4HG7A

Crystal structure of an mdm2/nutlin-3a complex
Total Genus 32

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
91
structure length
91
Chain Sequence
QIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDAAQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLV

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
AH1 (21-25)S1 (27-28)AH2 (32-41)AH3 (50-64)S2 (48-49)TVIII1 (69-72)EMPTYTII1 (77-80)S4 (90-92)S3 (74-76)TI1 (68-71)AH4 (81-86)Updating...
connected with : NaN
molecule tags Ligase
source organism Homo sapiens
publication title The structure of an MDM2-Nutlin-3a complex solved by the use of a validated MDM2 surface-entropy reduction mutant.
pubmed doi rcsb
molecule keywords E3 ubiquitin-protein ligase Mdm2
total genus 32
structure length 91
sequence length 91
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2012-10-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02201 SWIB SWIB/MDM2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.245.10 Mainly Alpha Orthogonal Bundle MDM2 SWIB/MDM2 domain 4hg7A00
4ZGKA 4ZYIA 3JZQA 4OQ3A 4EREA 2LZGA 4ERFA 1V32A 2N0UA 2GV2A 1YCRA 4WT2A 5LN2A 2VYRA 1Z1MA 2Z5TM 2Z5SM 3JZPA 3LBJE 3LNJA 5AFGA 3EQYA 4LWTA 3LBKA 4J7DA 3TJ2A 5C5AA 2RUHA 4QO4A 3LBLA 5HMHA 2N06A 3JZRA 1T4EA 4HBMA 3LNZA 4JVEA 1T4FM 4MDQA 4OCCA 3IUXA 3DABA 4JWRA 4ZYFA 4RXZA 4ZYCA 4LWVA 4ODFA 4UD7A 5HMIA 4UMNA 4MDNA 4DIJA 3U15A 4IPFA 2N0WA 3FE7A 4JV9A 3EQSA 5HMKA 1UHRA 4JSCA 4OGVA 2MWYA 4J7EA 4J74A 4OBAA 4LWUA 5TRFA 1TTVA 3DACA 3JZKA 3TPXA 3VZVA 3G03A 2MPSA 3TU1A 5LAYA 1V31A 2N14A 3IWYA 4ODEA 5LAVA 4JRGA 2AXIA 4QOCA 4JVRA 3JZOA 3V3BA 4J3EA 1RV1A 4HFZA 3FDOA 1YCQA 3W69A 4N5TA 4OGNA 5LAZA 4JV7A 5LAWA 3VBGA 3FEAA 4OGTA 3JZSA 4OASA 4UE1A 2M86B 4HG7A 4ZFIA
chains in the Genus database with same CATH superfamily
4ZGKA 4ZYIA 3JZQA 4OQ3A 4EREA 2LZGA 4ERFA 1V32A 2N0UA 2GV2A 1YCRA 4WT2A 5LN2A 2VYRA 1Z1MA 2Z5TM 2Z5SM 3JZPA 3LBJE 3LNJA 5AFGA 3EQYA 4LWTA 3LBKA 4J7DA 3TJ2A 5C5AA 2RUHA 4QO4A 3LBLA 5HMHA 2N06A 3JZRA 1T4EA 4HBMA 3LNZA 4JVEA 1T4FM 4MDQA 4OCCA 3IUXA 3DABA 4JWRA 4ZYFA 4RXZA 4ZYCA 4LWVA 4ODFA 4UD7A 5HMIA 4UMNA 4MDNA 4DIJA 3U15A 4IPFA 2N0WA 3FE7A 4JV9A 3EQSA 5HMKA 1UHRA 4JSCA 4OGVA 2MWYA 4J7EA 4J74A 4OBAA 4LWUA 5TRFA 1TTVA 3DACA 3JZKA 3TPXA 3VZVA 3G03A 2MPSA 3TU1A 5LAYA 1V31A 2N14A 3IWYA 4ODEA 5LAVA 4JRGA 2AXIA 4QOCA 4JVRA 3JZOA 3V3BA 4J3EA 1RV1A 4HFZA 3FDOA 1YCQA 3W69A 4N5TA 4OGNA 5LAZA 4JV7A 5LAWA 3VBGA 3FEAA 4OGTA 3JZSA 4OASA 4UE1A 2M86B 4HG7A 4ZFIA
chains in the Genus database with same CATH topology
4ZGKA 4ZYIA 3JZQA 4OQ3A 4EREA 2LZGA 4ERFA 1V32A 2N0UA 2GV2A 1YCRA 4WT2A 5LN2A 2VYRA 1Z1MA 2Z5TM 2Z5SM 3JZPA 3LBJE 3LNJA 5AFGA 3EQYA 4LWTA 3LBKA 4J7DA 3TJ2A 5C5AA 2RUHA 4QO4A 3LBLA 5HMHA 2N06A 3JZRA 1T4EA 4HBMA 3LNZA 4JVEA 1T4FM 4MDQA 4OCCA 3IUXA 3DABA 4JWRA 4ZYFA 4RXZA 4ZYCA 4LWVA 4ODFA 4UD7A 5HMIA 4UMNA 4MDNA 4DIJA 3U15A 4IPFA 2N0WA 3FE7A 4JV9A 3EQSA 5HMKA 1UHRA 4JSCA 4OGVA 2MWYA 4J7EA 4J74A 4OBAA 4LWUA 5TRFA 1TTVA 3DACA 3JZKA 3TPXA 3VZVA 3G03A 2MPSA 3TU1A 5LAYA 1V31A 2N14A 3IWYA 4ODEA 5LAVA 4JRGA 2AXIA 4QOCA 4JVRA 3JZOA 3V3BA 4J3EA 1RV1A 4HFZA 3FDOA 1YCQA 3W69A 4N5TA 4OGNA 5LAZA 4JV7A 5LAWA 3VBGA 3FEAA 4OGTA 3JZSA 4OASA 4UE1A 2M86B 4HG7A 4ZFIA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4ZGK A;  4ZYI A;  3JZQ A;  4OQ3 A;  4ERE A;  2LZG A;  4ERF A;  1V32 A;  2N0U A;  2GV2 A;  1YCR A;  4WT2 A;  5LN2 A;  2VYR A;  1Z1M A;  2Z5T M;  2Z5S M;  3JZP A;  3LBJ E;  3LNJ A;  5AFG A;  3EQY A;  4LWT A;  3LBK A;  4J7D A;  3TJ2 A;  5C5A A;  2RUH A;  4QO4 A;  3LBL A;  5HMH A;  2N06 A;  3JZR A;  1T4E A;  4HBM A;  3LNZ A;  4JVE A;  1T4F M;  4MDQ A;  4OCC A;  3IUX A;  3DAB A;  4JWR A;  4ZYF A;  4RXZ A;  4ZYC A;  4LWV A;  4ODF A;  4UD7 A;  5HMI A;  4UMN A;  4MDN A;  4DIJ A;  3U15 A;  4IPF A;  2N0W A;  3FE7 A;  4JV9 A;  3EQS A;  5HMK A;  1UHR A;  4JSC A;  4OGV A;  2MWY A;  4J7E A;  4J74 A;  4OBA A;  4LWU A;  5TRF A;  1TTV A;  3DAC A;  3JZK A;  3TPX A;  3VZV A;  3G03 A;  2MPS A;  3TU1 A;  5LAY A;  1V31 A;  2N14 A;  3IWY A;  4ODE A;  5LAV A;  4JRG A;  2AXI A;  4QOC A;  4JVR A;  3JZO A;  3V3B A;  4J3E A;  1RV1 A;  4HFZ A;  3FDO A;  1YCQ A;  3W69 A;  4N5T A;  4OGN A;  5LAZ A;  4JV7 A;  5LAW A;  3VBG A;  3FEA A;  4OGT A;  3JZS A;  4OAS A;  4UE1 A;  2M86 B;  4HG7 A;  4ZFI A; 
#chains in the Genus database with same CATH topology
 4ZGK A;  4ZYI A;  3JZQ A;  4OQ3 A;  4ERE A;  2LZG A;  4ERF A;  1V32 A;  2N0U A;  2GV2 A;  1YCR A;  4WT2 A;  5LN2 A;  2VYR A;  1Z1M A;  2Z5T M;  2Z5S M;  3JZP A;  3LBJ E;  3LNJ A;  5AFG A;  3EQY A;  4LWT A;  3LBK A;  4J7D A;  3TJ2 A;  5C5A A;  2RUH A;  4QO4 A;  3LBL A;  5HMH A;  2N06 A;  3JZR A;  1T4E A;  4HBM A;  3LNZ A;  4JVE A;  1T4F M;  4MDQ A;  4OCC A;  3IUX A;  3DAB A;  4JWR A;  4ZYF A;  4RXZ A;  4ZYC A;  4LWV A;  4ODF A;  4UD7 A;  5HMI A;  4UMN A;  4MDN A;  4DIJ A;  3U15 A;  4IPF A;  2N0W A;  3FE7 A;  4JV9 A;  3EQS A;  5HMK A;  1UHR A;  4JSC A;  4OGV A;  2MWY A;  4J7E A;  4J74 A;  4OBA A;  4LWU A;  5TRF A;  1TTV A;  3DAC A;  3JZK A;  3TPX A;  3VZV A;  3G03 A;  2MPS A;  3TU1 A;  5LAY A;  1V31 A;  2N14 A;  3IWY A;  4ODE A;  5LAV A;  4JRG A;  2AXI A;  4QOC A;  4JVR A;  3JZO A;  3V3B A;  4J3E A;  1RV1 A;  4HFZ A;  3FDO A;  1YCQ A;  3W69 A;  4N5T A;  4OGN A;  5LAZ A;  4JV7 A;  5LAW A;  3VBG A;  3FEA A;  4OGT A;  3JZS A;  4OAS A;  4UE1 A;  2M86 B;  4HG7 A;  4ZFI A; 
#chains in the Genus database with same CATH homology
 4ZGK A;  4ZYI A;  3JZQ A;  4OQ3 A;  4ERE A;  2LZG A;  4ERF A;  1V32 A;  2N0U A;  2GV2 A;  1YCR A;  4WT2 A;  5LN2 A;  2VYR A;  1Z1M A;  2Z5T M;  2Z5S M;  3JZP A;  3LBJ E;  3LNJ A;  5AFG A;  3EQY A;  4LWT A;  3LBK A;  4J7D A;  3TJ2 A;  5C5A A;  2RUH A;  4QO4 A;  3LBL A;  5HMH A;  2N06 A;  3JZR A;  1T4E A;  4HBM A;  3LNZ A;  4JVE A;  1T4F M;  4MDQ A;  4OCC A;  3IUX A;  3DAB A;  4JWR A;  4ZYF A;  4RXZ A;  4ZYC A;  4LWV A;  4ODF A;  4UD7 A;  5HMI A;  4UMN A;  4MDN A;  4DIJ A;  3U15 A;  4IPF A;  2N0W A;  3FE7 A;  4JV9 A;  3EQS A;  5HMK A;  1UHR A;  4JSC A;  4OGV A;  2MWY A;  4J7E A;  4J74 A;  4OBA A;  4LWU A;  5TRF A;  1TTV A;  3DAC A;  3JZK A;  3TPX A;  3VZV A;  3G03 A;  2MPS A;  3TU1 A;  5LAY A;  1V31 A;  2N14 A;  3IWY A;  4ODE A;  5LAV A;  4JRG A;  2AXI A;  4QOC A;  4JVR A;  3JZO A;  3V3B A;  4J3E A;  1RV1 A;  4HFZ A;  3FDO A;  1YCQ A;  3W69 A;  4N5T A;  4OGN A;  5LAZ A;  4JV7 A;  5LAW A;  3VBG A;  3FEA A;  4OGT A;  3JZS A;  4OAS A;  4UE1 A;  2M86 B;  4HG7 A;  4ZFI A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...

Application loaded.