2MPSA

Structure of complex of mdm2(3-109) and p73 tad(10-25)
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
107
structure length
107
Chain Sequence
NTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition
pubmed doi rcsb
molecule tags Ligase/peptide
source organism Homo sapiens
molecule keywords E3 ubiquitin-protein ligase Mdm2
total genus 26
structure length 107
sequence length 107
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2014-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02201 SWIB SWIB/MDM2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.245.10 Mainly Alpha Orthogonal Bundle MDM2 SWIB/MDM2 domain 2mpsA00
1T4EA 4N5TA 4OGVA 4JVEA 5LN2A 2N06A 4OASA 3EQYA 2RUHA 2GV2A 4IPFA 3FEAA 5HMIA 3DABA 2VYRA 4J74A 4ODFA 4LWTA 5HMHA 4JRGA 5LAZA 4JVRA 4HG7A 2Z5SM 3DACA 3W69A 1YCQA 5LAYA 5LAVA 4OGNA 3TU1A 3JZSA 4WT2A 3V3BA 4DIJA 4OBAA 4ZGKA 4HBMA 3LBLA 3LNJA 2N14A 4UD7A 3JZOA 3EQSA 1YCRA 2Z5TM 1TTVA 1Z1MA 3FDOA 4QO4A 4RXZA 2LZGA 3JZQA 4LWUA 3JZKA 4JWRA 5TRFA 4ODEA 5HMKA 3FE7A 4J7EA 3JZPA 4J3EA 3VZVA 4HFZA 4LWVA 4EREA 4ERFA 4UMNA 3LBKA 3G03A 3IWYA 5AFGA 4ZFIA 2MWYA 1V31A 4J7DA 4JV9A 3VBGA 4JSCA 2N0WA 4ZYFA 3U15A 4MDQA 4ZYCA 3TPXA 4MDNA 4OGTA 3JZRA 1RV1A 2M86B 2N0UA 2AXIA 4QOCA 4UE1A 3TJ2A 3IUXA 3LNZA 4JV7A 1T4FM 3LBJE 1V32A 4OCCA 4OQ3A 4ZYIA 2MPSA 5C5AA 1UHRA 5LAWA
chains in the Genus database with same CATH superfamily
1T4EA 4N5TA 4OGVA 4JVEA 5LN2A 2N06A 4OASA 3EQYA 2RUHA 2GV2A 4IPFA 3FEAA 5HMIA 3DABA 2VYRA 4J74A 4ODFA 4LWTA 5HMHA 4JRGA 5LAZA 4JVRA 4HG7A 2Z5SM 3DACA 3W69A 1YCQA 5LAYA 5LAVA 4OGNA 3TU1A 3JZSA 4WT2A 3V3BA 4DIJA 4OBAA 4ZGKA 4HBMA 3LBLA 3LNJA 2N14A 4UD7A 3JZOA 3EQSA 1YCRA 2Z5TM 1TTVA 1Z1MA 3FDOA 4QO4A 4RXZA 2LZGA 3JZQA 4LWUA 3JZKA 4JWRA 5TRFA 4ODEA 5HMKA 3FE7A 4J7EA 3JZPA 4J3EA 3VZVA 4HFZA 4LWVA 4EREA 4ERFA 4UMNA 3LBKA 3G03A 3IWYA 5AFGA 4ZFIA 2MWYA 1V31A 4J7DA 4JV9A 3VBGA 4JSCA 2N0WA 4ZYFA 3U15A 4MDQA 4ZYCA 3TPXA 4MDNA 4OGTA 3JZRA 1RV1A 2M86B 2N0UA 2AXIA 4QOCA 4UE1A 3TJ2A 3IUXA 3LNZA 4JV7A 1T4FM 3LBJE 1V32A 4OCCA 4OQ3A 4ZYIA 2MPSA 5C5AA 1UHRA 5LAWA
chains in the Genus database with same CATH topology
1T4EA 4N5TA 4OGVA 4JVEA 5LN2A 2N06A 4OASA 3EQYA 2RUHA 2GV2A 4IPFA 3FEAA 5HMIA 3DABA 2VYRA 4J74A 4ODFA 4LWTA 5HMHA 4JRGA 5LAZA 4JVRA 4HG7A 2Z5SM 3DACA 3W69A 1YCQA 5LAYA 5LAVA 4OGNA 3TU1A 3JZSA 4WT2A 3V3BA 4DIJA 4OBAA 4ZGKA 4HBMA 3LBLA 3LNJA 2N14A 4UD7A 3JZOA 3EQSA 1YCRA 2Z5TM 1TTVA 1Z1MA 3FDOA 4QO4A 4RXZA 2LZGA 3JZQA 4LWUA 3JZKA 4JWRA 5TRFA 4ODEA 5HMKA 3FE7A 4J7EA 3JZPA 4J3EA 3VZVA 4HFZA 4LWVA 4EREA 4ERFA 4UMNA 3LBKA 3G03A 3IWYA 5AFGA 4ZFIA 2MWYA 1V31A 4J7DA 4JV9A 3VBGA 4JSCA 2N0WA 4ZYFA 3U15A 4MDQA 4ZYCA 3TPXA 4MDNA 4OGTA 3JZRA 1RV1A 2M86B 2N0UA 2AXIA 4QOCA 4UE1A 3TJ2A 3IUXA 3LNZA 4JV7A 1T4FM 3LBJE 1V32A 4OCCA 4OQ3A 4ZYIA 2MPSA 5C5AA 1UHRA 5LAWA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1T4E A;  4N5T A;  4OGV A;  4JVE A;  5LN2 A;  2N06 A;  4OAS A;  3EQY A;  2RUH A;  2GV2 A;  4IPF A;  3FEA A;  5HMI A;  3DAB A;  2VYR A;  4J74 A;  4ODF A;  4LWT A;  5HMH A;  4JRG A;  5LAZ A;  4JVR A;  4HG7 A;  2Z5S M;  3DAC A;  3W69 A;  1YCQ A;  5LAY A;  5LAV A;  4OGN A;  3TU1 A;  3JZS A;  4WT2 A;  3V3B A;  4DIJ A;  4OBA A;  4ZGK A;  4HBM A;  3LBL A;  3LNJ A;  2N14 A;  4UD7 A;  3JZO A;  3EQS A;  1YCR A;  2Z5T M;  1TTV A;  1Z1M A;  3FDO A;  4QO4 A;  4RXZ A;  2LZG A;  3JZQ A;  4LWU A;  3JZK A;  4JWR A;  5TRF A;  4ODE A;  5HMK A;  3FE7 A;  4J7E A;  3JZP A;  4J3E A;  3VZV A;  4HFZ A;  4LWV A;  4ERE A;  4ERF A;  4UMN A;  3LBK A;  3G03 A;  3IWY A;  5AFG A;  4ZFI A;  2MWY A;  1V31 A;  4J7D A;  4JV9 A;  3VBG A;  4JSC A;  2N0W A;  4ZYF A;  3U15 A;  4MDQ A;  4ZYC A;  3TPX A;  4MDN A;  4OGT A;  3JZR A;  1RV1 A;  2M86 B;  2N0U A;  2AXI A;  4QOC A;  4UE1 A;  3TJ2 A;  3IUX A;  3LNZ A;  4JV7 A;  1T4F M;  3LBJ E;  1V32 A;  4OCC A;  4OQ3 A;  4ZYI A;  2MPS A;  5C5A A;  1UHR A;  5LAW A; 
#chains in the Genus database with same CATH topology
 1T4E A;  4N5T A;  4OGV A;  4JVE A;  5LN2 A;  2N06 A;  4OAS A;  3EQY A;  2RUH A;  2GV2 A;  4IPF A;  3FEA A;  5HMI A;  3DAB A;  2VYR A;  4J74 A;  4ODF A;  4LWT A;  5HMH A;  4JRG A;  5LAZ A;  4JVR A;  4HG7 A;  2Z5S M;  3DAC A;  3W69 A;  1YCQ A;  5LAY A;  5LAV A;  4OGN A;  3TU1 A;  3JZS A;  4WT2 A;  3V3B A;  4DIJ A;  4OBA A;  4ZGK A;  4HBM A;  3LBL A;  3LNJ A;  2N14 A;  4UD7 A;  3JZO A;  3EQS A;  1YCR A;  2Z5T M;  1TTV A;  1Z1M A;  3FDO A;  4QO4 A;  4RXZ A;  2LZG A;  3JZQ A;  4LWU A;  3JZK A;  4JWR A;  5TRF A;  4ODE A;  5HMK A;  3FE7 A;  4J7E A;  3JZP A;  4J3E A;  3VZV A;  4HFZ A;  4LWV A;  4ERE A;  4ERF A;  4UMN A;  3LBK A;  3G03 A;  3IWY A;  5AFG A;  4ZFI A;  2MWY A;  1V31 A;  4J7D A;  4JV9 A;  3VBG A;  4JSC A;  2N0W A;  4ZYF A;  3U15 A;  4MDQ A;  4ZYC A;  3TPX A;  4MDN A;  4OGT A;  3JZR A;  1RV1 A;  2M86 B;  2N0U A;  2AXI A;  4QOC A;  4UE1 A;  3TJ2 A;  3IUX A;  3LNZ A;  4JV7 A;  1T4F M;  3LBJ E;  1V32 A;  4OCC A;  4OQ3 A;  4ZYI A;  2MPS A;  5C5A A;  1UHR A;  5LAW A; 
#chains in the Genus database with same CATH homology
 1T4E A;  4N5T A;  4OGV A;  4JVE A;  5LN2 A;  2N06 A;  4OAS A;  3EQY A;  2RUH A;  2GV2 A;  4IPF A;  3FEA A;  5HMI A;  3DAB A;  2VYR A;  4J74 A;  4ODF A;  4LWT A;  5HMH A;  4JRG A;  5LAZ A;  4JVR A;  4HG7 A;  2Z5S M;  3DAC A;  3W69 A;  1YCQ A;  5LAY A;  5LAV A;  4OGN A;  3TU1 A;  3JZS A;  4WT2 A;  3V3B A;  4DIJ A;  4OBA A;  4ZGK A;  4HBM A;  3LBL A;  3LNJ A;  2N14 A;  4UD7 A;  3JZO A;  3EQS A;  1YCR A;  2Z5T M;  1TTV A;  1Z1M A;  3FDO A;  4QO4 A;  4RXZ A;  2LZG A;  3JZQ A;  4LWU A;  3JZK A;  4JWR A;  5TRF A;  4ODE A;  5HMK A;  3FE7 A;  4J7E A;  3JZP A;  4J3E A;  3VZV A;  4HFZ A;  4LWV A;  4ERE A;  4ERF A;  4UMN A;  3LBK A;  3G03 A;  3IWY A;  5AFG A;  4ZFI A;  2MWY A;  1V31 A;  4J7D A;  4JV9 A;  3VBG A;  4JSC A;  2N0W A;  4ZYF A;  3U15 A;  4MDQ A;  4ZYC A;  3TPX A;  4MDN A;  4OGT A;  3JZR A;  1RV1 A;  2M86 B;  2N0U A;  2AXI A;  4QOC A;  4UE1 A;  3TJ2 A;  3IUX A;  3LNZ A;  4JV7 A;  1T4F M;  3LBJ E;  1V32 A;  4OCC A;  4OQ3 A;  4ZYI A;  2MPS A;  5C5A A;  1UHR A;  5LAW A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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