5B4OA

Crystal structure of macrophage migration inhibitory factor in complex with btzo-14
Total Genus 36
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
36
sequence length
114
structure length
114
Chain Sequence
PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title BTZO-1, a cardioprotective agent, reveals that macrophage migration inhibitory factor regulates ARE-mediated gene expression
pubmed doi rcsb
molecule tags Isomerase
source organism Homo sapiens
molecule keywords Macrophage migration inhibitory factor
total genus 36
structure length 114
sequence length 114
chains with identical sequence B, C
ec nomenclature ec 5.3.2.1: Phenylpyruvate tautomerase.
pdb deposition date 2016-04-07

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01187 MIF Macrophage migration inhibitory factor (MIF)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.429.10 Alpha Beta 2-Layer Sandwich Macrophage Migration Inhibitory Factor Macrophage Migration Inhibitory Factor 5b4oA00
4OTBA 3EJ3A 1S0YB 4LKBA 1HFOA 2OS5A 1LJTA 4GRRA 4OTAA 4NWQB 3WNSA 4U5RA 1MFIA 4GUMA 3SMCA 3ABFA 1UIZA 3IJJA 2OP8A 3B9SA 4EVGA 3M20A 3MF7A 1CA7A 3N4DA 4X19A 2WKFA 4Z1TA 3RF4A 2ORMA 3EJ7A 4GRNA 4OSFA 1OTFA 3CE4A 2FM7A 5J7QA 4JJ9A 4X1CA 4LHOA 3JSFA 3C6VA 5CLNA 4OYQA 1GD0A 3MB2B 4GRQA 3L5VA 3T5SA 5BSIA 1MFFA 3WNTA 5BSCA 3EJ9B 2FLZA 4Z15A 1GYJA 2GDGA 3L5SA 3N4GA 2AALA 3L5RA 4P7SA 5BS9A 4DH4A 5HVSA 1MWWA 4ETGA 1OTGA 5CLOA 2WKBA 3E6QA 4U5PA 4P7MA 4OTCA 4P01A 5BSJA 4GRPA 4F2KA 4PLUA 3M21A 3U18A 2XCZA 3MF8A 3MJZA 1S0YA 3GADA 4TRFA 4WR8A 1DPTA 3L5PA 3EJ3B 3IJGA 3KERA 3L5UA 3JSGA 3JTUA 1GYXA 1FIMA 3RY0A 1GYYA 3N4HA 4K9GA 3FWTA 1U9DA 3WNRA 3L5TA 2FLTA 5EIZA 4FAZA 4XX8A 5J7PA 5B4OA 4JCUA 2WKFB 1GIFA 2OOHA 2AAJA 2AAGA 4NWPE 1BJPA 5HVVA 5HVTA 3EJ7B 4PKZA 3RF5A 1P1GA 3MB2A 3FWUA 4M1AA 3HOFA 3EJ9A 3KANA 4GROA 4X1CC 4LHPA 2X4KA 1GCZA 3DJIA 4XX7A 1CGQA 4FDXA 4P0HA 4Z1UA 4WRBA 3SMBA 3GACA 2OOZA 1MIFA 4Q3FA 3DJHA 4PKKA 4TRUA 2OOWA 3B64A 2OPAA 4GRUA 4EUIA 3MLCA
chains in the Genus database with same CATH superfamily
4OTBA 3EJ3A 1S0YB 4LKBA 1HFOA 2OS5A 1LJTA 4GRRA 4OTAA 4NWQB 3WNSA 4U5RA 1MFIA 4GUMA 3SMCA 3ABFA 1UIZA 3IJJA 2OP8A 3B9SA 4EVGA 3M20A 3MF7A 1CA7A 3N4DA 4X19A 2WKFA 4Z1TA 3RF4A 2ORMA 3EJ7A 4GRNA 4OSFA 1OTFA 3CE4A 2FM7A 5J7QA 4JJ9A 4X1CA 4LHOA 3JSFA 3C6VA 5CLNA 4OYQA 1GD0A 3MB2B 4GRQA 3L5VA 3T5SA 5BSIA 1MFFA 3WNTA 5BSCA 3EJ9B 2FLZA 4Z15A 1GYJA 2GDGA 3L5SA 3N4GA 2AALA 3L5RA 4P7SA 5BS9A 4DH4A 5HVSA 1MWWA 4ETGA 1OTGA 5CLOA 2WKBA 3E6QA 4U5PA 4P7MA 4OTCA 4P01A 5BSJA 4GRPA 4F2KA 4PLUA 3M21A 3U18A 2XCZA 3MF8A 3MJZA 1S0YA 3GADA 4TRFA 4WR8A 1DPTA 3L5PA 3EJ3B 3IJGA 3KERA 3L5UA 3JSGA 3JTUA 1GYXA 1FIMA 3RY0A 1GYYA 3N4HA 4K9GA 3FWTA 1U9DA 3WNRA 3L5TA 2FLTA 5EIZA 4FAZA 4XX8A 5J7PA 5B4OA 4JCUA 2WKFB 1GIFA 2OOHA 2AAJA 2AAGA 4NWPE 1BJPA 5HVVA 5HVTA 3EJ7B 4PKZA 3RF5A 1P1GA 3MB2A 3FWUA 4M1AA 3HOFA 3EJ9A 3KANA 4GROA 4X1CC 4LHPA 2X4KA 1GCZA 3DJIA 4XX7A 1CGQA 4FDXA 4P0HA 4Z1UA 4WRBA 3SMBA 3GACA 2OOZA 1MIFA 4Q3FA 3DJHA 4PKKA 4TRUA 2OOWA 3B64A 2OPAA 4GRUA 4EUIA 3MLCA
chains in the Genus database with same CATH topology
4OTBA 3EJ3A 1S0YB 4LKBA 1HFOA 2OS5A 1LJTA 4GRRA 4OTAA 4NWQB 3WNSA 4U5RA 1MFIA 4GUMA 3SMCA 3ABFA 1UIZA 3IJJA 2OP8A 3B9SA 4EVGA 3M20A 3MF7A 1CA7A 3N4DA 4X19A 2WKFA 4Z1TA 3RF4A 2ORMA 3EJ7A 4GRNA 4OSFA 1OTFA 3CE4A 2FM7A 5J7QA 4JJ9A 4X1CA 4LHOA 3JSFA 3C6VA 5CLNA 4OYQA 1GD0A 3MB2B 4GRQA 3L5VA 3T5SA 5BSIA 1MFFA 3WNTA 5BSCA 3EJ9B 2FLZA 4Z15A 1GYJA 2GDGA 3L5SA 3N4GA 2AALA 3L5RA 4P7SA 5BS9A 4DH4A 5HVSA 1MWWA 4ETGA 1OTGA 5CLOA 2WKBA 3E6QA 4U5PA 4P7MA 4OTCA 4P01A 5BSJA 4GRPA 4F2KA 4PLUA 3M21A 3U18A 2XCZA 3MF8A 3MJZA 1S0YA 3GADA 4TRFA 4WR8A 1DPTA 3L5PA 3EJ3B 3IJGA 3KERA 3L5UA 3JSGA 3JTUA 1GYXA 1FIMA 3RY0A 1GYYA 3N4HA 4K9GA 3FWTA 1U9DA 3WNRA 3L5TA 2FLTA 5EIZA 4FAZA 4XX8A 5J7PA 5B4OA 4JCUA 2WKFB 1GIFA 2OOHA 2AAJA 2AAGA 4NWPE 1BJPA 5HVVA 5HVTA 3EJ7B 4PKZA 3RF5A 1P1GA 3MB2A 3FWUA 4M1AA 3HOFA 3EJ9A 3KANA 4GROA 4X1CC 4LHPA 2X4KA 1GCZA 3DJIA 4XX7A 1CGQA 4FDXA 4P0HA 4Z1UA 4WRBA 3SMBA 3GACA 2OOZA 1MIFA 4Q3FA 3DJHA 4PKKA 4TRUA 2OOWA 3B64A 2OPAA 4GRUA 4EUIA 3MLCA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OTB A;  3EJ3 A;  1S0Y B;  4LKB A;  1HFO A;  2OS5 A;  1LJT A;  4GRR A;  4OTA A;  4NWQ B;  3WNS A;  4U5R A;  1MFI A;  4GUM A;  3SMC A;  3ABF A;  1UIZ A;  3IJJ A;  2OP8 A;  3B9S A;  4EVG A;  3M20 A;  3MF7 A;  1CA7 A;  3N4D A;  4X19 A;  2WKF A;  4Z1T A;  3RF4 A;  2ORM A;  3EJ7 A;  4GRN A;  4OSF A;  1OTF A;  3CE4 A;  2FM7 A;  5J7Q A;  4JJ9 A;  4X1C A;  4LHO A;  3JSF A;  3C6V A;  5CLN A;  4OYQ A;  1GD0 A;  3MB2 B;  4GRQ A;  3L5V A;  3T5S A;  5BSI A;  1MFF A;  3WNT A;  5BSC A;  3EJ9 B;  2FLZ A;  4Z15 A;  1GYJ A;  2GDG A;  3L5S A;  3N4G A;  2AAL A;  3L5R A;  4P7S A;  5BS9 A;  4DH4 A;  5HVS A;  1MWW A;  4ETG A;  1OTG A;  5CLO A;  2WKB A;  3E6Q A;  4U5P A;  4P7M A;  4OTC A;  4P01 A;  5BSJ A;  4GRP A;  4F2K A;  4PLU A;  3M21 A;  3U18 A;  2XCZ A;  3MF8 A;  3MJZ A;  1S0Y A;  3GAD A;  4TRF A;  4WR8 A;  1DPT A;  3L5P A;  3EJ3 B;  3IJG A;  3KER A;  3L5U A;  3JSG A;  3JTU A;  1GYX A;  1FIM A;  3RY0 A;  1GYY A;  3N4H A;  4K9G A;  3FWT A;  1U9D A;  3WNR A;  3L5T A;  2FLT A;  5EIZ A;  4FAZ A;  4XX8 A;  5J7P A;  5B4O A;  4JCU A;  2WKF B;  1GIF A;  2OOH A;  2AAJ A;  2AAG A;  4NWP E;  1BJP A;  5HVV A;  5HVT A;  3EJ7 B;  4PKZ A;  3RF5 A;  1P1G A;  3MB2 A;  3FWU A;  4M1A A;  3HOF A;  3EJ9 A;  3KAN A;  4GRO A;  4X1C C;  4LHP A;  2X4K A;  1GCZ A;  3DJI A;  4XX7 A;  1CGQ A;  4FDX A;  4P0H A;  4Z1U A;  4WRB A;  3SMB A;  3GAC A;  2OOZ A;  1MIF A;  4Q3F A;  3DJH A;  4PKK A;  4TRU A;  2OOW A;  3B64 A;  2OPA A;  4GRU A;  4EUI A;  3MLC A; 
#chains in the Genus database with same CATH topology
 4OTB A;  3EJ3 A;  1S0Y B;  4LKB A;  1HFO A;  2OS5 A;  1LJT A;  4GRR A;  4OTA A;  4NWQ B;  3WNS A;  4U5R A;  1MFI A;  4GUM A;  3SMC A;  3ABF A;  1UIZ A;  3IJJ A;  2OP8 A;  3B9S A;  4EVG A;  3M20 A;  3MF7 A;  1CA7 A;  3N4D A;  4X19 A;  2WKF A;  4Z1T A;  3RF4 A;  2ORM A;  3EJ7 A;  4GRN A;  4OSF A;  1OTF A;  3CE4 A;  2FM7 A;  5J7Q A;  4JJ9 A;  4X1C A;  4LHO A;  3JSF A;  3C6V A;  5CLN A;  4OYQ A;  1GD0 A;  3MB2 B;  4GRQ A;  3L5V A;  3T5S A;  5BSI A;  1MFF A;  3WNT A;  5BSC A;  3EJ9 B;  2FLZ A;  4Z15 A;  1GYJ A;  2GDG A;  3L5S A;  3N4G A;  2AAL A;  3L5R A;  4P7S A;  5BS9 A;  4DH4 A;  5HVS A;  1MWW A;  4ETG A;  1OTG A;  5CLO A;  2WKB A;  3E6Q A;  4U5P A;  4P7M A;  4OTC A;  4P01 A;  5BSJ A;  4GRP A;  4F2K A;  4PLU A;  3M21 A;  3U18 A;  2XCZ A;  3MF8 A;  3MJZ A;  1S0Y A;  3GAD A;  4TRF A;  4WR8 A;  1DPT A;  3L5P A;  3EJ3 B;  3IJG A;  3KER A;  3L5U A;  3JSG A;  3JTU A;  1GYX A;  1FIM A;  3RY0 A;  1GYY A;  3N4H A;  4K9G A;  3FWT A;  1U9D A;  3WNR A;  3L5T A;  2FLT A;  5EIZ A;  4FAZ A;  4XX8 A;  5J7P A;  5B4O A;  4JCU A;  2WKF B;  1GIF A;  2OOH A;  2AAJ A;  2AAG A;  4NWP E;  1BJP A;  5HVV A;  5HVT A;  3EJ7 B;  4PKZ A;  3RF5 A;  1P1G A;  3MB2 A;  3FWU A;  4M1A A;  3HOF A;  3EJ9 A;  3KAN A;  4GRO A;  4X1C C;  4LHP A;  2X4K A;  1GCZ A;  3DJI A;  4XX7 A;  1CGQ A;  4FDX A;  4P0H A;  4Z1U A;  4WRB A;  3SMB A;  3GAC A;  2OOZ A;  1MIF A;  4Q3F A;  3DJH A;  4PKK A;  4TRU A;  2OOW A;  3B64 A;  2OPA A;  4GRU A;  4EUI A;  3MLC A; 
#chains in the Genus database with same CATH homology
 4OTB A;  3EJ3 A;  1S0Y B;  4LKB A;  1HFO A;  2OS5 A;  1LJT A;  4GRR A;  4OTA A;  4NWQ B;  3WNS A;  4U5R A;  1MFI A;  4GUM A;  3SMC A;  3ABF A;  1UIZ A;  3IJJ A;  2OP8 A;  3B9S A;  4EVG A;  3M20 A;  3MF7 A;  1CA7 A;  3N4D A;  4X19 A;  2WKF A;  4Z1T A;  3RF4 A;  2ORM A;  3EJ7 A;  4GRN A;  4OSF A;  1OTF A;  3CE4 A;  2FM7 A;  5J7Q A;  4JJ9 A;  4X1C A;  4LHO A;  3JSF A;  3C6V A;  5CLN A;  4OYQ A;  1GD0 A;  3MB2 B;  4GRQ A;  3L5V A;  3T5S A;  5BSI A;  1MFF A;  3WNT A;  5BSC A;  3EJ9 B;  2FLZ A;  4Z15 A;  1GYJ A;  2GDG A;  3L5S A;  3N4G A;  2AAL A;  3L5R A;  4P7S A;  5BS9 A;  4DH4 A;  5HVS A;  1MWW A;  4ETG A;  1OTG A;  5CLO A;  2WKB A;  3E6Q A;  4U5P A;  4P7M A;  4OTC A;  4P01 A;  5BSJ A;  4GRP A;  4F2K A;  4PLU A;  3M21 A;  3U18 A;  2XCZ A;  3MF8 A;  3MJZ A;  1S0Y A;  3GAD A;  4TRF A;  4WR8 A;  1DPT A;  3L5P A;  3EJ3 B;  3IJG A;  3KER A;  3L5U A;  3JSG A;  3JTU A;  1GYX A;  1FIM A;  3RY0 A;  1GYY A;  3N4H A;  4K9G A;  3FWT A;  1U9D A;  3WNR A;  3L5T A;  2FLT A;  5EIZ A;  4FAZ A;  4XX8 A;  5J7P A;  5B4O A;  4JCU A;  2WKF B;  1GIF A;  2OOH A;  2AAJ A;  2AAG A;  4NWP E;  1BJP A;  5HVV A;  5HVT A;  3EJ7 B;  4PKZ A;  3RF5 A;  1P1G A;  3MB2 A;  3FWU A;  4M1A A;  3HOF A;  3EJ9 A;  3KAN A;  4GRO A;  4X1C C;  4LHP A;  2X4K A;  1GCZ A;  3DJI A;  4XX7 A;  1CGQ A;  4FDX A;  4P0H A;  4Z1U A;  4WRB A;  3SMB A;  3GAC A;  2OOZ A;  1MIF A;  4Q3F A;  3DJH A;  4PKK A;  4TRU A;  2OOW A;  3B64 A;  2OPA A;  4GRU A;  4EUI A;  3MLC A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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