2MPSA

Structure of complex of mdm2(3-109) and p73 tad(10-25)
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
107
structure length
107
Chain Sequence
NTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition
pubmed doi rcsb
molecule keywords E3 ubiquitin-protein ligase Mdm2
molecule tags Ligase/peptide
source organism Homo sapiens
total genus 26
structure length 107
sequence length 107
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2014-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02201 SWIB SWIB/MDM2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.245.10 Mainly Alpha Orthogonal Bundle MDM2 SWIB/MDM2 domain 2mpsA00
3TPXA 4JRGA 3DACA 1V32A 4JWRA 1YCQA 4JVRA 1Z1MA 4ERFA 1T4FM 3EQSA 5AFGA 1TTVA 4OQ3A 3G03A 2Z5SM 2N0WA 4OGNA 3TU1A 2N06A 1YCRA 4J74A 3IWYA 4OBAA 3LNJA 4JVEA 3V3BA 4LWUA 4HG7A 4J7DA 5LAVA 3LBKA 2N0UA 3FDOA 4HBMA 4OASA 4QO4A 4MDQA 4ODFA 5HMIA 5HMKA 3FE7A 3LBJE 4JV9A 3JZRA 3LBLA 4UE1A 2Z5TM 4IPFA 4DIJA 2RUHA 4J7EA 3W69A 4QOCA 5HMHA 2GV2A 3JZKA 3TJ2A 2N14A 5C5AA 5LAZA 1RV1A 2M86B 4UMNA 3JZQA 4LWVA 3JZOA 4OCCA 1UHRA 1T4EA 4MDNA 3JZPA 3IUXA 3VBGA 5LAYA 4N5TA 3DABA 4ZFIA 5LN2A 4JV7A 1V31A 4HFZA 3EQYA 4WT2A 4UD7A 4ZGKA 4JSCA 3VZVA 4RXZA 3U15A 3LNZA 4OGVA 5LAWA 4LWTA 2MPSA 4ZYFA 2VYRA 4J3EA 4ZYCA 4ODEA 2AXIA 3JZSA 3FEAA 5TRFA 4ZYIA 2MWYA 4EREA 2LZGA 4OGTA
chains in the Genus database with same CATH superfamily
3TPXA 4JRGA 3DACA 1V32A 4JWRA 1YCQA 4JVRA 1Z1MA 4ERFA 1T4FM 3EQSA 5AFGA 1TTVA 4OQ3A 3G03A 2Z5SM 2N0WA 4OGNA 3TU1A 2N06A 1YCRA 4J74A 3IWYA 4OBAA 3LNJA 4JVEA 3V3BA 4LWUA 4HG7A 4J7DA 5LAVA 3LBKA 2N0UA 3FDOA 4HBMA 4OASA 4QO4A 4MDQA 4ODFA 5HMIA 5HMKA 3FE7A 3LBJE 4JV9A 3JZRA 3LBLA 4UE1A 2Z5TM 4IPFA 4DIJA 2RUHA 4J7EA 3W69A 4QOCA 5HMHA 2GV2A 3JZKA 3TJ2A 2N14A 5C5AA 5LAZA 1RV1A 2M86B 4UMNA 3JZQA 4LWVA 3JZOA 4OCCA 1UHRA 1T4EA 4MDNA 3JZPA 3IUXA 3VBGA 5LAYA 4N5TA 3DABA 4ZFIA 5LN2A 4JV7A 1V31A 4HFZA 3EQYA 4WT2A 4UD7A 4ZGKA 4JSCA 3VZVA 4RXZA 3U15A 3LNZA 4OGVA 5LAWA 4LWTA 2MPSA 4ZYFA 2VYRA 4J3EA 4ZYCA 4ODEA 2AXIA 3JZSA 3FEAA 5TRFA 4ZYIA 2MWYA 4EREA 2LZGA 4OGTA
chains in the Genus database with same CATH topology
3TPXA 4JRGA 3DACA 1V32A 4JWRA 1YCQA 4JVRA 1Z1MA 4ERFA 1T4FM 3EQSA 5AFGA 1TTVA 4OQ3A 3G03A 2Z5SM 2N0WA 4OGNA 3TU1A 2N06A 1YCRA 4J74A 3IWYA 4OBAA 3LNJA 4JVEA 3V3BA 4LWUA 4HG7A 4J7DA 5LAVA 3LBKA 2N0UA 3FDOA 4HBMA 4OASA 4QO4A 4MDQA 4ODFA 5HMIA 5HMKA 3FE7A 3LBJE 4JV9A 3JZRA 3LBLA 4UE1A 2Z5TM 4IPFA 4DIJA 2RUHA 4J7EA 3W69A 4QOCA 5HMHA 2GV2A 3JZKA 3TJ2A 2N14A 5C5AA 5LAZA 1RV1A 2M86B 4UMNA 3JZQA 4LWVA 3JZOA 4OCCA 1UHRA 1T4EA 4MDNA 3JZPA 3IUXA 3VBGA 5LAYA 4N5TA 3DABA 4ZFIA 5LN2A 4JV7A 1V31A 4HFZA 3EQYA 4WT2A 4UD7A 4ZGKA 4JSCA 3VZVA 4RXZA 3U15A 3LNZA 4OGVA 5LAWA 4LWTA 2MPSA 4ZYFA 2VYRA 4J3EA 4ZYCA 4ODEA 2AXIA 3JZSA 3FEAA 5TRFA 4ZYIA 2MWYA 4EREA 2LZGA 4OGTA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 3TPX A;  4JRG A;  3DAC A;  1V32 A;  4JWR A;  1YCQ A;  4JVR A;  1Z1M A;  4ERF A;  1T4F M;  3EQS A;  5AFG A;  1TTV A;  4OQ3 A;  3G03 A;  2Z5S M;  2N0W A;  4OGN A;  3TU1 A;  2N06 A;  1YCR A;  4J74 A;  3IWY A;  4OBA A;  3LNJ A;  4JVE A;  3V3B A;  4LWU A;  4HG7 A;  4J7D A;  5LAV A;  3LBK A;  2N0U A;  3FDO A;  4HBM A;  4OAS A;  4QO4 A;  4MDQ A;  4ODF A;  5HMI A;  5HMK A;  3FE7 A;  3LBJ E;  4JV9 A;  3JZR A;  3LBL A;  4UE1 A;  2Z5T M;  4IPF A;  4DIJ A;  2RUH A;  4J7E A;  3W69 A;  4QOC A;  5HMH A;  2GV2 A;  3JZK A;  3TJ2 A;  2N14 A;  5C5A A;  5LAZ A;  1RV1 A;  2M86 B;  4UMN A;  3JZQ A;  4LWV A;  3JZO A;  4OCC A;  1UHR A;  1T4E A;  4MDN A;  3JZP A;  3IUX A;  3VBG A;  5LAY A;  4N5T A;  3DAB A;  4ZFI A;  5LN2 A;  4JV7 A;  1V31 A;  4HFZ A;  3EQY A;  4WT2 A;  4UD7 A;  4ZGK A;  4JSC A;  3VZV A;  4RXZ A;  3U15 A;  3LNZ A;  4OGV A;  5LAW A;  4LWT A;  2MPS A;  4ZYF A;  2VYR A;  4J3E A;  4ZYC A;  4ODE A;  2AXI A;  3JZS A;  3FEA A;  5TRF A;  4ZYI A;  2MWY A;  4ERE A;  2LZG A;  4OGT A; 
#chains in the Genus database with same CATH topology
 3TPX A;  4JRG A;  3DAC A;  1V32 A;  4JWR A;  1YCQ A;  4JVR A;  1Z1M A;  4ERF A;  1T4F M;  3EQS A;  5AFG A;  1TTV A;  4OQ3 A;  3G03 A;  2Z5S M;  2N0W A;  4OGN A;  3TU1 A;  2N06 A;  1YCR A;  4J74 A;  3IWY A;  4OBA A;  3LNJ A;  4JVE A;  3V3B A;  4LWU A;  4HG7 A;  4J7D A;  5LAV A;  3LBK A;  2N0U A;  3FDO A;  4HBM A;  4OAS A;  4QO4 A;  4MDQ A;  4ODF A;  5HMI A;  5HMK A;  3FE7 A;  3LBJ E;  4JV9 A;  3JZR A;  3LBL A;  4UE1 A;  2Z5T M;  4IPF A;  4DIJ A;  2RUH A;  4J7E A;  3W69 A;  4QOC A;  5HMH A;  2GV2 A;  3JZK A;  3TJ2 A;  2N14 A;  5C5A A;  5LAZ A;  1RV1 A;  2M86 B;  4UMN A;  3JZQ A;  4LWV A;  3JZO A;  4OCC A;  1UHR A;  1T4E A;  4MDN A;  3JZP A;  3IUX A;  3VBG A;  5LAY A;  4N5T A;  3DAB A;  4ZFI A;  5LN2 A;  4JV7 A;  1V31 A;  4HFZ A;  3EQY A;  4WT2 A;  4UD7 A;  4ZGK A;  4JSC A;  3VZV A;  4RXZ A;  3U15 A;  3LNZ A;  4OGV A;  5LAW A;  4LWT A;  2MPS A;  4ZYF A;  2VYR A;  4J3E A;  4ZYC A;  4ODE A;  2AXI A;  3JZS A;  3FEA A;  5TRF A;  4ZYI A;  2MWY A;  4ERE A;  2LZG A;  4OGT A; 
#chains in the Genus database with same CATH homology
 3TPX A;  4JRG A;  3DAC A;  1V32 A;  4JWR A;  1YCQ A;  4JVR A;  1Z1M A;  4ERF A;  1T4F M;  3EQS A;  5AFG A;  1TTV A;  4OQ3 A;  3G03 A;  2Z5S M;  2N0W A;  4OGN A;  3TU1 A;  2N06 A;  1YCR A;  4J74 A;  3IWY A;  4OBA A;  3LNJ A;  4JVE A;  3V3B A;  4LWU A;  4HG7 A;  4J7D A;  5LAV A;  3LBK A;  2N0U A;  3FDO A;  4HBM A;  4OAS A;  4QO4 A;  4MDQ A;  4ODF A;  5HMI A;  5HMK A;  3FE7 A;  3LBJ E;  4JV9 A;  3JZR A;  3LBL A;  4UE1 A;  2Z5T M;  4IPF A;  4DIJ A;  2RUH A;  4J7E A;  3W69 A;  4QOC A;  5HMH A;  2GV2 A;  3JZK A;  3TJ2 A;  2N14 A;  5C5A A;  5LAZ A;  1RV1 A;  2M86 B;  4UMN A;  3JZQ A;  4LWV A;  3JZO A;  4OCC A;  1UHR A;  1T4E A;  4MDN A;  3JZP A;  3IUX A;  3VBG A;  5LAY A;  4N5T A;  3DAB A;  4ZFI A;  5LN2 A;  4JV7 A;  1V31 A;  4HFZ A;  3EQY A;  4WT2 A;  4UD7 A;  4ZGK A;  4JSC A;  3VZV A;  4RXZ A;  3U15 A;  3LNZ A;  4OGV A;  5LAW A;  4LWT A;  2MPS A;  4ZYF A;  2VYR A;  4J3E A;  4ZYC A;  4ODE A;  2AXI A;  3JZS A;  3FEA A;  5TRF A;  4ZYI A;  2MWY A;  4ERE A;  2LZG A;  4OGT A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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