4WDCA

High-resolution crystal structure of water-soluble frac (mutation f16p)
Total Genus 51
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
51
sequence length
177
structure length
177
Chain Sequence
DVAGAVIDGAGLGPDVLKTVLEALGNVKRKIAVGIDNESGKTWTAMNTYFRSGTSDIVLPHKVAHGKALLYNGQKNRGPVATGVVGVIAYSMSDGNTLAVLFSVPYDYNWYSNWWNVRVYKGQKRADQRMYEELYYHRSPFRGDNGWHSRGLGYGLKSRGFMNSSGHAILEIHVTKA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Pore-Forming Toxin Requires a Specific Residue for Its Activity in Membranes with Particular Physicochemical Properties
pubmed doi rcsb
molecule tags Toxin
source organism Actinia fragacea
molecule keywords Fragaceatoxin C
total genus 51
structure length 177
sequence length 177
ec nomenclature
pdb deposition date 2014-09-08

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF06369 Anemone_cytotox Sea anemone cytotoxic protein
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.60.270.20 Mainly Beta Sandwich Mutm (Fpg) Protein; Chain: A, domain 2 Cytolysin/lectin 4wdcA00
4Z2FA 3ZWJA 3LIMA 1Y2WA 2KS4A 2L2BA 1GWYA 2OFEA 5BPGA 3ZWGA 3W9PA 1IAZA 4TSOA 2OFCA 1Y2XA 4TSQA 4TSYA 4TSNA 1O72A 1O71A 2OFDA 3QDVA 1TZQA 1Y2UA 3QDYA 3QDSA 4Z2SA 4YLDA 4Z2QA 1Y2VA 1X99A 3QDWA 4TSLA 1Y2TA 2L38A 1KD6A 4TSPA 3QDTA 3QDXA 3VWIA 3QDUA 1XI0A 4WDCA
chains in the Genus database with same CATH superfamily
4Z2FA 3ZWJA 3LIMA 4P1WB 1Y2WA 2KS4A 2L2BA 1GWYA 2OFEA 5BPGA 3ZWGA 3W9PA 4HPQB 1IAZA 4TSOA 2OFCA 1Y2XA 4JOXA 4TSQA 4TSYA 4OEBA 1O72A 1O71A 2OFDA 4TSNA 3QDVA 4WX5A 1TZQA 1Y2UA 3QDYA 3QDSA 4Z2SA 4YLDA 4Z2QA 5JHFB 1Y2VA 1X99A 3QDWA 3A57A 4TSLA 1Y2TA 2L38A 1KD6A 4TSPA 3QDTA 3QDXA 3VWIA 3QDUA 1XI0A 4WX3A 4WDCA
chains in the Genus database with same CATH topology
4Z2FA 3ZWJA 3LIMA 1Y2WA 2KS4A 2L2BA 1GWYA 2OFEA 5BPGA 3ZWGA 3W9PA 1IAZA 4TSOA 2OFCA 1Y2XA 4TSQA 4TSYA 4TSNA 1O72A 1O71A 2OFDA 3QDVA 1TZQA 1Y2UA 3QDYA 3QDSA 4Z2SA 4YLDA 4Z2QA 1Y2VA 1X99A 3QDWA 4TSLA 1Y2TA 2L38A 1KD6A 4TSPA 3QDTA 3QDXA 3VWIA 3QDUA 1XI0A 4WDCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4Z2F A;  3ZWJ A;  3LIM A;  1Y2W A;  2KS4 A;  2L2B A;  1GWY A;  2OFE A;  5BPG A;  3ZWG A;  3W9P A;  1IAZ A;  4TSO A;  2OFC A;  1Y2X A;  4TSQ A;  4TSY A;  4TSN A;  1O72 A;  1O71 A;  2OFD A;  3QDV A;  1TZQ A;  1Y2U A;  3QDY A;  3QDS A;  4Z2S A;  4YLD A;  4Z2Q A;  1Y2V A;  1X99 A;  3QDW A;  4TSL A;  1Y2T A;  2L38 A;  1KD6 A;  4TSP A;  3QDT A;  3QDX A;  3VWI A;  3QDU A;  1XI0 A;  4WDC A; 
#chains in the Genus database with same CATH topology
 4Z2F A;  3ZWJ A;  3LIM A;  4P1W B;  1Y2W A;  2KS4 A;  2L2B A;  1GWY A;  2OFE A;  5BPG A;  3ZWG A;  3W9P A;  4HPQ B;  1IAZ A;  4TSO A;  2OFC A;  1Y2X A;  4JOX A;  4TSQ A;  4TSY A;  4OEB A;  1O72 A;  1O71 A;  2OFD A;  4TSN A;  3QDV A;  4WX5 A;  1TZQ A;  1Y2U A;  3QDY A;  3QDS A;  4Z2S A;  4YLD A;  4Z2Q A;  5JHF B;  1Y2V A;  1X99 A;  3QDW A;  3A57 A;  4TSL A;  1Y2T A;  2L38 A;  1KD6 A;  4TSP A;  3QDT A;  3QDX A;  3VWI A;  3QDU A;  1XI0 A;  4WX3 A;  4WDC A; 
#chains in the Genus database with same CATH homology
 4Z2F A;  3ZWJ A;  3LIM A;  1Y2W A;  2KS4 A;  2L2B A;  1GWY A;  2OFE A;  5BPG A;  3ZWG A;  3W9P A;  1IAZ A;  4TSO A;  2OFC A;  1Y2X A;  4TSQ A;  4TSY A;  4TSN A;  1O72 A;  1O71 A;  2OFD A;  3QDV A;  1TZQ A;  1Y2U A;  3QDY A;  3QDS A;  4Z2S A;  4YLD A;  4Z2Q A;  1Y2V A;  1X99 A;  3QDW A;  4TSL A;  1Y2T A;  2L38 A;  1KD6 A;  4TSP A;  3QDT A;  3QDX A;  3VWI A;  3QDU A;  1XI0 A;  4WDC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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