2MPSA

Structure of complex of mdm2(3-109) and p73 tad(10-25)
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
107
structure length
107
Chain Sequence
NTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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molecule tags Ligase/peptide
molecule keywords E3 ubiquitin-protein ligase Mdm2
publication title Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition
pubmed doi rcsb
source organism Homo sapiens
total genus 26
structure length 107
sequence length 107
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2014-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02201 SWIB SWIB/MDM2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.245.10 Mainly Alpha Orthogonal Bundle MDM2 SWIB/MDM2 domain 2mpsA00
4J74A 4ZGKA 2Z5TM 3JZSA 3U15A 3JZRA 5HMIA 2MWYA 4UD7A 5LAZA 5LAYA 4JVEA 5TRFA 3LNZA 3FEAA 4MDNA 1YCQA 2RUHA 3EQSA 3JZQA 2M86B 5HMHA 3TPXA 3IUXA 1TTVA 3LBKA 3LBLA 2N14A 5LAVA 2N06A 3VZVA 1V32A 2N0UA 4JVRA 4LWTA 4IPFA 4ODEA 4MDQA 3IWYA 4JWRA 1RV1A 4HG7A 3JZKA 3G03A 3TJ2A 1Z1MA 4OASA 3LBJE 4N5TA 2VYRA 4WT2A 4ODFA 2GV2A 3V3BA 3LNJA 3JZOA 4OCCA 4JV7A 4LWVA 1UHRA 5LN2A 4OGVA 4EREA 1YCRA 4J7EA 3W69A 4DIJA 2LZGA 2MPSA 4J7DA 4ZYIA 4ZYCA 4RXZA 3JZPA 4JV9A 1T4FM 4OGTA 2N0WA 3TU1A 4JSCA 4LWUA 3FE7A 3DACA 3DABA 4QO4A 3FDOA 4QOCA 2AXIA 5HMKA 5AFGA 5LAWA 3EQYA 4HFZA 4ZYFA 4UE1A 4OGNA 4JRGA 4OBAA 4ERFA 4J3EA 4OQ3A 3VBGA 2Z5SM 4UMNA 5C5AA 4HBMA 1V31A 1T4EA 4ZFIA
chains in the Genus database with same CATH superfamily
4J74A 4ZGKA 2Z5TM 3JZSA 3U15A 3JZRA 5HMIA 2MWYA 4UD7A 5LAZA 5LAYA 4JVEA 5TRFA 3LNZA 3FEAA 4MDNA 1YCQA 2RUHA 3EQSA 3JZQA 2M86B 5HMHA 3TPXA 3IUXA 1TTVA 3LBKA 3LBLA 2N14A 5LAVA 2N06A 3VZVA 1V32A 2N0UA 4JVRA 4LWTA 4IPFA 4ODEA 4MDQA 3IWYA 4JWRA 1RV1A 4HG7A 3JZKA 3G03A 3TJ2A 1Z1MA 4OASA 3LBJE 4N5TA 2VYRA 4WT2A 4ODFA 2GV2A 3V3BA 3LNJA 3JZOA 4OCCA 4JV7A 4LWVA 1UHRA 5LN2A 4OGVA 4EREA 1YCRA 4J7EA 3W69A 4DIJA 2LZGA 2MPSA 4J7DA 4ZYIA 4ZYCA 4RXZA 3JZPA 4JV9A 1T4FM 4OGTA 2N0WA 3TU1A 4JSCA 4LWUA 3FE7A 3DACA 3DABA 4QO4A 3FDOA 4QOCA 2AXIA 5HMKA 5AFGA 5LAWA 3EQYA 4HFZA 4ZYFA 4UE1A 4OGNA 4JRGA 4OBAA 4ERFA 4J3EA 4OQ3A 3VBGA 2Z5SM 4UMNA 5C5AA 4HBMA 1V31A 1T4EA 4ZFIA
chains in the Genus database with same CATH topology
4J74A 4ZGKA 2Z5TM 3JZSA 3U15A 3JZRA 5HMIA 2MWYA 4UD7A 5LAZA 5LAYA 4JVEA 5TRFA 3LNZA 3FEAA 4MDNA 1YCQA 2RUHA 3EQSA 3JZQA 2M86B 5HMHA 3TPXA 3IUXA 1TTVA 3LBKA 3LBLA 2N14A 5LAVA 2N06A 3VZVA 1V32A 2N0UA 4JVRA 4LWTA 4IPFA 4ODEA 4MDQA 3IWYA 4JWRA 1RV1A 4HG7A 3JZKA 3G03A 3TJ2A 1Z1MA 4OASA 3LBJE 4N5TA 2VYRA 4WT2A 4ODFA 2GV2A 3V3BA 3LNJA 3JZOA 4OCCA 4JV7A 4LWVA 1UHRA 5LN2A 4OGVA 4EREA 1YCRA 4J7EA 3W69A 4DIJA 2LZGA 2MPSA 4J7DA 4ZYIA 4ZYCA 4RXZA 3JZPA 4JV9A 1T4FM 4OGTA 2N0WA 3TU1A 4JSCA 4LWUA 3FE7A 3DACA 3DABA 4QO4A 3FDOA 4QOCA 2AXIA 5HMKA 5AFGA 5LAWA 3EQYA 4HFZA 4ZYFA 4UE1A 4OGNA 4JRGA 4OBAA 4ERFA 4J3EA 4OQ3A 3VBGA 2Z5SM 4UMNA 5C5AA 4HBMA 1V31A 1T4EA 4ZFIA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 4J74 A;  4ZGK A;  2Z5T M;  3JZS A;  3U15 A;  3JZR A;  5HMI A;  2MWY A;  4UD7 A;  5LAZ A;  5LAY A;  4JVE A;  5TRF A;  3LNZ A;  3FEA A;  4MDN A;  1YCQ A;  2RUH A;  3EQS A;  3JZQ A;  2M86 B;  5HMH A;  3TPX A;  3IUX A;  1TTV A;  3LBK A;  3LBL A;  2N14 A;  5LAV A;  2N06 A;  3VZV A;  1V32 A;  2N0U A;  4JVR A;  4LWT A;  4IPF A;  4ODE A;  4MDQ A;  3IWY A;  4JWR A;  1RV1 A;  4HG7 A;  3JZK A;  3G03 A;  3TJ2 A;  1Z1M A;  4OAS A;  3LBJ E;  4N5T A;  2VYR A;  4WT2 A;  4ODF A;  2GV2 A;  3V3B A;  3LNJ A;  3JZO A;  4OCC A;  4JV7 A;  4LWV A;  1UHR A;  5LN2 A;  4OGV A;  4ERE A;  1YCR A;  4J7E A;  3W69 A;  4DIJ A;  2LZG A;  2MPS A;  4J7D A;  4ZYI A;  4ZYC A;  4RXZ A;  3JZP A;  4JV9 A;  1T4F M;  4OGT A;  2N0W A;  3TU1 A;  4JSC A;  4LWU A;  3FE7 A;  3DAC A;  3DAB A;  4QO4 A;  3FDO A;  4QOC A;  2AXI A;  5HMK A;  5AFG A;  5LAW A;  3EQY A;  4HFZ A;  4ZYF A;  4UE1 A;  4OGN A;  4JRG A;  4OBA A;  4ERF A;  4J3E A;  4OQ3 A;  3VBG A;  2Z5S M;  4UMN A;  5C5A A;  4HBM A;  1V31 A;  1T4E A;  4ZFI A; 
#chains in the Genus database with same CATH topology
 4J74 A;  4ZGK A;  2Z5T M;  3JZS A;  3U15 A;  3JZR A;  5HMI A;  2MWY A;  4UD7 A;  5LAZ A;  5LAY A;  4JVE A;  5TRF A;  3LNZ A;  3FEA A;  4MDN A;  1YCQ A;  2RUH A;  3EQS A;  3JZQ A;  2M86 B;  5HMH A;  3TPX A;  3IUX A;  1TTV A;  3LBK A;  3LBL A;  2N14 A;  5LAV A;  2N06 A;  3VZV A;  1V32 A;  2N0U A;  4JVR A;  4LWT A;  4IPF A;  4ODE A;  4MDQ A;  3IWY A;  4JWR A;  1RV1 A;  4HG7 A;  3JZK A;  3G03 A;  3TJ2 A;  1Z1M A;  4OAS A;  3LBJ E;  4N5T A;  2VYR A;  4WT2 A;  4ODF A;  2GV2 A;  3V3B A;  3LNJ A;  3JZO A;  4OCC A;  4JV7 A;  4LWV A;  1UHR A;  5LN2 A;  4OGV A;  4ERE A;  1YCR A;  4J7E A;  3W69 A;  4DIJ A;  2LZG A;  2MPS A;  4J7D A;  4ZYI A;  4ZYC A;  4RXZ A;  3JZP A;  4JV9 A;  1T4F M;  4OGT A;  2N0W A;  3TU1 A;  4JSC A;  4LWU A;  3FE7 A;  3DAC A;  3DAB A;  4QO4 A;  3FDO A;  4QOC A;  2AXI A;  5HMK A;  5AFG A;  5LAW A;  3EQY A;  4HFZ A;  4ZYF A;  4UE1 A;  4OGN A;  4JRG A;  4OBA A;  4ERF A;  4J3E A;  4OQ3 A;  3VBG A;  2Z5S M;  4UMN A;  5C5A A;  4HBM A;  1V31 A;  1T4E A;  4ZFI A; 
#chains in the Genus database with same CATH homology
 4J74 A;  4ZGK A;  2Z5T M;  3JZS A;  3U15 A;  3JZR A;  5HMI A;  2MWY A;  4UD7 A;  5LAZ A;  5LAY A;  4JVE A;  5TRF A;  3LNZ A;  3FEA A;  4MDN A;  1YCQ A;  2RUH A;  3EQS A;  3JZQ A;  2M86 B;  5HMH A;  3TPX A;  3IUX A;  1TTV A;  3LBK A;  3LBL A;  2N14 A;  5LAV A;  2N06 A;  3VZV A;  1V32 A;  2N0U A;  4JVR A;  4LWT A;  4IPF A;  4ODE A;  4MDQ A;  3IWY A;  4JWR A;  1RV1 A;  4HG7 A;  3JZK A;  3G03 A;  3TJ2 A;  1Z1M A;  4OAS A;  3LBJ E;  4N5T A;  2VYR A;  4WT2 A;  4ODF A;  2GV2 A;  3V3B A;  3LNJ A;  3JZO A;  4OCC A;  4JV7 A;  4LWV A;  1UHR A;  5LN2 A;  4OGV A;  4ERE A;  1YCR A;  4J7E A;  3W69 A;  4DIJ A;  2LZG A;  2MPS A;  4J7D A;  4ZYI A;  4ZYC A;  4RXZ A;  3JZP A;  4JV9 A;  1T4F M;  4OGT A;  2N0W A;  3TU1 A;  4JSC A;  4LWU A;  3FE7 A;  3DAC A;  3DAB A;  4QO4 A;  3FDO A;  4QOC A;  2AXI A;  5HMK A;  5AFG A;  5LAW A;  3EQY A;  4HFZ A;  4ZYF A;  4UE1 A;  4OGN A;  4JRG A;  4OBA A;  4ERF A;  4J3E A;  4OQ3 A;  3VBG A;  2Z5S M;  4UMN A;  5C5A A;  4HBM A;  1V31 A;  1T4E A;  4ZFI A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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