3NTZA

Design, synthesis, biological evaluation and x-ray crystal structures of novel classical 6,5,6-tricyclicbenzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors
Total Genus 54
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
54
sequence length
186
structure length
186
Chain Sequence
VGSLNCIVAVSQNMGIGKNGDLPWPPLRNEFRYFQRMTTTSSVEGKQNLVIMGKKTWFSIPEKNRPLKGRINLVLSRELKEPPQGAHFLSRSLDDALKLTEQPELANKVDMVWIVGGSSVYKEAMNHPGHLKLFVTRIMQDFESDTFFPEIDLEKYKLLPEYPGVLSDVQEEKGIKYKFEVYEKND
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Oxidoreductase/oxidoreductase inhibitor
molecule keywords Dihydrofolate reductase
publication title Design, synthesis, biological evaluation and X-ray crystal structure of novel classical 6,5,6-tricyclic benzo[4,5]thieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors.
pubmed doi rcsb
source organism Homo sapiens
total genus 54
structure length 186
sequence length 186
ec nomenclature ec 1.5.1.3: Dihydrofolate reductase.
pdb deposition date 2010-07-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00186 DHFR_1 Dihydrofolate reductase
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.40.430.10 Alpha Beta 3-Layer(aba) Sandwich Dihydrofolate Reductase, subunit A Dihydrofolate Reductase, subunit A 3ntzA00
3TQ8A 4DP3A 4XE6X 1J3KA 4KY8A 2CIGA 4KY4A 3I8AX 2FZJA 3KJRA 3KGYA 4PTHA 3NXXA 1RE7A 3SRRX 3NZ6X 3DRCA 5HSRA 1OHJA 2L28A 1DR3A 3SRUX 2HM9A 1E26A 4EIGA 2H2QA 4M6KA 2ANQA 3FY8X 3IROA 3ROAA 1AOEA 4Q6AA 4XT4A 3OCHA 2W3WA 1MVSA 5HQYA 3JSUA 5EAJA 1JOLA 4Q0DA 2FZIA 1RA1A 1RX8A 1DRAA 1RB2A 4OR7A 4KJJA 3NU0A 1D1GA 2W3VA 4KNEA 3SGYA 4IXED 3UM6A 2W3BA 5JA3A 3SQYX 4XT6A 3FQCA 1RD7A 1DDRA 4ELGA 3OAFA 1DIUA 1RX2A 3QYOA 3F0SX 2BL9A 5HT4A 3TQBA 5FDAA 4P68A 3TQAA 1BZFA 2KGKA 1HFQA 3ZPGA 2W9GA 4KM2A 3F0UX 3K2HA 3NRRA 4GH8A 2GD9A 1LY3A 3TD8A 3QLYA 4X5HA 4KL9A 4HA9A 5HUIA 3EEKA 3FREX 4DPHA 4FHBA 3QG2A 1AO8A 3Q1HA 3FL9A 4QHVA 1IA3A 4I13A 3GHVA 3QL3A 4LEKX 3NXTA 3DAUA 3NZ9X 4H98A 1PD8A 5HVBA 1RX4A 5HI6A 3R33A 5CC9A 3NXYA 2BLCA 4M2XA 4ELFA 1M79A 4QLEA 1PDBA 1DRFA 4RGCA 4PTJA 3K45A 1DHJA 1AI9A 3F8YA 4QJCA 4KLXA 3INVA 4KFJA 1U72A 3SRWX 1RX5A 5HF0X 2P4GA 3E0BA 4G8ZX 3CD2A 1DR5A 3FQ0A 4NX6A 1DHFA 2W9HA 3JVXA 4KAKA 1J3IA 1DR1A 4P3RA 3VCOA 3EELA 1ZDRA 4IXFX 1HFRA 2C2TA 3QLWA 1DR2A 4KYAA 4XT8A 3JWKA 3FL8A 3QLXA 4IXGX 1LUDA 2G6VA 1M78A 3FQVA 2ANOA 3FS6A 1DDSA 1DLRA 5DXVA 1DG8A 1DLSA 1U71A 4KM0A 4M7VA 1DAJA 1DF7A 1RX3A 3NZBX 3TQ9A 2JYBA 3DFRA 3N0HA 1RA3A 4EJ1A 4XRBA 4KD7A 4EILA 4HA7A 1RX7A 4HOGA 1IA4A 4PSTA 4M6JA 1RX1A 3GHCA 4QI9A 1LY4A 3K47A 4ELBA 3QYLA 2OIPA 4X5JA 3IRMA 3DATA 1CZ3A 3IA5A 3SRSX 2W3MA 4X5FA 3DG8A 4PSSA 4CD2A 3EEJA 3M08A 1HFPA 2INQA 4G3MA 3KFYA 3NXOA 3GHWA 5HF2X 3SAIA 1VJ3A 3K74A 2QK8A 4XT5A 4KJKA 3FRBX 1IA1A 3FRFX 1RC4A 1RA9A 4M7UA 3F0QX 2CD2A 3RG9A 3QLZA 3EX8A 3QL0A 4HOEA 3SA1A 3SR5X 4XT7A 1S3WA 5ECXA 2C2SA 3JWMA 2ITHA 1KMSA 3FQOA 3HJ3A 8DFRA 1DREA 4X5IA 1DG5A 3JW3A 3NTZA 4DFRA 3S3VA 3DL5A 1J3JA 4PDJA 1QZFA 3F91A 1PD9A 3JW5A 4Q0EA 3FQZA 3L3RA 1RA2A 1U70A 3SA2A 3CL9A 4X5GA 2D5NA 4H95A 3NZCX 4QLGA 5HT5A 3JTWA 3CLBA 3GYFA 1RH3A 1DRHA 3M09A 1KLKA 1RX9A 2O7PA 1RX6A 3KY8A 4H97A 3FY9X 7DFRA 3KJSA 3LG4A 3GI2A 1M7AA 2LF1A 1DYRA 2W9TA 3NXVA 1RB3A 3QLSA 2HXVA 4DDRA 1IA2A 5HSUA 2AZNA 3QLRA 2DRCA 5JG0X 2W9SA 2W3AA 3EIGA 2XW7A 4FGHA 3FYWX 4QLFA 1DR6A 4DPDA 1KMVA 2D0KA 1VDRA 1YHOA 4LAEX 4QJZD 3D80A 3UM5A 1S3UA 4LAGX 3FRAX 6DFRA 3IRNA 4P66A 5HPBA 4M6LA 3IX9A 1JOMA 3JWFA 1TDRA 3SRQX 4KBNA 4P3QA 4ELHA 1CD2A 2FZHA 3UM8A 3D84X 3S9UA 5HVEA 3FYVX 4EIZA 2DHFA 4G95A 3NXRA 3DL6A 1BOZA 4ECKA 3FRDX 2OBCA 4I1NA 4TU5X 1DG7A 3RO9A 3HBBA 3NZAX 3I3RA 3F0XX 4HOFA 3F0BX 1S3VA 1DHIA 4KJLA 5HQZA 1DRBA 4ELEA 1RF7A 1S3YA 4KEBA 3QFXA 1DYHA 5ECCA 3S7AA 4OSGA 3ZPCA 2HQPA 1DYJA 5CCCA 1RA8A 4LAHX 3CSEA 3FQFA 1RG7A 3EEMA 2BLAA 1OHKA 2B3ZA 1JUVA 1MVTA 3JWCA 4FGGA 4XECX 3F8ZA 1SEJA 4H96A 3DGAA 3NZDA 1DISA 1DR4A 4PSYA 1DR7A 1DYIA 3IA4A 5DFRA 2ZZAA 5E8QA 3F0VX 4Q67A 3SH2A 2BLBA 5U27A 3QGTA 5U26A 4NX7A
chains in the Genus database with same CATH superfamily
3TQ8A 4DP3A 4XE6X 1J3KA 4KY8A 2CIGA 4KY4A 3I8AX 2FZJA 3KJRA 3KGYA 4PTHA 3NXXA 1RE7A 3SRRX 3NZ6X 3DRCA 5HSRA 1OHJA 2L28A 1DR3A 3SRUX 2HM9A 1E26A 4EIGA 2H2QA 4M6KA 2ANQA 3FY8X 3IROA 3ROAA 1AOEA 4Q6AA 4XT4A 3OCHA 2W3WA 1MVSA 5HQYA 3JSUA 5EAJA 1JOLA 4Q0DA 2FZIA 1RA1A 1RX8A 1DRAA 1RB2A 4OR7A 4KJJA 3NU0A 1D1GA 2W3VA 4KNEA 3SGYA 4IXED 3UM6A 2W3BA 5JA3A 3SQYX 4XT6A 3FQCA 1RD7A 1DDRA 4ELGA 3OAFA 1DIUA 1RX2A 3QYOA 3F0SX 2BL9A 5HT4A 3TQBA 5FDAA 4P68A 3TQAA 1BZFA 2KGKA 1HFQA 3ZPGA 2W9GA 4KM2A 3F0UX 3K2HA 3NRRA 4GH8A 2GD9A 1LY3A 3TD8A 3QLYA 4X5HA 4KL9A 4HA9A 5HUIA 3EEKA 3FREX 4DPHA 4FHBA 3QG2A 1AO8A 3Q1HA 3FL9A 4QHVA 1IA3A 4I13A 3GHVA 3QL3A 4LEKX 3NXTA 3DAUA 3NZ9X 4H98A 1PD8A 5HVBA 1RX4A 5HI6A 3R33A 5CC9A 3NXYA 2BLCA 4M2XA 4ELFA 1M79A 4QLEA 1PDBA 1DRFA 4RGCA 4PTJA 3K45A 1DHJA 1AI9A 3F8YA 4QJCA 4KLXA 3INVA 4KFJA 1U72A 3SRWX 1RX5A 5HF0X 2P4GA 3E0BA 4G8ZX 3CD2A 1DR5A 3FQ0A 4NX6A 1DHFA 2W9HA 3JVXA 4KAKA 1J3IA 1DR1A 4P3RA 3VCOA 3EELA 1ZDRA 4IXFX 1HFRA 2C2TA 3QLWA 1DR2A 4KYAA 4XT8A 3JWKA 3FL8A 3QLXA 4IXGX 1LUDA 2G6VA 1M78A 3FQVA 2ANOA 3FS6A 1DDSA 1DLRA 5DXVA 1DG8A 1DLSA 1U71A 4KM0A 4M7VA 1DAJA 1DF7A 1RX3A 3NZBX 3TQ9A 2JYBA 3DFRA 3N0HA 1RA3A 4EJ1A 4XRBA 4KD7A 4EILA 4HA7A 1RX7A 4HOGA 1IA4A 4PSTA 4M6JA 1RX1A 3GHCA 4QI9A 1LY4A 3K47A 4ELBA 3QYLA 2OIPA 4X5JA 3IRMA 3DATA 1CZ3A 3IA5A 3SRSX 2W3MA 4X5FA 3DG8A 4PSSA 4CD2A 3EEJA 3M08A 1HFPA 2INQA 4G3MA 3KFYA 3NXOA 3GHWA 5HF2X 3SAIA 1VJ3A 3K74A 2QK8A 4XT5A 4KJKA 3FRBX 1IA1A 3FRFX 1RC4A 1RA9A 4M7UA 3F0QX 2CD2A 3RG9A 3QLZA 3EX8A 3QL0A 4HOEA 3SA1A 3SR5X 4XT7A 1S3WA 5ECXA 2C2SA 3JWMA 2ITHA 1KMSA 3FQOA 3HJ3A 8DFRA 1DREA 4X5IA 1DG5A 3JW3A 3NTZA 4DFRA 3S3VA 3DL5A 1J3JA 4PDJA 1QZFA 3F91A 1PD9A 3JW5A 4Q0EA 3FQZA 3L3RA 1RA2A 1U70A 3SA2A 3CL9A 4X5GA 2D5NA 4H95A 3NZCX 4QLGA 5HT5A 3JTWA 3CLBA 3GYFA 1RH3A 1DRHA 3M09A 1KLKA 1RX9A 2O7PA 1RX6A 3KY8A 4H97A 3FY9X 7DFRA 3KJSA 3LG4A 3GI2A 1M7AA 2LF1A 1DYRA 2W9TA 3NXVA 1RB3A 3QLSA 2HXVA 4DDRA 1IA2A 5HSUA 2AZNA 3QLRA 2DRCA 5JG0X 2W9SA 2W3AA 3EIGA 2XW7A 4FGHA 3FYWX 4QLFA 1DR6A 4DPDA 1KMVA 2D0KA 1VDRA 1YHOA 4LAEX 4QJZD 3D80A 3UM5A 1S3UA 4LAGX 3FRAX 6DFRA 3IRNA 4P66A 5HPBA 4M6LA 3IX9A 1JOMA 3JWFA 1TDRA 3SRQX 4KBNA 4P3QA 4ELHA 1CD2A 2FZHA 3UM8A 3D84X 3S9UA 5HVEA 3FYVX 4EIZA 2DHFA 4G95A 3NXRA 3DL6A 1BOZA 4ECKA 3FRDX 2OBCA 4I1NA 4TU5X 1DG7A 3RO9A 3HBBA 3NZAX 3I3RA 3F0XX 4HOFA 3F0BX 1S3VA 1DHIA 4KJLA 5HQZA 1DRBA 4ELEA 1RF7A 1S3YA 4KEBA 3QFXA 1DYHA 5ECCA 3S7AA 4OSGA 3ZPCA 2HQPA 1DYJA 5CCCA 1RA8A 4LAHX 3CSEA 3FQFA 1RG7A 3EEMA 2BLAA 1OHKA 2B3ZA 1JUVA 1MVTA 3JWCA 4FGGA 4XECX 3F8ZA 1SEJA 4H96A 3DGAA 3NZDA 1DISA 1DR4A 4PSYA 1DR7A 1DYIA 3IA4A 5DFRA 2ZZAA 5E8QA 3F0VX 4Q67A 3SH2A 2BLBA 5U27A 3QGTA 5U26A 4NX7A
chains in the Genus database with same CATH topology
3TQ8A 4DP3A 4XE6X 1J3KA 4KY8A 2CIGA 4KY4A 3I8AX 2FZJA 3KJRA 3KGYA 4PTHA 3NXXA 1RE7A 3SRRX 3NZ6X 3DRCA 5HSRA 1OHJA 2L28A 1DR3A 3SRUX 2HM9A 1E26A 4EIGA 2H2QA 4M6KA 2ANQA 3FY8X 3IROA 3ROAA 1AOEA 4Q6AA 4XT4A 3OCHA 2W3WA 1MVSA 5HQYA 3JSUA 5EAJA 1JOLA 4Q0DA 2FZIA 1RA1A 1RX8A 1DRAA 1RB2A 4OR7A 4KJJA 3NU0A 1D1GA 2W3VA 4KNEA 3SGYA 4IXED 3UM6A 2W3BA 5JA3A 3SQYX 4XT6A 3FQCA 1RD7A 1DDRA 4ELGA 3OAFA 1DIUA 1RX2A 3QYOA 3F0SX 2BL9A 5HT4A 3TQBA 5FDAA 4P68A 3TQAA 1BZFA 2KGKA 1HFQA 3ZPGA 2W9GA 4KM2A 3F0UX 3K2HA 3NRRA 4GH8A 2GD9A 1LY3A 3TD8A 3QLYA 4X5HA 4KL9A 4HA9A 5HUIA 3EEKA 3FREX 4DPHA 4FHBA 3QG2A 1AO8A 3Q1HA 3FL9A 4QHVA 1IA3A 4I13A 3GHVA 3QL3A 4LEKX 3NXTA 3DAUA 3NZ9X 4H98A 1PD8A 5HVBA 1RX4A 5HI6A 3R33A 5CC9A 3NXYA 2BLCA 4M2XA 4ELFA 1M79A 4QLEA 1PDBA 1DRFA 4RGCA 4PTJA 3K45A 1DHJA 1AI9A 3F8YA 4QJCA 4KLXA 3INVA 4KFJA 1U72A 3SRWX 1RX5A 5HF0X 2P4GA 3E0BA 4G8ZX 3CD2A 1DR5A 3FQ0A 4NX6A 1DHFA 2W9HA 3JVXA 4KAKA 1J3IA 1DR1A 4P3RA 3VCOA 3EELA 1ZDRA 4IXFX 1HFRA 2C2TA 3QLWA 1DR2A 4KYAA 4XT8A 3JWKA 3FL8A 3QLXA 4IXGX 1LUDA 2G6VA 1M78A 3FQVA 2ANOA 3FS6A 1DDSA 1DLRA 5DXVA 1DG8A 1DLSA 1U71A 4KM0A 4M7VA 1DAJA 1DF7A 1RX3A 3NZBX 3TQ9A 2JYBA 3DFRA 3N0HA 1RA3A 4EJ1A 4XRBA 4KD7A 4EILA 4HA7A 1RX7A 4HOGA 1IA4A 4PSTA 4M6JA 1RX1A 3GHCA 4QI9A 1LY4A 3K47A 4ELBA 3QYLA 2OIPA 4X5JA 3IRMA 3DATA 1CZ3A 3IA5A 3SRSX 2W3MA 4X5FA 3DG8A 4PSSA 4CD2A 3EEJA 3M08A 1HFPA 2INQA 4G3MA 3KFYA 3NXOA 3GHWA 5HF2X 3SAIA 1VJ3A 3K74A 2QK8A 4XT5A 4KJKA 3FRBX 1IA1A 3FRFX 1RC4A 1RA9A 4M7UA 3F0QX 2CD2A 3RG9A 3QLZA 3EX8A 3QL0A 4HOEA 3SA1A 3SR5X 4XT7A 1S3WA 5ECXA 2C2SA 3JWMA 2ITHA 1KMSA 3FQOA 3HJ3A 8DFRA 1DREA 4X5IA 1DG5A 3JW3A 3NTZA 4DFRA 3S3VA 3DL5A 1J3JA 4PDJA 1QZFA 3F91A 1PD9A 3JW5A 4Q0EA 3FQZA 3L3RA 1RA2A 1U70A 3SA2A 3CL9A 4X5GA 2D5NA 4H95A 3NZCX 4QLGA 5HT5A 3JTWA 3CLBA 3GYFA 1RH3A 1DRHA 3M09A 1KLKA 1RX9A 2O7PA 1RX6A 3KY8A 4H97A 3FY9X 7DFRA 3KJSA 3LG4A 3GI2A 1M7AA 2LF1A 1DYRA 2W9TA 3NXVA 1RB3A 3QLSA 2HXVA 4DDRA 1IA2A 5HSUA 2AZNA 3QLRA 2DRCA 5JG0X 2W9SA 2W3AA 3EIGA 2XW7A 4FGHA 3FYWX 4QLFA 1DR6A 4DPDA 1KMVA 2D0KA 1VDRA 1YHOA 4LAEX 4QJZD 3D80A 3UM5A 1S3UA 4LAGX 3FRAX 6DFRA 3IRNA 4P66A 5HPBA 4M6LA 3IX9A 1JOMA 3JWFA 1TDRA 3SRQX 4KBNA 4P3QA 4ELHA 1CD2A 2FZHA 3UM8A 3D84X 3S9UA 5HVEA 3FYVX 4EIZA 2DHFA 4G95A 3NXRA 3DL6A 1BOZA 4ECKA 3FRDX 2OBCA 4I1NA 4TU5X 1DG7A 3RO9A 3HBBA 3NZAX 3I3RA 3F0XX 4HOFA 3F0BX 1S3VA 1DHIA 4KJLA 5HQZA 1DRBA 4ELEA 1RF7A 1S3YA 4KEBA 3QFXA 1DYHA 5ECCA 3S7AA 4OSGA 3ZPCA 2HQPA 1DYJA 5CCCA 1RA8A 4LAHX 3CSEA 3FQFA 1RG7A 3EEMA 2BLAA 1OHKA 2B3ZA 1JUVA 1MVTA 3JWCA 4FGGA 4XECX 3F8ZA 1SEJA 4H96A 3DGAA 3NZDA 1DISA 1DR4A 4PSYA 1DR7A 1DYIA 3IA4A 5DFRA 2ZZAA 5E8QA 3F0VX 4Q67A 3SH2A 2BLBA 5U27A 3QGTA 5U26A 4NX7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3TQ8 A;  4DP3 A;  4XE6 X;  1J3K A;  4KY8 A;  2CIG A;  4KY4 A;  3I8A X;  2FZJ A;  3KJR A;  3KGY A;  4PTH A;  3NXX A;  1RE7 A;  3SRR X;  3NZ6 X;  3DRC A;  5HSR A;  1OHJ A;  2L28 A;  1DR3 A;  3SRU X;  2HM9 A;  1E26 A;  4EIG A;  2H2Q A;  4M6K A;  2ANQ A;  3FY8 X;  3IRO A;  3ROA A;  1AOE A;  4Q6A A;  4XT4 A;  3OCH A;  2W3W A;  1MVS A;  5HQY A;  3JSU A;  5EAJ A;  1JOL A;  4Q0D A;  2FZI A;  1RA1 A;  1RX8 A;  1DRA A;  1RB2 A;  4OR7 A;  4KJJ A;  3NU0 A;  1D1G A;  2W3V A;  4KNE A;  3SGY A;  4IXE D;  3UM6 A;  2W3B A;  5JA3 A;  3SQY X;  4XT6 A;  3FQC A;  1RD7 A;  1DDR A;  4ELG A;  3OAF A;  1DIU A;  1RX2 A;  3QYO A;  3F0S X;  2BL9 A;  5HT4 A;  3TQB A;  5FDA A;  4P68 A;  3TQA A;  1BZF A;  2KGK A;  1HFQ A;  3ZPG A;  2W9G A;  4KM2 A;  3F0U X;  3K2H A;  3NRR A;  4GH8 A;  2GD9 A;  1LY3 A;  3TD8 A;  3QLY A;  4X5H A;  4KL9 A;  4HA9 A;  5HUI A;  3EEK A;  3FRE X;  4DPH A;  4FHB A;  3QG2 A;  1AO8 A;  3Q1H A;  3FL9 A;  4QHV A;  1IA3 A;  4I13 A;  3GHV A;  3QL3 A;  4LEK X;  3NXT A;  3DAU A;  3NZ9 X;  4H98 A;  1PD8 A;  5HVB A;  1RX4 A;  5HI6 A;  3R33 A;  5CC9 A;  3NXY A;  2BLC A;  4M2X A;  4ELF A;  1M79 A;  4QLE A;  1PDB A;  1DRF A;  4RGC A;  4PTJ A;  3K45 A;  1DHJ A;  1AI9 A;  3F8Y A;  4QJC A;  4KLX A;  3INV A;  4KFJ A;  1U72 A;  3SRW X;  1RX5 A;  5HF0 X;  2P4G A;  3E0B A;  4G8Z X;  3CD2 A;  1DR5 A;  3FQ0 A;  4NX6 A;  1DHF A;  2W9H A;  3JVX A;  4KAK A;  1J3I A;  1DR1 A;  4P3R A;  3VCO A;  3EEL A;  1ZDR A;  4IXF X;  1HFR A;  2C2T A;  3QLW A;  1DR2 A;  4KYA A;  4XT8 A;  3JWK A;  3FL8 A;  3QLX A;  4IXG X;  1LUD A;  2G6V A;  1M78 A;  3FQV A;  2ANO A;  3FS6 A;  1DDS A;  1DLR A;  5DXV A;  1DG8 A;  1DLS A;  1U71 A;  4KM0 A;  4M7V A;  1DAJ A;  1DF7 A;  1RX3 A;  3NZB X;  3TQ9 A;  2JYB A;  3DFR A;  3N0H A;  1RA3 A;  4EJ1 A;  4XRB A;  4KD7 A;  4EIL A;  4HA7 A;  1RX7 A;  4HOG A;  1IA4 A;  4PST A;  4M6J A;  1RX1 A;  3GHC A;  4QI9 A;  1LY4 A;  3K47 A;  4ELB A;  3QYL A;  2OIP A;  4X5J A;  3IRM A;  3DAT A;  1CZ3 A;  3IA5 A;  3SRS X;  2W3M A;  4X5F A;  3DG8 A;  4PSS A;  4CD2 A;  3EEJ A;  3M08 A;  1HFP A;  2INQ A;  4G3M A;  3KFY A;  3NXO A;  3GHW A;  5HF2 X;  3SAI A;  1VJ3 A;  3K74 A;  2QK8 A;  4XT5 A;  4KJK A;  3FRB X;  1IA1 A;  3FRF X;  1RC4 A;  1RA9 A;  4M7U A;  3F0Q X;  2CD2 A;  3RG9 A;  3QLZ A;  3EX8 A;  3QL0 A;  4HOE A;  3SA1 A;  3SR5 X;  4XT7 A;  1S3W A;  5ECX A;  2C2S A;  3JWM A;  2ITH A;  1KMS A;  3FQO A;  3HJ3 A;  8DFR A;  1DRE A;  4X5I A;  1DG5 A;  3JW3 A;  3NTZ A;  4DFR A;  3S3V A;  3DL5 A;  1J3J A;  4PDJ A;  1QZF A;  3F91 A;  1PD9 A;  3JW5 A;  4Q0E A;  3FQZ A;  3L3R A;  1RA2 A;  1U70 A;  3SA2 A;  3CL9 A;  4X5G A;  2D5N A;  4H95 A;  3NZC X;  4QLG A;  5HT5 A;  3JTW A;  3CLB A;  3GYF A;  1RH3 A;  1DRH A;  3M09 A;  1KLK A;  1RX9 A;  2O7P A;  1RX6 A;  3KY8 A;  4H97 A;  3FY9 X;  7DFR A;  3KJS A;  3LG4 A;  3GI2 A;  1M7A A;  2LF1 A;  1DYR A;  2W9T A;  3NXV A;  1RB3 A;  3QLS A;  2HXV A;  4DDR A;  1IA2 A;  5HSU A;  2AZN A;  3QLR A;  2DRC A;  5JG0 X;  2W9S A;  2W3A A;  3EIG A;  2XW7 A;  4FGH A;  3FYW X;  4QLF A;  1DR6 A;  4DPD A;  1KMV A;  2D0K A;  1VDR A;  1YHO A;  4LAE X;  4QJZ D;  3D80 A;  3UM5 A;  1S3U A;  4LAG X;  3FRA X;  6DFR A;  3IRN A;  4P66 A;  5HPB A;  4M6L A;  3IX9 A;  1JOM A;  3JWF A;  1TDR A;  3SRQ X;  4KBN A;  4P3Q A;  4ELH A;  1CD2 A;  2FZH A;  3UM8 A;  3D84 X;  3S9U A;  5HVE A;  3FYV X;  4EIZ A;  2DHF A;  4G95 A;  3NXR A;  3DL6 A;  1BOZ A;  4ECK A;  3FRD X;  2OBC A;  4I1N A;  4TU5 X;  1DG7 A;  3RO9 A;  3HBB A;  3NZA X;  3I3R A;  3F0X X;  4HOF A;  3F0B X;  1S3V A;  1DHI A;  4KJL A;  5HQZ A;  1DRB A;  4ELE A;  1RF7 A;  1S3Y A;  4KEB A;  3QFX A;  1DYH A;  5ECC A;  3S7A A;  4OSG A;  3ZPC A;  2HQP A;  1DYJ A;  5CCC A;  1RA8 A;  4LAH X;  3CSE A;  3FQF A;  1RG7 A;  3EEM A;  2BLA A;  1OHK A;  2B3Z A;  1JUV A;  1MVT A;  3JWC A;  4FGG A;  4XEC X;  3F8Z A;  1SEJ A;  4H96 A;  3DGA A;  3NZD A;  1DIS A;  1DR4 A;  4PSY A;  1DR7 A;  1DYI A;  3IA4 A;  5DFR A;  2ZZA A;  5E8Q A;  3F0V X;  4Q67 A;  3SH2 A;  2BLB A;  5U27 A;  3QGT A;  5U26 A;  4NX7 A; 
#chains in the Genus database with same CATH topology
 3TQ8 A;  4DP3 A;  4XE6 X;  1J3K A;  4KY8 A;  2CIG A;  4KY4 A;  3I8A X;  2FZJ A;  3KJR A;  3KGY A;  4PTH A;  3NXX A;  1RE7 A;  3SRR X;  3NZ6 X;  3DRC A;  5HSR A;  1OHJ A;  2L28 A;  1DR3 A;  3SRU X;  2HM9 A;  1E26 A;  4EIG A;  2H2Q A;  4M6K A;  2ANQ A;  3FY8 X;  3IRO A;  3ROA A;  1AOE A;  4Q6A A;  4XT4 A;  3OCH A;  2W3W A;  1MVS A;  5HQY A;  3JSU A;  5EAJ A;  1JOL A;  4Q0D A;  2FZI A;  1RA1 A;  1RX8 A;  1DRA A;  1RB2 A;  4OR7 A;  4KJJ A;  3NU0 A;  1D1G A;  2W3V A;  4KNE A;  3SGY A;  4IXE D;  3UM6 A;  2W3B A;  5JA3 A;  3SQY X;  4XT6 A;  3FQC A;  1RD7 A;  1DDR A;  4ELG A;  3OAF A;  1DIU A;  1RX2 A;  3QYO A;  3F0S X;  2BL9 A;  5HT4 A;  3TQB A;  5FDA A;  4P68 A;  3TQA A;  1BZF A;  2KGK A;  1HFQ A;  3ZPG A;  2W9G A;  4KM2 A;  3F0U X;  3K2H A;  3NRR A;  4GH8 A;  2GD9 A;  1LY3 A;  3TD8 A;  3QLY A;  4X5H A;  4KL9 A;  4HA9 A;  5HUI A;  3EEK A;  3FRE X;  4DPH A;  4FHB A;  3QG2 A;  1AO8 A;  3Q1H A;  3FL9 A;  4QHV A;  1IA3 A;  4I13 A;  3GHV A;  3QL3 A;  4LEK X;  3NXT A;  3DAU A;  3NZ9 X;  4H98 A;  1PD8 A;  5HVB A;  1RX4 A;  5HI6 A;  3R33 A;  5CC9 A;  3NXY A;  2BLC A;  4M2X A;  4ELF A;  1M79 A;  4QLE A;  1PDB A;  1DRF A;  4RGC A;  4PTJ A;  3K45 A;  1DHJ A;  1AI9 A;  3F8Y A;  4QJC A;  4KLX A;  3INV A;  4KFJ A;  1U72 A;  3SRW X;  1RX5 A;  5HF0 X;  2P4G A;  3E0B A;  4G8Z X;  3CD2 A;  1DR5 A;  3FQ0 A;  4NX6 A;  1DHF A;  2W9H A;  3JVX A;  4KAK A;  1J3I A;  1DR1 A;  4P3R A;  3VCO A;  3EEL A;  1ZDR A;  4IXF X;  1HFR A;  2C2T A;  3QLW A;  1DR2 A;  4KYA A;  4XT8 A;  3JWK A;  3FL8 A;  3QLX A;  4IXG X;  1LUD A;  2G6V A;  1M78 A;  3FQV A;  2ANO A;  3FS6 A;  1DDS A;  1DLR A;  5DXV A;  1DG8 A;  1DLS A;  1U71 A;  4KM0 A;  4M7V A;  1DAJ A;  1DF7 A;  1RX3 A;  3NZB X;  3TQ9 A;  2JYB A;  3DFR A;  3N0H A;  1RA3 A;  4EJ1 A;  4XRB A;  4KD7 A;  4EIL A;  4HA7 A;  1RX7 A;  4HOG A;  1IA4 A;  4PST A;  4M6J A;  1RX1 A;  3GHC A;  4QI9 A;  1LY4 A;  3K47 A;  4ELB A;  3QYL A;  2OIP A;  4X5J A;  3IRM A;  3DAT A;  1CZ3 A;  3IA5 A;  3SRS X;  2W3M A;  4X5F A;  3DG8 A;  4PSS A;  4CD2 A;  3EEJ A;  3M08 A;  1HFP A;  2INQ A;  4G3M A;  3KFY A;  3NXO A;  3GHW A;  5HF2 X;  3SAI A;  1VJ3 A;  3K74 A;  2QK8 A;  4XT5 A;  4KJK A;  3FRB X;  1IA1 A;  3FRF X;  1RC4 A;  1RA9 A;  4M7U A;  3F0Q X;  2CD2 A;  3RG9 A;  3QLZ A;  3EX8 A;  3QL0 A;  4HOE A;  3SA1 A;  3SR5 X;  4XT7 A;  1S3W A;  5ECX A;  2C2S A;  3JWM A;  2ITH A;  1KMS A;  3FQO A;  3HJ3 A;  8DFR A;  1DRE A;  4X5I A;  1DG5 A;  3JW3 A;  3NTZ A;  4DFR A;  3S3V A;  3DL5 A;  1J3J A;  4PDJ A;  1QZF A;  3F91 A;  1PD9 A;  3JW5 A;  4Q0E A;  3FQZ A;  3L3R A;  1RA2 A;  1U70 A;  3SA2 A;  3CL9 A;  4X5G A;  2D5N A;  4H95 A;  3NZC X;  4QLG A;  5HT5 A;  3JTW A;  3CLB A;  3GYF A;  1RH3 A;  1DRH A;  3M09 A;  1KLK A;  1RX9 A;  2O7P A;  1RX6 A;  3KY8 A;  4H97 A;  3FY9 X;  7DFR A;  3KJS A;  3LG4 A;  3GI2 A;  1M7A A;  2LF1 A;  1DYR A;  2W9T A;  3NXV A;  1RB3 A;  3QLS A;  2HXV A;  4DDR A;  1IA2 A;  5HSU A;  2AZN A;  3QLR A;  2DRC A;  5JG0 X;  2W9S A;  2W3A A;  3EIG A;  2XW7 A;  4FGH A;  3FYW X;  4QLF A;  1DR6 A;  4DPD A;  1KMV A;  2D0K A;  1VDR A;  1YHO A;  4LAE X;  4QJZ D;  3D80 A;  3UM5 A;  1S3U A;  4LAG X;  3FRA X;  6DFR A;  3IRN A;  4P66 A;  5HPB A;  4M6L A;  3IX9 A;  1JOM A;  3JWF A;  1TDR A;  3SRQ X;  4KBN A;  4P3Q A;  4ELH A;  1CD2 A;  2FZH A;  3UM8 A;  3D84 X;  3S9U A;  5HVE A;  3FYV X;  4EIZ A;  2DHF A;  4G95 A;  3NXR A;  3DL6 A;  1BOZ A;  4ECK A;  3FRD X;  2OBC A;  4I1N A;  4TU5 X;  1DG7 A;  3RO9 A;  3HBB A;  3NZA X;  3I3R A;  3F0X X;  4HOF A;  3F0B X;  1S3V A;  1DHI A;  4KJL A;  5HQZ A;  1DRB A;  4ELE A;  1RF7 A;  1S3Y A;  4KEB A;  3QFX A;  1DYH A;  5ECC A;  3S7A A;  4OSG A;  3ZPC A;  2HQP A;  1DYJ A;  5CCC A;  1RA8 A;  4LAH X;  3CSE A;  3FQF A;  1RG7 A;  3EEM A;  2BLA A;  1OHK A;  2B3Z A;  1JUV A;  1MVT A;  3JWC A;  4FGG A;  4XEC X;  3F8Z A;  1SEJ A;  4H96 A;  3DGA A;  3NZD A;  1DIS A;  1DR4 A;  4PSY A;  1DR7 A;  1DYI A;  3IA4 A;  5DFR A;  2ZZA A;  5E8Q A;  3F0V X;  4Q67 A;  3SH2 A;  2BLB A;  5U27 A;  3QGT A;  5U26 A;  4NX7 A; 
#chains in the Genus database with same CATH homology
 3TQ8 A;  4DP3 A;  4XE6 X;  1J3K A;  4KY8 A;  2CIG A;  4KY4 A;  3I8A X;  2FZJ A;  3KJR A;  3KGY A;  4PTH A;  3NXX A;  1RE7 A;  3SRR X;  3NZ6 X;  3DRC A;  5HSR A;  1OHJ A;  2L28 A;  1DR3 A;  3SRU X;  2HM9 A;  1E26 A;  4EIG A;  2H2Q A;  4M6K A;  2ANQ A;  3FY8 X;  3IRO A;  3ROA A;  1AOE A;  4Q6A A;  4XT4 A;  3OCH A;  2W3W A;  1MVS A;  5HQY A;  3JSU A;  5EAJ A;  1JOL A;  4Q0D A;  2FZI A;  1RA1 A;  1RX8 A;  1DRA A;  1RB2 A;  4OR7 A;  4KJJ A;  3NU0 A;  1D1G A;  2W3V A;  4KNE A;  3SGY A;  4IXE D;  3UM6 A;  2W3B A;  5JA3 A;  3SQY X;  4XT6 A;  3FQC A;  1RD7 A;  1DDR A;  4ELG A;  3OAF A;  1DIU A;  1RX2 A;  3QYO A;  3F0S X;  2BL9 A;  5HT4 A;  3TQB A;  5FDA A;  4P68 A;  3TQA A;  1BZF A;  2KGK A;  1HFQ A;  3ZPG A;  2W9G A;  4KM2 A;  3F0U X;  3K2H A;  3NRR A;  4GH8 A;  2GD9 A;  1LY3 A;  3TD8 A;  3QLY A;  4X5H A;  4KL9 A;  4HA9 A;  5HUI A;  3EEK A;  3FRE X;  4DPH A;  4FHB A;  3QG2 A;  1AO8 A;  3Q1H A;  3FL9 A;  4QHV A;  1IA3 A;  4I13 A;  3GHV A;  3QL3 A;  4LEK X;  3NXT A;  3DAU A;  3NZ9 X;  4H98 A;  1PD8 A;  5HVB A;  1RX4 A;  5HI6 A;  3R33 A;  5CC9 A;  3NXY A;  2BLC A;  4M2X A;  4ELF A;  1M79 A;  4QLE A;  1PDB A;  1DRF A;  4RGC A;  4PTJ A;  3K45 A;  1DHJ A;  1AI9 A;  3F8Y A;  4QJC A;  4KLX A;  3INV A;  4KFJ A;  1U72 A;  3SRW X;  1RX5 A;  5HF0 X;  2P4G A;  3E0B A;  4G8Z X;  3CD2 A;  1DR5 A;  3FQ0 A;  4NX6 A;  1DHF A;  2W9H A;  3JVX A;  4KAK A;  1J3I A;  1DR1 A;  4P3R A;  3VCO A;  3EEL A;  1ZDR A;  4IXF X;  1HFR A;  2C2T A;  3QLW A;  1DR2 A;  4KYA A;  4XT8 A;  3JWK A;  3FL8 A;  3QLX A;  4IXG X;  1LUD A;  2G6V A;  1M78 A;  3FQV A;  2ANO A;  3FS6 A;  1DDS A;  1DLR A;  5DXV A;  1DG8 A;  1DLS A;  1U71 A;  4KM0 A;  4M7V A;  1DAJ A;  1DF7 A;  1RX3 A;  3NZB X;  3TQ9 A;  2JYB A;  3DFR A;  3N0H A;  1RA3 A;  4EJ1 A;  4XRB A;  4KD7 A;  4EIL A;  4HA7 A;  1RX7 A;  4HOG A;  1IA4 A;  4PST A;  4M6J A;  1RX1 A;  3GHC A;  4QI9 A;  1LY4 A;  3K47 A;  4ELB A;  3QYL A;  2OIP A;  4X5J A;  3IRM A;  3DAT A;  1CZ3 A;  3IA5 A;  3SRS X;  2W3M A;  4X5F A;  3DG8 A;  4PSS A;  4CD2 A;  3EEJ A;  3M08 A;  1HFP A;  2INQ A;  4G3M A;  3KFY A;  3NXO A;  3GHW A;  5HF2 X;  3SAI A;  1VJ3 A;  3K74 A;  2QK8 A;  4XT5 A;  4KJK A;  3FRB X;  1IA1 A;  3FRF X;  1RC4 A;  1RA9 A;  4M7U A;  3F0Q X;  2CD2 A;  3RG9 A;  3QLZ A;  3EX8 A;  3QL0 A;  4HOE A;  3SA1 A;  3SR5 X;  4XT7 A;  1S3W A;  5ECX A;  2C2S A;  3JWM A;  2ITH A;  1KMS A;  3FQO A;  3HJ3 A;  8DFR A;  1DRE A;  4X5I A;  1DG5 A;  3JW3 A;  3NTZ A;  4DFR A;  3S3V A;  3DL5 A;  1J3J A;  4PDJ A;  1QZF A;  3F91 A;  1PD9 A;  3JW5 A;  4Q0E A;  3FQZ A;  3L3R A;  1RA2 A;  1U70 A;  3SA2 A;  3CL9 A;  4X5G A;  2D5N A;  4H95 A;  3NZC X;  4QLG A;  5HT5 A;  3JTW A;  3CLB A;  3GYF A;  1RH3 A;  1DRH A;  3M09 A;  1KLK A;  1RX9 A;  2O7P A;  1RX6 A;  3KY8 A;  4H97 A;  3FY9 X;  7DFR A;  3KJS A;  3LG4 A;  3GI2 A;  1M7A A;  2LF1 A;  1DYR A;  2W9T A;  3NXV A;  1RB3 A;  3QLS A;  2HXV A;  4DDR A;  1IA2 A;  5HSU A;  2AZN A;  3QLR A;  2DRC A;  5JG0 X;  2W9S A;  2W3A A;  3EIG A;  2XW7 A;  4FGH A;  3FYW X;  4QLF A;  1DR6 A;  4DPD A;  1KMV A;  2D0K A;  1VDR A;  1YHO A;  4LAE X;  4QJZ D;  3D80 A;  3UM5 A;  1S3U A;  4LAG X;  3FRA X;  6DFR A;  3IRN A;  4P66 A;  5HPB A;  4M6L A;  3IX9 A;  1JOM A;  3JWF A;  1TDR A;  3SRQ X;  4KBN A;  4P3Q A;  4ELH A;  1CD2 A;  2FZH A;  3UM8 A;  3D84 X;  3S9U A;  5HVE A;  3FYV X;  4EIZ A;  2DHF A;  4G95 A;  3NXR A;  3DL6 A;  1BOZ A;  4ECK A;  3FRD X;  2OBC A;  4I1N A;  4TU5 X;  1DG7 A;  3RO9 A;  3HBB A;  3NZA X;  3I3R A;  3F0X X;  4HOF A;  3F0B X;  1S3V A;  1DHI A;  4KJL A;  5HQZ A;  1DRB A;  4ELE A;  1RF7 A;  1S3Y A;  4KEB A;  3QFX A;  1DYH A;  5ECC A;  3S7A A;  4OSG A;  3ZPC A;  2HQP A;  1DYJ A;  5CCC A;  1RA8 A;  4LAH X;  3CSE A;  3FQF A;  1RG7 A;  3EEM A;  2BLA A;  1OHK A;  2B3Z A;  1JUV A;  1MVT A;  3JWC A;  4FGG A;  4XEC X;  3F8Z A;  1SEJ A;  4H96 A;  3DGA A;  3NZD A;  1DIS A;  1DR4 A;  4PSY A;  1DR7 A;  1DYI A;  3IA4 A;  5DFR A;  2ZZA A;  5E8Q A;  3F0V X;  4Q67 A;  3SH2 A;  2BLB A;  5U27 A;  3QGT A;  5U26 A;  4NX7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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