2MLMA

Solution structure of sortase a from s. aureus in complex with benzo[d]isothiazol-3-one based inhibitor
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
148
structure length
148
Chain Sequence
MQAKPQIPKDKSKVAGYIEIPDADIKEPVYPGPATPEQLNRGVSFAEENESLDDQNISIAGHTFIDRPNYQFTNLKAAKKGSMVYFKVGNETRKYKMTSIRDVKPTDVEVLDEQKGKDKQLTLITCDDYNEKTGVWEKRKIFVATEVK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Discovery and structure-activity relationship studies of irreversible benzisothiazolinone-based inhibitors against Staphylococcus aureus sortase A transpeptidase.
pubmed doi rcsb
molecule tags Hydrolase/hydrolase inhibitor
source organism Staphylococcus aureus
molecule keywords Sortase family protein
total genus 27
structure length 148
sequence length 148
ec nomenclature
pdb deposition date 2014-03-03
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.40.260.10 Mainly Beta Beta Barrel Sortase; Chain: A; Sortase 2mlmA00
2W1KA 4G1HA 3FN5A 1QX6A 1NG5A 4D7WA 5GO5A 5GYJA 3RCCA 3G69A 2LN7A 3TB7A 5B23A 2XWGA 4O8TA 4O8LA 5JCVA 3PSQA 5CUWA 3TBEA 1T2PA 4G1JA 1IJAA 4UX7A 1QWZA 1T2OA 3RBJA 2OQZA 2RUIA 2KIDA 3FN7A 3RE9A 2W1JA 2MLMA 2WTSA 2OQWA 2KW8A 4O8LB 1QXAA 1RZ2A 5K9AA 3O0PA 3RBIA 4Y4QA 4D70A 4LFDA 3RBKA 3G66A 3FN6A 1T2WA
chains in the Genus database with same CATH superfamily
2W1KA 4G1HA 3FN5A 1QX6A 1NG5A 4D7WA 5GO5A 5GYJA 3RCCA 3G69A 2LN7A 3TB7A 5B23A 2XWGA 4O8TA 4O8LA 5JCVA 3PSQA 5CUWA 3TBEA 1T2PA 4G1JA 1IJAA 4UX7A 1QWZA 1T2OA 3RBJA 2OQZA 2RUIA 2KIDA 3FN7A 3RE9A 2W1JA 2MLMA 2WTSA 2OQWA 2KW8A 4O8LB 1QXAA 1RZ2A 5K9AA 3O0PA 3RBIA 4Y4QA 4D70A 4LFDA 3RBKA 3G66A 3FN6A 1T2WA
chains in the Genus database with same CATH topology
2W1KA 4G1HA 3FN5A 1QX6A 1NG5A 4D7WA 5GO5A 5GYJA 3RCCA 3G69A 2LN7A 3TB7A 5B23A 2XWGA 4O8TA 4O8LA 5JCVA 3PSQA 5CUWA 3TBEA 1T2PA 4G1JA 1IJAA 4UX7A 1QWZA 1T2OA 3RBJA 2OQZA 2RUIA 2KIDA 3FN7A 3RE9A 2W1JA 2MLMA 2WTSA 2OQWA 2KW8A 4O8LB 1QXAA 1RZ2A 5K9AA 3O0PA 3RBIA 4Y4QA 4D70A 4LFDA 3RBKA 3G66A 3FN6A 1T2WA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2W1K A;  4G1H A;  3FN5 A;  1QX6 A;  1NG5 A;  4D7W A;  5GO5 A;  5GYJ A;  3RCC A;  3G69 A;  2LN7 A;  3TB7 A;  5B23 A;  2XWG A;  4O8T A;  4O8L A;  5JCV A;  3PSQ A;  5CUW A;  3TBE A;  1T2P A;  4G1J A;  1IJA A;  4UX7 A;  1QWZ A;  1T2O A;  3RBJ A;  2OQZ A;  2RUI A;  2KID A;  3FN7 A;  3RE9 A;  2W1J A;  2MLM A;  2WTS A;  2OQW A;  2KW8 A;  4O8L B;  1QXA A;  1RZ2 A;  5K9A A;  3O0P A;  3RBI A;  4Y4Q A;  4D70 A;  4LFD A;  3RBK A;  3G66 A;  3FN6 A;  1T2W A; 
#chains in the Genus database with same CATH topology
 2W1K A;  4G1H A;  3FN5 A;  1QX6 A;  1NG5 A;  4D7W A;  5GO5 A;  5GYJ A;  3RCC A;  3G69 A;  2LN7 A;  3TB7 A;  5B23 A;  2XWG A;  4O8T A;  4O8L A;  5JCV A;  3PSQ A;  5CUW A;  3TBE A;  1T2P A;  4G1J A;  1IJA A;  4UX7 A;  1QWZ A;  1T2O A;  3RBJ A;  2OQZ A;  2RUI A;  2KID A;  3FN7 A;  3RE9 A;  2W1J A;  2MLM A;  2WTS A;  2OQW A;  2KW8 A;  4O8L B;  1QXA A;  1RZ2 A;  5K9A A;  3O0P A;  3RBI A;  4Y4Q A;  4D70 A;  4LFD A;  3RBK A;  3G66 A;  3FN6 A;  1T2W A; 
#chains in the Genus database with same CATH homology
 2W1K A;  4G1H A;  3FN5 A;  1QX6 A;  1NG5 A;  4D7W A;  5GO5 A;  5GYJ A;  3RCC A;  3G69 A;  2LN7 A;  3TB7 A;  5B23 A;  2XWG A;  4O8T A;  4O8L A;  5JCV A;  3PSQ A;  5CUW A;  3TBE A;  1T2P A;  4G1J A;  1IJA A;  4UX7 A;  1QWZ A;  1T2O A;  3RBJ A;  2OQZ A;  2RUI A;  2KID A;  3FN7 A;  3RE9 A;  2W1J A;  2MLM A;  2WTS A;  2OQW A;  2KW8 A;  4O8L B;  1QXA A;  1RZ2 A;  5K9A A;  3O0P A;  3RBI A;  4Y4Q A;  4D70 A;  4LFD A;  3RBK A;  3G66 A;  3FN6 A;  1T2W A; 
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similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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