4KRLA

Nanobody/vhh domain 7d12 in complex with domain iii of the extracellular region of egfr, ph 6.0
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
205
structure length
205
Chain Sequence
LEEKKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGREC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase/immune system
source organism Lama glama
publication title Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains.
pubmed doi rcsb
molecule keywords Nanobody/VHH domain 7D12
total genus 60
structure length 205
sequence length 205
ec nomenclature ec 2.7.10.1: Receptor protein-tyrosine kinase.
pdb deposition date 2013-05-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01030 Recep_L_domain Receptor L domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.80.20.20 Alpha Beta Alpha-Beta Horseshoe 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A Receptor L-domain 4krlA00
4LEOC 3U9UE 3LTGA 3NJPA 5SX4M 1NQLA 3I2TA 4KRLA 3H3BA 1YY9A 4KRPA 4OGAE 4KRMA 2HR7A 4P59A 3P0YA 3WLWA 4XSSE 1M6BA 3W11E 2AHXA 4XSTE 1IGRA 3MZWA 4HRMA 1N8ZC 1S78A 3LTFA 3N85A 3U7UA 3B2VA 3P11A 4HRLC 3C09A 3U2PA 3WSQA 4UV7A 1MOXA 1N8YC 3QWQA 4KROA 5J3HE 2A91A 3B2UA 5SX5M 1IVOA 3BE1A
chains in the Genus database with same CATH superfamily
4LEOC 3U9UE 3LTGA 3NJPA 5SX4M 1NQLA 3I2TA 4KRLA 3H3BA 1YY9A 4KRPA 4OGAE 4KRMA 2HR7A 4P59A 3P0YA 3WLWA 4XSSE 1M6BA 3W11E 2AHXA 4XSTE 1IGRA 3MZWA 4HRMA 1N8ZC 1S78A 3LTFA 3N85A 3U7UA 3B2VA 3P11A 4HRLC 3C09A 3U2PA 3WSQA 4UV7A 1MOXA 1N8YC 3QWQA 4KROA 5J3HE 2A91A 3B2UA 5SX5M 1IVOA 3BE1A
chains in the Genus database with same CATH topology
4LEOC 3U9UE 3LTGA 3NJPA 5SX4M 1NQLA 3I2TA 4KRLA 3H3BA 1YY9A 4KRPA 4OGAE 4KRMA 2HR7A 4P59A 3P0YA 3WLWA 4XSSE 1M6BA 3W11E 2AHXA 4XSTE 1IGRA 3MZWA 4HRMA 1N8ZC 1S78A 3LTFA 3N85A 3U7UA 3B2VA 3P11A 4HRLC 3C09A 3U2PA 3WSQA 4UV7A 1MOXA 1N8YC 3QWQA 4KROA 5J3HE 2A91A 3B2UA 5SX5M 1IVOA 3BE1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4LEO C;  3U9U E;  3LTG A;  3NJP A;  5SX4 M;  1NQL A;  3I2T A;  4KRL A;  3H3B A;  1YY9 A;  4KRP A;  4OGA E;  4KRM A;  2HR7 A;  4P59 A;  3P0Y A;  3WLW A;  4XSS E;  1M6B A;  3W11 E;  2AHX A;  4XST E;  1IGR A;  3MZW A;  4HRM A;  1N8Z C;  1S78 A;  3LTF A;  3N85 A;  3U7U A;  3B2V A;  3P11 A;  4HRL C;  3C09 A;  3U2P A;  3WSQ A;  4UV7 A;  1MOX A;  1N8Y C;  3QWQ A;  4KRO A;  5J3H E;  2A91 A;  3B2U A;  5SX5 M;  1IVO A;  3BE1 A; 
#chains in the Genus database with same CATH topology
 4LEO C;  3U9U E;  3LTG A;  3NJP A;  5SX4 M;  1NQL A;  3I2T A;  4KRL A;  3H3B A;  1YY9 A;  4KRP A;  4OGA E;  4KRM A;  2HR7 A;  4P59 A;  3P0Y A;  3WLW A;  4XSS E;  1M6B A;  3W11 E;  2AHX A;  4XST E;  1IGR A;  3MZW A;  4HRM A;  1N8Z C;  1S78 A;  3LTF A;  3N85 A;  3U7U A;  3B2V A;  3P11 A;  4HRL C;  3C09 A;  3U2P A;  3WSQ A;  4UV7 A;  1MOX A;  1N8Y C;  3QWQ A;  4KRO A;  5J3H E;  2A91 A;  3B2U A;  5SX5 M;  1IVO A;  3BE1 A; 
#chains in the Genus database with same CATH homology
 4LEO C;  3U9U E;  3LTG A;  3NJP A;  5SX4 M;  1NQL A;  3I2T A;  4KRL A;  3H3B A;  1YY9 A;  4KRP A;  4OGA E;  4KRM A;  2HR7 A;  4P59 A;  3P0Y A;  3WLW A;  4XSS E;  1M6B A;  3W11 E;  2AHX A;  4XST E;  1IGR A;  3MZW A;  4HRM A;  1N8Z C;  1S78 A;  3LTF A;  3N85 A;  3U7U A;  3B2V A;  3P11 A;  4HRL C;  3C09 A;  3U2P A;  3WSQ A;  4UV7 A;  1MOX A;  1N8Y C;  3QWQ A;  4KRO A;  5J3H E;  2A91 A;  3B2U A;  5SX5 M;  1IVO A;  3BE1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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