5TRFA 4ZGKA 5HMIA 3LBJE 4WT2A 3VBGA 3JZQA 1UHRA 1T4EA 4JVRA 2RUHA 3TJ2A 3LNJA 3EQSA 4HBMA 4LWVA 5LAWA 4OBAA 5C5AA 4OGVA 4ERFA 3DABA 2N14A 3EQYA 3JZSA 4HFZA 2N0UA 5LAYA 3V3BA 3VZVA 5HMKA 3JZRA 4RXZA 1YCQA 3LBLA 4ODEA 5LAVA 4LWUA 4QO4A 4JVEA 4JSCA 2GV2A 3JZOA 1V31A 3LNZA 3IUXA 4J74A 3FE7A 2M86B 4N5TA 4UD7A 4MDNA 2N0WA 4J7DA 4OGTA 4MDQA 4JV9A 4QOCA 2Z5TM 4EREA 2Z5SM 4J7EA 3TU1A 5AFGA 2N06A 1T4FM 1TTVA 2AXIA 4OASA 4OQ3A 3JZPA 4OCCA 4DIJA 3LBKA 3IWYA 2MWYA
chains in the Genus database with same CATH superfamily
5HMHA 4HG7A 2VYRA 4ODFA 4ZYCA 5LN2A 1V32A 4J3EA 4OGNA 4ZYFA 3W69A 2LZGA 1YCRA 2MPSA 3FEAA 4IPFA 4ZFIA 3TPXA 4JRGA 3DACA 4JV7A 3G03A 3JZKA 1RV1A 1Z1MA 4JWRA 4UMNA 4UE1A 4ZYIA 5LAZA 4LWTA 3U15A 3FDOA 5TRFA 4ZGKA 5HMIA 3LBJE 4WT2A 3VBGA 3JZQA 1UHRA 1T4EA 4JVRA 2RUHA 3TJ2A 3LNJA 3EQSA 4HBMA 4LWVA 5LAWA 4OBAA 5C5AA 4OGVA 4ERFA 3DABA 2N14A 3EQYA 3JZSA 4HFZA 2N0UA 5LAYA 3V3BA 3VZVA 5HMKA 3JZRA 4RXZA 1YCQA 3LBLA 4ODEA 5LAVA 4LWUA 4QO4A 4JVEA 4JSCA 2GV2A 3JZOA 1V31A 3LNZA 3IUXA 4J74A 3FE7A 2M86B 4N5TA 4UD7A 4MDNA 2N0WA 4J7DA 4OGTA 4MDQA 4JV9A 4QOCA 2Z5TM 4EREA 2Z5SM 4J7EA 3TU1A 5AFGA 2N06A 1T4FM 1TTVA 2AXIA 4OASA 4OQ3A 3JZPA 4OCCA 4DIJA 3LBKA 3IWYA 2MWYA
chains in the Genus database with same CATH topology
5HMHA 4HG7A 2VYRA 4ODFA 4ZYCA 5LN2A 1V32A 4J3EA 4OGNA 4ZYFA 3W69A 2LZGA 1YCRA 2MPSA 3FEAA 4IPFA 4ZFIA 3TPXA 4JRGA 3DACA 4JV7A 3G03A 3JZKA 1RV1A 1Z1MA 4JWRA 4UMNA 4UE1A 4ZYIA 5LAZA 4LWTA 3U15A 3FDOA 5TRFA 4ZGKA 5HMIA 3LBJE 4WT2A 3VBGA 3JZQA 1UHRA 1T4EA 4JVRA 2RUHA 3TJ2A 3LNJA 3EQSA 4HBMA 4LWVA 5LAWA 4OBAA 5C5AA 4OGVA 4ERFA 3DABA 2N14A 3EQYA 3JZSA 4HFZA 2N0UA 5LAYA 3V3BA 3VZVA 5HMKA 3JZRA 4RXZA 1YCQA 3LBLA 4ODEA 5LAVA 4LWUA 4QO4A 4JVEA 4JSCA 2GV2A 3JZOA 1V31A 3LNZA 3IUXA 4J74A 3FE7A 2M86B 4N5TA 4UD7A 4MDNA 2N0WA 4J7DA 4OGTA 4MDQA 4JV9A 4QOCA 2Z5TM 4EREA 2Z5SM 4J7EA 3TU1A 5AFGA 2N06A 1T4FM 1TTVA 2AXIA 4OASA 4OQ3A 3JZPA 4OCCA 4DIJA 3LBKA 3IWYA 2MWYA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5HMH A;  4HG7 A;  2VYR A;  4ODF A;  4ZYC A;  5LN2 A;  1V32 A;  4J3E A;  4OGN A;  4ZYF A;  3W69 A;  2LZG A;  1YCR A;  2MPS A;  3FEA A;  4IPF A;  4ZFI A;  3TPX A;  4JRG A;  3DAC A;  4JV7 A;  3G03 A;  3JZK A;  1RV1 A;  1Z1M A;  4JWR A;  4UMN A;  4UE1 A;  4ZYI A;  5LAZ A;  4LWT A;  3U15 A;  3FDO A;  5TRF A;  4ZGK A;  5HMI A;  3LBJ E;  4WT2 A;  3VBG A;  3JZQ A;  1UHR A;  1T4E A;  4JVR A;  2RUH A;  3TJ2 A;  3LNJ A;  3EQS A;  4HBM A;  4LWV A;  5LAW A;  4OBA A;  5C5A A;  4OGV A;  4ERF A;  3DAB A;  2N14 A;  3EQY A;  3JZS A;  4HFZ A;  2N0U A;  5LAY A;  3V3B A;  3VZV A;  5HMK A;  3JZR A;  4RXZ A;  1YCQ A;  3LBL A;  4ODE A;  5LAV A;  4LWU A;  4QO4 A;  4JVE A;  4JSC A;  2GV2 A;  3JZO A;  1V31 A;  3LNZ A;  3IUX A;  4J74 A;  3FE7 A;  2M86 B;  4N5T A;  4UD7 A;  4MDN A;  2N0W A;  4J7D A;  4OGT A;  4MDQ A;  4JV9 A;  4QOC A;  2Z5T M;  4ERE A;  2Z5S M;  4J7E A;  3TU1 A;  5AFG A;  2N06 A;  1T4F M;  1TTV A;  2AXI A;  4OAS A;  4OQ3 A;  3JZP A;  4OCC A;  4DIJ A;  3LBK A;  3IWY A;  2MWY A; 
#chains in the Genus database with same CATH topology
 5HMH A;  4HG7 A;  2VYR A;  4ODF A;  4ZYC A;  5LN2 A;  1V32 A;  4J3E A;  4OGN A;  4ZYF A;  3W69 A;  2LZG A;  1YCR A;  2MPS A;  3FEA A;  4IPF A;  4ZFI A;  3TPX A;  4JRG A;  3DAC A;  4JV7 A;  3G03 A;  3JZK A;  1RV1 A;  1Z1M A;  4JWR A;  4UMN A;  4UE1 A;  4ZYI A;  5LAZ A;  4LWT A;  3U15 A;  3FDO A;  5TRF A;  4ZGK A;  5HMI A;  3LBJ E;  4WT2 A;  3VBG A;  3JZQ A;  1UHR A;  1T4E A;  4JVR A;  2RUH A;  3TJ2 A;  3LNJ A;  3EQS A;  4HBM A;  4LWV A;  5LAW A;  4OBA A;  5C5A A;  4OGV A;  4ERF A;  3DAB A;  2N14 A;  3EQY A;  3JZS A;  4HFZ A;  2N0U A;  5LAY A;  3V3B A;  3VZV A;  5HMK A;  3JZR A;  4RXZ A;  1YCQ A;  3LBL A;  4ODE A;  5LAV A;  4LWU A;  4QO4 A;  4JVE A;  4JSC A;  2GV2 A;  3JZO A;  1V31 A;  3LNZ A;  3IUX A;  4J74 A;  3FE7 A;  2M86 B;  4N5T A;  4UD7 A;  4MDN A;  2N0W A;  4J7D A;  4OGT A;  4MDQ A;  4JV9 A;  4QOC A;  2Z5T M;  4ERE A;  2Z5S M;  4J7E A;  3TU1 A;  5AFG A;  2N06 A;  1T4F M;  1TTV A;  2AXI A;  4OAS A;  4OQ3 A;  3JZP A;  4OCC A;  4DIJ A;  3LBK A;  3IWY A;  2MWY A; 
#chains in the Genus database with same CATH homology
 5HMH A;  4HG7 A;  2VYR A;  4ODF A;  4ZYC A;  5LN2 A;  1V32 A;  4J3E A;  4OGN A;  4ZYF A;  3W69 A;  2LZG A;  1YCR A;  2MPS A;  3FEA A;  4IPF A;  4ZFI A;  3TPX A;  4JRG A;  3DAC A;  4JV7 A;  3G03 A;  3JZK A;  1RV1 A;  1Z1M A;  4JWR A;  4UMN A;  4UE1 A;  4ZYI A;  5LAZ A;  4LWT A;  3U15 A;  3FDO A;  5TRF A;  4ZGK A;  5HMI A;  3LBJ E;  4WT2 A;  3VBG A;  3JZQ A;  1UHR A;  1T4E A;  4JVR A;  2RUH A;  3TJ2 A;  3LNJ A;  3EQS A;  4HBM A;  4LWV A;  5LAW A;  4OBA A;  5C5A A;  4OGV A;  4ERF A;  3DAB A;  2N14 A;  3EQY A;  3JZS A;  4HFZ A;  2N0U A;  5LAY A;  3V3B A;  3VZV A;  5HMK A;  3JZR A;  4RXZ A;  1YCQ A;  3LBL A;  4ODE A;  5LAV A;  4LWU A;  4QO4 A;  4JVE A;  4JSC A;  2GV2 A;  3JZO A;  1V31 A;  3LNZ A;  3IUX A;  4J74 A;  3FE7 A;  2M86 B;  4N5T A;  4UD7 A;  4MDN A;  2N0W A;  4J7D A;  4OGT A;  4MDQ A;  4JV9 A;  4QOC A;  2Z5T M;  4ERE A;  2Z5S M;  4J7E A;  3TU1 A;  5AFG A;  2N06 A;  1T4F M;  1TTV A;  2AXI A;  4OAS A;  4OQ3 A;  3JZP A;  4OCC A;  4DIJ A;  3LBK A;  3IWY A;  2MWY A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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