4BZCA

Crystal structure of the tetrameric dgtp-bound wild type samhd1 catalytic core
Total Genus 166
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
166
sequence length
486
structure length
476
Chain Sequence
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCHDLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords DEOXYNUCLEOSIDE TRIPHOSPHATE TRIPHOSPHOHYDROLASE SAMHD1
publication title Mechanism of Allosteric Activation of Samhd1 by Dgtp
pubmed doi rcsb
source organism Homo sapiens
total genus 166
structure length 476
sequence length 486
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2013-07-25

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4bzcA01
4TO4A 5AO2A 5TK6A 5AO1A 2DQBA 4TNPA 4RXQA 4QG2A 4MDZA 2CQZA 4TO3A 4MZ7A 5AO3A 4TO2A 2PGSA 2OGIA 4ZWEA 4RXPA 1YNBA 3I7AA 4TNRA 5AO0A 3TMCA 5TK9A 4Q7HA 2GZ4A 4QG4A 3HC1A 4QFYA 5TKAA 4L1JB 3HI0A 2O6IA 4BZCA 2PAUA 2O08A 4TNZA 3U1NA 2Q14A 2HEKA 3LJXA 4TO6A 4QFZA 3NR1A 3CCGA 4QFXA 3KH1A 4ME4A 3IRHA 4QG0A 3RF0A 3TMDA 4MLMA 4N71A 4QG1A 3TMBA 4TNYA 4MLNA 4RXRA 1YOYA 1VQRA 4R8ZA 4L7WA 3MEMA 2FLOA 4RXOA 4TO0A 2PAQA 3BG2A 3MZOA 4L1JA 3M1TA 4L7EA 4LRLA 2PARA 3NQWA 4ZWGA 4XDSA 2PQ7A 4TO5A 5AO4A 4TNXA 4MCWA 4RXSA 5TK7A 3P3QA 3TM8A 1VJ7A 1XX7A 5TK8A 4N6WA 1U6ZA 4BZBA 4TNQA 4X9EA 4DMBA 4TO1A
chains in the Genus database with same CATH superfamily
4QQZA 4TO4A 5AO2A 5TK6A 5AO1A 2DQBA 4TNPA 4RXQA 4QG2A 3SKDA 4MDZA 2CQZA 4TO3A 3SK9A 4MZ7A 4Q2DA 5AO3A 4TO2A 2PGSA 2OGIA 4ZWEA 4RXPA 1YNBA 3I7AA 4TNRA 5AO0A 3TMCA 5TK9A 4Q7HA 2GZ4A 4QG4A 4QQXA 3HC1A 4QFYA 5TKAA 4L1JB 3HI0A 2O6IA 4BZCA 2PAUA 2O08A 4TNZA 3U1NA 2Q14A 3KQ5A 2HEKA 3LJXA 4TO6A 4QFZA 3NR1A 3CCGA 4QQYA 4QFXA 3KH1A 4ME4A 3IRHA 4QG0A 3RF0A 3TMDA 4MLMA 4N71A 4QG1A 3TMBA 4TNYA 4MLNA 4RXRA 1YOYA 1VQRA 4R8ZA 4L7WA 3MEMA 2FLOA 3S4LA 4RXOA 4TO0A 2PAQA 3BG2A 3MZOA 4L1JA 3M1TA 4L7EA 4LRLA 2PARA 3NQWA 4ZWGA 4XDSA 2PQ7A 4TO5A 5AO4A 4TNXA 4MCWA 4RXSA 5TK7A 3P3QA 3TM8A 1VJ7A 1XX7A 5TK8A 3GW7A 4N6WA 1U6ZA 4QQWA 4BZBA 4TNQA 4X9EA 4Q2CA 4DMBA 4TO1A
chains in the Genus database with same CATH topology
4QQZA 4TO4A 5AO2A 5TK6A 5AO1A 2DQBA 4TNPA 4RXQA 4QG2A 3SKDA 4MDZA 2CQZA 4TO3A 3SK9A 4MZ7A 4Q2DA 5AO3A 4TO2A 2PGSA 2OGIA 4ZWEA 4RXPA 1YNBA 3I7AA 4TNRA 5AO0A 3TMCA 5TK9A 4Q7HA 2GZ4A 4QG4A 4QQXA 3HC1A 4QFYA 5TKAA 4L1JB 3HI0A 2O6IA 4BZCA 2PAUA 2O08A 4TNZA 3U1NA 2Q14A 3KQ5A 2HEKA 3LJXA 4TO6A 4QFZA 3NR1A 3CCGA 4QQYA 4QFXA 3KH1A 4ME4A 3IRHA 4QG0A 3RF0A 3TMDA 4MLMA 4N71A 4QG1A 3TMBA 4TNYA 4MLNA 4RXRA 1YOYA 1VQRA 4R8ZA 4L7WA 3MEMA 2FLOA 3S4LA 4RXOA 4TO0A 2PAQA 3BG2A 3MZOA 4L1JA 3M1TA 4L7EA 4LRLA 2PARA 3NQWA 4ZWGA 4XDSA 2PQ7A 4TO5A 5AO4A 4TNXA 4MCWA 4RXSA 5TK7A 3P3QA 3TM8A 1VJ7A 1XX7A 5TK8A 3GW7A 4N6WA 1U6ZA 4QQWA 4BZBA 4TNQA 4X9EA 4Q2CA 4DMBA 4TO1A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4TO4 A;  5AO2 A;  5TK6 A;  5AO1 A;  2DQB A;  4TNP A;  4RXQ A;  4QG2 A;  4MDZ A;  2CQZ A;  4TO3 A;  4MZ7 A;  5AO3 A;  4TO2 A;  2PGS A;  2OGI A;  4ZWE A;  4RXP A;  1YNB A;  3I7A A;  4TNR A;  5AO0 A;  3TMC A;  5TK9 A;  4Q7H A;  2GZ4 A;  4QG4 A;  3HC1 A;  4QFY A;  5TKA A;  4L1J B;  3HI0 A;  2O6I A;  4BZC A;  2PAU A;  2O08 A;  4TNZ A;  3U1N A;  2Q14 A;  2HEK A;  3LJX A;  4TO6 A;  4QFZ A;  3NR1 A;  3CCG A;  4QFX A;  3KH1 A;  4ME4 A;  3IRH A;  4QG0 A;  3RF0 A;  3TMD A;  4MLM A;  4N71 A;  4QG1 A;  3TMB A;  4TNY A;  4MLN A;  4RXR A;  1YOY A;  1VQR A;  4R8Z A;  4L7W A;  3MEM A;  2FLO A;  4RXO A;  4TO0 A;  2PAQ A;  3BG2 A;  3MZO A;  4L1J A;  3M1T A;  4L7E A;  4LRL A;  2PAR A;  3NQW A;  4ZWG A;  4XDS A;  2PQ7 A;  4TO5 A;  5AO4 A;  4TNX A;  4MCW A;  4RXS A;  5TK7 A;  3P3Q A;  3TM8 A;  1VJ7 A;  1XX7 A;  5TK8 A;  4N6W A;  1U6Z A;  4BZB A;  4TNQ A;  4X9E A;  4DMB A;  4TO1 A; 
#chains in the Genus database with same CATH topology
 4QQZ A;  4TO4 A;  5AO2 A;  5TK6 A;  5AO1 A;  2DQB A;  4TNP A;  4RXQ A;  4QG2 A;  3SKD A;  4MDZ A;  2CQZ A;  4TO3 A;  3SK9 A;  4MZ7 A;  4Q2D A;  5AO3 A;  4TO2 A;  2PGS A;  2OGI A;  4ZWE A;  4RXP A;  1YNB A;  3I7A A;  4TNR A;  5AO0 A;  3TMC A;  5TK9 A;  4Q7H A;  2GZ4 A;  4QG4 A;  4QQX A;  3HC1 A;  4QFY A;  5TKA A;  4L1J B;  3HI0 A;  2O6I A;  4BZC A;  2PAU A;  2O08 A;  4TNZ A;  3U1N A;  2Q14 A;  3KQ5 A;  2HEK A;  3LJX A;  4TO6 A;  4QFZ A;  3NR1 A;  3CCG A;  4QQY A;  4QFX A;  3KH1 A;  4ME4 A;  3IRH A;  4QG0 A;  3RF0 A;  3TMD A;  4MLM A;  4N71 A;  4QG1 A;  3TMB A;  4TNY A;  4MLN A;  4RXR A;  1YOY A;  1VQR A;  4R8Z A;  4L7W A;  3MEM A;  2FLO A;  3S4L A;  4RXO A;  4TO0 A;  2PAQ A;  3BG2 A;  3MZO A;  4L1J A;  3M1T A;  4L7E A;  4LRL A;  2PAR A;  3NQW A;  4ZWG A;  4XDS A;  2PQ7 A;  4TO5 A;  5AO4 A;  4TNX A;  4MCW A;  4RXS A;  5TK7 A;  3P3Q A;  3TM8 A;  1VJ7 A;  1XX7 A;  5TK8 A;  3GW7 A;  4N6W A;  1U6Z A;  4QQW A;  4BZB A;  4TNQ A;  4X9E A;  4Q2C A;  4DMB A;  4TO1 A; 
#chains in the Genus database with same CATH homology
 4QQZ A;  4TO4 A;  5AO2 A;  5TK6 A;  5AO1 A;  2DQB A;  4TNP A;  4RXQ A;  4QG2 A;  3SKD A;  4MDZ A;  2CQZ A;  4TO3 A;  3SK9 A;  4MZ7 A;  4Q2D A;  5AO3 A;  4TO2 A;  2PGS A;  2OGI A;  4ZWE A;  4RXP A;  1YNB A;  3I7A A;  4TNR A;  5AO0 A;  3TMC A;  5TK9 A;  4Q7H A;  2GZ4 A;  4QG4 A;  4QQX A;  3HC1 A;  4QFY A;  5TKA A;  4L1J B;  3HI0 A;  2O6I A;  4BZC A;  2PAU A;  2O08 A;  4TNZ A;  3U1N A;  2Q14 A;  3KQ5 A;  2HEK A;  3LJX A;  4TO6 A;  4QFZ A;  3NR1 A;  3CCG A;  4QQY A;  4QFX A;  3KH1 A;  4ME4 A;  3IRH A;  4QG0 A;  3RF0 A;  3TMD A;  4MLM A;  4N71 A;  4QG1 A;  3TMB A;  4TNY A;  4MLN A;  4RXR A;  1YOY A;  1VQR A;  4R8Z A;  4L7W A;  3MEM A;  2FLO A;  3S4L A;  4RXO A;  4TO0 A;  2PAQ A;  3BG2 A;  3MZO A;  4L1J A;  3M1T A;  4L7E A;  4LRL A;  2PAR A;  3NQW A;  4ZWG A;  4XDS A;  2PQ7 A;  4TO5 A;  5AO4 A;  4TNX A;  4MCW A;  4RXS A;  5TK7 A;  3P3Q A;  3TM8 A;  1VJ7 A;  1XX7 A;  5TK8 A;  3GW7 A;  4N6W A;  1U6Z A;  4QQW A;  4BZB A;  4TNQ A;  4X9E A;  4Q2C A;  4DMB A;  4TO1 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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