5HVTA

Crystal structure of macrophage migration inhibitory factor (mif) with a potent inhibitor (nvs-2)
Total Genus 34
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
34
sequence length
114
structure length
114
Chain Sequence
PMFIVNTNVPRASVPDGFLSELTQQLAQATGKPPQYIAVHVVPDQLMAFGGSSEPCALCSLHSIGKIGGAQNRSYSKLLCGLLAERLRISPDRVYINYYDMNAANVGWNNSTFA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title A Fluorescence Polarization Assay for Binding to Macrophage Migration Inhibitory Factor and Crystal Structures for Complexes of Two Potent Inhibitors.
pubmed doi rcsb
molecule tags Isomerase/isomerase inhibitor
source organism Homo sapiens
molecule keywords Macrophage migration inhibitory factor
total genus 34
structure length 114
sequence length 114
chains with identical sequence B, C
ec nomenclature ec 5.3.2.1: Phenylpyruvate tautomerase.
pdb deposition date 2016-01-28

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01187 MIF Macrophage migration inhibitory factor (MIF)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.429.10 Alpha Beta 2-Layer Sandwich Macrophage Migration Inhibitory Factor Macrophage Migration Inhibitory Factor 5hvtA00
5J7QA 1OTGA 3MB2A 4GRRA 1DPTA 2FLTA 4OTAA 1S0YA 2OP8A 1MWWA 4OSFA 4FAZA 3MF8A 4PLUA 4GRQA 3L5RA 3KANA 4M1AA 3WNTA 5HVTA 4GROA 1GYJA 3CE4A 3WNSA 2AAGA 4LHPA 4OTBA 3SMBA 4LKBA 3U18A 1GCZA 3MJZA 1HFOA 4WR8A 4PKKA 1UIZA 1MIFA 1MFFA 3L5TA 2GDGA 1LJTA 4P7MA 1FIMA 3ABFA 3JSGA 3FWTA 3FWUA 4JCUA 1CA7A 3T5SA 4X1CC 1OTFA 3RY0A 3E6QA 5CLOA 1P1GA 3JTUA 2FM7A 1GYYA 3GADA 2WKBA 3B9SA 4P7SA 1U9DA 4LHOA 3EJ3B 5HVSA 3IJJA 3EJ7B 3L5PA 2WKFB 3N4GA 4X1CA 3JSFA 5BSJA 3EJ9B 4DH4A 3IJGA 3L5UA 4WRBA 3SMCA 3EJ7A 4GUMA 3KERA 2AALA 1GD0A 4ETGA 3HOFA 1GYXA 5CLNA 1MFIA 2OS5A 2OOZA 5EIZA 5BS9A 3MB2B 3B64A 5BSCA 4OYQA 2ORMA 3L5VA 4Z1UA 3M21A 1S0YB 4GRUA 3MLCA 4GRPA 3N4HA 4U5RA 4P01A 3EJ3A 4Q3FA 5B4OA 1CGQA 1BJPA 3WNRA 2OPAA 4XX8A 3RF4A 3DJHA 3DJIA 3N4DA 2WKFA 2FLZA 4NWQB 2AAJA 3GACA 3EJ9A 2OOHA 1GIFA 3RF5A 4TRFA 4F2KA 4OTCA 4XX7A 4X19A 5J7PA 2XCZA 4NWPE 4K9GA 4EUIA 4JJ9A 3C6VA 4PKZA 3M20A 4Z15A 4U5PA 4GRNA 4P0HA 5HVVA 4TRUA 3MF7A 2X4KA 3L5SA 4FDXA 4Z1TA 2OOWA 5BSIA 4EVGA
chains in the Genus database with same CATH superfamily
5J7QA 1OTGA 3MB2A 4GRRA 1DPTA 2FLTA 4OTAA 1S0YA 2OP8A 1MWWA 4OSFA 4FAZA 3MF8A 4PLUA 4GRQA 3L5RA 3KANA 4M1AA 3WNTA 5HVTA 4GROA 1GYJA 3CE4A 3WNSA 2AAGA 4LHPA 4OTBA 3SMBA 4LKBA 3U18A 1GCZA 3MJZA 1HFOA 4WR8A 4PKKA 1UIZA 1MIFA 1MFFA 3L5TA 2GDGA 1LJTA 4P7MA 1FIMA 3ABFA 3JSGA 3FWTA 3FWUA 4JCUA 1CA7A 3T5SA 4X1CC 1OTFA 3RY0A 3E6QA 5CLOA 1P1GA 3JTUA 2FM7A 1GYYA 3GADA 2WKBA 3B9SA 4P7SA 1U9DA 4LHOA 3EJ3B 5HVSA 3IJJA 3EJ7B 3L5PA 2WKFB 3N4GA 4X1CA 3JSFA 5BSJA 3EJ9B 4DH4A 3IJGA 3L5UA 4WRBA 3SMCA 3EJ7A 4GUMA 3KERA 2AALA 1GD0A 4ETGA 3HOFA 1GYXA 5CLNA 1MFIA 2OS5A 2OOZA 5EIZA 5BS9A 3MB2B 3B64A 5BSCA 4OYQA 2ORMA 3L5VA 4Z1UA 3M21A 1S0YB 4GRUA 3MLCA 4GRPA 3N4HA 4U5RA 4P01A 3EJ3A 4Q3FA 5B4OA 1CGQA 1BJPA 3WNRA 2OPAA 4XX8A 3RF4A 3DJHA 3DJIA 3N4DA 2WKFA 2FLZA 4NWQB 2AAJA 3GACA 3EJ9A 2OOHA 1GIFA 3RF5A 4TRFA 4F2KA 4OTCA 4XX7A 4X19A 5J7PA 2XCZA 4NWPE 4K9GA 4EUIA 4JJ9A 3C6VA 4PKZA 3M20A 4Z15A 4U5PA 4GRNA 4P0HA 5HVVA 4TRUA 3MF7A 2X4KA 3L5SA 4FDXA 4Z1TA 2OOWA 5BSIA 4EVGA
chains in the Genus database with same CATH topology
5J7QA 1OTGA 3MB2A 4GRRA 1DPTA 2FLTA 4OTAA 1S0YA 2OP8A 1MWWA 4OSFA 4FAZA 3MF8A 4PLUA 4GRQA 3L5RA 3KANA 4M1AA 3WNTA 5HVTA 4GROA 1GYJA 3CE4A 3WNSA 2AAGA 4LHPA 4OTBA 3SMBA 4LKBA 3U18A 1GCZA 3MJZA 1HFOA 4WR8A 4PKKA 1UIZA 1MIFA 1MFFA 3L5TA 2GDGA 1LJTA 4P7MA 1FIMA 3ABFA 3JSGA 3FWTA 3FWUA 4JCUA 1CA7A 3T5SA 4X1CC 1OTFA 3RY0A 3E6QA 5CLOA 1P1GA 3JTUA 2FM7A 1GYYA 3GADA 2WKBA 3B9SA 4P7SA 1U9DA 4LHOA 3EJ3B 5HVSA 3IJJA 3EJ7B 3L5PA 2WKFB 3N4GA 4X1CA 3JSFA 5BSJA 3EJ9B 4DH4A 3IJGA 3L5UA 4WRBA 3SMCA 3EJ7A 4GUMA 3KERA 2AALA 1GD0A 4ETGA 3HOFA 1GYXA 5CLNA 1MFIA 2OS5A 2OOZA 5EIZA 5BS9A 3MB2B 3B64A 5BSCA 4OYQA 2ORMA 3L5VA 4Z1UA 3M21A 1S0YB 4GRUA 3MLCA 4GRPA 3N4HA 4U5RA 4P01A 3EJ3A 4Q3FA 5B4OA 1CGQA 1BJPA 3WNRA 2OPAA 4XX8A 3RF4A 3DJHA 3DJIA 3N4DA 2WKFA 2FLZA 4NWQB 2AAJA 3GACA 3EJ9A 2OOHA 1GIFA 3RF5A 4TRFA 4F2KA 4OTCA 4XX7A 4X19A 5J7PA 2XCZA 4NWPE 4K9GA 4EUIA 4JJ9A 3C6VA 4PKZA 3M20A 4Z15A 4U5PA 4GRNA 4P0HA 5HVVA 4TRUA 3MF7A 2X4KA 3L5SA 4FDXA 4Z1TA 2OOWA 5BSIA 4EVGA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5J7Q A;  1OTG A;  3MB2 A;  4GRR A;  1DPT A;  2FLT A;  4OTA A;  1S0Y A;  2OP8 A;  1MWW A;  4OSF A;  4FAZ A;  3MF8 A;  4PLU A;  4GRQ A;  3L5R A;  3KAN A;  4M1A A;  3WNT A;  5HVT A;  4GRO A;  1GYJ A;  3CE4 A;  3WNS A;  2AAG A;  4LHP A;  4OTB A;  3SMB A;  4LKB A;  3U18 A;  1GCZ A;  3MJZ A;  1HFO A;  4WR8 A;  4PKK A;  1UIZ A;  1MIF A;  1MFF A;  3L5T A;  2GDG A;  1LJT A;  4P7M A;  1FIM A;  3ABF A;  3JSG A;  3FWT A;  3FWU A;  4JCU A;  1CA7 A;  3T5S A;  4X1C C;  1OTF A;  3RY0 A;  3E6Q A;  5CLO A;  1P1G A;  3JTU A;  2FM7 A;  1GYY A;  3GAD A;  2WKB A;  3B9S A;  4P7S A;  1U9D A;  4LHO A;  3EJ3 B;  5HVS A;  3IJJ A;  3EJ7 B;  3L5P A;  2WKF B;  3N4G A;  4X1C A;  3JSF A;  5BSJ A;  3EJ9 B;  4DH4 A;  3IJG A;  3L5U A;  4WRB A;  3SMC A;  3EJ7 A;  4GUM A;  3KER A;  2AAL A;  1GD0 A;  4ETG A;  3HOF A;  1GYX A;  5CLN A;  1MFI A;  2OS5 A;  2OOZ A;  5EIZ A;  5BS9 A;  3MB2 B;  3B64 A;  5BSC A;  4OYQ A;  2ORM A;  3L5V A;  4Z1U A;  3M21 A;  1S0Y B;  4GRU A;  3MLC A;  4GRP A;  3N4H A;  4U5R A;  4P01 A;  3EJ3 A;  4Q3F A;  5B4O A;  1CGQ A;  1BJP A;  3WNR A;  2OPA A;  4XX8 A;  3RF4 A;  3DJH A;  3DJI A;  3N4D A;  2WKF A;  2FLZ A;  4NWQ B;  2AAJ A;  3GAC A;  3EJ9 A;  2OOH A;  1GIF A;  3RF5 A;  4TRF A;  4F2K A;  4OTC A;  4XX7 A;  4X19 A;  5J7P A;  2XCZ A;  4NWP E;  4K9G A;  4EUI A;  4JJ9 A;  3C6V A;  4PKZ A;  3M20 A;  4Z15 A;  4U5P A;  4GRN A;  4P0H A;  5HVV A;  4TRU A;  3MF7 A;  2X4K A;  3L5S A;  4FDX A;  4Z1T A;  2OOW A;  5BSI A;  4EVG A; 
#chains in the Genus database with same CATH topology
 5J7Q A;  1OTG A;  3MB2 A;  4GRR A;  1DPT A;  2FLT A;  4OTA A;  1S0Y A;  2OP8 A;  1MWW A;  4OSF A;  4FAZ A;  3MF8 A;  4PLU A;  4GRQ A;  3L5R A;  3KAN A;  4M1A A;  3WNT A;  5HVT A;  4GRO A;  1GYJ A;  3CE4 A;  3WNS A;  2AAG A;  4LHP A;  4OTB A;  3SMB A;  4LKB A;  3U18 A;  1GCZ A;  3MJZ A;  1HFO A;  4WR8 A;  4PKK A;  1UIZ A;  1MIF A;  1MFF A;  3L5T A;  2GDG A;  1LJT A;  4P7M A;  1FIM A;  3ABF A;  3JSG A;  3FWT A;  3FWU A;  4JCU A;  1CA7 A;  3T5S A;  4X1C C;  1OTF A;  3RY0 A;  3E6Q A;  5CLO A;  1P1G A;  3JTU A;  2FM7 A;  1GYY A;  3GAD A;  2WKB A;  3B9S A;  4P7S A;  1U9D A;  4LHO A;  3EJ3 B;  5HVS A;  3IJJ A;  3EJ7 B;  3L5P A;  2WKF B;  3N4G A;  4X1C A;  3JSF A;  5BSJ A;  3EJ9 B;  4DH4 A;  3IJG A;  3L5U A;  4WRB A;  3SMC A;  3EJ7 A;  4GUM A;  3KER A;  2AAL A;  1GD0 A;  4ETG A;  3HOF A;  1GYX A;  5CLN A;  1MFI A;  2OS5 A;  2OOZ A;  5EIZ A;  5BS9 A;  3MB2 B;  3B64 A;  5BSC A;  4OYQ A;  2ORM A;  3L5V A;  4Z1U A;  3M21 A;  1S0Y B;  4GRU A;  3MLC A;  4GRP A;  3N4H A;  4U5R A;  4P01 A;  3EJ3 A;  4Q3F A;  5B4O A;  1CGQ A;  1BJP A;  3WNR A;  2OPA A;  4XX8 A;  3RF4 A;  3DJH A;  3DJI A;  3N4D A;  2WKF A;  2FLZ A;  4NWQ B;  2AAJ A;  3GAC A;  3EJ9 A;  2OOH A;  1GIF A;  3RF5 A;  4TRF A;  4F2K A;  4OTC A;  4XX7 A;  4X19 A;  5J7P A;  2XCZ A;  4NWP E;  4K9G A;  4EUI A;  4JJ9 A;  3C6V A;  4PKZ A;  3M20 A;  4Z15 A;  4U5P A;  4GRN A;  4P0H A;  5HVV A;  4TRU A;  3MF7 A;  2X4K A;  3L5S A;  4FDX A;  4Z1T A;  2OOW A;  5BSI A;  4EVG A; 
#chains in the Genus database with same CATH homology
 5J7Q A;  1OTG A;  3MB2 A;  4GRR A;  1DPT A;  2FLT A;  4OTA A;  1S0Y A;  2OP8 A;  1MWW A;  4OSF A;  4FAZ A;  3MF8 A;  4PLU A;  4GRQ A;  3L5R A;  3KAN A;  4M1A A;  3WNT A;  5HVT A;  4GRO A;  1GYJ A;  3CE4 A;  3WNS A;  2AAG A;  4LHP A;  4OTB A;  3SMB A;  4LKB A;  3U18 A;  1GCZ A;  3MJZ A;  1HFO A;  4WR8 A;  4PKK A;  1UIZ A;  1MIF A;  1MFF A;  3L5T A;  2GDG A;  1LJT A;  4P7M A;  1FIM A;  3ABF A;  3JSG A;  3FWT A;  3FWU A;  4JCU A;  1CA7 A;  3T5S A;  4X1C C;  1OTF A;  3RY0 A;  3E6Q A;  5CLO A;  1P1G A;  3JTU A;  2FM7 A;  1GYY A;  3GAD A;  2WKB A;  3B9S A;  4P7S A;  1U9D A;  4LHO A;  3EJ3 B;  5HVS A;  3IJJ A;  3EJ7 B;  3L5P A;  2WKF B;  3N4G A;  4X1C A;  3JSF A;  5BSJ A;  3EJ9 B;  4DH4 A;  3IJG A;  3L5U A;  4WRB A;  3SMC A;  3EJ7 A;  4GUM A;  3KER A;  2AAL A;  1GD0 A;  4ETG A;  3HOF A;  1GYX A;  5CLN A;  1MFI A;  2OS5 A;  2OOZ A;  5EIZ A;  5BS9 A;  3MB2 B;  3B64 A;  5BSC A;  4OYQ A;  2ORM A;  3L5V A;  4Z1U A;  3M21 A;  1S0Y B;  4GRU A;  3MLC A;  4GRP A;  3N4H A;  4U5R A;  4P01 A;  3EJ3 A;  4Q3F A;  5B4O A;  1CGQ A;  1BJP A;  3WNR A;  2OPA A;  4XX8 A;  3RF4 A;  3DJH A;  3DJI A;  3N4D A;  2WKF A;  2FLZ A;  4NWQ B;  2AAJ A;  3GAC A;  3EJ9 A;  2OOH A;  1GIF A;  3RF5 A;  4TRF A;  4F2K A;  4OTC A;  4XX7 A;  4X19 A;  5J7P A;  2XCZ A;  4NWP E;  4K9G A;  4EUI A;  4JJ9 A;  3C6V A;  4PKZ A;  3M20 A;  4Z15 A;  4U5P A;  4GRN A;  4P0H A;  5HVV A;  4TRU A;  3MF7 A;  2X4K A;  3L5S A;  4FDX A;  4Z1T A;  2OOW A;  5BSI A;  4EVG A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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