4P0HA

Crystal structure analysis of macrophage migration inhibitory factor in complex with dimethylformamide
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
113
structure length
113
Chain Sequence
PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTF
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title An Analysis of MIF Structural Features that Control Functional Activation of CD74.
pubmed doi rcsb
molecule tags Isomerase/isomerase inhibitor
source organism Homo sapiens
molecule keywords Macrophage migration inhibitory factor
total genus 32
structure length 113
sequence length 113
chains with identical sequence B, C
ec nomenclature ec 5.3.2.1: Phenylpyruvate tautomerase.
pdb deposition date 2014-02-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01187 MIF Macrophage migration inhibitory factor (MIF)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.429.10 Alpha Beta 2-Layer Sandwich Macrophage Migration Inhibitory Factor Macrophage Migration Inhibitory Factor 4p0hA00
3MB2B 3SMBA 3MF7A 1GIFA 1MWWA 1DPTA 4TRFA 3EJ9B 4EUIA 4Z15A 3EJ3B 3N4DA 2OS5A 4X19A 2XCZA 1FIMA 1GYXA 3DJIA 3M21A 4GRUA 1S0YA 2AAJA 3L5RA 2FM7A 3MF8A 3L5VA 4U5RA 4FAZA 4EVGA 1GYYA 4X1CC 1OTGA 3U18A 5B4OA 3B9SA 4GRPA 4U5PA 1GYJA 4OYQA 2AAGA 5CLOA 3EJ7A 2FLZA 4JJ9A 4P7MA 4WR8A 5HVTA 1P1GA 5BSIA 5BS9A 3FWTA 5HVSA 3L5UA 2ORMA 4TRUA 3CE4A 3KERA 4PKKA 2OOHA 2OOWA 5J7QA 1GCZA 3GADA 4PLUA 3RF5A 1S0YB 2FLTA 3HOFA 3WNRA 2WKBA 4XX8A 4Z1TA 3SMCA 3JTUA 2OP8A 3ABFA 4P01A 3RF4A 4GROA 3L5SA 3N4HA 3DJHA 2OPAA 3E6QA 4LHOA 3JSGA 5BSJA 5J7PA 4Z1UA 3MJZA 4P7SA 4P0HA 3IJJA 3EJ9A 4JCUA 4OTCA 3WNTA 1OTFA 3EJ7B 4GRRA 4OTBA 4NWQB 1U9DA 3IJGA 3KANA 4OSFA 4OTAA 3B64A 1BJPA 4DH4A 5EIZA 4GUMA 4XX7A 4GRNA 2WKFA 4FDXA 4NWPE 3MLCA 2OOZA 3L5PA 2AALA 1CA7A 1MIFA 4PKZA 3MB2A 3T5SA 1MFIA 1MFFA 3JSFA 3EJ3A 3GACA 3N4GA 4LHPA 4F2KA 4GRQA 4M1AA 4Q3FA 4K9GA 3M20A 1HFOA 3FWUA 1GD0A 1CGQA 1LJTA 2GDGA 3C6VA 5BSCA 2WKFB 2X4KA 4X1CA 1UIZA 3WNSA 3L5TA 4WRBA 4LKBA 5CLNA 3RY0A 4ETGA 5HVVA
chains in the Genus database with same CATH superfamily
3MB2B 3SMBA 3MF7A 1GIFA 1MWWA 1DPTA 4TRFA 3EJ9B 4EUIA 4Z15A 3EJ3B 3N4DA 2OS5A 4X19A 2XCZA 1FIMA 1GYXA 3DJIA 3M21A 4GRUA 1S0YA 2AAJA 3L5RA 2FM7A 3MF8A 3L5VA 4U5RA 4FAZA 4EVGA 1GYYA 4X1CC 1OTGA 3U18A 5B4OA 3B9SA 4GRPA 4U5PA 1GYJA 4OYQA 2AAGA 5CLOA 3EJ7A 2FLZA 4JJ9A 4P7MA 4WR8A 5HVTA 1P1GA 5BSIA 5BS9A 3FWTA 5HVSA 3L5UA 2ORMA 4TRUA 3CE4A 3KERA 4PKKA 2OOHA 2OOWA 5J7QA 1GCZA 3GADA 4PLUA 3RF5A 1S0YB 2FLTA 3HOFA 3WNRA 2WKBA 4XX8A 4Z1TA 3SMCA 3JTUA 2OP8A 3ABFA 4P01A 3RF4A 4GROA 3L5SA 3N4HA 3DJHA 2OPAA 3E6QA 4LHOA 3JSGA 5BSJA 5J7PA 4Z1UA 3MJZA 4P7SA 4P0HA 3IJJA 3EJ9A 4JCUA 4OTCA 3WNTA 1OTFA 3EJ7B 4GRRA 4OTBA 4NWQB 1U9DA 3IJGA 3KANA 4OSFA 4OTAA 3B64A 1BJPA 4DH4A 5EIZA 4GUMA 4XX7A 4GRNA 2WKFA 4FDXA 4NWPE 3MLCA 2OOZA 3L5PA 2AALA 1CA7A 1MIFA 4PKZA 3MB2A 3T5SA 1MFIA 1MFFA 3JSFA 3EJ3A 3GACA 3N4GA 4LHPA 4F2KA 4GRQA 4M1AA 4Q3FA 4K9GA 3M20A 1HFOA 3FWUA 1GD0A 1CGQA 1LJTA 2GDGA 3C6VA 5BSCA 2WKFB 2X4KA 4X1CA 1UIZA 3WNSA 3L5TA 4WRBA 4LKBA 5CLNA 3RY0A 4ETGA 5HVVA
chains in the Genus database with same CATH topology
3MB2B 3SMBA 3MF7A 1GIFA 1MWWA 1DPTA 4TRFA 3EJ9B 4EUIA 4Z15A 3EJ3B 3N4DA 2OS5A 4X19A 2XCZA 1FIMA 1GYXA 3DJIA 3M21A 4GRUA 1S0YA 2AAJA 3L5RA 2FM7A 3MF8A 3L5VA 4U5RA 4FAZA 4EVGA 1GYYA 4X1CC 1OTGA 3U18A 5B4OA 3B9SA 4GRPA 4U5PA 1GYJA 4OYQA 2AAGA 5CLOA 3EJ7A 2FLZA 4JJ9A 4P7MA 4WR8A 5HVTA 1P1GA 5BSIA 5BS9A 3FWTA 5HVSA 3L5UA 2ORMA 4TRUA 3CE4A 3KERA 4PKKA 2OOHA 2OOWA 5J7QA 1GCZA 3GADA 4PLUA 3RF5A 1S0YB 2FLTA 3HOFA 3WNRA 2WKBA 4XX8A 4Z1TA 3SMCA 3JTUA 2OP8A 3ABFA 4P01A 3RF4A 4GROA 3L5SA 3N4HA 3DJHA 2OPAA 3E6QA 4LHOA 3JSGA 5BSJA 5J7PA 4Z1UA 3MJZA 4P7SA 4P0HA 3IJJA 3EJ9A 4JCUA 4OTCA 3WNTA 1OTFA 3EJ7B 4GRRA 4OTBA 4NWQB 1U9DA 3IJGA 3KANA 4OSFA 4OTAA 3B64A 1BJPA 4DH4A 5EIZA 4GUMA 4XX7A 4GRNA 2WKFA 4FDXA 4NWPE 3MLCA 2OOZA 3L5PA 2AALA 1CA7A 1MIFA 4PKZA 3MB2A 3T5SA 1MFIA 1MFFA 3JSFA 3EJ3A 3GACA 3N4GA 4LHPA 4F2KA 4GRQA 4M1AA 4Q3FA 4K9GA 3M20A 1HFOA 3FWUA 1GD0A 1CGQA 1LJTA 2GDGA 3C6VA 5BSCA 2WKFB 2X4KA 4X1CA 1UIZA 3WNSA 3L5TA 4WRBA 4LKBA 5CLNA 3RY0A 4ETGA 5HVVA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3MB2 B;  3SMB A;  3MF7 A;  1GIF A;  1MWW A;  1DPT A;  4TRF A;  3EJ9 B;  4EUI A;  4Z15 A;  3EJ3 B;  3N4D A;  2OS5 A;  4X19 A;  2XCZ A;  1FIM A;  1GYX A;  3DJI A;  3M21 A;  4GRU A;  1S0Y A;  2AAJ A;  3L5R A;  2FM7 A;  3MF8 A;  3L5V A;  4U5R A;  4FAZ A;  4EVG A;  1GYY A;  4X1C C;  1OTG A;  3U18 A;  5B4O A;  3B9S A;  4GRP A;  4U5P A;  1GYJ A;  4OYQ A;  2AAG A;  5CLO A;  3EJ7 A;  2FLZ A;  4JJ9 A;  4P7M A;  4WR8 A;  5HVT A;  1P1G A;  5BSI A;  5BS9 A;  3FWT A;  5HVS A;  3L5U A;  2ORM A;  4TRU A;  3CE4 A;  3KER A;  4PKK A;  2OOH A;  2OOW A;  5J7Q A;  1GCZ A;  3GAD A;  4PLU A;  3RF5 A;  1S0Y B;  2FLT A;  3HOF A;  3WNR A;  2WKB A;  4XX8 A;  4Z1T A;  3SMC A;  3JTU A;  2OP8 A;  3ABF A;  4P01 A;  3RF4 A;  4GRO A;  3L5S A;  3N4H A;  3DJH A;  2OPA A;  3E6Q A;  4LHO A;  3JSG A;  5BSJ A;  5J7P A;  4Z1U A;  3MJZ A;  4P7S A;  4P0H A;  3IJJ A;  3EJ9 A;  4JCU A;  4OTC A;  3WNT A;  1OTF A;  3EJ7 B;  4GRR A;  4OTB A;  4NWQ B;  1U9D A;  3IJG A;  3KAN A;  4OSF A;  4OTA A;  3B64 A;  1BJP A;  4DH4 A;  5EIZ A;  4GUM A;  4XX7 A;  4GRN A;  2WKF A;  4FDX A;  4NWP E;  3MLC A;  2OOZ A;  3L5P A;  2AAL A;  1CA7 A;  1MIF A;  4PKZ A;  3MB2 A;  3T5S A;  1MFI A;  1MFF A;  3JSF A;  3EJ3 A;  3GAC A;  3N4G A;  4LHP A;  4F2K A;  4GRQ A;  4M1A A;  4Q3F A;  4K9G A;  3M20 A;  1HFO A;  3FWU A;  1GD0 A;  1CGQ A;  1LJT A;  2GDG A;  3C6V A;  5BSC A;  2WKF B;  2X4K A;  4X1C A;  1UIZ A;  3WNS A;  3L5T A;  4WRB A;  4LKB A;  5CLN A;  3RY0 A;  4ETG A;  5HVV A; 
#chains in the Genus database with same CATH topology
 3MB2 B;  3SMB A;  3MF7 A;  1GIF A;  1MWW A;  1DPT A;  4TRF A;  3EJ9 B;  4EUI A;  4Z15 A;  3EJ3 B;  3N4D A;  2OS5 A;  4X19 A;  2XCZ A;  1FIM A;  1GYX A;  3DJI A;  3M21 A;  4GRU A;  1S0Y A;  2AAJ A;  3L5R A;  2FM7 A;  3MF8 A;  3L5V A;  4U5R A;  4FAZ A;  4EVG A;  1GYY A;  4X1C C;  1OTG A;  3U18 A;  5B4O A;  3B9S A;  4GRP A;  4U5P A;  1GYJ A;  4OYQ A;  2AAG A;  5CLO A;  3EJ7 A;  2FLZ A;  4JJ9 A;  4P7M A;  4WR8 A;  5HVT A;  1P1G A;  5BSI A;  5BS9 A;  3FWT A;  5HVS A;  3L5U A;  2ORM A;  4TRU A;  3CE4 A;  3KER A;  4PKK A;  2OOH A;  2OOW A;  5J7Q A;  1GCZ A;  3GAD A;  4PLU A;  3RF5 A;  1S0Y B;  2FLT A;  3HOF A;  3WNR A;  2WKB A;  4XX8 A;  4Z1T A;  3SMC A;  3JTU A;  2OP8 A;  3ABF A;  4P01 A;  3RF4 A;  4GRO A;  3L5S A;  3N4H A;  3DJH A;  2OPA A;  3E6Q A;  4LHO A;  3JSG A;  5BSJ A;  5J7P A;  4Z1U A;  3MJZ A;  4P7S A;  4P0H A;  3IJJ A;  3EJ9 A;  4JCU A;  4OTC A;  3WNT A;  1OTF A;  3EJ7 B;  4GRR A;  4OTB A;  4NWQ B;  1U9D A;  3IJG A;  3KAN A;  4OSF A;  4OTA A;  3B64 A;  1BJP A;  4DH4 A;  5EIZ A;  4GUM A;  4XX7 A;  4GRN A;  2WKF A;  4FDX A;  4NWP E;  3MLC A;  2OOZ A;  3L5P A;  2AAL A;  1CA7 A;  1MIF A;  4PKZ A;  3MB2 A;  3T5S A;  1MFI A;  1MFF A;  3JSF A;  3EJ3 A;  3GAC A;  3N4G A;  4LHP A;  4F2K A;  4GRQ A;  4M1A A;  4Q3F A;  4K9G A;  3M20 A;  1HFO A;  3FWU A;  1GD0 A;  1CGQ A;  1LJT A;  2GDG A;  3C6V A;  5BSC A;  2WKF B;  2X4K A;  4X1C A;  1UIZ A;  3WNS A;  3L5T A;  4WRB A;  4LKB A;  5CLN A;  3RY0 A;  4ETG A;  5HVV A; 
#chains in the Genus database with same CATH homology
 3MB2 B;  3SMB A;  3MF7 A;  1GIF A;  1MWW A;  1DPT A;  4TRF A;  3EJ9 B;  4EUI A;  4Z15 A;  3EJ3 B;  3N4D A;  2OS5 A;  4X19 A;  2XCZ A;  1FIM A;  1GYX A;  3DJI A;  3M21 A;  4GRU A;  1S0Y A;  2AAJ A;  3L5R A;  2FM7 A;  3MF8 A;  3L5V A;  4U5R A;  4FAZ A;  4EVG A;  1GYY A;  4X1C C;  1OTG A;  3U18 A;  5B4O A;  3B9S A;  4GRP A;  4U5P A;  1GYJ A;  4OYQ A;  2AAG A;  5CLO A;  3EJ7 A;  2FLZ A;  4JJ9 A;  4P7M A;  4WR8 A;  5HVT A;  1P1G A;  5BSI A;  5BS9 A;  3FWT A;  5HVS A;  3L5U A;  2ORM A;  4TRU A;  3CE4 A;  3KER A;  4PKK A;  2OOH A;  2OOW A;  5J7Q A;  1GCZ A;  3GAD A;  4PLU A;  3RF5 A;  1S0Y B;  2FLT A;  3HOF A;  3WNR A;  2WKB A;  4XX8 A;  4Z1T A;  3SMC A;  3JTU A;  2OP8 A;  3ABF A;  4P01 A;  3RF4 A;  4GRO A;  3L5S A;  3N4H A;  3DJH A;  2OPA A;  3E6Q A;  4LHO A;  3JSG A;  5BSJ A;  5J7P A;  4Z1U A;  3MJZ A;  4P7S A;  4P0H A;  3IJJ A;  3EJ9 A;  4JCU A;  4OTC A;  3WNT A;  1OTF A;  3EJ7 B;  4GRR A;  4OTB A;  4NWQ B;  1U9D A;  3IJG A;  3KAN A;  4OSF A;  4OTA A;  3B64 A;  1BJP A;  4DH4 A;  5EIZ A;  4GUM A;  4XX7 A;  4GRN A;  2WKF A;  4FDX A;  4NWP E;  3MLC A;  2OOZ A;  3L5P A;  2AAL A;  1CA7 A;  1MIF A;  4PKZ A;  3MB2 A;  3T5S A;  1MFI A;  1MFF A;  3JSF A;  3EJ3 A;  3GAC A;  3N4G A;  4LHP A;  4F2K A;  4GRQ A;  4M1A A;  4Q3F A;  4K9G A;  3M20 A;  1HFO A;  3FWU A;  1GD0 A;  1CGQ A;  1LJT A;  2GDG A;  3C6V A;  5BSC A;  2WKF B;  2X4K A;  4X1C A;  1UIZ A;  3WNS A;  3L5T A;  4WRB A;  4LKB A;  5CLN A;  3RY0 A;  4ETG A;  5HVV A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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