2N06A

Mdmx-298
Total Genus 25
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
25
sequence length
89
structure length
89
Chain Sequence
QINQVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVTLAT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Monitoring Ligand-Induced Protein Ordering in Drug Discovery.
pubmed doi rcsb
molecule tags Signaling protein
source organism Homo sapiens
molecule keywords Protein Mdm4
total genus 25
structure length 89
sequence length 89
ec nomenclature
pdb deposition date 2015-03-04

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02201 SWIB SWIB/MDM2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.245.10 Mainly Alpha Orthogonal Bundle MDM2 SWIB/MDM2 domain 2n06A00
4HBMA 3VZVA 4RXZA 4OQ3A 4HG7A 4LWVA 3JZKA 4LWUA 4N5TA 3TU1A 4ODFA 4ZYIA 4IPFA 1T4EA 4ZGKA 5HMHA 4LWTA 5HMIA 2N06A 3FE7A 4ERFA 5LAVA 2VYRA 5AFGA 1Z1MA 5LAZA 4ZFIA 4J7DA 1YCQA 4OBAA 5TRFA 3JZOA 3U15A 4JVRA 3LBJE 2MPSA 3LBLA 4EREA 3DABA 2N14A 3JZRA 4JRGA 3EQSA 4ODEA 5LN2A 4JWRA 1T4FM 4MDNA 4OGTA 4UE1A 3TPXA 2Z5TM 1V32A 5LAWA 2N0WA 4J7EA 4JSCA 2MWYA 2RUHA 4OGVA 3JZPA 4OASA 1RV1A 1TTVA 3G03A 2Z5SM 5LAYA 4QO4A 4UD7A 4ZYFA 2M86B 4OGNA 4HFZA 2AXIA 2LZGA 3V3BA 1UHRA 3IWYA 3TJ2A 3VBGA 4OCCA 5HMKA 3LBKA 4UMNA 2GV2A 4MDQA 4J3EA 3LNZA 3DACA 3W69A 3LNJA 4DIJA 4JV9A 4QOCA 1V31A 3EQYA 3FDOA 4JVEA 3JZQA 4J74A 4ZYCA 5C5AA 4WT2A 1YCRA 3IUXA 2N0UA 3FEAA 4JV7A 3JZSA
chains in the Genus database with same CATH superfamily
4HBMA 3VZVA 4RXZA 4OQ3A 4HG7A 4LWVA 3JZKA 4LWUA 4N5TA 3TU1A 4ODFA 4ZYIA 4IPFA 1T4EA 4ZGKA 5HMHA 4LWTA 5HMIA 2N06A 3FE7A 4ERFA 5LAVA 2VYRA 5AFGA 1Z1MA 5LAZA 4ZFIA 4J7DA 1YCQA 4OBAA 5TRFA 3JZOA 3U15A 4JVRA 3LBJE 2MPSA 3LBLA 4EREA 3DABA 2N14A 3JZRA 4JRGA 3EQSA 4ODEA 5LN2A 4JWRA 1T4FM 4MDNA 4OGTA 4UE1A 3TPXA 2Z5TM 1V32A 5LAWA 2N0WA 4J7EA 4JSCA 2MWYA 2RUHA 4OGVA 3JZPA 4OASA 1RV1A 1TTVA 3G03A 2Z5SM 5LAYA 4QO4A 4UD7A 4ZYFA 2M86B 4OGNA 4HFZA 2AXIA 2LZGA 3V3BA 1UHRA 3IWYA 3TJ2A 3VBGA 4OCCA 5HMKA 3LBKA 4UMNA 2GV2A 4MDQA 4J3EA 3LNZA 3DACA 3W69A 3LNJA 4DIJA 4JV9A 4QOCA 1V31A 3EQYA 3FDOA 4JVEA 3JZQA 4J74A 4ZYCA 5C5AA 4WT2A 1YCRA 3IUXA 2N0UA 3FEAA 4JV7A 3JZSA
chains in the Genus database with same CATH topology
4HBMA 3VZVA 4RXZA 4OQ3A 4HG7A 4LWVA 3JZKA 4LWUA 4N5TA 3TU1A 4ODFA 4ZYIA 4IPFA 1T4EA 4ZGKA 5HMHA 4LWTA 5HMIA 2N06A 3FE7A 4ERFA 5LAVA 2VYRA 5AFGA 1Z1MA 5LAZA 4ZFIA 4J7DA 1YCQA 4OBAA 5TRFA 3JZOA 3U15A 4JVRA 3LBJE 2MPSA 3LBLA 4EREA 3DABA 2N14A 3JZRA 4JRGA 3EQSA 4ODEA 5LN2A 4JWRA 1T4FM 4MDNA 4OGTA 4UE1A 3TPXA 2Z5TM 1V32A 5LAWA 2N0WA 4J7EA 4JSCA 2MWYA 2RUHA 4OGVA 3JZPA 4OASA 1RV1A 1TTVA 3G03A 2Z5SM 5LAYA 4QO4A 4UD7A 4ZYFA 2M86B 4OGNA 4HFZA 2AXIA 2LZGA 3V3BA 1UHRA 3IWYA 3TJ2A 3VBGA 4OCCA 5HMKA 3LBKA 4UMNA 2GV2A 4MDQA 4J3EA 3LNZA 3DACA 3W69A 3LNJA 4DIJA 4JV9A 4QOCA 1V31A 3EQYA 3FDOA 4JVEA 3JZQA 4J74A 4ZYCA 5C5AA 4WT2A 1YCRA 3IUXA 2N0UA 3FEAA 4JV7A 3JZSA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4HBM A;  3VZV A;  4RXZ A;  4OQ3 A;  4HG7 A;  4LWV A;  3JZK A;  4LWU A;  4N5T A;  3TU1 A;  4ODF A;  4ZYI A;  4IPF A;  1T4E A;  4ZGK A;  5HMH A;  4LWT A;  5HMI A;  2N06 A;  3FE7 A;  4ERF A;  5LAV A;  2VYR A;  5AFG A;  1Z1M A;  5LAZ A;  4ZFI A;  4J7D A;  1YCQ A;  4OBA A;  5TRF A;  3JZO A;  3U15 A;  4JVR A;  3LBJ E;  2MPS A;  3LBL A;  4ERE A;  3DAB A;  2N14 A;  3JZR A;  4JRG A;  3EQS A;  4ODE A;  5LN2 A;  4JWR A;  1T4F M;  4MDN A;  4OGT A;  4UE1 A;  3TPX A;  2Z5T M;  1V32 A;  5LAW A;  2N0W A;  4J7E A;  4JSC A;  2MWY A;  2RUH A;  4OGV A;  3JZP A;  4OAS A;  1RV1 A;  1TTV A;  3G03 A;  2Z5S M;  5LAY A;  4QO4 A;  4UD7 A;  4ZYF A;  2M86 B;  4OGN A;  4HFZ A;  2AXI A;  2LZG A;  3V3B A;  1UHR A;  3IWY A;  3TJ2 A;  3VBG A;  4OCC A;  5HMK A;  3LBK A;  4UMN A;  2GV2 A;  4MDQ A;  4J3E A;  3LNZ A;  3DAC A;  3W69 A;  3LNJ A;  4DIJ A;  4JV9 A;  4QOC A;  1V31 A;  3EQY A;  3FDO A;  4JVE A;  3JZQ A;  4J74 A;  4ZYC A;  5C5A A;  4WT2 A;  1YCR A;  3IUX A;  2N0U A;  3FEA A;  4JV7 A;  3JZS A; 
#chains in the Genus database with same CATH topology
 4HBM A;  3VZV A;  4RXZ A;  4OQ3 A;  4HG7 A;  4LWV A;  3JZK A;  4LWU A;  4N5T A;  3TU1 A;  4ODF A;  4ZYI A;  4IPF A;  1T4E A;  4ZGK A;  5HMH A;  4LWT A;  5HMI A;  2N06 A;  3FE7 A;  4ERF A;  5LAV A;  2VYR A;  5AFG A;  1Z1M A;  5LAZ A;  4ZFI A;  4J7D A;  1YCQ A;  4OBA A;  5TRF A;  3JZO A;  3U15 A;  4JVR A;  3LBJ E;  2MPS A;  3LBL A;  4ERE A;  3DAB A;  2N14 A;  3JZR A;  4JRG A;  3EQS A;  4ODE A;  5LN2 A;  4JWR A;  1T4F M;  4MDN A;  4OGT A;  4UE1 A;  3TPX A;  2Z5T M;  1V32 A;  5LAW A;  2N0W A;  4J7E A;  4JSC A;  2MWY A;  2RUH A;  4OGV A;  3JZP A;  4OAS A;  1RV1 A;  1TTV A;  3G03 A;  2Z5S M;  5LAY A;  4QO4 A;  4UD7 A;  4ZYF A;  2M86 B;  4OGN A;  4HFZ A;  2AXI A;  2LZG A;  3V3B A;  1UHR A;  3IWY A;  3TJ2 A;  3VBG A;  4OCC A;  5HMK A;  3LBK A;  4UMN A;  2GV2 A;  4MDQ A;  4J3E A;  3LNZ A;  3DAC A;  3W69 A;  3LNJ A;  4DIJ A;  4JV9 A;  4QOC A;  1V31 A;  3EQY A;  3FDO A;  4JVE A;  3JZQ A;  4J74 A;  4ZYC A;  5C5A A;  4WT2 A;  1YCR A;  3IUX A;  2N0U A;  3FEA A;  4JV7 A;  3JZS A; 
#chains in the Genus database with same CATH homology
 4HBM A;  3VZV A;  4RXZ A;  4OQ3 A;  4HG7 A;  4LWV A;  3JZK A;  4LWU A;  4N5T A;  3TU1 A;  4ODF A;  4ZYI A;  4IPF A;  1T4E A;  4ZGK A;  5HMH A;  4LWT A;  5HMI A;  2N06 A;  3FE7 A;  4ERF A;  5LAV A;  2VYR A;  5AFG A;  1Z1M A;  5LAZ A;  4ZFI A;  4J7D A;  1YCQ A;  4OBA A;  5TRF A;  3JZO A;  3U15 A;  4JVR A;  3LBJ E;  2MPS A;  3LBL A;  4ERE A;  3DAB A;  2N14 A;  3JZR A;  4JRG A;  3EQS A;  4ODE A;  5LN2 A;  4JWR A;  1T4F M;  4MDN A;  4OGT A;  4UE1 A;  3TPX A;  2Z5T M;  1V32 A;  5LAW A;  2N0W A;  4J7E A;  4JSC A;  2MWY A;  2RUH A;  4OGV A;  3JZP A;  4OAS A;  1RV1 A;  1TTV A;  3G03 A;  2Z5S M;  5LAY A;  4QO4 A;  4UD7 A;  4ZYF A;  2M86 B;  4OGN A;  4HFZ A;  2AXI A;  2LZG A;  3V3B A;  1UHR A;  3IWY A;  3TJ2 A;  3VBG A;  4OCC A;  5HMK A;  3LBK A;  4UMN A;  2GV2 A;  4MDQ A;  4J3E A;  3LNZ A;  3DAC A;  3W69 A;  3LNJ A;  4DIJ A;  4JV9 A;  4QOC A;  1V31 A;  3EQY A;  3FDO A;  4JVE A;  3JZQ A;  4J74 A;  4ZYC A;  5C5A A;  4WT2 A;  1YCR A;  3IUX A;  2N0U A;  3FEA A;  4JV7 A;  3JZS A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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