4LHOA

Crystal structure of fg41malonate semialdehyde decarboxylase inhibited by 3-bromopropiolate
Total Genus 40
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
40
sequence length
131
structure length
131
Chain Sequence
PLIRIDLTSDRSREQRRAIADAVHDALVEVLAIPARDRFQILTAHDPSDIIAEDAGLGFQRSPSVVIIHVFTQAGRTIETKQRVFAAITESLAPIGVAGSDVFIAITENAPHDWSFGFGSAQYVTGELAIP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Kinetic, Mutational, and Structural Analysis of Malonate Semialdehyde Decarboxylase from Coryneform Bacterium Strain FG41: Mechanistic Implications for the Decarboxylase and Hydratase Activities.
pubmed doi rcsb
molecule tags Isomerase/isomerase inhibitor
source organism Coryneform bacterium
molecule keywords FG41 Malonate Semialdehyde Decarboxylase
total genus 40
structure length 131
sequence length 131
chains with identical sequence B, C, D, E
ec nomenclature ec 4.1.1.-:
pdb deposition date 2013-07-01

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF14552 Tautomerase_2 Tautomerase enzyme
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.429.10 Alpha Beta 2-Layer Sandwich Macrophage Migration Inhibitory Factor Macrophage Migration Inhibitory Factor 4lhoA00
3CE4A 3N4DA 3E6QA 2FM7A 1MIFA 2WKFB 3L5VA 1U9DA 3T5SA 4F2KA 5CLNA 1GIFA 2OPAA 2FLZA 3L5RA 4PKZA 1UIZA 3HOFA 3MF7A 4LKBA 3EJ7A 1S0YB 4P01A 1DPTA 2X4KA 4XX7A 3KERA 3N4HA 4P7SA 3JSFA 3GACA 3EJ9B 3MLCA 4X19A 3WNRA 5HVSA 3JTUA 1P1GA 4GRNA 5J7PA 1GD0A 3EJ3A 4GRPA 3B9SA 2GDGA 1CGQA 2OS5A 3FWUA 4Q3FA 4GROA 4Z15A 3SMCA 3L5PA 3L5UA 4U5PA 4PLUA 1OTGA 4XX8A 5J7QA 4OSFA 4DH4A 2WKBA 4JJ9A 1GCZA 2AAGA 4X1CC 2AAJA 2AALA 4JCUA 3MB2A 3RF4A 1MFFA 4GRRA 3WNTA 4TRFA 5BS9A 4OTAA 3DJHA 3EJ9A 4WR8A 5B4OA 3M20A 5BSIA 4P0HA 3RY0A 3SMBA 4M1AA 2OOHA 4OYQA 4OTCA 4P7MA 2WKFA 4ETGA 5EIZA 1FIMA 2OP8A 1CA7A 3L5TA 3WNSA 4NWQB 4TRUA 3MJZA 3M21A 4OTBA 4PKKA 5BSCA 1GYXA 3DJIA 3ABFA 5HVVA 2FLTA 5HVTA 1S0YA 1BJPA 4NWPE 3IJJA 4GRQA 2XCZA 1GYYA 4GRUA 2OOWA 4FAZA 2ORMA 4LHPA 4FDXA 4EVGA 4Z1TA 1MFIA 3GADA 3EJ7B 1LJTA 3JSGA 5BSJA 4EUIA 1MWWA 3IJGA 3L5SA 3N4GA 4LHOA 4WRBA 3KANA 5CLOA 1HFOA 3U18A 4K9GA 3FWTA 3B64A 3RF5A 3C6VA 3MB2B 1GYJA 4U5RA 4X1CA 1OTFA 2OOZA 4GUMA 3MF8A 4Z1UA 3EJ3B
chains in the Genus database with same CATH superfamily
3CE4A 3N4DA 3E6QA 2FM7A 1MIFA 2WKFB 3L5VA 1U9DA 3T5SA 4F2KA 5CLNA 1GIFA 2OPAA 2FLZA 3L5RA 4PKZA 1UIZA 3HOFA 3MF7A 4LKBA 3EJ7A 1S0YB 4P01A 1DPTA 2X4KA 4XX7A 3KERA 3N4HA 4P7SA 3JSFA 3GACA 3EJ9B 3MLCA 4X19A 3WNRA 5HVSA 3JTUA 1P1GA 4GRNA 5J7PA 1GD0A 3EJ3A 4GRPA 3B9SA 2GDGA 1CGQA 2OS5A 3FWUA 4Q3FA 4GROA 4Z15A 3SMCA 3L5PA 3L5UA 4U5PA 4PLUA 1OTGA 4XX8A 5J7QA 4OSFA 4DH4A 2WKBA 4JJ9A 1GCZA 2AAGA 4X1CC 2AAJA 2AALA 4JCUA 3MB2A 3RF4A 1MFFA 4GRRA 3WNTA 4TRFA 5BS9A 4OTAA 3DJHA 3EJ9A 4WR8A 5B4OA 3M20A 5BSIA 4P0HA 3RY0A 3SMBA 4M1AA 2OOHA 4OYQA 4OTCA 4P7MA 2WKFA 4ETGA 5EIZA 1FIMA 2OP8A 1CA7A 3L5TA 3WNSA 4NWQB 4TRUA 3MJZA 3M21A 4OTBA 4PKKA 5BSCA 1GYXA 3DJIA 3ABFA 5HVVA 2FLTA 5HVTA 1S0YA 1BJPA 4NWPE 3IJJA 4GRQA 2XCZA 1GYYA 4GRUA 2OOWA 4FAZA 2ORMA 4LHPA 4FDXA 4EVGA 4Z1TA 1MFIA 3GADA 3EJ7B 1LJTA 3JSGA 5BSJA 4EUIA 1MWWA 3IJGA 3L5SA 3N4GA 4LHOA 4WRBA 3KANA 5CLOA 1HFOA 3U18A 4K9GA 3FWTA 3B64A 3RF5A 3C6VA 3MB2B 1GYJA 4U5RA 4X1CA 1OTFA 2OOZA 4GUMA 3MF8A 4Z1UA 3EJ3B
chains in the Genus database with same CATH topology
3CE4A 3N4DA 3E6QA 2FM7A 1MIFA 2WKFB 3L5VA 1U9DA 3T5SA 4F2KA 5CLNA 1GIFA 2OPAA 2FLZA 3L5RA 4PKZA 1UIZA 3HOFA 3MF7A 4LKBA 3EJ7A 1S0YB 4P01A 1DPTA 2X4KA 4XX7A 3KERA 3N4HA 4P7SA 3JSFA 3GACA 3EJ9B 3MLCA 4X19A 3WNRA 5HVSA 3JTUA 1P1GA 4GRNA 5J7PA 1GD0A 3EJ3A 4GRPA 3B9SA 2GDGA 1CGQA 2OS5A 3FWUA 4Q3FA 4GROA 4Z15A 3SMCA 3L5PA 3L5UA 4U5PA 4PLUA 1OTGA 4XX8A 5J7QA 4OSFA 4DH4A 2WKBA 4JJ9A 1GCZA 2AAGA 4X1CC 2AAJA 2AALA 4JCUA 3MB2A 3RF4A 1MFFA 4GRRA 3WNTA 4TRFA 5BS9A 4OTAA 3DJHA 3EJ9A 4WR8A 5B4OA 3M20A 5BSIA 4P0HA 3RY0A 3SMBA 4M1AA 2OOHA 4OYQA 4OTCA 4P7MA 2WKFA 4ETGA 5EIZA 1FIMA 2OP8A 1CA7A 3L5TA 3WNSA 4NWQB 4TRUA 3MJZA 3M21A 4OTBA 4PKKA 5BSCA 1GYXA 3DJIA 3ABFA 5HVVA 2FLTA 5HVTA 1S0YA 1BJPA 4NWPE 3IJJA 4GRQA 2XCZA 1GYYA 4GRUA 2OOWA 4FAZA 2ORMA 4LHPA 4FDXA 4EVGA 4Z1TA 1MFIA 3GADA 3EJ7B 1LJTA 3JSGA 5BSJA 4EUIA 1MWWA 3IJGA 3L5SA 3N4GA 4LHOA 4WRBA 3KANA 5CLOA 1HFOA 3U18A 4K9GA 3FWTA 3B64A 3RF5A 3C6VA 3MB2B 1GYJA 4U5RA 4X1CA 1OTFA 2OOZA 4GUMA 3MF8A 4Z1UA 3EJ3B
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CE4 A;  3N4D A;  3E6Q A;  2FM7 A;  1MIF A;  2WKF B;  3L5V A;  1U9D A;  3T5S A;  4F2K A;  5CLN A;  1GIF A;  2OPA A;  2FLZ A;  3L5R A;  4PKZ A;  1UIZ A;  3HOF A;  3MF7 A;  4LKB A;  3EJ7 A;  1S0Y B;  4P01 A;  1DPT A;  2X4K A;  4XX7 A;  3KER A;  3N4H A;  4P7S A;  3JSF A;  3GAC A;  3EJ9 B;  3MLC A;  4X19 A;  3WNR A;  5HVS A;  3JTU A;  1P1G A;  4GRN A;  5J7P A;  1GD0 A;  3EJ3 A;  4GRP A;  3B9S A;  2GDG A;  1CGQ A;  2OS5 A;  3FWU A;  4Q3F A;  4GRO A;  4Z15 A;  3SMC A;  3L5P A;  3L5U A;  4U5P A;  4PLU A;  1OTG A;  4XX8 A;  5J7Q A;  4OSF A;  4DH4 A;  2WKB A;  4JJ9 A;  1GCZ A;  2AAG A;  4X1C C;  2AAJ A;  2AAL A;  4JCU A;  3MB2 A;  3RF4 A;  1MFF A;  4GRR A;  3WNT A;  4TRF A;  5BS9 A;  4OTA A;  3DJH A;  3EJ9 A;  4WR8 A;  5B4O A;  3M20 A;  5BSI A;  4P0H A;  3RY0 A;  3SMB A;  4M1A A;  2OOH A;  4OYQ A;  4OTC A;  4P7M A;  2WKF A;  4ETG A;  5EIZ A;  1FIM A;  2OP8 A;  1CA7 A;  3L5T A;  3WNS A;  4NWQ B;  4TRU A;  3MJZ A;  3M21 A;  4OTB A;  4PKK A;  5BSC A;  1GYX A;  3DJI A;  3ABF A;  5HVV A;  2FLT A;  5HVT A;  1S0Y A;  1BJP A;  4NWP E;  3IJJ A;  4GRQ A;  2XCZ A;  1GYY A;  4GRU A;  2OOW A;  4FAZ A;  2ORM A;  4LHP A;  4FDX A;  4EVG A;  4Z1T A;  1MFI A;  3GAD A;  3EJ7 B;  1LJT A;  3JSG A;  5BSJ A;  4EUI A;  1MWW A;  3IJG A;  3L5S A;  3N4G A;  4LHO A;  4WRB A;  3KAN A;  5CLO A;  1HFO A;  3U18 A;  4K9G A;  3FWT A;  3B64 A;  3RF5 A;  3C6V A;  3MB2 B;  1GYJ A;  4U5R A;  4X1C A;  1OTF A;  2OOZ A;  4GUM A;  3MF8 A;  4Z1U A;  3EJ3 B; 
#chains in the Genus database with same CATH topology
 3CE4 A;  3N4D A;  3E6Q A;  2FM7 A;  1MIF A;  2WKF B;  3L5V A;  1U9D A;  3T5S A;  4F2K A;  5CLN A;  1GIF A;  2OPA A;  2FLZ A;  3L5R A;  4PKZ A;  1UIZ A;  3HOF A;  3MF7 A;  4LKB A;  3EJ7 A;  1S0Y B;  4P01 A;  1DPT A;  2X4K A;  4XX7 A;  3KER A;  3N4H A;  4P7S A;  3JSF A;  3GAC A;  3EJ9 B;  3MLC A;  4X19 A;  3WNR A;  5HVS A;  3JTU A;  1P1G A;  4GRN A;  5J7P A;  1GD0 A;  3EJ3 A;  4GRP A;  3B9S A;  2GDG A;  1CGQ A;  2OS5 A;  3FWU A;  4Q3F A;  4GRO A;  4Z15 A;  3SMC A;  3L5P A;  3L5U A;  4U5P A;  4PLU A;  1OTG A;  4XX8 A;  5J7Q A;  4OSF A;  4DH4 A;  2WKB A;  4JJ9 A;  1GCZ A;  2AAG A;  4X1C C;  2AAJ A;  2AAL A;  4JCU A;  3MB2 A;  3RF4 A;  1MFF A;  4GRR A;  3WNT A;  4TRF A;  5BS9 A;  4OTA A;  3DJH A;  3EJ9 A;  4WR8 A;  5B4O A;  3M20 A;  5BSI A;  4P0H A;  3RY0 A;  3SMB A;  4M1A A;  2OOH A;  4OYQ A;  4OTC A;  4P7M A;  2WKF A;  4ETG A;  5EIZ A;  1FIM A;  2OP8 A;  1CA7 A;  3L5T A;  3WNS A;  4NWQ B;  4TRU A;  3MJZ A;  3M21 A;  4OTB A;  4PKK A;  5BSC A;  1GYX A;  3DJI A;  3ABF A;  5HVV A;  2FLT A;  5HVT A;  1S0Y A;  1BJP A;  4NWP E;  3IJJ A;  4GRQ A;  2XCZ A;  1GYY A;  4GRU A;  2OOW A;  4FAZ A;  2ORM A;  4LHP A;  4FDX A;  4EVG A;  4Z1T A;  1MFI A;  3GAD A;  3EJ7 B;  1LJT A;  3JSG A;  5BSJ A;  4EUI A;  1MWW A;  3IJG A;  3L5S A;  3N4G A;  4LHO A;  4WRB A;  3KAN A;  5CLO A;  1HFO A;  3U18 A;  4K9G A;  3FWT A;  3B64 A;  3RF5 A;  3C6V A;  3MB2 B;  1GYJ A;  4U5R A;  4X1C A;  1OTF A;  2OOZ A;  4GUM A;  3MF8 A;  4Z1U A;  3EJ3 B; 
#chains in the Genus database with same CATH homology
 3CE4 A;  3N4D A;  3E6Q A;  2FM7 A;  1MIF A;  2WKF B;  3L5V A;  1U9D A;  3T5S A;  4F2K A;  5CLN A;  1GIF A;  2OPA A;  2FLZ A;  3L5R A;  4PKZ A;  1UIZ A;  3HOF A;  3MF7 A;  4LKB A;  3EJ7 A;  1S0Y B;  4P01 A;  1DPT A;  2X4K A;  4XX7 A;  3KER A;  3N4H A;  4P7S A;  3JSF A;  3GAC A;  3EJ9 B;  3MLC A;  4X19 A;  3WNR A;  5HVS A;  3JTU A;  1P1G A;  4GRN A;  5J7P A;  1GD0 A;  3EJ3 A;  4GRP A;  3B9S A;  2GDG A;  1CGQ A;  2OS5 A;  3FWU A;  4Q3F A;  4GRO A;  4Z15 A;  3SMC A;  3L5P A;  3L5U A;  4U5P A;  4PLU A;  1OTG A;  4XX8 A;  5J7Q A;  4OSF A;  4DH4 A;  2WKB A;  4JJ9 A;  1GCZ A;  2AAG A;  4X1C C;  2AAJ A;  2AAL A;  4JCU A;  3MB2 A;  3RF4 A;  1MFF A;  4GRR A;  3WNT A;  4TRF A;  5BS9 A;  4OTA A;  3DJH A;  3EJ9 A;  4WR8 A;  5B4O A;  3M20 A;  5BSI A;  4P0H A;  3RY0 A;  3SMB A;  4M1A A;  2OOH A;  4OYQ A;  4OTC A;  4P7M A;  2WKF A;  4ETG A;  5EIZ A;  1FIM A;  2OP8 A;  1CA7 A;  3L5T A;  3WNS A;  4NWQ B;  4TRU A;  3MJZ A;  3M21 A;  4OTB A;  4PKK A;  5BSC A;  1GYX A;  3DJI A;  3ABF A;  5HVV A;  2FLT A;  5HVT A;  1S0Y A;  1BJP A;  4NWP E;  3IJJ A;  4GRQ A;  2XCZ A;  1GYY A;  4GRU A;  2OOW A;  4FAZ A;  2ORM A;  4LHP A;  4FDX A;  4EVG A;  4Z1T A;  1MFI A;  3GAD A;  3EJ7 B;  1LJT A;  3JSG A;  5BSJ A;  4EUI A;  1MWW A;  3IJG A;  3L5S A;  3N4G A;  4LHO A;  4WRB A;  3KAN A;  5CLO A;  1HFO A;  3U18 A;  4K9G A;  3FWT A;  3B64 A;  3RF5 A;  3C6V A;  3MB2 B;  1GYJ A;  4U5R A;  4X1C A;  1OTF A;  2OOZ A;  4GUM A;  3MF8 A;  4Z1U A;  3EJ3 B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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