4ZWGA

Crystal structure of the gtp-datp-bound catalytic core of samhd1 phosphomimetic t592e mutant
Total Genus 164
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
164
sequence length
468
structure length
461
Chain Sequence
TMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLEEDSLWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKP
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
publication title Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of Thr-592.
pubmed doi rcsb
source organism Homo sapiens
total genus 164
structure length 461
sequence length 468
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2015-05-19

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4zwgA01
3LJXA 2PQ7A 2PARA 3BG2A 5TK7A 1YOYA 4L1JA 3I7AA 3HI0A 3KH1A 4TNZA 4N6WA 3HC1A 3IRHA 2DQBA 1U6ZA 2HEKA 5AO3A 4RXPA 4X9EA 4N71A 2PGSA 3NQWA 4MLNA 5AO4A 4TNYA 2OGIA 4QG0A 4BZBA 1VJ7A 5TK6A 4QFXA 4TO2A 4TO5A 4QFYA 4RXQA 1XX7A 2Q14A 3P3QA 4QFZA 3U1NA 2CQZA 4ZWEA 2O08A 5AO0A 4TNQA 4Q7HA 4XDSA 4DMBA 3RF0A 4RXRA 4RXSA 3NR1A 4QG4A 4L7WA 3TMDA 4LRLA 4TO1A 4R8ZA 3TMBA 3MZOA 2PAUA 2PAQA 3M1TA 4MLMA 1VQRA 4TO6A 4TO0A 5AO2A 4ZWGA 1YNBA 4MZ7A 2FLOA 4QG1A 4ME4A 4TNRA 3TMCA 4TNPA 5TKAA 2O6IA 4TO3A 5TK9A 4TO4A 3CCGA 4L7EA 4L1JB 4TNXA 3TM8A 4MDZA 2GZ4A 5TK8A 4MCWA 4BZCA 3MEMA 4QG2A 4RXOA 5AO1A
chains in the Genus database with same CATH superfamily
3LJXA 2PQ7A 2PARA 3BG2A 5TK7A 1YOYA 4L1JA 3I7AA 3HI0A 3KH1A 4TNZA 3KQ5A 4Q2DA 4N6WA 3HC1A 3IRHA 2DQBA 1U6ZA 2HEKA 5AO3A 4RXPA 4X9EA 4QQYA 4N71A 2PGSA 3NQWA 4MLNA 5AO4A 4TNYA 2OGIA 4QG0A 4BZBA 1VJ7A 5TK6A 4QQWA 4QFXA 4TO2A 4TO5A 4QFYA 4RXQA 1XX7A 2Q14A 3P3QA 4QFZA 3U1NA 3SKDA 2CQZA 4ZWEA 2O08A 5AO0A 4TNQA 3SK9A 4Q7HA 4XDSA 4DMBA 3RF0A 4Q2CA 4RXRA 4RXSA 3NR1A 4QG4A 4QQZA 4L7WA 3TMDA 4LRLA 4TO1A 4R8ZA 3TMBA 3MZOA 2PAUA 2PAQA 3S4LA 3M1TA 4MLMA 1VQRA 4TO6A 4TO0A 5AO2A 4ZWGA 1YNBA 4MZ7A 2FLOA 4QG1A 4ME4A 4TNRA 3TMCA 4TNPA 5TKAA 2O6IA 4TO3A 5TK9A 4TO4A 3CCGA 3GW7A 4L7EA 4L1JB 4TNXA 3TM8A 4MDZA 2GZ4A 5TK8A 4MCWA 4BZCA 3MEMA 4QG2A 4RXOA 5AO1A 4QQXA
chains in the Genus database with same CATH topology
3LJXA 2PQ7A 2PARA 3BG2A 5TK7A 1YOYA 4L1JA 3I7AA 3HI0A 3KH1A 4TNZA 3KQ5A 4Q2DA 4N6WA 3HC1A 3IRHA 2DQBA 1U6ZA 2HEKA 5AO3A 4RXPA 4X9EA 4QQYA 4N71A 2PGSA 3NQWA 4MLNA 5AO4A 4TNYA 2OGIA 4QG0A 4BZBA 1VJ7A 5TK6A 4QQWA 4QFXA 4TO2A 4TO5A 4QFYA 4RXQA 1XX7A 2Q14A 3P3QA 4QFZA 3U1NA 3SKDA 2CQZA 4ZWEA 2O08A 5AO0A 4TNQA 3SK9A 4Q7HA 4XDSA 4DMBA 3RF0A 4Q2CA 4RXRA 4RXSA 3NR1A 4QG4A 4QQZA 4L7WA 3TMDA 4LRLA 4TO1A 4R8ZA 3TMBA 3MZOA 2PAUA 2PAQA 3S4LA 3M1TA 4MLMA 1VQRA 4TO6A 4TO0A 5AO2A 4ZWGA 1YNBA 4MZ7A 2FLOA 4QG1A 4ME4A 4TNRA 3TMCA 4TNPA 5TKAA 2O6IA 4TO3A 5TK9A 4TO4A 3CCGA 3GW7A 4L7EA 4L1JB 4TNXA 3TM8A 4MDZA 2GZ4A 5TK8A 4MCWA 4BZCA 3MEMA 4QG2A 4RXOA 5AO1A 4QQXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3LJX A;  2PQ7 A;  2PAR A;  3BG2 A;  5TK7 A;  1YOY A;  4L1J A;  3I7A A;  3HI0 A;  3KH1 A;  4TNZ A;  4N6W A;  3HC1 A;  3IRH A;  2DQB A;  1U6Z A;  2HEK A;  5AO3 A;  4RXP A;  4X9E A;  4N71 A;  2PGS A;  3NQW A;  4MLN A;  5AO4 A;  4TNY A;  2OGI A;  4QG0 A;  4BZB A;  1VJ7 A;  5TK6 A;  4QFX A;  4TO2 A;  4TO5 A;  4QFY A;  4RXQ A;  1XX7 A;  2Q14 A;  3P3Q A;  4QFZ A;  3U1N A;  2CQZ A;  4ZWE A;  2O08 A;  5AO0 A;  4TNQ A;  4Q7H A;  4XDS A;  4DMB A;  3RF0 A;  4RXR A;  4RXS A;  3NR1 A;  4QG4 A;  4L7W A;  3TMD A;  4LRL A;  4TO1 A;  4R8Z A;  3TMB A;  3MZO A;  2PAU A;  2PAQ A;  3M1T A;  4MLM A;  1VQR A;  4TO6 A;  4TO0 A;  5AO2 A;  4ZWG A;  1YNB A;  4MZ7 A;  2FLO A;  4QG1 A;  4ME4 A;  4TNR A;  3TMC A;  4TNP A;  5TKA A;  2O6I A;  4TO3 A;  5TK9 A;  4TO4 A;  3CCG A;  4L7E A;  4L1J B;  4TNX A;  3TM8 A;  4MDZ A;  2GZ4 A;  5TK8 A;  4MCW A;  4BZC A;  3MEM A;  4QG2 A;  4RXO A;  5AO1 A; 
#chains in the Genus database with same CATH topology
 3LJX A;  2PQ7 A;  2PAR A;  3BG2 A;  5TK7 A;  1YOY A;  4L1J A;  3I7A A;  3HI0 A;  3KH1 A;  4TNZ A;  3KQ5 A;  4Q2D A;  4N6W A;  3HC1 A;  3IRH A;  2DQB A;  1U6Z A;  2HEK A;  5AO3 A;  4RXP A;  4X9E A;  4QQY A;  4N71 A;  2PGS A;  3NQW A;  4MLN A;  5AO4 A;  4TNY A;  2OGI A;  4QG0 A;  4BZB A;  1VJ7 A;  5TK6 A;  4QQW A;  4QFX A;  4TO2 A;  4TO5 A;  4QFY A;  4RXQ A;  1XX7 A;  2Q14 A;  3P3Q A;  4QFZ A;  3U1N A;  3SKD A;  2CQZ A;  4ZWE A;  2O08 A;  5AO0 A;  4TNQ A;  3SK9 A;  4Q7H A;  4XDS A;  4DMB A;  3RF0 A;  4Q2C A;  4RXR A;  4RXS A;  3NR1 A;  4QG4 A;  4QQZ A;  4L7W A;  3TMD A;  4LRL A;  4TO1 A;  4R8Z A;  3TMB A;  3MZO A;  2PAU A;  2PAQ A;  3S4L A;  3M1T A;  4MLM A;  1VQR A;  4TO6 A;  4TO0 A;  5AO2 A;  4ZWG A;  1YNB A;  4MZ7 A;  2FLO A;  4QG1 A;  4ME4 A;  4TNR A;  3TMC A;  4TNP A;  5TKA A;  2O6I A;  4TO3 A;  5TK9 A;  4TO4 A;  3CCG A;  3GW7 A;  4L7E A;  4L1J B;  4TNX A;  3TM8 A;  4MDZ A;  2GZ4 A;  5TK8 A;  4MCW A;  4BZC A;  3MEM A;  4QG2 A;  4RXO A;  5AO1 A;  4QQX A; 
#chains in the Genus database with same CATH homology
 3LJX A;  2PQ7 A;  2PAR A;  3BG2 A;  5TK7 A;  1YOY A;  4L1J A;  3I7A A;  3HI0 A;  3KH1 A;  4TNZ A;  3KQ5 A;  4Q2D A;  4N6W A;  3HC1 A;  3IRH A;  2DQB A;  1U6Z A;  2HEK A;  5AO3 A;  4RXP A;  4X9E A;  4QQY A;  4N71 A;  2PGS A;  3NQW A;  4MLN A;  5AO4 A;  4TNY A;  2OGI A;  4QG0 A;  4BZB A;  1VJ7 A;  5TK6 A;  4QQW A;  4QFX A;  4TO2 A;  4TO5 A;  4QFY A;  4RXQ A;  1XX7 A;  2Q14 A;  3P3Q A;  4QFZ A;  3U1N A;  3SKD A;  2CQZ A;  4ZWE A;  2O08 A;  5AO0 A;  4TNQ A;  3SK9 A;  4Q7H A;  4XDS A;  4DMB A;  3RF0 A;  4Q2C A;  4RXR A;  4RXS A;  3NR1 A;  4QG4 A;  4QQZ A;  4L7W A;  3TMD A;  4LRL A;  4TO1 A;  4R8Z A;  3TMB A;  3MZO A;  2PAU A;  2PAQ A;  3S4L A;  3M1T A;  4MLM A;  1VQR A;  4TO6 A;  4TO0 A;  5AO2 A;  4ZWG A;  1YNB A;  4MZ7 A;  2FLO A;  4QG1 A;  4ME4 A;  4TNR A;  3TMC A;  4TNP A;  5TKA A;  2O6I A;  4TO3 A;  5TK9 A;  4TO4 A;  3CCG A;  3GW7 A;  4L7E A;  4L1J B;  4TNX A;  3TM8 A;  4MDZ A;  2GZ4 A;  5TK8 A;  4MCW A;  4BZC A;  3MEM A;  4QG2 A;  4RXO A;  5AO1 A;  4QQX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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