4KRLA

Nanobody/vhh domain 7d12 in complex with domain iii of the extracellular region of egfr, ph 6.0
Total Genus 60
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
60
sequence length
205
structure length
205
Chain Sequence
LEEKKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGREC
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transferase/immune system
molecule keywords Nanobody/VHH domain 7D12
publication title Structural Evaluation of EGFR Inhibition Mechanisms for Nanobodies/VHH Domains.
pubmed doi rcsb
source organism Lama glama
total genus 60
structure length 205
sequence length 205
ec nomenclature ec 2.7.10.1: Receptor protein-tyrosine kinase.
pdb deposition date 2013-05-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01030 Recep_L_domain Receptor L domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.80.20.20 Alpha Beta Alpha-Beta Horseshoe 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A Receptor L-domain 4krlA00
4KRMA 2A91A 4KROA 3H3BA 1NQLA 4HRLC 4LEOC 3NJPA 3U7UA 4KRLA 3B2VA 1IGRA 3LTGA 5SX4M 1N8ZC 4KRPA 3P0YA 3B2UA 2AHXA 1MOXA 3N85A 3U9UE 4UV7A 3W11E 3QWQA 3C09A 4P59A 3WSQA 3LTFA 4XSSE 3MZWA 1S78A 2HR7A 5SX5M 4OGAE 3U2PA 1IVOA 3I2TA 1N8YC 1M6BA 1YY9A 3P11A 4HRMA 4XSTE 5J3HE 3BE1A 3WLWA
chains in the Genus database with same CATH superfamily
4KRMA 2A91A 4KROA 3H3BA 1NQLA 4HRLC 4LEOC 3NJPA 3U7UA 4KRLA 3B2VA 1IGRA 3LTGA 5SX4M 1N8ZC 4KRPA 3P0YA 3B2UA 2AHXA 1MOXA 3N85A 3U9UE 4UV7A 3W11E 3QWQA 3C09A 4P59A 3WSQA 3LTFA 4XSSE 3MZWA 1S78A 2HR7A 5SX5M 4OGAE 3U2PA 1IVOA 3I2TA 1N8YC 1M6BA 1YY9A 3P11A 4HRMA 4XSTE 5J3HE 3BE1A 3WLWA
chains in the Genus database with same CATH topology
4KRMA 2A91A 4KROA 3H3BA 1NQLA 4HRLC 4LEOC 3NJPA 3U7UA 4KRLA 3B2VA 1IGRA 3LTGA 5SX4M 1N8ZC 4KRPA 3P0YA 3B2UA 2AHXA 1MOXA 3N85A 3U9UE 4UV7A 3W11E 3QWQA 3C09A 4P59A 3WSQA 3LTFA 4XSSE 3MZWA 1S78A 2HR7A 5SX5M 4OGAE 3U2PA 1IVOA 3I2TA 1N8YC 1M6BA 1YY9A 3P11A 4HRMA 4XSTE 5J3HE 3BE1A 3WLWA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4KRM A;  2A91 A;  4KRO A;  3H3B A;  1NQL A;  4HRL C;  4LEO C;  3NJP A;  3U7U A;  4KRL A;  3B2V A;  1IGR A;  3LTG A;  5SX4 M;  1N8Z C;  4KRP A;  3P0Y A;  3B2U A;  2AHX A;  1MOX A;  3N85 A;  3U9U E;  4UV7 A;  3W11 E;  3QWQ A;  3C09 A;  4P59 A;  3WSQ A;  3LTF A;  4XSS E;  3MZW A;  1S78 A;  2HR7 A;  5SX5 M;  4OGA E;  3U2P A;  1IVO A;  3I2T A;  1N8Y C;  1M6B A;  1YY9 A;  3P11 A;  4HRM A;  4XST E;  5J3H E;  3BE1 A;  3WLW A; 
#chains in the Genus database with same CATH topology
 4KRM A;  2A91 A;  4KRO A;  3H3B A;  1NQL A;  4HRL C;  4LEO C;  3NJP A;  3U7U A;  4KRL A;  3B2V A;  1IGR A;  3LTG A;  5SX4 M;  1N8Z C;  4KRP A;  3P0Y A;  3B2U A;  2AHX A;  1MOX A;  3N85 A;  3U9U E;  4UV7 A;  3W11 E;  3QWQ A;  3C09 A;  4P59 A;  3WSQ A;  3LTF A;  4XSS E;  3MZW A;  1S78 A;  2HR7 A;  5SX5 M;  4OGA E;  3U2P A;  1IVO A;  3I2T A;  1N8Y C;  1M6B A;  1YY9 A;  3P11 A;  4HRM A;  4XST E;  5J3H E;  3BE1 A;  3WLW A; 
#chains in the Genus database with same CATH homology
 4KRM A;  2A91 A;  4KRO A;  3H3B A;  1NQL A;  4HRL C;  4LEO C;  3NJP A;  3U7U A;  4KRL A;  3B2V A;  1IGR A;  3LTG A;  5SX4 M;  1N8Z C;  4KRP A;  3P0Y A;  3B2U A;  2AHX A;  1MOX A;  3N85 A;  3U9U E;  4UV7 A;  3W11 E;  3QWQ A;  3C09 A;  4P59 A;  3WSQ A;  3LTF A;  4XSS E;  3MZW A;  1S78 A;  2HR7 A;  5SX5 M;  4OGA E;  3U2P A;  1IVO A;  3I2T A;  1N8Y C;  1M6B A;  1YY9 A;  3P11 A;  4HRM A;  4XST E;  5J3H E;  3BE1 A;  3WLW A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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