3FE7A

Crystal structure of hdmx bound to the p53-peptidomimetic ac-phe-met-aib-pmp-trp-glu-ac3c-leu-nh2 at 1.35a
Total Genus 28
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
28
sequence length
83
structure length
83
Chain Sequence
QVRPKLPLLKILHAAGAQGEMFTVKEVMHYLGQYIMVKQLYDQQEQHMVYCGGDLLGELLGRQSFSVKDPSPLYDMLRKNLVT
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Crystal Structures of Human MdmX (HdmX) in Complex with p53 Peptide Analogues Reveal Surprising Conformational Changes
pubmed doi rcsb
molecule tags Cell cycle
source organism Homo sapiens
molecule keywords Mdm4 protein
total genus 28
structure length 83
sequence length 83
ec nomenclature
pdb deposition date 2008-11-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02201 SWIB SWIB/MDM2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.245.10 Mainly Alpha Orthogonal Bundle MDM2 SWIB/MDM2 domain 3fe7A00
4UD7A 4OCCA 4HBMA 3JZSA 1UHRA 3IWYA 4JVEA 5LN2A 5TRFA 3LBKA 1V32A 2N06A 4IPFA 1YCQA 2LZGA 3EQYA 3EQSA 3TU1A 5LAWA 4J3EA 5HMKA 4ZGKA 3TPXA 3V3BA 4JVRA 4ODEA 5HMIA 4JV9A 5LAZA 2N0WA 2MPSA 4N5TA 3DACA 3JZKA 4LWVA 3JZRA 4JSCA 4RXZA 4WT2A 4ZYFA 5AFGA 1T4FM 4LWUA 3G03A 4OGTA 3JZQA 4JV7A 5C5AA 2MWYA 4JWRA 3FE7A 4J74A 3IUXA 4MDNA 4ZYCA 4EREA 4DIJA 3FEAA 3VBGA 2VYRA 1Z1MA 2Z5TM 3JZOA 3TJ2A 1T4EA 4LWTA 4ZYIA 2AXIA 1TTVA 4OGNA 2N0UA 2RUHA 2Z5SM 4QO4A 3LBJE 3LNZA 4ERFA 4ZFIA 2M86B 1V31A 4J7DA 4OBAA 3W69A 3DABA 3LBLA 3VZVA 4UMNA 4QOCA 3LNJA 5LAYA 4J7EA 4HFZA 3U15A 4OASA 4MDQA 3FDOA 1RV1A 1YCRA 4UE1A 2N14A 4JRGA 3JZPA 4OGVA 4HG7A 5LAVA 4ODFA 2GV2A 5HMHA 4OQ3A
chains in the Genus database with same CATH superfamily
4UD7A 4OCCA 4HBMA 3JZSA 1UHRA 3IWYA 4JVEA 5LN2A 5TRFA 3LBKA 1V32A 2N06A 4IPFA 1YCQA 2LZGA 3EQYA 3EQSA 3TU1A 5LAWA 4J3EA 5HMKA 4ZGKA 3TPXA 3V3BA 4JVRA 4ODEA 5HMIA 4JV9A 5LAZA 2N0WA 2MPSA 4N5TA 3DACA 3JZKA 4LWVA 3JZRA 4JSCA 4RXZA 4WT2A 4ZYFA 5AFGA 1T4FM 4LWUA 3G03A 4OGTA 3JZQA 4JV7A 5C5AA 2MWYA 4JWRA 3FE7A 4J74A 3IUXA 4MDNA 4ZYCA 4EREA 4DIJA 3FEAA 3VBGA 2VYRA 1Z1MA 2Z5TM 3JZOA 3TJ2A 1T4EA 4LWTA 4ZYIA 2AXIA 1TTVA 4OGNA 2N0UA 2RUHA 2Z5SM 4QO4A 3LBJE 3LNZA 4ERFA 4ZFIA 2M86B 1V31A 4J7DA 4OBAA 3W69A 3DABA 3LBLA 3VZVA 4UMNA 4QOCA 3LNJA 5LAYA 4J7EA 4HFZA 3U15A 4OASA 4MDQA 3FDOA 1RV1A 1YCRA 4UE1A 2N14A 4JRGA 3JZPA 4OGVA 4HG7A 5LAVA 4ODFA 2GV2A 5HMHA 4OQ3A
chains in the Genus database with same CATH topology
4UD7A 4OCCA 4HBMA 3JZSA 1UHRA 3IWYA 4JVEA 5LN2A 5TRFA 3LBKA 1V32A 2N06A 4IPFA 1YCQA 2LZGA 3EQYA 3EQSA 3TU1A 5LAWA 4J3EA 5HMKA 4ZGKA 3TPXA 3V3BA 4JVRA 4ODEA 5HMIA 4JV9A 5LAZA 2N0WA 2MPSA 4N5TA 3DACA 3JZKA 4LWVA 3JZRA 4JSCA 4RXZA 4WT2A 4ZYFA 5AFGA 1T4FM 4LWUA 3G03A 4OGTA 3JZQA 4JV7A 5C5AA 2MWYA 4JWRA 3FE7A 4J74A 3IUXA 4MDNA 4ZYCA 4EREA 4DIJA 3FEAA 3VBGA 2VYRA 1Z1MA 2Z5TM 3JZOA 3TJ2A 1T4EA 4LWTA 4ZYIA 2AXIA 1TTVA 4OGNA 2N0UA 2RUHA 2Z5SM 4QO4A 3LBJE 3LNZA 4ERFA 4ZFIA 2M86B 1V31A 4J7DA 4OBAA 3W69A 3DABA 3LBLA 3VZVA 4UMNA 4QOCA 3LNJA 5LAYA 4J7EA 4HFZA 3U15A 4OASA 4MDQA 3FDOA 1RV1A 1YCRA 4UE1A 2N14A 4JRGA 3JZPA 4OGVA 4HG7A 5LAVA 4ODFA 2GV2A 5HMHA 4OQ3A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UD7 A;  4OCC A;  4HBM A;  3JZS A;  1UHR A;  3IWY A;  4JVE A;  5LN2 A;  5TRF A;  3LBK A;  1V32 A;  2N06 A;  4IPF A;  1YCQ A;  2LZG A;  3EQY A;  3EQS A;  3TU1 A;  5LAW A;  4J3E A;  5HMK A;  4ZGK A;  3TPX A;  3V3B A;  4JVR A;  4ODE A;  5HMI A;  4JV9 A;  5LAZ A;  2N0W A;  2MPS A;  4N5T A;  3DAC A;  3JZK A;  4LWV A;  3JZR A;  4JSC A;  4RXZ A;  4WT2 A;  4ZYF A;  5AFG A;  1T4F M;  4LWU A;  3G03 A;  4OGT A;  3JZQ A;  4JV7 A;  5C5A A;  2MWY A;  4JWR A;  3FE7 A;  4J74 A;  3IUX A;  4MDN A;  4ZYC A;  4ERE A;  4DIJ A;  3FEA A;  3VBG A;  2VYR A;  1Z1M A;  2Z5T M;  3JZO A;  3TJ2 A;  1T4E A;  4LWT A;  4ZYI A;  2AXI A;  1TTV A;  4OGN A;  2N0U A;  2RUH A;  2Z5S M;  4QO4 A;  3LBJ E;  3LNZ A;  4ERF A;  4ZFI A;  2M86 B;  1V31 A;  4J7D A;  4OBA A;  3W69 A;  3DAB A;  3LBL A;  3VZV A;  4UMN A;  4QOC A;  3LNJ A;  5LAY A;  4J7E A;  4HFZ A;  3U15 A;  4OAS A;  4MDQ A;  3FDO A;  1RV1 A;  1YCR A;  4UE1 A;  2N14 A;  4JRG A;  3JZP A;  4OGV A;  4HG7 A;  5LAV A;  4ODF A;  2GV2 A;  5HMH A;  4OQ3 A; 
#chains in the Genus database with same CATH topology
 4UD7 A;  4OCC A;  4HBM A;  3JZS A;  1UHR A;  3IWY A;  4JVE A;  5LN2 A;  5TRF A;  3LBK A;  1V32 A;  2N06 A;  4IPF A;  1YCQ A;  2LZG A;  3EQY A;  3EQS A;  3TU1 A;  5LAW A;  4J3E A;  5HMK A;  4ZGK A;  3TPX A;  3V3B A;  4JVR A;  4ODE A;  5HMI A;  4JV9 A;  5LAZ A;  2N0W A;  2MPS A;  4N5T A;  3DAC A;  3JZK A;  4LWV A;  3JZR A;  4JSC A;  4RXZ A;  4WT2 A;  4ZYF A;  5AFG A;  1T4F M;  4LWU A;  3G03 A;  4OGT A;  3JZQ A;  4JV7 A;  5C5A A;  2MWY A;  4JWR A;  3FE7 A;  4J74 A;  3IUX A;  4MDN A;  4ZYC A;  4ERE A;  4DIJ A;  3FEA A;  3VBG A;  2VYR A;  1Z1M A;  2Z5T M;  3JZO A;  3TJ2 A;  1T4E A;  4LWT A;  4ZYI A;  2AXI A;  1TTV A;  4OGN A;  2N0U A;  2RUH A;  2Z5S M;  4QO4 A;  3LBJ E;  3LNZ A;  4ERF A;  4ZFI A;  2M86 B;  1V31 A;  4J7D A;  4OBA A;  3W69 A;  3DAB A;  3LBL A;  3VZV A;  4UMN A;  4QOC A;  3LNJ A;  5LAY A;  4J7E A;  4HFZ A;  3U15 A;  4OAS A;  4MDQ A;  3FDO A;  1RV1 A;  1YCR A;  4UE1 A;  2N14 A;  4JRG A;  3JZP A;  4OGV A;  4HG7 A;  5LAV A;  4ODF A;  2GV2 A;  5HMH A;  4OQ3 A; 
#chains in the Genus database with same CATH homology
 4UD7 A;  4OCC A;  4HBM A;  3JZS A;  1UHR A;  3IWY A;  4JVE A;  5LN2 A;  5TRF A;  3LBK A;  1V32 A;  2N06 A;  4IPF A;  1YCQ A;  2LZG A;  3EQY A;  3EQS A;  3TU1 A;  5LAW A;  4J3E A;  5HMK A;  4ZGK A;  3TPX A;  3V3B A;  4JVR A;  4ODE A;  5HMI A;  4JV9 A;  5LAZ A;  2N0W A;  2MPS A;  4N5T A;  3DAC A;  3JZK A;  4LWV A;  3JZR A;  4JSC A;  4RXZ A;  4WT2 A;  4ZYF A;  5AFG A;  1T4F M;  4LWU A;  3G03 A;  4OGT A;  3JZQ A;  4JV7 A;  5C5A A;  2MWY A;  4JWR A;  3FE7 A;  4J74 A;  3IUX A;  4MDN A;  4ZYC A;  4ERE A;  4DIJ A;  3FEA A;  3VBG A;  2VYR A;  1Z1M A;  2Z5T M;  3JZO A;  3TJ2 A;  1T4E A;  4LWT A;  4ZYI A;  2AXI A;  1TTV A;  4OGN A;  2N0U A;  2RUH A;  2Z5S M;  4QO4 A;  3LBJ E;  3LNZ A;  4ERF A;  4ZFI A;  2M86 B;  1V31 A;  4J7D A;  4OBA A;  3W69 A;  3DAB A;  3LBL A;  3VZV A;  4UMN A;  4QOC A;  3LNJ A;  5LAY A;  4J7E A;  4HFZ A;  3U15 A;  4OAS A;  4MDQ A;  3FDO A;  1RV1 A;  1YCR A;  4UE1 A;  2N14 A;  4JRG A;  3JZP A;  4OGV A;  4HG7 A;  5LAV A;  4ODF A;  2GV2 A;  5HMH A;  4OQ3 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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