4QFZA

Crystal structure of the tetrameric dgtp/dttp-bound samhd1 (rn206) mutant catalytic core
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
sequence length
487
structure length
481
Chain Sequence
DTMKVINDPIHGHIELHPLLVRIIDTPQFQRLRYIKQLGGGYYVFPGASHNRFEHSLGVGYLAGCLVHALGEKQPELQISERDVLCVQIAGLCRNLGHGPFSHMFDGRFIPLARPEVKWTHEQGSVMMFEHLINSNGIKPVMEQYGLIPEEDICFIKEQIVGPLELWPYKGRPENKSFLYEIVSNKRNGIDVDKWDYFARDCHHLGIQNNFDYKRFIKFARVCEVDNELRICARDKEVGNLYDMFHTRNSLHRRAYQHKVGNIIDTMITDAFLKADDYIEITGAGGKKYRISTAIDDMEAYTKLTDNIFLEILYSTDPKLKDAREILKQIEYRNLFKYVGETQPTGQIKIKREDYESLPKEVASAKPKVLLDVKLKAEDFIVDVINMDYGMQEKNPIDHVSFYCKTAPNRAIRITKNQVSQLLPEKFAEQLIRVYCKKVDRKSLYAARQYFVQWCADRNFTKPQDGDVIAPLITPQKKEWN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Hydrolase
molecule keywords Deoxynucleoside triphosphate triphosphohydrolase SAMHD1
publication title Structural Basis of Allosteric Activation of Sterile alpha Motif and Histidine-Aspartate Domain-containing Protein 1 (SAMHD1) by Nucleoside Triphosphates.
pubmed doi rcsb
source organism Homo sapiens
total genus 162
structure length 481
sequence length 487
chains with identical sequence B, C, D
ec nomenclature ec 3.1.5.-:
pdb deposition date 2014-05-22

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF01966 HD HD domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.3210.10 Mainly Alpha Orthogonal Bundle Hypothetical protein af1432 Hypothetical protein af1432 4qfzA01
5AO0A 3HI0A 4L7WA 3TMDA 4RXPA 2GZ4A 4QG1A 2FLOA 3CCGA 3MEMA 5TK9A 4R8ZA 4ME4A 4MDZA 4TO0A 4RXSA 4MCWA 2PAUA 2PAQA 5AO3A 1VJ7A 4QG2A 2PGSA 5TK7A 4BZCA 2O6IA 2HEKA 4TNXA 4RXRA 4DMBA 4TNRA 4N71A 3I7AA 4N6WA 2Q14A 2PARA 3M1TA 4BZBA 4ZWGA 3RF0A 3KH1A 3NQWA 4TO2A 4XDSA 3U1NA 4TNQA 1U6ZA 4TNZA 4QFXA 4TO6A 3BG2A 4RXOA 3NR1A 4MLMA 4TO5A 4MZ7A 4TO4A 3MZOA 4TNPA 4ZWEA 4LRLA 3LJXA 4TO1A 5AO4A 1VQRA 2OGIA 5TKAA 5AO1A 4TNYA 2DQBA 1YNBA 2O08A 2CQZA 4MLNA 4QG0A 4L7EA 4QFZA 4RXQA 5TK6A 3TMBA 3HC1A 5AO2A 4TO3A 5TK8A 3TMCA 4Q7HA 1YOYA 4L1JB 4QG4A 4QFYA 3P3QA 4X9EA 1XX7A 3TM8A 3IRHA 2PQ7A 4L1JA
chains in the Genus database with same CATH superfamily
5AO0A 3HI0A 4L7WA 3TMDA 4RXPA 2GZ4A 4QG1A 2FLOA 4Q2DA 3CCGA 3MEMA 5TK9A 4QQYA 4R8ZA 4ME4A 4MDZA 4TO0A 4RXSA 4MCWA 2PAUA 2PAQA 5AO3A 1VJ7A 4QG2A 2PGSA 5TK7A 4BZCA 2O6IA 2HEKA 4TNXA 4RXRA 4DMBA 4TNRA 4N71A 3I7AA 4N6WA 2Q14A 2PARA 3M1TA 4BZBA 4ZWGA 3RF0A 3KH1A 3NQWA 4TO2A 4XDSA 3U1NA 4TNQA 1U6ZA 4TNZA 4QQWA 4QFXA 4TO6A 3BG2A 4RXOA 3KQ5A 3NR1A 4MLMA 4TO5A 4QQZA 4MZ7A 4TO4A 3MZOA 4QQXA 3S4LA 4TNPA 4ZWEA 4LRLA 3LJXA 4TO1A 5AO4A 1VQRA 2OGIA 5TKAA 3SK9A 5AO1A 4TNYA 2DQBA 1YNBA 2O08A 2CQZA 4MLNA 4QG0A 4L7EA 4QFZA 4RXQA 5TK6A 3SKDA 3TMBA 3HC1A 3GW7A 5AO2A 4TO3A 5TK8A 3TMCA 4Q7HA 1YOYA 4L1JB 4Q2CA 4QG4A 4QFYA 3P3QA 4X9EA 1XX7A 3TM8A 3IRHA 2PQ7A 4L1JA
chains in the Genus database with same CATH topology
5AO0A 3HI0A 4L7WA 3TMDA 4RXPA 2GZ4A 4QG1A 2FLOA 4Q2DA 3CCGA 3MEMA 5TK9A 4QQYA 4R8ZA 4ME4A 4MDZA 4TO0A 4RXSA 4MCWA 2PAUA 2PAQA 5AO3A 1VJ7A 4QG2A 2PGSA 5TK7A 4BZCA 2O6IA 2HEKA 4TNXA 4RXRA 4DMBA 4TNRA 4N71A 3I7AA 4N6WA 2Q14A 2PARA 3M1TA 4BZBA 4ZWGA 3RF0A 3KH1A 3NQWA 4TO2A 4XDSA 3U1NA 4TNQA 1U6ZA 4TNZA 4QQWA 4QFXA 4TO6A 3BG2A 4RXOA 3KQ5A 3NR1A 4MLMA 4TO5A 4QQZA 4MZ7A 4TO4A 3MZOA 4QQXA 3S4LA 4TNPA 4ZWEA 4LRLA 3LJXA 4TO1A 5AO4A 1VQRA 2OGIA 5TKAA 3SK9A 5AO1A 4TNYA 2DQBA 1YNBA 2O08A 2CQZA 4MLNA 4QG0A 4L7EA 4QFZA 4RXQA 5TK6A 3SKDA 3TMBA 3HC1A 3GW7A 5AO2A 4TO3A 5TK8A 3TMCA 4Q7HA 1YOYA 4L1JB 4Q2CA 4QG4A 4QFYA 3P3QA 4X9EA 1XX7A 3TM8A 3IRHA 2PQ7A 4L1JA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 5AO0 A;  3HI0 A;  4L7W A;  3TMD A;  4RXP A;  2GZ4 A;  4QG1 A;  2FLO A;  3CCG A;  3MEM A;  5TK9 A;  4R8Z A;  4ME4 A;  4MDZ A;  4TO0 A;  4RXS A;  4MCW A;  2PAU A;  2PAQ A;  5AO3 A;  1VJ7 A;  4QG2 A;  2PGS A;  5TK7 A;  4BZC A;  2O6I A;  2HEK A;  4TNX A;  4RXR A;  4DMB A;  4TNR A;  4N71 A;  3I7A A;  4N6W A;  2Q14 A;  2PAR A;  3M1T A;  4BZB A;  4ZWG A;  3RF0 A;  3KH1 A;  3NQW A;  4TO2 A;  4XDS A;  3U1N A;  4TNQ A;  1U6Z A;  4TNZ A;  4QFX A;  4TO6 A;  3BG2 A;  4RXO A;  3NR1 A;  4MLM A;  4TO5 A;  4MZ7 A;  4TO4 A;  3MZO A;  4TNP A;  4ZWE A;  4LRL A;  3LJX A;  4TO1 A;  5AO4 A;  1VQR A;  2OGI A;  5TKA A;  5AO1 A;  4TNY A;  2DQB A;  1YNB A;  2O08 A;  2CQZ A;  4MLN A;  4QG0 A;  4L7E A;  4QFZ A;  4RXQ A;  5TK6 A;  3TMB A;  3HC1 A;  5AO2 A;  4TO3 A;  5TK8 A;  3TMC A;  4Q7H A;  1YOY A;  4L1J B;  4QG4 A;  4QFY A;  3P3Q A;  4X9E A;  1XX7 A;  3TM8 A;  3IRH A;  2PQ7 A;  4L1J A; 
#chains in the Genus database with same CATH topology
 5AO0 A;  3HI0 A;  4L7W A;  3TMD A;  4RXP A;  2GZ4 A;  4QG1 A;  2FLO A;  4Q2D A;  3CCG A;  3MEM A;  5TK9 A;  4QQY A;  4R8Z A;  4ME4 A;  4MDZ A;  4TO0 A;  4RXS A;  4MCW A;  2PAU A;  2PAQ A;  5AO3 A;  1VJ7 A;  4QG2 A;  2PGS A;  5TK7 A;  4BZC A;  2O6I A;  2HEK A;  4TNX A;  4RXR A;  4DMB A;  4TNR A;  4N71 A;  3I7A A;  4N6W A;  2Q14 A;  2PAR A;  3M1T A;  4BZB A;  4ZWG A;  3RF0 A;  3KH1 A;  3NQW A;  4TO2 A;  4XDS A;  3U1N A;  4TNQ A;  1U6Z A;  4TNZ A;  4QQW A;  4QFX A;  4TO6 A;  3BG2 A;  4RXO A;  3KQ5 A;  3NR1 A;  4MLM A;  4TO5 A;  4QQZ A;  4MZ7 A;  4TO4 A;  3MZO A;  4QQX A;  3S4L A;  4TNP A;  4ZWE A;  4LRL A;  3LJX A;  4TO1 A;  5AO4 A;  1VQR A;  2OGI A;  5TKA A;  3SK9 A;  5AO1 A;  4TNY A;  2DQB A;  1YNB A;  2O08 A;  2CQZ A;  4MLN A;  4QG0 A;  4L7E A;  4QFZ A;  4RXQ A;  5TK6 A;  3SKD A;  3TMB A;  3HC1 A;  3GW7 A;  5AO2 A;  4TO3 A;  5TK8 A;  3TMC A;  4Q7H A;  1YOY A;  4L1J B;  4Q2C A;  4QG4 A;  4QFY A;  3P3Q A;  4X9E A;  1XX7 A;  3TM8 A;  3IRH A;  2PQ7 A;  4L1J A; 
#chains in the Genus database with same CATH homology
 5AO0 A;  3HI0 A;  4L7W A;  3TMD A;  4RXP A;  2GZ4 A;  4QG1 A;  2FLO A;  4Q2D A;  3CCG A;  3MEM A;  5TK9 A;  4QQY A;  4R8Z A;  4ME4 A;  4MDZ A;  4TO0 A;  4RXS A;  4MCW A;  2PAU A;  2PAQ A;  5AO3 A;  1VJ7 A;  4QG2 A;  2PGS A;  5TK7 A;  4BZC A;  2O6I A;  2HEK A;  4TNX A;  4RXR A;  4DMB A;  4TNR A;  4N71 A;  3I7A A;  4N6W A;  2Q14 A;  2PAR A;  3M1T A;  4BZB A;  4ZWG A;  3RF0 A;  3KH1 A;  3NQW A;  4TO2 A;  4XDS A;  3U1N A;  4TNQ A;  1U6Z A;  4TNZ A;  4QQW A;  4QFX A;  4TO6 A;  3BG2 A;  4RXO A;  3KQ5 A;  3NR1 A;  4MLM A;  4TO5 A;  4QQZ A;  4MZ7 A;  4TO4 A;  3MZO A;  4QQX A;  3S4L A;  4TNP A;  4ZWE A;  4LRL A;  3LJX A;  4TO1 A;  5AO4 A;  1VQR A;  2OGI A;  5TKA A;  3SK9 A;  5AO1 A;  4TNY A;  2DQB A;  1YNB A;  2O08 A;  2CQZ A;  4MLN A;  4QG0 A;  4L7E A;  4QFZ A;  4RXQ A;  5TK6 A;  3SKD A;  3TMB A;  3HC1 A;  3GW7 A;  5AO2 A;  4TO3 A;  5TK8 A;  3TMC A;  4Q7H A;  1YOY A;  4L1J B;  4Q2C A;  4QG4 A;  4QFY A;  3P3Q A;  4X9E A;  1XX7 A;  3TM8 A;  3IRH A;  2PQ7 A;  4L1J A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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