4HRNC

Structural basis for eliciting a cytotoxic effect in her2-overexpressing cancer cells via binding to the extracellular domain of her2
Total Genus 9
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
9
sequence length
71
structure length
71
Chain Sequence
CSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQDGSVTCFGPEADQCVACAHYKDPPFCVARCP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase/de novo protein
molecule keywords Designed Ankyrin Repeat Protein H10-2-G
publication title Structural Basis for Eliciting a Cytotoxic Effect in HER2-Overexpressing Cancer Cells via Binding to the Extracellular Domain of HER2.
pubmed doi rcsb
source organism Synthetic
total genus 9
structure length 71
sequence length 71
chains with identical sequence D
ec nomenclature ec 2.7.10.1: Receptor protein-tyrosine kinase.
pdb deposition date 2012-10-28
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.220.10 Mainly Beta Ribbon Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 4hrnC00
4UV7A 3LTGA 4C9EB 1MOXA 3P11A 2AHXA 4KRPA 4OGAE 3NJPA 4BSOA 4CDKE 4C9VB 3B2VA 4C9UB 1YY9A 4KNGM 4C8WI 4C9AB 2A91A 3N85A 1IGRA 4BSPA 4HRNC 4BSRC 4C8VA 4P59A 4BSSC 3MZWA 4BSUC 1S78A 1N8YC 3I2TA 4KT1E 4LI2B 3U7UA 1IVOA 3WSQA 4C9RB 1NQLA 3W11E 3QWQA 5J3HE 3BE1A 4XSSE 4C99B 3U2PA 4LEOC 2HR7A 3LTFA 3U9UE 4QXFC 1N8ZC 4KROA 4XSTE 3WLWA 4UFRB 1M6BA
chains in the Genus database with same CATH superfamily
4UV7A 3LTGA 4C9EB 1MOXA 3P11A 2AHXA 4KRPA 4OGAE 3NJPA 4BSOA 4CDKE 4C9VB 3B2VA 4C9UB 1YY9A 4KNGM 4C8WI 4C9AB 2A91A 3N85A 1IGRA 4BSPA 4HRNC 4BSRC 4C8VA 4P59A 4BSSC 3MZWA 4BSUC 1S78A 1N8YC 3I2TA 4KT1E 4LI2B 3U7UA 1IVOA 3WSQA 4C9RB 1NQLA 3W11E 3QWQA 5J3HE 3BE1A 4XSSE 4C99B 3U2PA 4LEOC 2HR7A 3LTFA 3U9UE 4QXFC 1N8ZC 4KROA 4XSTE 3WLWA 4UFRB 1M6BA
chains in the Genus database with same CATH topology
4UV7A 3LTGA 4C9EB 1MOXA 3P11A 2AHXA 4KRPA 4OGAE 3NJPA 4BSOA 4CDKE 4C9VB 3B2VA 4C9UB 1YY9A 4KNGM 4C8WI 4C9AB 2A91A 3N85A 1IGRA 4BSPA 4HRNC 4BSRC 4C8VA 4P59A 4BSSC 3MZWA 4BSUC 1S78A 1N8YC 3I2TA 4KT1E 4LI2B 3U7UA 1IVOA 3WSQA 4C9RB 1NQLA 3W11E 3QWQA 5J3HE 3BE1A 4XSSE 4C99B 3U2PA 4LEOC 2HR7A 3LTFA 3U9UE 4QXFC 1N8ZC 4KROA 4XSTE 3WLWA 4UFRB 1M6BA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4UV7 A;  3LTG A;  4C9E B;  1MOX A;  3P11 A;  2AHX A;  4KRP A;  4OGA E;  3NJP A;  4BSO A;  4CDK E;  4C9V B;  3B2V A;  4C9U B;  1YY9 A;  4KNG M;  4C8W I;  4C9A B;  2A91 A;  3N85 A;  1IGR A;  4BSP A;  4HRN C;  4BSR C;  4C8V A;  4P59 A;  4BSS C;  3MZW A;  4BSU C;  1S78 A;  1N8Y C;  3I2T A;  4KT1 E;  4LI2 B;  3U7U A;  1IVO A;  3WSQ A;  4C9R B;  1NQL A;  3W11 E;  3QWQ A;  5J3H E;  3BE1 A;  4XSS E;  4C99 B;  3U2P A;  4LEO C;  2HR7 A;  3LTF A;  3U9U E;  4QXF C;  1N8Z C;  4KRO A;  4XST E;  3WLW A;  4UFR B;  1M6B A; 
#chains in the Genus database with same CATH topology
 4UV7 A;  3LTG A;  4C9E B;  1MOX A;  3P11 A;  2AHX A;  4KRP A;  4OGA E;  3NJP A;  4BSO A;  4CDK E;  4C9V B;  3B2V A;  4C9U B;  1YY9 A;  4KNG M;  4C8W I;  4C9A B;  2A91 A;  3N85 A;  1IGR A;  4BSP A;  4HRN C;  4BSR C;  4C8V A;  4P59 A;  4BSS C;  3MZW A;  4BSU C;  1S78 A;  1N8Y C;  3I2T A;  4KT1 E;  4LI2 B;  3U7U A;  1IVO A;  3WSQ A;  4C9R B;  1NQL A;  3W11 E;  3QWQ A;  5J3H E;  3BE1 A;  4XSS E;  4C99 B;  3U2P A;  4LEO C;  2HR7 A;  3LTF A;  3U9U E;  4QXF C;  1N8Z C;  4KRO A;  4XST E;  3WLW A;  4UFR B;  1M6B A; 
#chains in the Genus database with same CATH homology
 4UV7 A;  3LTG A;  4C9E B;  1MOX A;  3P11 A;  2AHX A;  4KRP A;  4OGA E;  3NJP A;  4BSO A;  4CDK E;  4C9V B;  3B2V A;  4C9U B;  1YY9 A;  4KNG M;  4C8W I;  4C9A B;  2A91 A;  3N85 A;  1IGR A;  4BSP A;  4HRN C;  4BSR C;  4C8V A;  4P59 A;  4BSS C;  3MZW A;  4BSU C;  1S78 A;  1N8Y C;  3I2T A;  4KT1 E;  4LI2 B;  3U7U A;  1IVO A;  3WSQ A;  4C9R B;  1NQL A;  3W11 E;  3QWQ A;  5J3H E;  3BE1 A;  4XSS E;  4C99 B;  3U2P A;  4LEO C;  2HR7 A;  3LTF A;  3U9U E;  4QXF C;  1N8Z C;  4KRO A;  4XST E;  3WLW A;  4UFR B;  1M6B A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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