2MPSA

Structure of complex of mdm2(3-109) and p73 tad(10-25)
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
107
structure length
107
Chain Sequence
NTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.


  Genus data interpretation
Chord Diagram
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publication title Structural convergence of unstructured p53 family transactivation domains in MDM2 recognition
pubmed doi rcsb
molecule tags Ligase/peptide
source organism Homo sapiens
molecule keywords E3 ubiquitin-protein ligase Mdm2
total genus 26
structure length 107
sequence length 107
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2014-06-02

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02201 SWIB SWIB/MDM2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.245.10 Mainly Alpha Orthogonal Bundle MDM2 SWIB/MDM2 domain 2mpsA00
1TTVA 2MWYA 4ZYIA 5LAYA 3VZVA 5HMHA 5LAZA 4LWVA 4OBAA 3TPXA 4UD7A 5LN2A 3DACA 4JVEA 1T4EA 4MDNA 4JV9A 2AXIA 4DIJA 4UMNA 4ZGKA 4HBMA 3FEAA 1YCQA 3FDOA 4OQ3A 3VBGA 4RXZA 4J7DA 1T4FM 4N5TA 3U15A 3EQSA 5LAWA 2N0UA 4HG7A 3EQYA 4JSCA 4HFZA 4UE1A 1Z1MA 4QO4A 4LWUA 1RV1A 2VYRA 3LNZA 4ZFIA 3G03A 3W69A 4OGNA 4IPFA 4WT2A 4ZYCA 4J3EA 3LNJA 3JZOA 3LBKA 3LBLA 4JVRA 2Z5SM 3V3BA 4LWTA 4OCCA 3DABA 2N0WA 2GV2A 1YCRA 3JZKA 4ERFA 3IWYA 3JZSA 3LBJE 4ODFA 4J74A 2N06A 2M86B 5AFGA 3JZPA 2N14A 1V31A 4JWRA 1V32A 4OASA 3JZQA 4J7EA 4QOCA 4OGTA 5C5AA 5HMKA 1UHRA 3FE7A 5HMIA 3TU1A 4ZYFA 2LZGA 5LAVA 3JZRA 4MDQA 2MPSA 4ODEA 4JV7A 5TRFA 4EREA 3IUXA 2Z5TM 4JRGA 3TJ2A 4OGVA 2RUHA
chains in the Genus database with same CATH superfamily
1TTVA 2MWYA 4ZYIA 5LAYA 3VZVA 5HMHA 5LAZA 4LWVA 4OBAA 3TPXA 4UD7A 5LN2A 3DACA 4JVEA 1T4EA 4MDNA 4JV9A 2AXIA 4DIJA 4UMNA 4ZGKA 4HBMA 3FEAA 1YCQA 3FDOA 4OQ3A 3VBGA 4RXZA 4J7DA 1T4FM 4N5TA 3U15A 3EQSA 5LAWA 2N0UA 4HG7A 3EQYA 4JSCA 4HFZA 4UE1A 1Z1MA 4QO4A 4LWUA 1RV1A 2VYRA 3LNZA 4ZFIA 3G03A 3W69A 4OGNA 4IPFA 4WT2A 4ZYCA 4J3EA 3LNJA 3JZOA 3LBKA 3LBLA 4JVRA 2Z5SM 3V3BA 4LWTA 4OCCA 3DABA 2N0WA 2GV2A 1YCRA 3JZKA 4ERFA 3IWYA 3JZSA 3LBJE 4ODFA 4J74A 2N06A 2M86B 5AFGA 3JZPA 2N14A 1V31A 4JWRA 1V32A 4OASA 3JZQA 4J7EA 4QOCA 4OGTA 5C5AA 5HMKA 1UHRA 3FE7A 5HMIA 3TU1A 4ZYFA 2LZGA 5LAVA 3JZRA 4MDQA 2MPSA 4ODEA 4JV7A 5TRFA 4EREA 3IUXA 2Z5TM 4JRGA 3TJ2A 4OGVA 2RUHA
chains in the Genus database with same CATH topology
1TTVA 2MWYA 4ZYIA 5LAYA 3VZVA 5HMHA 5LAZA 4LWVA 4OBAA 3TPXA 4UD7A 5LN2A 3DACA 4JVEA 1T4EA 4MDNA 4JV9A 2AXIA 4DIJA 4UMNA 4ZGKA 4HBMA 3FEAA 1YCQA 3FDOA 4OQ3A 3VBGA 4RXZA 4J7DA 1T4FM 4N5TA 3U15A 3EQSA 5LAWA 2N0UA 4HG7A 3EQYA 4JSCA 4HFZA 4UE1A 1Z1MA 4QO4A 4LWUA 1RV1A 2VYRA 3LNZA 4ZFIA 3G03A 3W69A 4OGNA 4IPFA 4WT2A 4ZYCA 4J3EA 3LNJA 3JZOA 3LBKA 3LBLA 4JVRA 2Z5SM 3V3BA 4LWTA 4OCCA 3DABA 2N0WA 2GV2A 1YCRA 3JZKA 4ERFA 3IWYA 3JZSA 3LBJE 4ODFA 4J74A 2N06A 2M86B 5AFGA 3JZPA 2N14A 1V31A 4JWRA 1V32A 4OASA 3JZQA 4J7EA 4QOCA 4OGTA 5C5AA 5HMKA 1UHRA 3FE7A 5HMIA 3TU1A 4ZYFA 2LZGA 5LAVA 3JZRA 4MDQA 2MPSA 4ODEA 4JV7A 5TRFA 4EREA 3IUXA 2Z5TM 4JRGA 3TJ2A 4OGVA 2RUHA
chains in the Genus database with same CATH homology

  
#chains in the Genus database with same CATH superfamily
 1TTV A;  2MWY A;  4ZYI A;  5LAY A;  3VZV A;  5HMH A;  5LAZ A;  4LWV A;  4OBA A;  3TPX A;  4UD7 A;  5LN2 A;  3DAC A;  4JVE A;  1T4E A;  4MDN A;  4JV9 A;  2AXI A;  4DIJ A;  4UMN A;  4ZGK A;  4HBM A;  3FEA A;  1YCQ A;  3FDO A;  4OQ3 A;  3VBG A;  4RXZ A;  4J7D A;  1T4F M;  4N5T A;  3U15 A;  3EQS A;  5LAW A;  2N0U A;  4HG7 A;  3EQY A;  4JSC A;  4HFZ A;  4UE1 A;  1Z1M A;  4QO4 A;  4LWU A;  1RV1 A;  2VYR A;  3LNZ A;  4ZFI A;  3G03 A;  3W69 A;  4OGN A;  4IPF A;  4WT2 A;  4ZYC A;  4J3E A;  3LNJ A;  3JZO A;  3LBK A;  3LBL A;  4JVR A;  2Z5S M;  3V3B A;  4LWT A;  4OCC A;  3DAB A;  2N0W A;  2GV2 A;  1YCR A;  3JZK A;  4ERF A;  3IWY A;  3JZS A;  3LBJ E;  4ODF A;  4J74 A;  2N06 A;  2M86 B;  5AFG A;  3JZP A;  2N14 A;  1V31 A;  4JWR A;  1V32 A;  4OAS A;  3JZQ A;  4J7E A;  4QOC A;  4OGT A;  5C5A A;  5HMK A;  1UHR A;  3FE7 A;  5HMI A;  3TU1 A;  4ZYF A;  2LZG A;  5LAV A;  3JZR A;  4MDQ A;  2MPS A;  4ODE A;  4JV7 A;  5TRF A;  4ERE A;  3IUX A;  2Z5T M;  4JRG A;  3TJ2 A;  4OGV A;  2RUH A; 
#chains in the Genus database with same CATH topology
 1TTV A;  2MWY A;  4ZYI A;  5LAY A;  3VZV A;  5HMH A;  5LAZ A;  4LWV A;  4OBA A;  3TPX A;  4UD7 A;  5LN2 A;  3DAC A;  4JVE A;  1T4E A;  4MDN A;  4JV9 A;  2AXI A;  4DIJ A;  4UMN A;  4ZGK A;  4HBM A;  3FEA A;  1YCQ A;  3FDO A;  4OQ3 A;  3VBG A;  4RXZ A;  4J7D A;  1T4F M;  4N5T A;  3U15 A;  3EQS A;  5LAW A;  2N0U A;  4HG7 A;  3EQY A;  4JSC A;  4HFZ A;  4UE1 A;  1Z1M A;  4QO4 A;  4LWU A;  1RV1 A;  2VYR A;  3LNZ A;  4ZFI A;  3G03 A;  3W69 A;  4OGN A;  4IPF A;  4WT2 A;  4ZYC A;  4J3E A;  3LNJ A;  3JZO A;  3LBK A;  3LBL A;  4JVR A;  2Z5S M;  3V3B A;  4LWT A;  4OCC A;  3DAB A;  2N0W A;  2GV2 A;  1YCR A;  3JZK A;  4ERF A;  3IWY A;  3JZS A;  3LBJ E;  4ODF A;  4J74 A;  2N06 A;  2M86 B;  5AFG A;  3JZP A;  2N14 A;  1V31 A;  4JWR A;  1V32 A;  4OAS A;  3JZQ A;  4J7E A;  4QOC A;  4OGT A;  5C5A A;  5HMK A;  1UHR A;  3FE7 A;  5HMI A;  3TU1 A;  4ZYF A;  2LZG A;  5LAV A;  3JZR A;  4MDQ A;  2MPS A;  4ODE A;  4JV7 A;  5TRF A;  4ERE A;  3IUX A;  2Z5T M;  4JRG A;  3TJ2 A;  4OGV A;  2RUH A; 
#chains in the Genus database with same CATH homology
 1TTV A;  2MWY A;  4ZYI A;  5LAY A;  3VZV A;  5HMH A;  5LAZ A;  4LWV A;  4OBA A;  3TPX A;  4UD7 A;  5LN2 A;  3DAC A;  4JVE A;  1T4E A;  4MDN A;  4JV9 A;  2AXI A;  4DIJ A;  4UMN A;  4ZGK A;  4HBM A;  3FEA A;  1YCQ A;  3FDO A;  4OQ3 A;  3VBG A;  4RXZ A;  4J7D A;  1T4F M;  4N5T A;  3U15 A;  3EQS A;  5LAW A;  2N0U A;  4HG7 A;  3EQY A;  4JSC A;  4HFZ A;  4UE1 A;  1Z1M A;  4QO4 A;  4LWU A;  1RV1 A;  2VYR A;  3LNZ A;  4ZFI A;  3G03 A;  3W69 A;  4OGN A;  4IPF A;  4WT2 A;  4ZYC A;  4J3E A;  3LNJ A;  3JZO A;  3LBK A;  3LBL A;  4JVR A;  2Z5S M;  3V3B A;  4LWT A;  4OCC A;  3DAB A;  2N0W A;  2GV2 A;  1YCR A;  3JZK A;  4ERF A;  3IWY A;  3JZS A;  3LBJ E;  4ODF A;  4J74 A;  2N06 A;  2M86 B;  5AFG A;  3JZP A;  2N14 A;  1V31 A;  4JWR A;  1V32 A;  4OAS A;  3JZQ A;  4J7E A;  4QOC A;  4OGT A;  5C5A A;  5HMK A;  1UHR A;  3FE7 A;  5HMI A;  3TU1 A;  4ZYF A;  2LZG A;  5LAV A;  3JZR A;  4MDQ A;  2MPS A;  4ODE A;  4JV7 A;  5TRF A;  4ERE A;  3IUX A;  2Z5T M;  4JRG A;  3TJ2 A;  4OGV A;  2RUH A;
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

  
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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