4ONDA

Ancestral steroid receptor 2 dbd helix mutant - ere dna complex
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
72
structure length
72
Chain Sequence
QKVCLICGDEASGCHYGVLTCEGCKAFFKRAVEGQHNYLCAGRNDCIIDKIRRKNCPACRLRKCLQAGMTLG
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Transcription/dna
source organism Synthetic construct
publication title Evolution of DNA specificity in a transcription factor family produced a new gene regulatory module.
pubmed doi rcsb
molecule keywords Ancestral SR2 Helix Mutant
total genus 12
structure length 72
sequence length 72
chains with identical sequence B, E, F
ec nomenclature
pdb deposition date 2014-01-28
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.50.10 Alpha Beta 2-Layer Sandwich Erythroid Transcription Factor GATA-1; Chain A Erythroid Transcription Factor GATA-1, subunit A 4ondA00
1HLZA 3DFVC 6GATA 1LV3A 4AA6A 4HN5A 3G8UA 3FYLA 4GATA 1R4OA 2EBLA 1R0NB 4TNTA 4OV7A 3G99A 3G97A 1KB2A 5KRBB 2A66A 2HANA 2KAEA 1R0OA 5CC1A 2NLLB 1HCPA 2GATA 5EMQA 5EMPA 1DSZB 1R4RA 3G6TA 1YNWB 4CN7A 5CC0A 4CN3D 3DZYA 3VEKC 5CBXA 2VUTI 3GATA 5EMCA 3G9OA 1A6YA 1GNFA 3DZUD 4HN6A 1LO1A 4HC9A 3G9IA 4CN3A 1HCQA 5E6AA 5CBYA 2ENVA 3G6RA 2NLLA 3DZUA 1GA5A 3M9EA 5E6BA 4OLNA 3DFXA 3E00D 1DSZA 4IQRA 1YNWA 7GATA 2HANB 1R0NA 5E6DA 2VUSI 2GDAA 5CBZA 3CBBA 1GATA 4NQAB 1CITA 1RXRA 4HC7A 4OORA 5E6CA 1LATA 2VUUI 2FF0A 3G9JA 3G6QA 3G6PA 4ONDA 1GDCA 3G9MA 1GAUA 5E69A 3G8XA 3VD6C 4CN2C 4HCAA 1BY4A 4TMAI 1R0OB 1KB6A 2M9WA 4CN5A 1HRAA 3G9PA 3E00A 5GATA 1R4IA 1RGDA 2C7AA 3G6UA 3DZYD 1KB4A 5L0MA 1GLUA
chains in the Genus database with same CATH superfamily
1HLZA 3DFVC 6GATA 1LV3A 4AA6A 4HN5A 3G8UA 3FYLA 4GATA 1R4OA 2EBLA 1R0NB 4TNTA 4OV7A 3G99A 3G97A 1KB2A 5KRBB 2A66A 2HANA 2KAEA 1R0OA 5CC1A 2NLLB 1HCPA 2GATA 5EMQA 5EMPA 1DSZB 1R4RA 3G6TA 1YNWB 4CN7A 5CC0A 4CN3D 3DZYA 3VEKC 5CBXA 2VUTI 3GATA 5EMCA 3G9OA 1A6YA 1GNFA 2DS5A 3DZUD 4HN6A 1LO1A 4HC9A 3G9IA 4CN3A 1HCQA 5E6AA 5CBYA 2ENVA 3G6RA 2NLLA 2DS6A 3G27A 3DZUA 1GA5A 3M9EA 5E6BA 4OLNA 3DFXA 3E00D 1DSZA 4IQRA 1YNWA 7GATA 2HANB 1R0NA 5E6DA 2VUSI 2GDAA 5CBZA 3CBBA 1GATA 4NQAB 1CITA 1RXRA 4HC7A 4OORA 5E6CA 1LATA 2VUUI 2FF0A 3G9JA 3G6QA 3G6PA 4ONDA 1GDCA 2DS8A 3G9MA 1GAUA 5E69A 3G8XA 3VD6C 4CN2C 4HCAA 1BY4A 4TMAI 1R0OB 1KB6A 2M9WA 4CN5A 1HRAA 3G9PA 3E00A 5GATA 1R4IA 1RGDA 2C7AA 3G6UA 3DZYD 1KB4A 5L0MA 1GLUA
chains in the Genus database with same CATH topology
1HLZA 3DFVC 6GATA 1LV3A 4AA6A 4HN5A 3G8UA 3FYLA 4GATA 1R4OA 2EBLA 1R0NB 4TNTA 4OV7A 3G99A 3G97A 1KB2A 5KRBB 2A66A 2HANA 2KAEA 1R0OA 5CC1A 2NLLB 1HCPA 2GATA 5EMQA 5EMPA 1DSZB 1R4RA 3G6TA 1YNWB 4CN7A 5CC0A 4CN3D 3DZYA 3VEKC 5CBXA 2VUTI 3GATA 5EMCA 3G9OA 1A6YA 1GNFA 3DZUD 4HN6A 1LO1A 4HC9A 3G9IA 4CN3A 1HCQA 5E6AA 5CBYA 2ENVA 3G6RA 2NLLA 3DZUA 1GA5A 3M9EA 5E6BA 4OLNA 3DFXA 3E00D 1DSZA 4IQRA 1YNWA 7GATA 2HANB 1R0NA 5E6DA 2VUSI 2GDAA 5CBZA 3CBBA 1GATA 4NQAB 1CITA 1RXRA 4HC7A 4OORA 5E6CA 1LATA 2VUUI 2FF0A 3G9JA 3G6QA 3G6PA 4ONDA 1GDCA 3G9MA 1GAUA 5E69A 3G8XA 3VD6C 4CN2C 4HCAA 1BY4A 4TMAI 1R0OB 1KB6A 2M9WA 4CN5A 1HRAA 3G9PA 3E00A 5GATA 1R4IA 1RGDA 2C7AA 3G6UA 3DZYD 1KB4A 5L0MA 1GLUA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1HLZ A;  3DFV C;  6GAT A;  1LV3 A;  4AA6 A;  4HN5 A;  3G8U A;  3FYL A;  4GAT A;  1R4O A;  2EBL A;  1R0N B;  4TNT A;  4OV7 A;  3G99 A;  3G97 A;  1KB2 A;  5KRB B;  2A66 A;  2HAN A;  2KAE A;  1R0O A;  5CC1 A;  2NLL B;  1HCP A;  2GAT A;  5EMQ A;  5EMP A;  1DSZ B;  1R4R A;  3G6T A;  1YNW B;  4CN7 A;  5CC0 A;  4CN3 D;  3DZY A;  3VEK C;  5CBX A;  2VUT I;  3GAT A;  5EMC A;  3G9O A;  1A6Y A;  1GNF A;  3DZU D;  4HN6 A;  1LO1 A;  4HC9 A;  3G9I A;  4CN3 A;  1HCQ A;  5E6A A;  5CBY A;  2ENV A;  3G6R A;  2NLL A;  3DZU A;  1GA5 A;  3M9E A;  5E6B A;  4OLN A;  3DFX A;  3E00 D;  1DSZ A;  4IQR A;  1YNW A;  7GAT A;  2HAN B;  1R0N A;  5E6D A;  2VUS I;  2GDA A;  5CBZ A;  3CBB A;  1GAT A;  4NQA B;  1CIT A;  1RXR A;  4HC7 A;  4OOR A;  5E6C A;  1LAT A;  2VUU I;  2FF0 A;  3G9J A;  3G6Q A;  3G6P A;  4OND A;  1GDC A;  3G9M A;  1GAU A;  5E69 A;  3G8X A;  3VD6 C;  4CN2 C;  4HCA A;  1BY4 A;  4TMA I;  1R0O B;  1KB6 A;  2M9W A;  4CN5 A;  1HRA A;  3G9P A;  3E00 A;  5GAT A;  1R4I A;  1RGD A;  2C7A A;  3G6U A;  3DZY D;  1KB4 A;  5L0M A;  1GLU A; 
#chains in the Genus database with same CATH topology
 1HLZ A;  3DFV C;  6GAT A;  1LV3 A;  4AA6 A;  4HN5 A;  3G8U A;  3FYL A;  4GAT A;  1R4O A;  2EBL A;  1R0N B;  4TNT A;  4OV7 A;  3G99 A;  3G97 A;  1KB2 A;  5KRB B;  2A66 A;  2HAN A;  2KAE A;  1R0O A;  5CC1 A;  2NLL B;  1HCP A;  2GAT A;  5EMQ A;  5EMP A;  1DSZ B;  1R4R A;  3G6T A;  1YNW B;  4CN7 A;  5CC0 A;  4CN3 D;  3DZY A;  3VEK C;  5CBX A;  2VUT I;  3GAT A;  5EMC A;  3G9O A;  1A6Y A;  1GNF A;  2DS5 A;  3DZU D;  4HN6 A;  1LO1 A;  4HC9 A;  3G9I A;  4CN3 A;  1HCQ A;  5E6A A;  5CBY A;  2ENV A;  3G6R A;  2NLL A;  2DS6 A;  3G27 A;  3DZU A;  1GA5 A;  3M9E A;  5E6B A;  4OLN A;  3DFX A;  3E00 D;  1DSZ A;  4IQR A;  1YNW A;  7GAT A;  2HAN B;  1R0N A;  5E6D A;  2VUS I;  2GDA A;  5CBZ A;  3CBB A;  1GAT A;  4NQA B;  1CIT A;  1RXR A;  4HC7 A;  4OOR A;  5E6C A;  1LAT A;  2VUU I;  2FF0 A;  3G9J A;  3G6Q A;  3G6P A;  4OND A;  1GDC A;  2DS8 A;  3G9M A;  1GAU A;  5E69 A;  3G8X A;  3VD6 C;  4CN2 C;  4HCA A;  1BY4 A;  4TMA I;  1R0O B;  1KB6 A;  2M9W A;  4CN5 A;  1HRA A;  3G9P A;  3E00 A;  5GAT A;  1R4I A;  1RGD A;  2C7A A;  3G6U A;  3DZY D;  1KB4 A;  5L0M A;  1GLU A; 
#chains in the Genus database with same CATH homology
 1HLZ A;  3DFV C;  6GAT A;  1LV3 A;  4AA6 A;  4HN5 A;  3G8U A;  3FYL A;  4GAT A;  1R4O A;  2EBL A;  1R0N B;  4TNT A;  4OV7 A;  3G99 A;  3G97 A;  1KB2 A;  5KRB B;  2A66 A;  2HAN A;  2KAE A;  1R0O A;  5CC1 A;  2NLL B;  1HCP A;  2GAT A;  5EMQ A;  5EMP A;  1DSZ B;  1R4R A;  3G6T A;  1YNW B;  4CN7 A;  5CC0 A;  4CN3 D;  3DZY A;  3VEK C;  5CBX A;  2VUT I;  3GAT A;  5EMC A;  3G9O A;  1A6Y A;  1GNF A;  3DZU D;  4HN6 A;  1LO1 A;  4HC9 A;  3G9I A;  4CN3 A;  1HCQ A;  5E6A A;  5CBY A;  2ENV A;  3G6R A;  2NLL A;  3DZU A;  1GA5 A;  3M9E A;  5E6B A;  4OLN A;  3DFX A;  3E00 D;  1DSZ A;  4IQR A;  1YNW A;  7GAT A;  2HAN B;  1R0N A;  5E6D A;  2VUS I;  2GDA A;  5CBZ A;  3CBB A;  1GAT A;  4NQA B;  1CIT A;  1RXR A;  4HC7 A;  4OOR A;  5E6C A;  1LAT A;  2VUU I;  2FF0 A;  3G9J A;  3G6Q A;  3G6P A;  4OND A;  1GDC A;  3G9M A;  1GAU A;  5E69 A;  3G8X A;  3VD6 C;  4CN2 C;  4HCA A;  1BY4 A;  4TMA I;  1R0O B;  1KB6 A;  2M9W A;  4CN5 A;  1HRA A;  3G9P A;  3E00 A;  5GAT A;  1R4I A;  1RGD A;  2C7A A;  3G6U A;  3DZY D;  1KB4 A;  5L0M A;  1GLU A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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