3IUXA

Crystal structure of human mdm2 in complex with a potent miniature protein inhibitor (18-residues)
Total Genus 27
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
83
structure length
83
Chain Sequence
LVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Apamin as a template for structure-based rational design of potent peptide activators of p53.
pubmed doi rcsb
molecule tags Ligase
molecule keywords E3 ubiquitin-protein ligase Mdm2
total genus 27
structure length 83
sequence length 83
chains with identical sequence C
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2009-08-31

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02201 SWIB SWIB/MDM2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.245.10 Mainly Alpha Orthogonal Bundle MDM2 SWIB/MDM2 domain 3iuxA00
5LAYA 3VZVA 3TU1A 1UHRA 4OASA 2N0WA 4JVRA 3G03A 5LAZA 5LAWA 3V3BA 2RUHA 4LWUA 3DABA 2N06A 5HMHA 5C5AA 2N0UA 5TRFA 3FE7A 4JRGA 3JZPA 3JZRA 2M86B 3IUXA 3TPXA 2GV2A 4EREA 3VBGA 1T4FM 3LBJE 4J74A 4ZGKA 4WT2A 4JWRA 4IPFA 4HG7A 4OGVA 4ERFA 4ODEA 4ZYFA 4UMNA 4MDNA 4MDQA 4J7DA 4QO4A 4UE1A 3JZQA 2Z5SM 1YCRA 4HBMA 2N14A 4OBAA 4JVEA 4JV7A 2MWYA 4QOCA 2LZGA 5HMIA 4J3EA 4RXZA 3IWYA 5HMKA 4OGNA 4UD7A 1YCQA 3EQSA 4LWTA 4ZYCA 1V31A 3JZSA 3LNZA 5AFGA 4ODFA 4OCCA 3DACA 3TJ2A 3EQYA 4J7EA 4HFZA 4DIJA 3LNJA 2VYRA 1TTVA 3W69A 3LBKA 1T4EA 4JSCA 4LWVA 2AXIA 4ZYIA 1RV1A 4OQ3A 4OGTA 1Z1MA 3JZOA 2Z5TM 3LBLA 2MPSA 3FDOA 4N5TA 3U15A 4JV9A 1V32A 5LAVA 4ZFIA 3FEAA 5LN2A 3JZKA
chains in the Genus database with same CATH superfamily
5LAYA 3VZVA 3TU1A 1UHRA 4OASA 2N0WA 4JVRA 3G03A 5LAZA 5LAWA 3V3BA 2RUHA 4LWUA 3DABA 2N06A 5HMHA 5C5AA 2N0UA 5TRFA 3FE7A 4JRGA 3JZPA 3JZRA 2M86B 3IUXA 3TPXA 2GV2A 4EREA 3VBGA 1T4FM 3LBJE 4J74A 4ZGKA 4WT2A 4JWRA 4IPFA 4HG7A 4OGVA 4ERFA 4ODEA 4ZYFA 4UMNA 4MDNA 4MDQA 4J7DA 4QO4A 4UE1A 3JZQA 2Z5SM 1YCRA 4HBMA 2N14A 4OBAA 4JVEA 4JV7A 2MWYA 4QOCA 2LZGA 5HMIA 4J3EA 4RXZA 3IWYA 5HMKA 4OGNA 4UD7A 1YCQA 3EQSA 4LWTA 4ZYCA 1V31A 3JZSA 3LNZA 5AFGA 4ODFA 4OCCA 3DACA 3TJ2A 3EQYA 4J7EA 4HFZA 4DIJA 3LNJA 2VYRA 1TTVA 3W69A 3LBKA 1T4EA 4JSCA 4LWVA 2AXIA 4ZYIA 1RV1A 4OQ3A 4OGTA 1Z1MA 3JZOA 2Z5TM 3LBLA 2MPSA 3FDOA 4N5TA 3U15A 4JV9A 1V32A 5LAVA 4ZFIA 3FEAA 5LN2A 3JZKA
chains in the Genus database with same CATH topology
5LAYA 3VZVA 3TU1A 1UHRA 4OASA 2N0WA 4JVRA 3G03A 5LAZA 5LAWA 3V3BA 2RUHA 4LWUA 3DABA 2N06A 5HMHA 5C5AA 2N0UA 5TRFA 3FE7A 4JRGA 3JZPA 3JZRA 2M86B 3IUXA 3TPXA 2GV2A 4EREA 3VBGA 1T4FM 3LBJE 4J74A 4ZGKA 4WT2A 4JWRA 4IPFA 4HG7A 4OGVA 4ERFA 4ODEA 4ZYFA 4UMNA 4MDNA 4MDQA 4J7DA 4QO4A 4UE1A 3JZQA 2Z5SM 1YCRA 4HBMA 2N14A 4OBAA 4JVEA 4JV7A 2MWYA 4QOCA 2LZGA 5HMIA 4J3EA 4RXZA 3IWYA 5HMKA 4OGNA 4UD7A 1YCQA 3EQSA 4LWTA 4ZYCA 1V31A 3JZSA 3LNZA 5AFGA 4ODFA 4OCCA 3DACA 3TJ2A 3EQYA 4J7EA 4HFZA 4DIJA 3LNJA 2VYRA 1TTVA 3W69A 3LBKA 1T4EA 4JSCA 4LWVA 2AXIA 4ZYIA 1RV1A 4OQ3A 4OGTA 1Z1MA 3JZOA 2Z5TM 3LBLA 2MPSA 3FDOA 4N5TA 3U15A 4JV9A 1V32A 5LAVA 4ZFIA 3FEAA 5LN2A 3JZKA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5LAY A;  3VZV A;  3TU1 A;  1UHR A;  4OAS A;  2N0W A;  4JVR A;  3G03 A;  5LAZ A;  5LAW A;  3V3B A;  2RUH A;  4LWU A;  3DAB A;  2N06 A;  5HMH A;  5C5A A;  2N0U A;  5TRF A;  3FE7 A;  4JRG A;  3JZP A;  3JZR A;  2M86 B;  3IUX A;  3TPX A;  2GV2 A;  4ERE A;  3VBG A;  1T4F M;  3LBJ E;  4J74 A;  4ZGK A;  4WT2 A;  4JWR A;  4IPF A;  4HG7 A;  4OGV A;  4ERF A;  4ODE A;  4ZYF A;  4UMN A;  4MDN A;  4MDQ A;  4J7D A;  4QO4 A;  4UE1 A;  3JZQ A;  2Z5S M;  1YCR A;  4HBM A;  2N14 A;  4OBA A;  4JVE A;  4JV7 A;  2MWY A;  4QOC A;  2LZG A;  5HMI A;  4J3E A;  4RXZ A;  3IWY A;  5HMK A;  4OGN A;  4UD7 A;  1YCQ A;  3EQS A;  4LWT A;  4ZYC A;  1V31 A;  3JZS A;  3LNZ A;  5AFG A;  4ODF A;  4OCC A;  3DAC A;  3TJ2 A;  3EQY A;  4J7E A;  4HFZ A;  4DIJ A;  3LNJ A;  2VYR A;  1TTV A;  3W69 A;  3LBK A;  1T4E A;  4JSC A;  4LWV A;  2AXI A;  4ZYI A;  1RV1 A;  4OQ3 A;  4OGT A;  1Z1M A;  3JZO A;  2Z5T M;  3LBL A;  2MPS A;  3FDO A;  4N5T A;  3U15 A;  4JV9 A;  1V32 A;  5LAV A;  4ZFI A;  3FEA A;  5LN2 A;  3JZK A; 
#chains in the Genus database with same CATH topology
 5LAY A;  3VZV A;  3TU1 A;  1UHR A;  4OAS A;  2N0W A;  4JVR A;  3G03 A;  5LAZ A;  5LAW A;  3V3B A;  2RUH A;  4LWU A;  3DAB A;  2N06 A;  5HMH A;  5C5A A;  2N0U A;  5TRF A;  3FE7 A;  4JRG A;  3JZP A;  3JZR A;  2M86 B;  3IUX A;  3TPX A;  2GV2 A;  4ERE A;  3VBG A;  1T4F M;  3LBJ E;  4J74 A;  4ZGK A;  4WT2 A;  4JWR A;  4IPF A;  4HG7 A;  4OGV A;  4ERF A;  4ODE A;  4ZYF A;  4UMN A;  4MDN A;  4MDQ A;  4J7D A;  4QO4 A;  4UE1 A;  3JZQ A;  2Z5S M;  1YCR A;  4HBM A;  2N14 A;  4OBA A;  4JVE A;  4JV7 A;  2MWY A;  4QOC A;  2LZG A;  5HMI A;  4J3E A;  4RXZ A;  3IWY A;  5HMK A;  4OGN A;  4UD7 A;  1YCQ A;  3EQS A;  4LWT A;  4ZYC A;  1V31 A;  3JZS A;  3LNZ A;  5AFG A;  4ODF A;  4OCC A;  3DAC A;  3TJ2 A;  3EQY A;  4J7E A;  4HFZ A;  4DIJ A;  3LNJ A;  2VYR A;  1TTV A;  3W69 A;  3LBK A;  1T4E A;  4JSC A;  4LWV A;  2AXI A;  4ZYI A;  1RV1 A;  4OQ3 A;  4OGT A;  1Z1M A;  3JZO A;  2Z5T M;  3LBL A;  2MPS A;  3FDO A;  4N5T A;  3U15 A;  4JV9 A;  1V32 A;  5LAV A;  4ZFI A;  3FEA A;  5LN2 A;  3JZK A; 
#chains in the Genus database with same CATH homology
 5LAY A;  3VZV A;  3TU1 A;  1UHR A;  4OAS A;  2N0W A;  4JVR A;  3G03 A;  5LAZ A;  5LAW A;  3V3B A;  2RUH A;  4LWU A;  3DAB A;  2N06 A;  5HMH A;  5C5A A;  2N0U A;  5TRF A;  3FE7 A;  4JRG A;  3JZP A;  3JZR A;  2M86 B;  3IUX A;  3TPX A;  2GV2 A;  4ERE A;  3VBG A;  1T4F M;  3LBJ E;  4J74 A;  4ZGK A;  4WT2 A;  4JWR A;  4IPF A;  4HG7 A;  4OGV A;  4ERF A;  4ODE A;  4ZYF A;  4UMN A;  4MDN A;  4MDQ A;  4J7D A;  4QO4 A;  4UE1 A;  3JZQ A;  2Z5S M;  1YCR A;  4HBM A;  2N14 A;  4OBA A;  4JVE A;  4JV7 A;  2MWY A;  4QOC A;  2LZG A;  5HMI A;  4J3E A;  4RXZ A;  3IWY A;  5HMK A;  4OGN A;  4UD7 A;  1YCQ A;  3EQS A;  4LWT A;  4ZYC A;  1V31 A;  3JZS A;  3LNZ A;  5AFG A;  4ODF A;  4OCC A;  3DAC A;  3TJ2 A;  3EQY A;  4J7E A;  4HFZ A;  4DIJ A;  3LNJ A;  2VYR A;  1TTV A;  3W69 A;  3LBK A;  1T4E A;  4JSC A;  4LWV A;  2AXI A;  4ZYI A;  1RV1 A;  4OQ3 A;  4OGT A;  1Z1M A;  3JZO A;  2Z5T M;  3LBL A;  2MPS A;  3FDO A;  4N5T A;  3U15 A;  4JV9 A;  1V32 A;  5LAV A;  4ZFI A;  3FEA A;  5LN2 A;  3JZK A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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