2GV2A

Mdm2 in complex with an 8-mer p53 peptide analogue
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
88
structure length
88
Chain Sequence
ETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVNQ
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystallographic Analysis of an 8-mer p53 Peptide Analogue Complexed with MDM2.
pubmed doi rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords Ubiquitin-protein ligase E3 Mdm2
total genus 32
structure length 88
sequence length 88
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2006-05-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02201 SWIB SWIB/MDM2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.245.10 Mainly Alpha Orthogonal Bundle MDM2 SWIB/MDM2 domain 2gv2A00
4OGNA 4JVRA 3FEAA 1V32A 3EQSA 4ZGKA 5AFGA 3LNZA 3DABA 1UHRA 4LWVA 4UE1A 4HFZA 3JZQA 1TTVA 3JZOA 3TU1A 4HG7A 2MPSA 5HMHA 4EREA 4OCCA 4OBAA 4ODEA 5LAYA 3VZVA 3V3BA 2N0UA 4JV7A 3DACA 4J7DA 5C5AA 4LWUA 1Z1MA 4QO4A 3FDOA 4OGVA 2N06A 4LWTA 3TJ2A 5LAVA 4HBMA 5LN2A 3IWYA 4OASA 4ZYCA 4IPFA 5HMKA 4MDQA 4QOCA 3EQYA 1YCQA 3JZSA 5LAWA 2N0WA 4JVEA 4JV9A 4J74A 3U15A 4ERFA 3JZKA 2LZGA 4ODFA 3W69A 4OGTA 4DIJA 4RXZA 3LNJA 1T4EA 1YCRA 3VBGA 4ZFIA 5HMIA 3LBLA 4ZYFA 3TPXA 4JRGA 1V31A 2AXIA 4JWRA 2Z5TM 3LBKA 4JSCA 4MDNA 2MWYA 5LAZA 4UD7A 2Z5SM 3FE7A 2GV2A 3IUXA 2VYRA 4ZYIA 2N14A 1T4FM 3JZPA 4J7EA 3G03A 4OQ3A 4J3EA 4N5TA 4UMNA 1RV1A 2RUHA 3LBJE 4WT2A 5TRFA 2M86B 3JZRA
chains in the Genus database with same CATH superfamily
4OGNA 4JVRA 3FEAA 1V32A 3EQSA 4ZGKA 5AFGA 3LNZA 3DABA 1UHRA 4LWVA 4UE1A 4HFZA 3JZQA 1TTVA 3JZOA 3TU1A 4HG7A 2MPSA 5HMHA 4EREA 4OCCA 4OBAA 4ODEA 5LAYA 3VZVA 3V3BA 2N0UA 4JV7A 3DACA 4J7DA 5C5AA 4LWUA 1Z1MA 4QO4A 3FDOA 4OGVA 2N06A 4LWTA 3TJ2A 5LAVA 4HBMA 5LN2A 3IWYA 4OASA 4ZYCA 4IPFA 5HMKA 4MDQA 4QOCA 3EQYA 1YCQA 3JZSA 5LAWA 2N0WA 4JVEA 4JV9A 4J74A 3U15A 4ERFA 3JZKA 2LZGA 4ODFA 3W69A 4OGTA 4DIJA 4RXZA 3LNJA 1T4EA 1YCRA 3VBGA 4ZFIA 5HMIA 3LBLA 4ZYFA 3TPXA 4JRGA 1V31A 2AXIA 4JWRA 2Z5TM 3LBKA 4JSCA 4MDNA 2MWYA 5LAZA 4UD7A 2Z5SM 3FE7A 2GV2A 3IUXA 2VYRA 4ZYIA 2N14A 1T4FM 3JZPA 4J7EA 3G03A 4OQ3A 4J3EA 4N5TA 4UMNA 1RV1A 2RUHA 3LBJE 4WT2A 5TRFA 2M86B 3JZRA
chains in the Genus database with same CATH topology
4OGNA 4JVRA 3FEAA 1V32A 3EQSA 4ZGKA 5AFGA 3LNZA 3DABA 1UHRA 4LWVA 4UE1A 4HFZA 3JZQA 1TTVA 3JZOA 3TU1A 4HG7A 2MPSA 5HMHA 4EREA 4OCCA 4OBAA 4ODEA 5LAYA 3VZVA 3V3BA 2N0UA 4JV7A 3DACA 4J7DA 5C5AA 4LWUA 1Z1MA 4QO4A 3FDOA 4OGVA 2N06A 4LWTA 3TJ2A 5LAVA 4HBMA 5LN2A 3IWYA 4OASA 4ZYCA 4IPFA 5HMKA 4MDQA 4QOCA 3EQYA 1YCQA 3JZSA 5LAWA 2N0WA 4JVEA 4JV9A 4J74A 3U15A 4ERFA 3JZKA 2LZGA 4ODFA 3W69A 4OGTA 4DIJA 4RXZA 3LNJA 1T4EA 1YCRA 3VBGA 4ZFIA 5HMIA 3LBLA 4ZYFA 3TPXA 4JRGA 1V31A 2AXIA 4JWRA 2Z5TM 3LBKA 4JSCA 4MDNA 2MWYA 5LAZA 4UD7A 2Z5SM 3FE7A 2GV2A 3IUXA 2VYRA 4ZYIA 2N14A 1T4FM 3JZPA 4J7EA 3G03A 4OQ3A 4J3EA 4N5TA 4UMNA 1RV1A 2RUHA 3LBJE 4WT2A 5TRFA 2M86B 3JZRA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OGN A;  4JVR A;  3FEA A;  1V32 A;  3EQS A;  4ZGK A;  5AFG A;  3LNZ A;  3DAB A;  1UHR A;  4LWV A;  4UE1 A;  4HFZ A;  3JZQ A;  1TTV A;  3JZO A;  3TU1 A;  4HG7 A;  2MPS A;  5HMH A;  4ERE A;  4OCC A;  4OBA A;  4ODE A;  5LAY A;  3VZV A;  3V3B A;  2N0U A;  4JV7 A;  3DAC A;  4J7D A;  5C5A A;  4LWU A;  1Z1M A;  4QO4 A;  3FDO A;  4OGV A;  2N06 A;  4LWT A;  3TJ2 A;  5LAV A;  4HBM A;  5LN2 A;  3IWY A;  4OAS A;  4ZYC A;  4IPF A;  5HMK A;  4MDQ A;  4QOC A;  3EQY A;  1YCQ A;  3JZS A;  5LAW A;  2N0W A;  4JVE A;  4JV9 A;  4J74 A;  3U15 A;  4ERF A;  3JZK A;  2LZG A;  4ODF A;  3W69 A;  4OGT A;  4DIJ A;  4RXZ A;  3LNJ A;  1T4E A;  1YCR A;  3VBG A;  4ZFI A;  5HMI A;  3LBL A;  4ZYF A;  3TPX A;  4JRG A;  1V31 A;  2AXI A;  4JWR A;  2Z5T M;  3LBK A;  4JSC A;  4MDN A;  2MWY A;  5LAZ A;  4UD7 A;  2Z5S M;  3FE7 A;  2GV2 A;  3IUX A;  2VYR A;  4ZYI A;  2N14 A;  1T4F M;  3JZP A;  4J7E A;  3G03 A;  4OQ3 A;  4J3E A;  4N5T A;  4UMN A;  1RV1 A;  2RUH A;  3LBJ E;  4WT2 A;  5TRF A;  2M86 B;  3JZR A; 
#chains in the Genus database with same CATH topology
 4OGN A;  4JVR A;  3FEA A;  1V32 A;  3EQS A;  4ZGK A;  5AFG A;  3LNZ A;  3DAB A;  1UHR A;  4LWV A;  4UE1 A;  4HFZ A;  3JZQ A;  1TTV A;  3JZO A;  3TU1 A;  4HG7 A;  2MPS A;  5HMH A;  4ERE A;  4OCC A;  4OBA A;  4ODE A;  5LAY A;  3VZV A;  3V3B A;  2N0U A;  4JV7 A;  3DAC A;  4J7D A;  5C5A A;  4LWU A;  1Z1M A;  4QO4 A;  3FDO A;  4OGV A;  2N06 A;  4LWT A;  3TJ2 A;  5LAV A;  4HBM A;  5LN2 A;  3IWY A;  4OAS A;  4ZYC A;  4IPF A;  5HMK A;  4MDQ A;  4QOC A;  3EQY A;  1YCQ A;  3JZS A;  5LAW A;  2N0W A;  4JVE A;  4JV9 A;  4J74 A;  3U15 A;  4ERF A;  3JZK A;  2LZG A;  4ODF A;  3W69 A;  4OGT A;  4DIJ A;  4RXZ A;  3LNJ A;  1T4E A;  1YCR A;  3VBG A;  4ZFI A;  5HMI A;  3LBL A;  4ZYF A;  3TPX A;  4JRG A;  1V31 A;  2AXI A;  4JWR A;  2Z5T M;  3LBK A;  4JSC A;  4MDN A;  2MWY A;  5LAZ A;  4UD7 A;  2Z5S M;  3FE7 A;  2GV2 A;  3IUX A;  2VYR A;  4ZYI A;  2N14 A;  1T4F M;  3JZP A;  4J7E A;  3G03 A;  4OQ3 A;  4J3E A;  4N5T A;  4UMN A;  1RV1 A;  2RUH A;  3LBJ E;  4WT2 A;  5TRF A;  2M86 B;  3JZR A; 
#chains in the Genus database with same CATH homology
 4OGN A;  4JVR A;  3FEA A;  1V32 A;  3EQS A;  4ZGK A;  5AFG A;  3LNZ A;  3DAB A;  1UHR A;  4LWV A;  4UE1 A;  4HFZ A;  3JZQ A;  1TTV A;  3JZO A;  3TU1 A;  4HG7 A;  2MPS A;  5HMH A;  4ERE A;  4OCC A;  4OBA A;  4ODE A;  5LAY A;  3VZV A;  3V3B A;  2N0U A;  4JV7 A;  3DAC A;  4J7D A;  5C5A A;  4LWU A;  1Z1M A;  4QO4 A;  3FDO A;  4OGV A;  2N06 A;  4LWT A;  3TJ2 A;  5LAV A;  4HBM A;  5LN2 A;  3IWY A;  4OAS A;  4ZYC A;  4IPF A;  5HMK A;  4MDQ A;  4QOC A;  3EQY A;  1YCQ A;  3JZS A;  5LAW A;  2N0W A;  4JVE A;  4JV9 A;  4J74 A;  3U15 A;  4ERF A;  3JZK A;  2LZG A;  4ODF A;  3W69 A;  4OGT A;  4DIJ A;  4RXZ A;  3LNJ A;  1T4E A;  1YCR A;  3VBG A;  4ZFI A;  5HMI A;  3LBL A;  4ZYF A;  3TPX A;  4JRG A;  1V31 A;  2AXI A;  4JWR A;  2Z5T M;  3LBK A;  4JSC A;  4MDN A;  2MWY A;  5LAZ A;  4UD7 A;  2Z5S M;  3FE7 A;  2GV2 A;  3IUX A;  2VYR A;  4ZYI A;  2N14 A;  1T4F M;  3JZP A;  4J7E A;  3G03 A;  4OQ3 A;  4J3E A;  4N5T A;  4UMN A;  1RV1 A;  2RUH A;  3LBJ E;  4WT2 A;  5TRF A;  2M86 B;  3JZR A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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