4K0AA

Crystal structure of cd4-mimetic miniprotein m48u7 in complex with hiv-1 yu2 gp120
Total Genus 91
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
91
sequence length
352
structure length
337
Chain Sequence
VWKEATTTLFCASDAKAYDTEVHNVWATHACVPTDPNPQEVKLENVTENFNMWKNNMVEQMHEDIISLWDQSLKPCVKLTGGSVITQACPKVSFEPIPIHYCAPAGFAILKCNDKKFNGTGPCTNVSTVQCTHGIRPVVSTQLLLNGSLAEEEIVIRSENFTNNAKTIIVQLNESVVINCTRPNNDIRQAHCNLSKTQWENTLEQIAIKLKEQFGNNKTIIFNPSSGGDPEIVTHSFNCGGEFFYCNSTQLFTWNDTGRNITLPCRIKQIINMWQEVGKAMYAPPIRGQIRCSSNITGLLLTRDGGKNGTEIFRPGGGDMRDNWRSELYKYKVVKIE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Basis for Highly Effective HIV-1 Neutralization by CD4-Mimetic Miniproteins Revealed by 1.5 A Cocrystal Structure of gp120 and M48U1.
pubmed doi rcsb
molecule tags Viral protein/inhibitor
source organism Human immunodeficiency virus 1
molecule keywords HIV-1 YU2 gp120 glycoprotein
total genus 91
structure length 337
sequence length 352
ec nomenclature
pdb deposition date 2013-04-03
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.170.40.20 Mainly Beta Beta Complex HIV Envelope Protein Gp120; Chain G Human immunodeficiency virus 1, Gp160, envelope glycoprotein 4k0aA01
5FA2A 3NGBA 5F9WA 4OLYG 2NY4A 4OM0G 4RFNA 5TE4G 4DVSA 4RX4E 1G9MG 5F9OG 1GC1G 4DVVA 4LSTG 2B4CG 4R2GA 4R4FA 3TGRA 3IDXG 4YFLE 4JPWG 4XNZA 5T33G 4OLVG 4JZZA 4DKVA 4XVTG 2QADA 4RWYA 3HI1G 1RZKG 4RFOG 4XMPG 4S1SG 3SE8G 4LSSG 5TE7G 4J6RG 4I53A 4XVSG 4LSRG 3TGQA 2NY0A 4DKRA 2NXYA 2BF1A 4K0AA 4JB9G 4I54A 4P9HG 4S1RG 2NY3A 4H8WG 5I9QA 5F4PA 4OLXG 4OLUG 4YDLA 1G9NG 4OM1G 4DVWA 4YDKG 5F4LA 4OLWG 4DKOA 5KJRG 3SE9G 3IDYA 3LQAG 4YDJG 3TGTA 5TE6G 4DVTA 4JKPG 4XNYG 4YE4G 5CAYG 4JM2E 4RZ8A 3TGSA 4LSUG 2I5YG 2NY1A 2NY6A 4LSVG 3RJQA 4DVXA 4OLZG 3JWDA 4LSPG 4JZWA 4S1QG 5F4UA 3JWOA 4JDTG 1YYMG 3U7YG 3FUSA 4R4NA 2NY2A 5F4RA 4DKPA 4JPVG 4YDIG 5IGXG 1YYLG 5F96G 5FECC 5CD5A 4DVRG 4LAJA 2NXZA 4KA2A 3TIHA 4DKUA 2I60G 4LSQG 2NY5G 2NY7G 4DKQA 1RZJG
chains in the Genus database with same CATH superfamily
5FA2A 3NGBA 5F9WA 4OLYG 2NY4A 4OM0G 4RFNA 5TE4G 4DVSA 4RX4E 1G9MG 5F9OG 1GC1G 4DVVA 4LSTG 2B4CG 4R2GA 4R4FA 3TGRA 3IDXG 4YFLE 4JPWG 4XNZA 5T33G 4OLVG 4JZZA 4DKVA 4XVTG 2QADA 4RWYA 3HI1G 1RZKG 4RFOG 4XMPG 4S1SG 3SE8G 4LSSG 5TE7G 4J6RG 4I53A 4XVSG 4LSRG 3TGQA 2NY0A 4DKRA 2NXYA 2BF1A 4K0AA 4JB9G 4I54A 4P9HG 4S1RG 2NY3A 4H8WG 5I9QA 5F4PA 4OLXG 4OLUG 4YDLA 1G9NG 4OM1G 4DVWA 4YDKG 5F4LA 4OLWG 4DKOA 5KJRG 3SE9G 3IDYA 3LQAG 4YDJG 3TGTA 5TE6G 4DVTA 4JKPG 4XNYG 4YE4G 5CAYG 4JM2E 4RZ8A 3TGSA 4LSUG 2I5YG 2NY1A 2NY6A 4LSVG 3RJQA 4DVXA 4OLZG 3JWDA 4LSPG 4JZWA 4S1QG 5F4UA 3JWOA 4JDTG 1YYMG 3U7YG 3FUSA 4R4NA 2NY2A 5F4RA 4DKPA 4JPVG 4YDIG 5IGXG 1YYLG 5F96G 5FECC 5CD5A 4DVRG 4LAJA 2NXZA 4KA2A 3TIHA 4DKUA 2I60G 4LSQG 2NY5G 2NY7G 4DKQA 1RZJG
chains in the Genus database with same CATH topology
5FA2A 3NGBA 5F9WA 4OLYG 2NY4A 4OM0G 4RFNA 5TE4G 4DVSA 4RX4E 1G9MG 5F9OG 1GC1G 4DVVA 4LSTG 2B4CG 4R2GA 4R4FA 3TGRA 3IDXG 4YFLE 4JPWG 4XNZA 5T33G 4OLVG 4JZZA 4DKVA 4XVTG 2QADA 4RWYA 3HI1G 1RZKG 4RFOG 4XMPG 4S1SG 3SE8G 4LSSG 5TE7G 4J6RG 4I53A 4XVSG 4LSRG 3TGQA 2NY0A 4DKRA 2NXYA 2BF1A 4K0AA 4JB9G 4I54A 4P9HG 4S1RG 2NY3A 4H8WG 5I9QA 5F4PA 4OLXG 4OLUG 4YDLA 1G9NG 4OM1G 4DVWA 4YDKG 5F4LA 4OLWG 4DKOA 5KJRG 3SE9G 3IDYA 3LQAG 4YDJG 3TGTA 5TE6G 4DVTA 4JKPG 4XNYG 4YE4G 5CAYG 4JM2E 4RZ8A 3TGSA 4LSUG 2I5YG 2NY1A 2NY6A 4LSVG 3RJQA 4DVXA 4OLZG 3JWDA 4LSPG 4JZWA 4S1QG 5F4UA 3JWOA 4JDTG 1YYMG 3U7YG 3FUSA 4R4NA 2NY2A 5F4RA 4DKPA 4JPVG 4YDIG 5IGXG 1YYLG 5F96G 5FECC 5CD5A 4DVRG 4LAJA 2NXZA 4KA2A 3TIHA 4DKUA 2I60G 4LSQG 2NY5G 2NY7G 4DKQA 1RZJG
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5FA2 A;  3NGB A;  5F9W A;  4OLY G;  2NY4 A;  4OM0 G;  4RFN A;  5TE4 G;  4DVS A;  4RX4 E;  1G9M G;  5F9O G;  1GC1 G;  4DVV A;  4LST G;  2B4C G;  4R2G A;  4R4F A;  3TGR A;  3IDX G;  4YFL E;  4JPW G;  4XNZ A;  5T33 G;  4OLV G;  4JZZ A;  4DKV A;  4XVT G;  2QAD A;  4RWY A;  3HI1 G;  1RZK G;  4RFO G;  4XMP G;  4S1S G;  3SE8 G;  4LSS G;  5TE7 G;  4J6R G;  4I53 A;  4XVS G;  4LSR G;  3TGQ A;  2NY0 A;  4DKR A;  2NXY A;  2BF1 A;  4K0A A;  4JB9 G;  4I54 A;  4P9H G;  4S1R G;  2NY3 A;  4H8W G;  5I9Q A;  5F4P A;  4OLX G;  4OLU G;  4YDL A;  1G9N G;  4OM1 G;  4DVW A;  4YDK G;  5F4L A;  4OLW G;  4DKO A;  5KJR G;  3SE9 G;  3IDY A;  3LQA G;  4YDJ G;  3TGT A;  5TE6 G;  4DVT A;  4JKP G;  4XNY G;  4YE4 G;  5CAY G;  4JM2 E;  4RZ8 A;  3TGS A;  4LSU G;  2I5Y G;  2NY1 A;  2NY6 A;  4LSV G;  3RJQ A;  4DVX A;  4OLZ G;  3JWD A;  4LSP G;  4JZW A;  4S1Q G;  5F4U A;  3JWO A;  4JDT G;  1YYM G;  3U7Y G;  3FUS A;  4R4N A;  2NY2 A;  5F4R A;  4DKP A;  4JPV G;  4YDI G;  5IGX G;  1YYL G;  5F96 G;  5FEC C;  5CD5 A;  4DVR G;  4LAJ A;  2NXZ A;  4KA2 A;  3TIH A;  4DKU A;  2I60 G;  4LSQ G;  2NY5 G;  2NY7 G;  4DKQ A;  1RZJ G; 
#chains in the Genus database with same CATH topology
 5FA2 A;  3NGB A;  5F9W A;  4OLY G;  2NY4 A;  4OM0 G;  4RFN A;  5TE4 G;  4DVS A;  4RX4 E;  1G9M G;  5F9O G;  1GC1 G;  4DVV A;  4LST G;  2B4C G;  4R2G A;  4R4F A;  3TGR A;  3IDX G;  4YFL E;  4JPW G;  4XNZ A;  5T33 G;  4OLV G;  4JZZ A;  4DKV A;  4XVT G;  2QAD A;  4RWY A;  3HI1 G;  1RZK G;  4RFO G;  4XMP G;  4S1S G;  3SE8 G;  4LSS G;  5TE7 G;  4J6R G;  4I53 A;  4XVS G;  4LSR G;  3TGQ A;  2NY0 A;  4DKR A;  2NXY A;  2BF1 A;  4K0A A;  4JB9 G;  4I54 A;  4P9H G;  4S1R G;  2NY3 A;  4H8W G;  5I9Q A;  5F4P A;  4OLX G;  4OLU G;  4YDL A;  1G9N G;  4OM1 G;  4DVW A;  4YDK G;  5F4L A;  4OLW G;  4DKO A;  5KJR G;  3SE9 G;  3IDY A;  3LQA G;  4YDJ G;  3TGT A;  5TE6 G;  4DVT A;  4JKP G;  4XNY G;  4YE4 G;  5CAY G;  4JM2 E;  4RZ8 A;  3TGS A;  4LSU G;  2I5Y G;  2NY1 A;  2NY6 A;  4LSV G;  3RJQ A;  4DVX A;  4OLZ G;  3JWD A;  4LSP G;  4JZW A;  4S1Q G;  5F4U A;  3JWO A;  4JDT G;  1YYM G;  3U7Y G;  3FUS A;  4R4N A;  2NY2 A;  5F4R A;  4DKP A;  4JPV G;  4YDI G;  5IGX G;  1YYL G;  5F96 G;  5FEC C;  5CD5 A;  4DVR G;  4LAJ A;  2NXZ A;  4KA2 A;  3TIH A;  4DKU A;  2I60 G;  4LSQ G;  2NY5 G;  2NY7 G;  4DKQ A;  1RZJ G; 
#chains in the Genus database with same CATH homology
 5FA2 A;  3NGB A;  5F9W A;  4OLY G;  2NY4 A;  4OM0 G;  4RFN A;  5TE4 G;  4DVS A;  4RX4 E;  1G9M G;  5F9O G;  1GC1 G;  4DVV A;  4LST G;  2B4C G;  4R2G A;  4R4F A;  3TGR A;  3IDX G;  4YFL E;  4JPW G;  4XNZ A;  5T33 G;  4OLV G;  4JZZ A;  4DKV A;  4XVT G;  2QAD A;  4RWY A;  3HI1 G;  1RZK G;  4RFO G;  4XMP G;  4S1S G;  3SE8 G;  4LSS G;  5TE7 G;  4J6R G;  4I53 A;  4XVS G;  4LSR G;  3TGQ A;  2NY0 A;  4DKR A;  2NXY A;  2BF1 A;  4K0A A;  4JB9 G;  4I54 A;  4P9H G;  4S1R G;  2NY3 A;  4H8W G;  5I9Q A;  5F4P A;  4OLX G;  4OLU G;  4YDL A;  1G9N G;  4OM1 G;  4DVW A;  4YDK G;  5F4L A;  4OLW G;  4DKO A;  5KJR G;  3SE9 G;  3IDY A;  3LQA G;  4YDJ G;  3TGT A;  5TE6 G;  4DVT A;  4JKP G;  4XNY G;  4YE4 G;  5CAY G;  4JM2 E;  4RZ8 A;  3TGS A;  4LSU G;  2I5Y G;  2NY1 A;  2NY6 A;  4LSV G;  3RJQ A;  4DVX A;  4OLZ G;  3JWD A;  4LSP G;  4JZW A;  4S1Q G;  5F4U A;  3JWO A;  4JDT G;  1YYM G;  3U7Y G;  3FUS A;  4R4N A;  2NY2 A;  5F4R A;  4DKP A;  4JPV G;  4YDI G;  5IGX G;  1YYL G;  5F96 G;  5FEC C;  5CD5 A;  4DVR G;  4LAJ A;  2NXZ A;  4KA2 A;  3TIH A;  4DKU A;  2I60 G;  4LSQ G;  2NY5 G;  2NY7 G;  4DKQ A;  1RZJ G; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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