5C5AA

Crystal structure of hdm2 in complex with nutlin-3a
Total Genus 26
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
26
sequence length
92
structure length
92
Chain Sequence
PASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGDLFGVPSFSVKEHRKIYTMIYRNLVVVN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title NMR Molecular Replacement, NMR2
rcsb
molecule tags Ligase
source organism Homo sapiens
molecule keywords E3 ubiquitin-protein ligase Mdm2
total genus 26
structure length 92
sequence length 92
chains with identical sequence B
ec nomenclature ec 2.3.2.27: RING-type E3 ubiquitin transferase.
pdb deposition date 2015-06-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF02201 SWIB SWIB/MDM2 domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.245.10 Mainly Alpha Orthogonal Bundle MDM2 SWIB/MDM2 domain 5c5aA00
4OBAA 3VZVA 4OASA 5LAWA 3JZSA 4RXZA 2N0WA 4JRGA 4OGNA 2M86B 1YCQA 2MWYA 4ZGKA 4ZYCA 3TJ2A 5HMKA 4JVEA 3V3BA 4IPFA 4HFZA 4HBMA 4JV7A 4DIJA 3LBLA 1YCRA 4LWUA 4EREA 3IWYA 2N14A 2LZGA 1V31A 3LBKA 4ODEA 3VBGA 4WT2A 2N06A 5LN2A 4ZYIA 5HMIA 3LNJA 4OGVA 4LWTA 1UHRA 4QO4A 3DACA 4UE1A 3IUXA 4UMNA 3U15A 5TRFA 4J3EA 4J7DA 2RUHA 2MPSA 3DABA 2VYRA 4JVRA 3FDOA 4LWVA 4N5TA 2Z5TM 1T4EA 4UD7A 4JSCA 5HMHA 3FEAA 1RV1A 3FE7A 2Z5SM 3EQSA 4JV9A 4ZYFA 3TPXA 5C5AA 4OQ3A 5LAYA 3JZRA 3TU1A 3EQYA 2N0UA 4OCCA 4HG7A 4ZFIA 3LNZA 4JWRA 2GV2A 3JZOA 3W69A 1T4FM 4QOCA 1TTVA 4MDQA 5AFGA 4ODFA 1V32A 4ERFA 3JZQA 4J74A 1Z1MA 3JZPA 5LAZA 2AXIA 4J7EA 4OGTA 3G03A 5LAVA 3JZKA 4MDNA 3LBJE
chains in the Genus database with same CATH superfamily
4OBAA 3VZVA 4OASA 5LAWA 3JZSA 4RXZA 2N0WA 4JRGA 4OGNA 2M86B 1YCQA 2MWYA 4ZGKA 4ZYCA 3TJ2A 5HMKA 4JVEA 3V3BA 4IPFA 4HFZA 4HBMA 4JV7A 4DIJA 3LBLA 1YCRA 4LWUA 4EREA 3IWYA 2N14A 2LZGA 1V31A 3LBKA 4ODEA 3VBGA 4WT2A 2N06A 5LN2A 4ZYIA 5HMIA 3LNJA 4OGVA 4LWTA 1UHRA 4QO4A 3DACA 4UE1A 3IUXA 4UMNA 3U15A 5TRFA 4J3EA 4J7DA 2RUHA 2MPSA 3DABA 2VYRA 4JVRA 3FDOA 4LWVA 4N5TA 2Z5TM 1T4EA 4UD7A 4JSCA 5HMHA 3FEAA 1RV1A 3FE7A 2Z5SM 3EQSA 4JV9A 4ZYFA 3TPXA 5C5AA 4OQ3A 5LAYA 3JZRA 3TU1A 3EQYA 2N0UA 4OCCA 4HG7A 4ZFIA 3LNZA 4JWRA 2GV2A 3JZOA 3W69A 1T4FM 4QOCA 1TTVA 4MDQA 5AFGA 4ODFA 1V32A 4ERFA 3JZQA 4J74A 1Z1MA 3JZPA 5LAZA 2AXIA 4J7EA 4OGTA 3G03A 5LAVA 3JZKA 4MDNA 3LBJE
chains in the Genus database with same CATH topology
4OBAA 3VZVA 4OASA 5LAWA 3JZSA 4RXZA 2N0WA 4JRGA 4OGNA 2M86B 1YCQA 2MWYA 4ZGKA 4ZYCA 3TJ2A 5HMKA 4JVEA 3V3BA 4IPFA 4HFZA 4HBMA 4JV7A 4DIJA 3LBLA 1YCRA 4LWUA 4EREA 3IWYA 2N14A 2LZGA 1V31A 3LBKA 4ODEA 3VBGA 4WT2A 2N06A 5LN2A 4ZYIA 5HMIA 3LNJA 4OGVA 4LWTA 1UHRA 4QO4A 3DACA 4UE1A 3IUXA 4UMNA 3U15A 5TRFA 4J3EA 4J7DA 2RUHA 2MPSA 3DABA 2VYRA 4JVRA 3FDOA 4LWVA 4N5TA 2Z5TM 1T4EA 4UD7A 4JSCA 5HMHA 3FEAA 1RV1A 3FE7A 2Z5SM 3EQSA 4JV9A 4ZYFA 3TPXA 5C5AA 4OQ3A 5LAYA 3JZRA 3TU1A 3EQYA 2N0UA 4OCCA 4HG7A 4ZFIA 3LNZA 4JWRA 2GV2A 3JZOA 3W69A 1T4FM 4QOCA 1TTVA 4MDQA 5AFGA 4ODFA 1V32A 4ERFA 3JZQA 4J74A 1Z1MA 3JZPA 5LAZA 2AXIA 4J7EA 4OGTA 3G03A 5LAVA 3JZKA 4MDNA 3LBJE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4OBA A;  3VZV A;  4OAS A;  5LAW A;  3JZS A;  4RXZ A;  2N0W A;  4JRG A;  4OGN A;  2M86 B;  1YCQ A;  2MWY A;  4ZGK A;  4ZYC A;  3TJ2 A;  5HMK A;  4JVE A;  3V3B A;  4IPF A;  4HFZ A;  4HBM A;  4JV7 A;  4DIJ A;  3LBL A;  1YCR A;  4LWU A;  4ERE A;  3IWY A;  2N14 A;  2LZG A;  1V31 A;  3LBK A;  4ODE A;  3VBG A;  4WT2 A;  2N06 A;  5LN2 A;  4ZYI A;  5HMI A;  3LNJ A;  4OGV A;  4LWT A;  1UHR A;  4QO4 A;  3DAC A;  4UE1 A;  3IUX A;  4UMN A;  3U15 A;  5TRF A;  4J3E A;  4J7D A;  2RUH A;  2MPS A;  3DAB A;  2VYR A;  4JVR A;  3FDO A;  4LWV A;  4N5T A;  2Z5T M;  1T4E A;  4UD7 A;  4JSC A;  5HMH A;  3FEA A;  1RV1 A;  3FE7 A;  2Z5S M;  3EQS A;  4JV9 A;  4ZYF A;  3TPX A;  5C5A A;  4OQ3 A;  5LAY A;  3JZR A;  3TU1 A;  3EQY A;  2N0U A;  4OCC A;  4HG7 A;  4ZFI A;  3LNZ A;  4JWR A;  2GV2 A;  3JZO A;  3W69 A;  1T4F M;  4QOC A;  1TTV A;  4MDQ A;  5AFG A;  4ODF A;  1V32 A;  4ERF A;  3JZQ A;  4J74 A;  1Z1M A;  3JZP A;  5LAZ A;  2AXI A;  4J7E A;  4OGT A;  3G03 A;  5LAV A;  3JZK A;  4MDN A;  3LBJ E; 
#chains in the Genus database with same CATH topology
 4OBA A;  3VZV A;  4OAS A;  5LAW A;  3JZS A;  4RXZ A;  2N0W A;  4JRG A;  4OGN A;  2M86 B;  1YCQ A;  2MWY A;  4ZGK A;  4ZYC A;  3TJ2 A;  5HMK A;  4JVE A;  3V3B A;  4IPF A;  4HFZ A;  4HBM A;  4JV7 A;  4DIJ A;  3LBL A;  1YCR A;  4LWU A;  4ERE A;  3IWY A;  2N14 A;  2LZG A;  1V31 A;  3LBK A;  4ODE A;  3VBG A;  4WT2 A;  2N06 A;  5LN2 A;  4ZYI A;  5HMI A;  3LNJ A;  4OGV A;  4LWT A;  1UHR A;  4QO4 A;  3DAC A;  4UE1 A;  3IUX A;  4UMN A;  3U15 A;  5TRF A;  4J3E A;  4J7D A;  2RUH A;  2MPS A;  3DAB A;  2VYR A;  4JVR A;  3FDO A;  4LWV A;  4N5T A;  2Z5T M;  1T4E A;  4UD7 A;  4JSC A;  5HMH A;  3FEA A;  1RV1 A;  3FE7 A;  2Z5S M;  3EQS A;  4JV9 A;  4ZYF A;  3TPX A;  5C5A A;  4OQ3 A;  5LAY A;  3JZR A;  3TU1 A;  3EQY A;  2N0U A;  4OCC A;  4HG7 A;  4ZFI A;  3LNZ A;  4JWR A;  2GV2 A;  3JZO A;  3W69 A;  1T4F M;  4QOC A;  1TTV A;  4MDQ A;  5AFG A;  4ODF A;  1V32 A;  4ERF A;  3JZQ A;  4J74 A;  1Z1M A;  3JZP A;  5LAZ A;  2AXI A;  4J7E A;  4OGT A;  3G03 A;  5LAV A;  3JZK A;  4MDN A;  3LBJ E; 
#chains in the Genus database with same CATH homology
 4OBA A;  3VZV A;  4OAS A;  5LAW A;  3JZS A;  4RXZ A;  2N0W A;  4JRG A;  4OGN A;  2M86 B;  1YCQ A;  2MWY A;  4ZGK A;  4ZYC A;  3TJ2 A;  5HMK A;  4JVE A;  3V3B A;  4IPF A;  4HFZ A;  4HBM A;  4JV7 A;  4DIJ A;  3LBL A;  1YCR A;  4LWU A;  4ERE A;  3IWY A;  2N14 A;  2LZG A;  1V31 A;  3LBK A;  4ODE A;  3VBG A;  4WT2 A;  2N06 A;  5LN2 A;  4ZYI A;  5HMI A;  3LNJ A;  4OGV A;  4LWT A;  1UHR A;  4QO4 A;  3DAC A;  4UE1 A;  3IUX A;  4UMN A;  3U15 A;  5TRF A;  4J3E A;  4J7D A;  2RUH A;  2MPS A;  3DAB A;  2VYR A;  4JVR A;  3FDO A;  4LWV A;  4N5T A;  2Z5T M;  1T4E A;  4UD7 A;  4JSC A;  5HMH A;  3FEA A;  1RV1 A;  3FE7 A;  2Z5S M;  3EQS A;  4JV9 A;  4ZYF A;  3TPX A;  5C5A A;  4OQ3 A;  5LAY A;  3JZR A;  3TU1 A;  3EQY A;  2N0U A;  4OCC A;  4HG7 A;  4ZFI A;  3LNZ A;  4JWR A;  2GV2 A;  3JZO A;  3W69 A;  1T4F M;  4QOC A;  1TTV A;  4MDQ A;  5AFG A;  4ODF A;  1V32 A;  4ERF A;  3JZQ A;  4J74 A;  1Z1M A;  3JZP A;  5LAZ A;  2AXI A;  4J7E A;  4OGT A;  3G03 A;  5LAV A;  3JZK A;  4MDN A;  3LBJ E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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