3TPXA

Crystal structure of human mdm2 in complex with a trifluoromethylated d-peptide inhibitor
Total Genus 27
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
27
sequence length
84
structure length
84
Chain Sequence
TLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVV
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
publication title An Ultrahigh Affinity d-Peptide Antagonist Of MDM2.
pubmed doi rcsb
molecule tags Ligase/ligase inhibitor
molecule keywords E3 ubiquitin-protein ligase Mdm2
total genus 27
structure length 84
sequence length 84
chains with identical sequence C, E
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2011-09-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02201 SWIB SWIB/MDM2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.245.10 Mainly Alpha Orthogonal Bundle MDM2 SWIB/MDM2 domain 3tpxA00
2N0UA 4MDNA 2MWYA 4N5TA 4OQ3A 4J3EA 4OCCA 4WT2A 3JZPA 3IWYA 1T4EA 4J74A 3LBKA 2Z5SM 2Z5TM 4DIJA 4ERFA 4OBAA 3G03A 3TPXA 4QOCA 1T4FM 3FE7A 3VBGA 4OGVA 1YCQA 4JWRA 4EREA 3FEAA 4ODEA 4OASA 4OGTA 4JV7A 4JV9A 3FDOA 4UE1A 2AXIA 4JRGA 3LNZA 3JZKA 5C5AA 5LAVA 3LBJE 4J7EA 1V32A 5TRFA 3JZRA 5LAYA 3JZOA 4QO4A 3TJ2A 2N14A 3DABA 3TU1A 3LNJA 4LWTA 4UMNA 2GV2A 2N06A 5HMIA 3JZSA 1TTVA 1V31A 3IUXA 1Z1MA 3LBLA 4UD7A 3EQYA 3JZQA 3EQSA 5HMKA 4OGNA 4ZYFA 2VYRA 5AFGA 4HBMA 4J7DA 1YCRA 4ZYIA 5LN2A 5HMHA 5LAWA 1RV1A 2N0WA 2LZGA 4ODFA 4LWUA 5LAZA 2M86B 2MPSA 3DACA 4HG7A 3U15A 3V3BA 3W69A 4ZYCA 4JVRA 4ZGKA 1UHRA 4JSCA 3VZVA 2RUHA 4IPFA 4JVEA 4MDQA 4ZFIA 4RXZA 4LWVA 4HFZA
chains in the Genus database with same CATH superfamily
2N0UA 4MDNA 2MWYA 4N5TA 4OQ3A 4J3EA 4OCCA 4WT2A 3JZPA 3IWYA 1T4EA 4J74A 3LBKA 2Z5SM 2Z5TM 4DIJA 4ERFA 4OBAA 3G03A 3TPXA 4QOCA 1T4FM 3FE7A 3VBGA 4OGVA 1YCQA 4JWRA 4EREA 3FEAA 4ODEA 4OASA 4OGTA 4JV7A 4JV9A 3FDOA 4UE1A 2AXIA 4JRGA 3LNZA 3JZKA 5C5AA 5LAVA 3LBJE 4J7EA 1V32A 5TRFA 3JZRA 5LAYA 3JZOA 4QO4A 3TJ2A 2N14A 3DABA 3TU1A 3LNJA 4LWTA 4UMNA 2GV2A 2N06A 5HMIA 3JZSA 1TTVA 1V31A 3IUXA 1Z1MA 3LBLA 4UD7A 3EQYA 3JZQA 3EQSA 5HMKA 4OGNA 4ZYFA 2VYRA 5AFGA 4HBMA 4J7DA 1YCRA 4ZYIA 5LN2A 5HMHA 5LAWA 1RV1A 2N0WA 2LZGA 4ODFA 4LWUA 5LAZA 2M86B 2MPSA 3DACA 4HG7A 3U15A 3V3BA 3W69A 4ZYCA 4JVRA 4ZGKA 1UHRA 4JSCA 3VZVA 2RUHA 4IPFA 4JVEA 4MDQA 4ZFIA 4RXZA 4LWVA 4HFZA
chains in the Genus database with same CATH topology
2N0UA 4MDNA 2MWYA 4N5TA 4OQ3A 4J3EA 4OCCA 4WT2A 3JZPA 3IWYA 1T4EA 4J74A 3LBKA 2Z5SM 2Z5TM 4DIJA 4ERFA 4OBAA 3G03A 3TPXA 4QOCA 1T4FM 3FE7A 3VBGA 4OGVA 1YCQA 4JWRA 4EREA 3FEAA 4ODEA 4OASA 4OGTA 4JV7A 4JV9A 3FDOA 4UE1A 2AXIA 4JRGA 3LNZA 3JZKA 5C5AA 5LAVA 3LBJE 4J7EA 1V32A 5TRFA 3JZRA 5LAYA 3JZOA 4QO4A 3TJ2A 2N14A 3DABA 3TU1A 3LNJA 4LWTA 4UMNA 2GV2A 2N06A 5HMIA 3JZSA 1TTVA 1V31A 3IUXA 1Z1MA 3LBLA 4UD7A 3EQYA 3JZQA 3EQSA 5HMKA 4OGNA 4ZYFA 2VYRA 5AFGA 4HBMA 4J7DA 1YCRA 4ZYIA 5LN2A 5HMHA 5LAWA 1RV1A 2N0WA 2LZGA 4ODFA 4LWUA 5LAZA 2M86B 2MPSA 3DACA 4HG7A 3U15A 3V3BA 3W69A 4ZYCA 4JVRA 4ZGKA 1UHRA 4JSCA 3VZVA 2RUHA 4IPFA 4JVEA 4MDQA 4ZFIA 4RXZA 4LWVA 4HFZA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2N0U A;  4MDN A;  2MWY A;  4N5T A;  4OQ3 A;  4J3E A;  4OCC A;  4WT2 A;  3JZP A;  3IWY A;  1T4E A;  4J74 A;  3LBK A;  2Z5S M;  2Z5T M;  4DIJ A;  4ERF A;  4OBA A;  3G03 A;  3TPX A;  4QOC A;  1T4F M;  3FE7 A;  3VBG A;  4OGV A;  1YCQ A;  4JWR A;  4ERE A;  3FEA A;  4ODE A;  4OAS A;  4OGT A;  4JV7 A;  4JV9 A;  3FDO A;  4UE1 A;  2AXI A;  4JRG A;  3LNZ A;  3JZK A;  5C5A A;  5LAV A;  3LBJ E;  4J7E A;  1V32 A;  5TRF A;  3JZR A;  5LAY A;  3JZO A;  4QO4 A;  3TJ2 A;  2N14 A;  3DAB A;  3TU1 A;  3LNJ A;  4LWT A;  4UMN A;  2GV2 A;  2N06 A;  5HMI A;  3JZS A;  1TTV A;  1V31 A;  3IUX A;  1Z1M A;  3LBL A;  4UD7 A;  3EQY A;  3JZQ A;  3EQS A;  5HMK A;  4OGN A;  4ZYF A;  2VYR A;  5AFG A;  4HBM A;  4J7D A;  1YCR A;  4ZYI A;  5LN2 A;  5HMH A;  5LAW A;  1RV1 A;  2N0W A;  2LZG A;  4ODF A;  4LWU A;  5LAZ A;  2M86 B;  2MPS A;  3DAC A;  4HG7 A;  3U15 A;  3V3B A;  3W69 A;  4ZYC A;  4JVR A;  4ZGK A;  1UHR A;  4JSC A;  3VZV A;  2RUH A;  4IPF A;  4JVE A;  4MDQ A;  4ZFI A;  4RXZ A;  4LWV A;  4HFZ A; 
#chains in the Genus database with same CATH topology
 2N0U A;  4MDN A;  2MWY A;  4N5T A;  4OQ3 A;  4J3E A;  4OCC A;  4WT2 A;  3JZP A;  3IWY A;  1T4E A;  4J74 A;  3LBK A;  2Z5S M;  2Z5T M;  4DIJ A;  4ERF A;  4OBA A;  3G03 A;  3TPX A;  4QOC A;  1T4F M;  3FE7 A;  3VBG A;  4OGV A;  1YCQ A;  4JWR A;  4ERE A;  3FEA A;  4ODE A;  4OAS A;  4OGT A;  4JV7 A;  4JV9 A;  3FDO A;  4UE1 A;  2AXI A;  4JRG A;  3LNZ A;  3JZK A;  5C5A A;  5LAV A;  3LBJ E;  4J7E A;  1V32 A;  5TRF A;  3JZR A;  5LAY A;  3JZO A;  4QO4 A;  3TJ2 A;  2N14 A;  3DAB A;  3TU1 A;  3LNJ A;  4LWT A;  4UMN A;  2GV2 A;  2N06 A;  5HMI A;  3JZS A;  1TTV A;  1V31 A;  3IUX A;  1Z1M A;  3LBL A;  4UD7 A;  3EQY A;  3JZQ A;  3EQS A;  5HMK A;  4OGN A;  4ZYF A;  2VYR A;  5AFG A;  4HBM A;  4J7D A;  1YCR A;  4ZYI A;  5LN2 A;  5HMH A;  5LAW A;  1RV1 A;  2N0W A;  2LZG A;  4ODF A;  4LWU A;  5LAZ A;  2M86 B;  2MPS A;  3DAC A;  4HG7 A;  3U15 A;  3V3B A;  3W69 A;  4ZYC A;  4JVR A;  4ZGK A;  1UHR A;  4JSC A;  3VZV A;  2RUH A;  4IPF A;  4JVE A;  4MDQ A;  4ZFI A;  4RXZ A;  4LWV A;  4HFZ A; 
#chains in the Genus database with same CATH homology
 2N0U A;  4MDN A;  2MWY A;  4N5T A;  4OQ3 A;  4J3E A;  4OCC A;  4WT2 A;  3JZP A;  3IWY A;  1T4E A;  4J74 A;  3LBK A;  2Z5S M;  2Z5T M;  4DIJ A;  4ERF A;  4OBA A;  3G03 A;  3TPX A;  4QOC A;  1T4F M;  3FE7 A;  3VBG A;  4OGV A;  1YCQ A;  4JWR A;  4ERE A;  3FEA A;  4ODE A;  4OAS A;  4OGT A;  4JV7 A;  4JV9 A;  3FDO A;  4UE1 A;  2AXI A;  4JRG A;  3LNZ A;  3JZK A;  5C5A A;  5LAV A;  3LBJ E;  4J7E A;  1V32 A;  5TRF A;  3JZR A;  5LAY A;  3JZO A;  4QO4 A;  3TJ2 A;  2N14 A;  3DAB A;  3TU1 A;  3LNJ A;  4LWT A;  4UMN A;  2GV2 A;  2N06 A;  5HMI A;  3JZS A;  1TTV A;  1V31 A;  3IUX A;  1Z1M A;  3LBL A;  4UD7 A;  3EQY A;  3JZQ A;  3EQS A;  5HMK A;  4OGN A;  4ZYF A;  2VYR A;  5AFG A;  4HBM A;  4J7D A;  1YCR A;  4ZYI A;  5LN2 A;  5HMH A;  5LAW A;  1RV1 A;  2N0W A;  2LZG A;  4ODF A;  4LWU A;  5LAZ A;  2M86 B;  2MPS A;  3DAC A;  4HG7 A;  3U15 A;  3V3B A;  3W69 A;  4ZYC A;  4JVR A;  4ZGK A;  1UHR A;  4JSC A;  3VZV A;  2RUH A;  4IPF A;  4JVE A;  4MDQ A;  4ZFI A;  4RXZ A;  4LWV A;  4HFZ A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...