4KRLA

Nanobody/vhh domain 7d12 in complex with domain iii of the extracellular region of egfr, ph 6.0
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
205
structure length
205
Chain Sequence
LEEKKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGREC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains.
pubmed doi rcsb
molecule tags Transferase/immune system
source organism Lama glama
molecule keywords Nanobody/VHH domain 7D12
total genus 60
structure length 205
sequence length 205
ec nomenclature ec 2.7.10.1: Receptor protein-tyrosine kinase.
pdb deposition date 2013-05-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01030 Recep_L_domain Receptor L domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.80.20.20 Alpha Beta Alpha-Beta Horseshoe 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A Receptor L-domain 4krlA00
3B2VA 4UV7A 3BE1A 3P0YA 1MOXA 3WSQA 3P11A 3W11E 5SX5M 3QWQA 5J3HE 4KRLA 3U7UA 3LTGA 3I2TA 4KROA 3H3BA 4HRMA 1S78A 5SX4M 1M6BA 4OGAE 2HR7A 2A91A 1IGRA 4XSSE 1IVOA 3U9UE 3U2PA 3NJPA 1NQLA 4XSTE 4P59A 1YY9A 3WLWA 3LTFA 3MZWA 4HRLC 1N8YC 4KRPA 4KRMA 2AHXA 3N85A 4LEOC 3C09A 1N8ZC 3B2UA
chains in the Genus database with same CATH superfamily
3B2VA 4UV7A 3BE1A 3P0YA 1MOXA 3WSQA 3P11A 3W11E 5SX5M 3QWQA 5J3HE 4KRLA 3U7UA 3LTGA 3I2TA 4KROA 3H3BA 4HRMA 1S78A 5SX4M 1M6BA 4OGAE 2HR7A 2A91A 1IGRA 4XSSE 1IVOA 3U9UE 3U2PA 3NJPA 1NQLA 4XSTE 4P59A 1YY9A 3WLWA 3LTFA 3MZWA 4HRLC 1N8YC 4KRPA 4KRMA 2AHXA 3N85A 4LEOC 3C09A 1N8ZC 3B2UA
chains in the Genus database with same CATH topology
3B2VA 4UV7A 3BE1A 3P0YA 1MOXA 3WSQA 3P11A 3W11E 5SX5M 3QWQA 5J3HE 4KRLA 3U7UA 3LTGA 3I2TA 4KROA 3H3BA 4HRMA 1S78A 5SX4M 1M6BA 4OGAE 2HR7A 2A91A 1IGRA 4XSSE 1IVOA 3U9UE 3U2PA 3NJPA 1NQLA 4XSTE 4P59A 1YY9A 3WLWA 3LTFA 3MZWA 4HRLC 1N8YC 4KRPA 4KRMA 2AHXA 3N85A 4LEOC 3C09A 1N8ZC 3B2UA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3B2V A;  4UV7 A;  3BE1 A;  3P0Y A;  1MOX A;  3WSQ A;  3P11 A;  3W11 E;  5SX5 M;  3QWQ A;  5J3H E;  4KRL A;  3U7U A;  3LTG A;  3I2T A;  4KRO A;  3H3B A;  4HRM A;  1S78 A;  5SX4 M;  1M6B A;  4OGA E;  2HR7 A;  2A91 A;  1IGR A;  4XSS E;  1IVO A;  3U9U E;  3U2P A;  3NJP A;  1NQL A;  4XST E;  4P59 A;  1YY9 A;  3WLW A;  3LTF A;  3MZW A;  4HRL C;  1N8Y C;  4KRP A;  4KRM A;  2AHX A;  3N85 A;  4LEO C;  3C09 A;  1N8Z C;  3B2U A; 
#chains in the Genus database with same CATH topology
 3B2V A;  4UV7 A;  3BE1 A;  3P0Y A;  1MOX A;  3WSQ A;  3P11 A;  3W11 E;  5SX5 M;  3QWQ A;  5J3H E;  4KRL A;  3U7U A;  3LTG A;  3I2T A;  4KRO A;  3H3B A;  4HRM A;  1S78 A;  5SX4 M;  1M6B A;  4OGA E;  2HR7 A;  2A91 A;  1IGR A;  4XSS E;  1IVO A;  3U9U E;  3U2P A;  3NJP A;  1NQL A;  4XST E;  4P59 A;  1YY9 A;  3WLW A;  3LTF A;  3MZW A;  4HRL C;  1N8Y C;  4KRP A;  4KRM A;  2AHX A;  3N85 A;  4LEO C;  3C09 A;  1N8Z C;  3B2U A; 
#chains in the Genus database with same CATH homology
 3B2V A;  4UV7 A;  3BE1 A;  3P0Y A;  1MOX A;  3WSQ A;  3P11 A;  3W11 E;  5SX5 M;  3QWQ A;  5J3H E;  4KRL A;  3U7U A;  3LTG A;  3I2T A;  4KRO A;  3H3B A;  4HRM A;  1S78 A;  5SX4 M;  1M6B A;  4OGA E;  2HR7 A;  2A91 A;  1IGR A;  4XSS E;  1IVO A;  3U9U E;  3U2P A;  3NJP A;  1NQL A;  4XST E;  4P59 A;  1YY9 A;  3WLW A;  3LTF A;  3MZW A;  4HRL C;  1N8Y C;  4KRP A;  4KRM A;  2AHX A;  3N85 A;  4LEO C;  3C09 A;  1N8Z C;  3B2U A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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