4BZBA

Crystal structure of the tetrameric dgtp-bound samhd1 mutant catalytic core
Total Genus 165
Loading diagram...

The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
165
sequence length
487
structure length
481
Chain Sequence
DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
Loading diagram...

The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
{{ tooltip.sname }} connected with {{ tooltip.tname }} : {{qFormat(tooltip.svalue) }}
molecule tags Hydrolase
molecule keywords DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1
publication title Mechanism of Allosteric Activation of Samhd1 by Dgtp
pubmed doi rcsb
source organism Homo sapiens
total genus 165
structure length 481
sequence length 487
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2013-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4bzbA01
4QG4A 4MZ7A 4TNXA 1YNBA 4QG1A 4RXQA 1YOYA 2PAQA 4L7WA 4LRLA 4MCWA 4N6WA 5TK6A 2PAUA 2PQ7A 4L1JA 3BG2A 3P3QA 3NQWA 3TMDA 5TK7A 3TM8A 2OGIA 5AO4A 4L1JB 4N71A 5TK8A 4TO1A 2PGSA 4MLNA 3KH1A 4TO4A 4TO3A 3TMBA 2FLOA 4QFXA 2O6IA 4Q7HA 3MZOA 4TNYA 2Q14A 3M1TA 3TMCA 2O08A 4TO5A 3RF0A 1U6ZA 3MEMA 5AO2A 4QFYA 4BZCA 4QG0A 4TO0A 3I7AA 4RXOA 3HC1A 5TK9A 4TNZA 4QFZA 4MLMA 3CCGA 3IRHA 4MDZA 4L7EA 5AO1A 4X9EA 4TO2A 4TNPA 3LJXA 1VQRA 4R8ZA 4XDSA 2CQZA 1VJ7A 4ZWEA 4ZWGA 4RXPA 4DMBA 4TNRA 2DQBA 3HI0A 2HEKA 3NR1A 4TO6A 5AO0A 1XX7A 4ME4A 4BZBA 2PARA 3U1NA 5AO3A 4TNQA 4RXRA 4QG2A 2GZ4A 4RXSA 5TKAA
chains in the Genus database with same CATH superfamily
4QG4A 4MZ7A 4TNXA 4QQXA 1YNBA 4QG1A 4RXQA 1YOYA 2PAQA 3KQ5A 4L7WA 4LRLA 4MCWA 4N6WA 5TK6A 2PAUA 2PQ7A 4L1JA 3BG2A 3P3QA 3NQWA 3S4LA 3TMDA 5TK7A 3TM8A 2OGIA 5AO4A 4L1JB 4N71A 5TK8A 4TO1A 2PGSA 4MLNA 4Q2DA 3KH1A 4TO4A 4TO3A 3TMBA 2FLOA 4QFXA 2O6IA 4Q7HA 3MZOA 4TNYA 2Q14A 3M1TA 3TMCA 2O08A 4TO5A 3RF0A 3SKDA 1U6ZA 3MEMA 5AO2A 4QFYA 4BZCA 3SK9A 4QG0A 4TO0A 3I7AA 4RXOA 3HC1A 5TK9A 4TNZA 4QFZA 4MLMA 3CCGA 3IRHA 4QQZA 4MDZA 4QQYA 4Q2CA 4L7EA 5AO1A 4X9EA 4TO2A 4TNPA 3LJXA 1VQRA 4R8ZA 4XDSA 2CQZA 1VJ7A 4ZWEA 4ZWGA 4RXPA 4DMBA 4TNRA 2DQBA 3HI0A 2HEKA 3NR1A 4TO6A 5AO0A 1XX7A 4ME4A 4BZBA 2PARA 3U1NA 5AO3A 4TNQA 4RXRA 4QQWA 3GW7A 4QG2A 2GZ4A 4RXSA 5TKAA
chains in the Genus database with same CATH topology
4QG4A 4MZ7A 4TNXA 4QQXA 1YNBA 4QG1A 4RXQA 1YOYA 2PAQA 3KQ5A 4L7WA 4LRLA 4MCWA 4N6WA 5TK6A 2PAUA 2PQ7A 4L1JA 3BG2A 3P3QA 3NQWA 3S4LA 3TMDA 5TK7A 3TM8A 2OGIA 5AO4A 4L1JB 4N71A 5TK8A 4TO1A 2PGSA 4MLNA 4Q2DA 3KH1A 4TO4A 4TO3A 3TMBA 2FLOA 4QFXA 2O6IA 4Q7HA 3MZOA 4TNYA 2Q14A 3M1TA 3TMCA 2O08A 4TO5A 3RF0A 3SKDA 1U6ZA 3MEMA 5AO2A 4QFYA 4BZCA 3SK9A 4QG0A 4TO0A 3I7AA 4RXOA 3HC1A 5TK9A 4TNZA 4QFZA 4MLMA 3CCGA 3IRHA 4QQZA 4MDZA 4QQYA 4Q2CA 4L7EA 5AO1A 4X9EA 4TO2A 4TNPA 3LJXA 1VQRA 4R8ZA 4XDSA 2CQZA 1VJ7A 4ZWEA 4ZWGA 4RXPA 4DMBA 4TNRA 2DQBA 3HI0A 2HEKA 3NR1A 4TO6A 5AO0A 1XX7A 4ME4A 4BZBA 2PARA 3U1NA 5AO3A 4TNQA 4RXRA 4QQWA 3GW7A 4QG2A 2GZ4A 4RXSA 5TKAA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4QG4 A;  4MZ7 A;  4TNX A;  1YNB A;  4QG1 A;  4RXQ A;  1YOY A;  2PAQ A;  4L7W A;  4LRL A;  4MCW A;  4N6W A;  5TK6 A;  2PAU A;  2PQ7 A;  4L1J A;  3BG2 A;  3P3Q A;  3NQW A;  3TMD A;  5TK7 A;  3TM8 A;  2OGI A;  5AO4 A;  4L1J B;  4N71 A;  5TK8 A;  4TO1 A;  2PGS A;  4MLN A;  3KH1 A;  4TO4 A;  4TO3 A;  3TMB A;  2FLO A;  4QFX A;  2O6I A;  4Q7H A;  3MZO A;  4TNY A;  2Q14 A;  3M1T A;  3TMC A;  2O08 A;  4TO5 A;  3RF0 A;  1U6Z A;  3MEM A;  5AO2 A;  4QFY A;  4BZC A;  4QG0 A;  4TO0 A;  3I7A A;  4RXO A;  3HC1 A;  5TK9 A;  4TNZ A;  4QFZ A;  4MLM A;  3CCG A;  3IRH A;  4MDZ A;  4L7E A;  5AO1 A;  4X9E A;  4TO2 A;  4TNP A;  3LJX A;  1VQR A;  4R8Z A;  4XDS A;  2CQZ A;  1VJ7 A;  4ZWE A;  4ZWG A;  4RXP A;  4DMB A;  4TNR A;  2DQB A;  3HI0 A;  2HEK A;  3NR1 A;  4TO6 A;  5AO0 A;  1XX7 A;  4ME4 A;  4BZB A;  2PAR A;  3U1N A;  5AO3 A;  4TNQ A;  4RXR A;  4QG2 A;  2GZ4 A;  4RXS A;  5TKA A; 
#chains in the Genus database with same CATH topology
 4QG4 A;  4MZ7 A;  4TNX A;  4QQX A;  1YNB A;  4QG1 A;  4RXQ A;  1YOY A;  2PAQ A;  3KQ5 A;  4L7W A;  4LRL A;  4MCW A;  4N6W A;  5TK6 A;  2PAU A;  2PQ7 A;  4L1J A;  3BG2 A;  3P3Q A;  3NQW A;  3S4L A;  3TMD A;  5TK7 A;  3TM8 A;  2OGI A;  5AO4 A;  4L1J B;  4N71 A;  5TK8 A;  4TO1 A;  2PGS A;  4MLN A;  4Q2D A;  3KH1 A;  4TO4 A;  4TO3 A;  3TMB A;  2FLO A;  4QFX A;  2O6I A;  4Q7H A;  3MZO A;  4TNY A;  2Q14 A;  3M1T A;  3TMC A;  2O08 A;  4TO5 A;  3RF0 A;  3SKD A;  1U6Z A;  3MEM A;  5AO2 A;  4QFY A;  4BZC A;  3SK9 A;  4QG0 A;  4TO0 A;  3I7A A;  4RXO A;  3HC1 A;  5TK9 A;  4TNZ A;  4QFZ A;  4MLM A;  3CCG A;  3IRH A;  4QQZ A;  4MDZ A;  4QQY A;  4Q2C A;  4L7E A;  5AO1 A;  4X9E A;  4TO2 A;  4TNP A;  3LJX A;  1VQR A;  4R8Z A;  4XDS A;  2CQZ A;  1VJ7 A;  4ZWE A;  4ZWG A;  4RXP A;  4DMB A;  4TNR A;  2DQB A;  3HI0 A;  2HEK A;  3NR1 A;  4TO6 A;  5AO0 A;  1XX7 A;  4ME4 A;  4BZB A;  2PAR A;  3U1N A;  5AO3 A;  4TNQ A;  4RXR A;  4QQW A;  3GW7 A;  4QG2 A;  2GZ4 A;  4RXS A;  5TKA A; 
#chains in the Genus database with same CATH homology
 4QG4 A;  4MZ7 A;  4TNX A;  4QQX A;  1YNB A;  4QG1 A;  4RXQ A;  1YOY A;  2PAQ A;  3KQ5 A;  4L7W A;  4LRL A;  4MCW A;  4N6W A;  5TK6 A;  2PAU A;  2PQ7 A;  4L1J A;  3BG2 A;  3P3Q A;  3NQW A;  3S4L A;  3TMD A;  5TK7 A;  3TM8 A;  2OGI A;  5AO4 A;  4L1J B;  4N71 A;  5TK8 A;  4TO1 A;  2PGS A;  4MLN A;  4Q2D A;  3KH1 A;  4TO4 A;  4TO3 A;  3TMB A;  2FLO A;  4QFX A;  2O6I A;  4Q7H A;  3MZO A;  4TNY A;  2Q14 A;  3M1T A;  3TMC A;  2O08 A;  4TO5 A;  3RF0 A;  3SKD A;  1U6Z A;  3MEM A;  5AO2 A;  4QFY A;  4BZC A;  3SK9 A;  4QG0 A;  4TO0 A;  3I7A A;  4RXO A;  3HC1 A;  5TK9 A;  4TNZ A;  4QFZ A;  4MLM A;  3CCG A;  3IRH A;  4QQZ A;  4MDZ A;  4QQY A;  4Q2C A;  4L7E A;  5AO1 A;  4X9E A;  4TO2 A;  4TNP A;  3LJX A;  1VQR A;  4R8Z A;  4XDS A;  2CQZ A;  1VJ7 A;  4ZWE A;  4ZWG A;  4RXP A;  4DMB A;  4TNR A;  2DQB A;  3HI0 A;  2HEK A;  3NR1 A;  4TO6 A;  5AO0 A;  1XX7 A;  4ME4 A;  4BZB A;  2PAR A;  3U1N A;  5AO3 A;  4TNQ A;  4RXR A;  4QQW A;  3GW7 A;  4QG2 A;  2GZ4 A;  4RXS A;  5TKA A; 
...loading similar chains, please wait...
similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
...loading similar chains, please wait...
#similar chains, but unknotted
...loading similar chains, please wait...
#similar chains in the pdb database (?% sequence similarity)
...loading similar chains, please wait...