4NWPE

Computationally designed two-component self-assembling tetrahedral cage, t33-21, crystallized in space group r32
Total Genus 32
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
32
sequence length
118
structure length
118
Chain Sequence
PHLVIEATANLRLETSPGELLEQANKALFASGQFGEADIKSRFVTLEAYRQGTAAVERAYLHACLSILDGRDIATRTLLGASLCAVLAEAVAGGGEEGVQVSVEVREMERLSYAKRVV
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Accurate design of co-assembling multi-component protein nanomaterials.
pubmed doi rcsb
molecule tags Protein binding
source organism Pyrococcus horikoshii
molecule keywords Putative uncharacterized protein
total genus 32
structure length 118
sequence length 118
chains with identical sequence F, G, H
ec nomenclature
pdb deposition date 2013-12-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
E PF02962 CHMI 5-carboxymethyl-2-hydroxymuconate isomerase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.429.10 Alpha Beta 2-Layer Sandwich Macrophage Migration Inhibitory Factor Macrophage Migration Inhibitory Factor 4nwpE00
2ORMA 3IJJA 2WKBA 1LJTA 4GRPA 4GRQA 5EIZA 3MF7A 4PLUA 3DJIA 3CE4A 4U5RA 4P0HA 1FIMA 5BSIA 1GCZA 3EJ3B 3EJ9B 1BJPA 3MF8A 4GRRA 3KERA 4LHOA 4X19A 1CA7A 3FWUA 4XX7A 5HVTA 1GYYA 4XX8A 2OPAA 4PKKA 1MFFA 3N4DA 4OSFA 4GUMA 4M1AA 4U5PA 2OOZA 2FLZA 3RF5A 5HVSA 3MB2A 3N4HA 4OTBA 3SMCA 3B64A 4JJ9A 1MWWA 5J7PA 4GROA 1U9DA 5HVVA 2WKFB 4JCUA 5B4OA 3WNSA 3L5RA 4X1CA 3N4GA 4OYQA 3T5SA 3FWTA 4OTCA 3L5SA 2OS5A 3GACA 3WNTA 4TRFA 5CLOA 4Z1TA 4P01A 2AALA 3EJ3A 1S0YB 3EJ9A 3MLCA 3M21A 5BS9A 3B9SA 4NWPE 1MIFA 1P1GA 4Z15A 4FDXA 4LHPA 2XCZA 2AAGA 1UIZA 3RF4A 2GDGA 3L5VA 4WRBA 1GD0A 1OTFA 4Z1UA 3JTUA 4TRUA 3MB2B 1HFOA 2FLTA 3DJHA 3EJ7B 4PKZA 5BSJA 1GYXA 4ETGA 3JSFA 4P7MA 4OTAA 2WKFA 3L5UA 5J7QA 1DPTA 2X4KA 3L5TA 5CLNA 5BSCA 4GRNA 3ABFA 3C6VA 3L5PA 3M20A 3JSGA 2OP8A 4Q3FA 1S0YA 3KANA 4NWQB 3HOFA 4K9GA 3IJGA 4EUIA 3U18A 3SMBA 2AAJA 4P7SA 4X1CC 1GIFA 2OOWA 1OTGA 4WR8A 4FAZA 1CGQA 3GADA 3E6QA 2OOHA 3RY0A 1MFIA 4F2KA 3MJZA 2FM7A 4LKBA 4EVGA 4GRUA 3WNRA 4DH4A 3EJ7A 1GYJA
chains in the Genus database with same CATH superfamily
2ORMA 3IJJA 2WKBA 1LJTA 4GRPA 4GRQA 5EIZA 3MF7A 4PLUA 3DJIA 3CE4A 4U5RA 4P0HA 1FIMA 5BSIA 1GCZA 3EJ3B 3EJ9B 1BJPA 3MF8A 4GRRA 3KERA 4LHOA 4X19A 1CA7A 3FWUA 4XX7A 5HVTA 1GYYA 4XX8A 2OPAA 4PKKA 1MFFA 3N4DA 4OSFA 4GUMA 4M1AA 4U5PA 2OOZA 2FLZA 3RF5A 5HVSA 3MB2A 3N4HA 4OTBA 3SMCA 3B64A 4JJ9A 1MWWA 5J7PA 4GROA 1U9DA 5HVVA 2WKFB 4JCUA 5B4OA 3WNSA 3L5RA 4X1CA 3N4GA 4OYQA 3T5SA 3FWTA 4OTCA 3L5SA 2OS5A 3GACA 3WNTA 4TRFA 5CLOA 4Z1TA 4P01A 2AALA 3EJ3A 1S0YB 3EJ9A 3MLCA 3M21A 5BS9A 3B9SA 4NWPE 1MIFA 1P1GA 4Z15A 4FDXA 4LHPA 2XCZA 2AAGA 1UIZA 3RF4A 2GDGA 3L5VA 4WRBA 1GD0A 1OTFA 4Z1UA 3JTUA 4TRUA 3MB2B 1HFOA 2FLTA 3DJHA 3EJ7B 4PKZA 5BSJA 1GYXA 4ETGA 3JSFA 4P7MA 4OTAA 2WKFA 3L5UA 5J7QA 1DPTA 2X4KA 3L5TA 5CLNA 5BSCA 4GRNA 3ABFA 3C6VA 3L5PA 3M20A 3JSGA 2OP8A 4Q3FA 1S0YA 3KANA 4NWQB 3HOFA 4K9GA 3IJGA 4EUIA 3U18A 3SMBA 2AAJA 4P7SA 4X1CC 1GIFA 2OOWA 1OTGA 4WR8A 4FAZA 1CGQA 3GADA 3E6QA 2OOHA 3RY0A 1MFIA 4F2KA 3MJZA 2FM7A 4LKBA 4EVGA 4GRUA 3WNRA 4DH4A 3EJ7A 1GYJA
chains in the Genus database with same CATH topology
2ORMA 3IJJA 2WKBA 1LJTA 4GRPA 4GRQA 5EIZA 3MF7A 4PLUA 3DJIA 3CE4A 4U5RA 4P0HA 1FIMA 5BSIA 1GCZA 3EJ3B 3EJ9B 1BJPA 3MF8A 4GRRA 3KERA 4LHOA 4X19A 1CA7A 3FWUA 4XX7A 5HVTA 1GYYA 4XX8A 2OPAA 4PKKA 1MFFA 3N4DA 4OSFA 4GUMA 4M1AA 4U5PA 2OOZA 2FLZA 3RF5A 5HVSA 3MB2A 3N4HA 4OTBA 3SMCA 3B64A 4JJ9A 1MWWA 5J7PA 4GROA 1U9DA 5HVVA 2WKFB 4JCUA 5B4OA 3WNSA 3L5RA 4X1CA 3N4GA 4OYQA 3T5SA 3FWTA 4OTCA 3L5SA 2OS5A 3GACA 3WNTA 4TRFA 5CLOA 4Z1TA 4P01A 2AALA 3EJ3A 1S0YB 3EJ9A 3MLCA 3M21A 5BS9A 3B9SA 4NWPE 1MIFA 1P1GA 4Z15A 4FDXA 4LHPA 2XCZA 2AAGA 1UIZA 3RF4A 2GDGA 3L5VA 4WRBA 1GD0A 1OTFA 4Z1UA 3JTUA 4TRUA 3MB2B 1HFOA 2FLTA 3DJHA 3EJ7B 4PKZA 5BSJA 1GYXA 4ETGA 3JSFA 4P7MA 4OTAA 2WKFA 3L5UA 5J7QA 1DPTA 2X4KA 3L5TA 5CLNA 5BSCA 4GRNA 3ABFA 3C6VA 3L5PA 3M20A 3JSGA 2OP8A 4Q3FA 1S0YA 3KANA 4NWQB 3HOFA 4K9GA 3IJGA 4EUIA 3U18A 3SMBA 2AAJA 4P7SA 4X1CC 1GIFA 2OOWA 1OTGA 4WR8A 4FAZA 1CGQA 3GADA 3E6QA 2OOHA 3RY0A 1MFIA 4F2KA 3MJZA 2FM7A 4LKBA 4EVGA 4GRUA 3WNRA 4DH4A 3EJ7A 1GYJA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2ORM A;  3IJJ A;  2WKB A;  1LJT A;  4GRP A;  4GRQ A;  5EIZ A;  3MF7 A;  4PLU A;  3DJI A;  3CE4 A;  4U5R A;  4P0H A;  1FIM A;  5BSI A;  1GCZ A;  3EJ3 B;  3EJ9 B;  1BJP A;  3MF8 A;  4GRR A;  3KER A;  4LHO A;  4X19 A;  1CA7 A;  3FWU A;  4XX7 A;  5HVT A;  1GYY A;  4XX8 A;  2OPA A;  4PKK A;  1MFF A;  3N4D A;  4OSF A;  4GUM A;  4M1A A;  4U5P A;  2OOZ A;  2FLZ A;  3RF5 A;  5HVS A;  3MB2 A;  3N4H A;  4OTB A;  3SMC A;  3B64 A;  4JJ9 A;  1MWW A;  5J7P A;  4GRO A;  1U9D A;  5HVV A;  2WKF B;  4JCU A;  5B4O A;  3WNS A;  3L5R A;  4X1C A;  3N4G A;  4OYQ A;  3T5S A;  3FWT A;  4OTC A;  3L5S A;  2OS5 A;  3GAC A;  3WNT A;  4TRF A;  5CLO A;  4Z1T A;  4P01 A;  2AAL A;  3EJ3 A;  1S0Y B;  3EJ9 A;  3MLC A;  3M21 A;  5BS9 A;  3B9S A;  4NWP E;  1MIF A;  1P1G A;  4Z15 A;  4FDX A;  4LHP A;  2XCZ A;  2AAG A;  1UIZ A;  3RF4 A;  2GDG A;  3L5V A;  4WRB A;  1GD0 A;  1OTF A;  4Z1U A;  3JTU A;  4TRU A;  3MB2 B;  1HFO A;  2FLT A;  3DJH A;  3EJ7 B;  4PKZ A;  5BSJ A;  1GYX A;  4ETG A;  3JSF A;  4P7M A;  4OTA A;  2WKF A;  3L5U A;  5J7Q A;  1DPT A;  2X4K A;  3L5T A;  5CLN A;  5BSC A;  4GRN A;  3ABF A;  3C6V A;  3L5P A;  3M20 A;  3JSG A;  2OP8 A;  4Q3F A;  1S0Y A;  3KAN A;  4NWQ B;  3HOF A;  4K9G A;  3IJG A;  4EUI A;  3U18 A;  3SMB A;  2AAJ A;  4P7S A;  4X1C C;  1GIF A;  2OOW A;  1OTG A;  4WR8 A;  4FAZ A;  1CGQ A;  3GAD A;  3E6Q A;  2OOH A;  3RY0 A;  1MFI A;  4F2K A;  3MJZ A;  2FM7 A;  4LKB A;  4EVG A;  4GRU A;  3WNR A;  4DH4 A;  3EJ7 A;  1GYJ A; 
#chains in the Genus database with same CATH topology
 2ORM A;  3IJJ A;  2WKB A;  1LJT A;  4GRP A;  4GRQ A;  5EIZ A;  3MF7 A;  4PLU A;  3DJI A;  3CE4 A;  4U5R A;  4P0H A;  1FIM A;  5BSI A;  1GCZ A;  3EJ3 B;  3EJ9 B;  1BJP A;  3MF8 A;  4GRR A;  3KER A;  4LHO A;  4X19 A;  1CA7 A;  3FWU A;  4XX7 A;  5HVT A;  1GYY A;  4XX8 A;  2OPA A;  4PKK A;  1MFF A;  3N4D A;  4OSF A;  4GUM A;  4M1A A;  4U5P A;  2OOZ A;  2FLZ A;  3RF5 A;  5HVS A;  3MB2 A;  3N4H A;  4OTB A;  3SMC A;  3B64 A;  4JJ9 A;  1MWW A;  5J7P A;  4GRO A;  1U9D A;  5HVV A;  2WKF B;  4JCU A;  5B4O A;  3WNS A;  3L5R A;  4X1C A;  3N4G A;  4OYQ A;  3T5S A;  3FWT A;  4OTC A;  3L5S A;  2OS5 A;  3GAC A;  3WNT A;  4TRF A;  5CLO A;  4Z1T A;  4P01 A;  2AAL A;  3EJ3 A;  1S0Y B;  3EJ9 A;  3MLC A;  3M21 A;  5BS9 A;  3B9S A;  4NWP E;  1MIF A;  1P1G A;  4Z15 A;  4FDX A;  4LHP A;  2XCZ A;  2AAG A;  1UIZ A;  3RF4 A;  2GDG A;  3L5V A;  4WRB A;  1GD0 A;  1OTF A;  4Z1U A;  3JTU A;  4TRU A;  3MB2 B;  1HFO A;  2FLT A;  3DJH A;  3EJ7 B;  4PKZ A;  5BSJ A;  1GYX A;  4ETG A;  3JSF A;  4P7M A;  4OTA A;  2WKF A;  3L5U A;  5J7Q A;  1DPT A;  2X4K A;  3L5T A;  5CLN A;  5BSC A;  4GRN A;  3ABF A;  3C6V A;  3L5P A;  3M20 A;  3JSG A;  2OP8 A;  4Q3F A;  1S0Y A;  3KAN A;  4NWQ B;  3HOF A;  4K9G A;  3IJG A;  4EUI A;  3U18 A;  3SMB A;  2AAJ A;  4P7S A;  4X1C C;  1GIF A;  2OOW A;  1OTG A;  4WR8 A;  4FAZ A;  1CGQ A;  3GAD A;  3E6Q A;  2OOH A;  3RY0 A;  1MFI A;  4F2K A;  3MJZ A;  2FM7 A;  4LKB A;  4EVG A;  4GRU A;  3WNR A;  4DH4 A;  3EJ7 A;  1GYJ A; 
#chains in the Genus database with same CATH homology
 2ORM A;  3IJJ A;  2WKB A;  1LJT A;  4GRP A;  4GRQ A;  5EIZ A;  3MF7 A;  4PLU A;  3DJI A;  3CE4 A;  4U5R A;  4P0H A;  1FIM A;  5BSI A;  1GCZ A;  3EJ3 B;  3EJ9 B;  1BJP A;  3MF8 A;  4GRR A;  3KER A;  4LHO A;  4X19 A;  1CA7 A;  3FWU A;  4XX7 A;  5HVT A;  1GYY A;  4XX8 A;  2OPA A;  4PKK A;  1MFF A;  3N4D A;  4OSF A;  4GUM A;  4M1A A;  4U5P A;  2OOZ A;  2FLZ A;  3RF5 A;  5HVS A;  3MB2 A;  3N4H A;  4OTB A;  3SMC A;  3B64 A;  4JJ9 A;  1MWW A;  5J7P A;  4GRO A;  1U9D A;  5HVV A;  2WKF B;  4JCU A;  5B4O A;  3WNS A;  3L5R A;  4X1C A;  3N4G A;  4OYQ A;  3T5S A;  3FWT A;  4OTC A;  3L5S A;  2OS5 A;  3GAC A;  3WNT A;  4TRF A;  5CLO A;  4Z1T A;  4P01 A;  2AAL A;  3EJ3 A;  1S0Y B;  3EJ9 A;  3MLC A;  3M21 A;  5BS9 A;  3B9S A;  4NWP E;  1MIF A;  1P1G A;  4Z15 A;  4FDX A;  4LHP A;  2XCZ A;  2AAG A;  1UIZ A;  3RF4 A;  2GDG A;  3L5V A;  4WRB A;  1GD0 A;  1OTF A;  4Z1U A;  3JTU A;  4TRU A;  3MB2 B;  1HFO A;  2FLT A;  3DJH A;  3EJ7 B;  4PKZ A;  5BSJ A;  1GYX A;  4ETG A;  3JSF A;  4P7M A;  4OTA A;  2WKF A;  3L5U A;  5J7Q A;  1DPT A;  2X4K A;  3L5T A;  5CLN A;  5BSC A;  4GRN A;  3ABF A;  3C6V A;  3L5P A;  3M20 A;  3JSG A;  2OP8 A;  4Q3F A;  1S0Y A;  3KAN A;  4NWQ B;  3HOF A;  4K9G A;  3IJG A;  4EUI A;  3U18 A;  3SMB A;  2AAJ A;  4P7S A;  4X1C C;  1GIF A;  2OOW A;  1OTG A;  4WR8 A;  4FAZ A;  1CGQ A;  3GAD A;  3E6Q A;  2OOH A;  3RY0 A;  1MFI A;  4F2K A;  3MJZ A;  2FM7 A;  4LKB A;  4EVG A;  4GRU A;  3WNR A;  4DH4 A;  3EJ7 A;  1GYJ A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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