2AAGA

Crystal structures of the wild-type, mutant-p1a and inactivated malonate semialdehyde decarboxylase: a structural basis for the decarboxylase and hydratase activities
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
129
structure length
129
Chain Sequence
PLLKFDLFYGRTDAQIKSLLDAAHGAMVDAFGVPANDRYQTVSQHRPGEMVLEDTGLGYGRSSAVVLLTVISRPRSEEQKVCFYKLLTGALERDCGISPDDVIVALVENSDADWSFGRGRAEFLTGDLV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of the Wild-Type, P1A Mutant, and Inactivated Malonate Semialdehyde Decarboxylase: A Structural Basis for the Decarboxylase and Hydratase Activities
pubmed doi rcsb
molecule tags Lyase
source organism Pseudomonas pavonaceae
molecule keywords Malonate Semialdehyde Decarboxylase
total genus 38
structure length 129
sequence length 129
chains with identical sequence B, C, D, E, F
ec nomenclature ec 4.1.1.-:
pdb deposition date 2005-07-13

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF14552 Tautomerase_2 Tautomerase enzyme
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.429.10 Alpha Beta 2-Layer Sandwich Macrophage Migration Inhibitory Factor Macrophage Migration Inhibitory Factor 2aagA00
2OOWA 1GCZA 3T5SA 4GRQA 4TRUA 4Z1TA 2GDGA 3RF5A 4F2KA 3M21A 3FWUA 4GRRA 1P1GA 3MJZA 3ABFA 4OTCA 1BJPA 3WNSA 2OS5A 5BSJA 1MFIA 3SMCA 5J7QA 2OOZA 3JSGA 4P01A 4XX7A 3N4GA 3MB2A 3SMBA 4WR8A 1LJTA 1GYXA 2AAJA 3L5TA 3M20A 3RY0A 4GRUA 4OYQA 5B4OA 3CE4A 3EJ7B 4U5PA 2FM7A 2WKBA 4FAZA 3U18A 3GACA 2OPAA 5BSIA 2AALA 1OTGA 4JJ9A 2WKFA 2OP8A 4LHOA 5EIZA 4P7SA 3WNTA 1GYYA 3JTUA 2FLZA 2XCZA 3N4HA 2FLTA 4FDXA 4OSFA 4GROA 4WRBA 1S0YA 1U9DA 3MLCA 3L5UA 4GRNA 4NWQB 3N4DA 1DPTA 3IJJA 3EJ3A 3EJ7A 2OOHA 4X19A 5BS9A 3B64A 1MIFA 2X4KA 5J7PA 4P7MA 4Z1UA 1CGQA 5CLNA 1FIMA 3EJ9B 4OTBA 1OTFA 1HFOA 4XX8A 3KERA 4X1CC 3MB2B 3DJIA 5BSCA 4EVGA 4GUMA 3IJGA 3L5VA 3MF8A 4DH4A 4P0HA 3FWTA 3WNRA 4PKZA 3L5SA 1GIFA 4OTAA 4PKKA 5HVSA 4PLUA 3MF7A 4Q3FA 4Z15A 3HOFA 3E6QA 2WKFB 3KANA 4GRPA 3RF4A 1UIZA 2ORMA 4JCUA 1GD0A 4ETGA 3B9SA 4U5RA 3DJHA 2AAGA 3EJ9A 3GADA 1S0YB 4LHPA 1MWWA 3L5PA 3C6VA 4EUIA 4X1CA 4LKBA 5CLOA 4K9GA 1MFFA 3EJ3B 4M1AA 4TRFA 1CA7A 3L5RA 1GYJA 4NWPE 5HVVA 3JSFA 5HVTA
chains in the Genus database with same CATH superfamily
2OOWA 1GCZA 3T5SA 4GRQA 4TRUA 4Z1TA 2GDGA 3RF5A 4F2KA 3M21A 3FWUA 4GRRA 1P1GA 3MJZA 3ABFA 4OTCA 1BJPA 3WNSA 2OS5A 5BSJA 1MFIA 3SMCA 5J7QA 2OOZA 3JSGA 4P01A 4XX7A 3N4GA 3MB2A 3SMBA 4WR8A 1LJTA 1GYXA 2AAJA 3L5TA 3M20A 3RY0A 4GRUA 4OYQA 5B4OA 3CE4A 3EJ7B 4U5PA 2FM7A 2WKBA 4FAZA 3U18A 3GACA 2OPAA 5BSIA 2AALA 1OTGA 4JJ9A 2WKFA 2OP8A 4LHOA 5EIZA 4P7SA 3WNTA 1GYYA 3JTUA 2FLZA 2XCZA 3N4HA 2FLTA 4FDXA 4OSFA 4GROA 4WRBA 1S0YA 1U9DA 3MLCA 3L5UA 4GRNA 4NWQB 3N4DA 1DPTA 3IJJA 3EJ3A 3EJ7A 2OOHA 4X19A 5BS9A 3B64A 1MIFA 2X4KA 5J7PA 4P7MA 4Z1UA 1CGQA 5CLNA 1FIMA 3EJ9B 4OTBA 1OTFA 1HFOA 4XX8A 3KERA 4X1CC 3MB2B 3DJIA 5BSCA 4EVGA 4GUMA 3IJGA 3L5VA 3MF8A 4DH4A 4P0HA 3FWTA 3WNRA 4PKZA 3L5SA 1GIFA 4OTAA 4PKKA 5HVSA 4PLUA 3MF7A 4Q3FA 4Z15A 3HOFA 3E6QA 2WKFB 3KANA 4GRPA 3RF4A 1UIZA 2ORMA 4JCUA 1GD0A 4ETGA 3B9SA 4U5RA 3DJHA 2AAGA 3EJ9A 3GADA 1S0YB 4LHPA 1MWWA 3L5PA 3C6VA 4EUIA 4X1CA 4LKBA 5CLOA 4K9GA 1MFFA 3EJ3B 4M1AA 4TRFA 1CA7A 3L5RA 1GYJA 4NWPE 5HVVA 3JSFA 5HVTA
chains in the Genus database with same CATH topology
2OOWA 1GCZA 3T5SA 4GRQA 4TRUA 4Z1TA 2GDGA 3RF5A 4F2KA 3M21A 3FWUA 4GRRA 1P1GA 3MJZA 3ABFA 4OTCA 1BJPA 3WNSA 2OS5A 5BSJA 1MFIA 3SMCA 5J7QA 2OOZA 3JSGA 4P01A 4XX7A 3N4GA 3MB2A 3SMBA 4WR8A 1LJTA 1GYXA 2AAJA 3L5TA 3M20A 3RY0A 4GRUA 4OYQA 5B4OA 3CE4A 3EJ7B 4U5PA 2FM7A 2WKBA 4FAZA 3U18A 3GACA 2OPAA 5BSIA 2AALA 1OTGA 4JJ9A 2WKFA 2OP8A 4LHOA 5EIZA 4P7SA 3WNTA 1GYYA 3JTUA 2FLZA 2XCZA 3N4HA 2FLTA 4FDXA 4OSFA 4GROA 4WRBA 1S0YA 1U9DA 3MLCA 3L5UA 4GRNA 4NWQB 3N4DA 1DPTA 3IJJA 3EJ3A 3EJ7A 2OOHA 4X19A 5BS9A 3B64A 1MIFA 2X4KA 5J7PA 4P7MA 4Z1UA 1CGQA 5CLNA 1FIMA 3EJ9B 4OTBA 1OTFA 1HFOA 4XX8A 3KERA 4X1CC 3MB2B 3DJIA 5BSCA 4EVGA 4GUMA 3IJGA 3L5VA 3MF8A 4DH4A 4P0HA 3FWTA 3WNRA 4PKZA 3L5SA 1GIFA 4OTAA 4PKKA 5HVSA 4PLUA 3MF7A 4Q3FA 4Z15A 3HOFA 3E6QA 2WKFB 3KANA 4GRPA 3RF4A 1UIZA 2ORMA 4JCUA 1GD0A 4ETGA 3B9SA 4U5RA 3DJHA 2AAGA 3EJ9A 3GADA 1S0YB 4LHPA 1MWWA 3L5PA 3C6VA 4EUIA 4X1CA 4LKBA 5CLOA 4K9GA 1MFFA 3EJ3B 4M1AA 4TRFA 1CA7A 3L5RA 1GYJA 4NWPE 5HVVA 3JSFA 5HVTA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2OOW A;  1GCZ A;  3T5S A;  4GRQ A;  4TRU A;  4Z1T A;  2GDG A;  3RF5 A;  4F2K A;  3M21 A;  3FWU A;  4GRR A;  1P1G A;  3MJZ A;  3ABF A;  4OTC A;  1BJP A;  3WNS A;  2OS5 A;  5BSJ A;  1MFI A;  3SMC A;  5J7Q A;  2OOZ A;  3JSG A;  4P01 A;  4XX7 A;  3N4G A;  3MB2 A;  3SMB A;  4WR8 A;  1LJT A;  1GYX A;  2AAJ A;  3L5T A;  3M20 A;  3RY0 A;  4GRU A;  4OYQ A;  5B4O A;  3CE4 A;  3EJ7 B;  4U5P A;  2FM7 A;  2WKB A;  4FAZ A;  3U18 A;  3GAC A;  2OPA A;  5BSI A;  2AAL A;  1OTG A;  4JJ9 A;  2WKF A;  2OP8 A;  4LHO A;  5EIZ A;  4P7S A;  3WNT A;  1GYY A;  3JTU A;  2FLZ A;  2XCZ A;  3N4H A;  2FLT A;  4FDX A;  4OSF A;  4GRO A;  4WRB A;  1S0Y A;  1U9D A;  3MLC A;  3L5U A;  4GRN A;  4NWQ B;  3N4D A;  1DPT A;  3IJJ A;  3EJ3 A;  3EJ7 A;  2OOH A;  4X19 A;  5BS9 A;  3B64 A;  1MIF A;  2X4K A;  5J7P A;  4P7M A;  4Z1U A;  1CGQ A;  5CLN A;  1FIM A;  3EJ9 B;  4OTB A;  1OTF A;  1HFO A;  4XX8 A;  3KER A;  4X1C C;  3MB2 B;  3DJI A;  5BSC A;  4EVG A;  4GUM A;  3IJG A;  3L5V A;  3MF8 A;  4DH4 A;  4P0H A;  3FWT A;  3WNR A;  4PKZ A;  3L5S A;  1GIF A;  4OTA A;  4PKK A;  5HVS A;  4PLU A;  3MF7 A;  4Q3F A;  4Z15 A;  3HOF A;  3E6Q A;  2WKF B;  3KAN A;  4GRP A;  3RF4 A;  1UIZ A;  2ORM A;  4JCU A;  1GD0 A;  4ETG A;  3B9S A;  4U5R A;  3DJH A;  2AAG A;  3EJ9 A;  3GAD A;  1S0Y B;  4LHP A;  1MWW A;  3L5P A;  3C6V A;  4EUI A;  4X1C A;  4LKB A;  5CLO A;  4K9G A;  1MFF A;  3EJ3 B;  4M1A A;  4TRF A;  1CA7 A;  3L5R A;  1GYJ A;  4NWP E;  5HVV A;  3JSF A;  5HVT A; 
#chains in the Genus database with same CATH topology
 2OOW A;  1GCZ A;  3T5S A;  4GRQ A;  4TRU A;  4Z1T A;  2GDG A;  3RF5 A;  4F2K A;  3M21 A;  3FWU A;  4GRR A;  1P1G A;  3MJZ A;  3ABF A;  4OTC A;  1BJP A;  3WNS A;  2OS5 A;  5BSJ A;  1MFI A;  3SMC A;  5J7Q A;  2OOZ A;  3JSG A;  4P01 A;  4XX7 A;  3N4G A;  3MB2 A;  3SMB A;  4WR8 A;  1LJT A;  1GYX A;  2AAJ A;  3L5T A;  3M20 A;  3RY0 A;  4GRU A;  4OYQ A;  5B4O A;  3CE4 A;  3EJ7 B;  4U5P A;  2FM7 A;  2WKB A;  4FAZ A;  3U18 A;  3GAC A;  2OPA A;  5BSI A;  2AAL A;  1OTG A;  4JJ9 A;  2WKF A;  2OP8 A;  4LHO A;  5EIZ A;  4P7S A;  3WNT A;  1GYY A;  3JTU A;  2FLZ A;  2XCZ A;  3N4H A;  2FLT A;  4FDX A;  4OSF A;  4GRO A;  4WRB A;  1S0Y A;  1U9D A;  3MLC A;  3L5U A;  4GRN A;  4NWQ B;  3N4D A;  1DPT A;  3IJJ A;  3EJ3 A;  3EJ7 A;  2OOH A;  4X19 A;  5BS9 A;  3B64 A;  1MIF A;  2X4K A;  5J7P A;  4P7M A;  4Z1U A;  1CGQ A;  5CLN A;  1FIM A;  3EJ9 B;  4OTB A;  1OTF A;  1HFO A;  4XX8 A;  3KER A;  4X1C C;  3MB2 B;  3DJI A;  5BSC A;  4EVG A;  4GUM A;  3IJG A;  3L5V A;  3MF8 A;  4DH4 A;  4P0H A;  3FWT A;  3WNR A;  4PKZ A;  3L5S A;  1GIF A;  4OTA A;  4PKK A;  5HVS A;  4PLU A;  3MF7 A;  4Q3F A;  4Z15 A;  3HOF A;  3E6Q A;  2WKF B;  3KAN A;  4GRP A;  3RF4 A;  1UIZ A;  2ORM A;  4JCU A;  1GD0 A;  4ETG A;  3B9S A;  4U5R A;  3DJH A;  2AAG A;  3EJ9 A;  3GAD A;  1S0Y B;  4LHP A;  1MWW A;  3L5P A;  3C6V A;  4EUI A;  4X1C A;  4LKB A;  5CLO A;  4K9G A;  1MFF A;  3EJ3 B;  4M1A A;  4TRF A;  1CA7 A;  3L5R A;  1GYJ A;  4NWP E;  5HVV A;  3JSF A;  5HVT A; 
#chains in the Genus database with same CATH homology
 2OOW A;  1GCZ A;  3T5S A;  4GRQ A;  4TRU A;  4Z1T A;  2GDG A;  3RF5 A;  4F2K A;  3M21 A;  3FWU A;  4GRR A;  1P1G A;  3MJZ A;  3ABF A;  4OTC A;  1BJP A;  3WNS A;  2OS5 A;  5BSJ A;  1MFI A;  3SMC A;  5J7Q A;  2OOZ A;  3JSG A;  4P01 A;  4XX7 A;  3N4G A;  3MB2 A;  3SMB A;  4WR8 A;  1LJT A;  1GYX A;  2AAJ A;  3L5T A;  3M20 A;  3RY0 A;  4GRU A;  4OYQ A;  5B4O A;  3CE4 A;  3EJ7 B;  4U5P A;  2FM7 A;  2WKB A;  4FAZ A;  3U18 A;  3GAC A;  2OPA A;  5BSI A;  2AAL A;  1OTG A;  4JJ9 A;  2WKF A;  2OP8 A;  4LHO A;  5EIZ A;  4P7S A;  3WNT A;  1GYY A;  3JTU A;  2FLZ A;  2XCZ A;  3N4H A;  2FLT A;  4FDX A;  4OSF A;  4GRO A;  4WRB A;  1S0Y A;  1U9D A;  3MLC A;  3L5U A;  4GRN A;  4NWQ B;  3N4D A;  1DPT A;  3IJJ A;  3EJ3 A;  3EJ7 A;  2OOH A;  4X19 A;  5BS9 A;  3B64 A;  1MIF A;  2X4K A;  5J7P A;  4P7M A;  4Z1U A;  1CGQ A;  5CLN A;  1FIM A;  3EJ9 B;  4OTB A;  1OTF A;  1HFO A;  4XX8 A;  3KER A;  4X1C C;  3MB2 B;  3DJI A;  5BSC A;  4EVG A;  4GUM A;  3IJG A;  3L5V A;  3MF8 A;  4DH4 A;  4P0H A;  3FWT A;  3WNR A;  4PKZ A;  3L5S A;  1GIF A;  4OTA A;  4PKK A;  5HVS A;  4PLU A;  3MF7 A;  4Q3F A;  4Z15 A;  3HOF A;  3E6Q A;  2WKF B;  3KAN A;  4GRP A;  3RF4 A;  1UIZ A;  2ORM A;  4JCU A;  1GD0 A;  4ETG A;  3B9S A;  4U5R A;  3DJH A;  2AAG A;  3EJ9 A;  3GAD A;  1S0Y B;  4LHP A;  1MWW A;  3L5P A;  3C6V A;  4EUI A;  4X1C A;  4LKB A;  5CLO A;  4K9G A;  1MFF A;  3EJ3 B;  4M1A A;  4TRF A;  1CA7 A;  3L5R A;  1GYJ A;  4NWP E;  5HVV A;  3JSF A;  5HVT A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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