4MK0G

Crystal structure of g protein-coupled receptor kinase 2 in complex with a a rationally designed paroxetine derivative
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
59
structure length
59
Chain Sequence
TASIAQARKLVEQLKMEANIDRIKVSKAAADLMAYCEAHAKEDPLLTPVPASENPFREK
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Signaling protein/inhibitor
molecule keywords Beta-adrenergic receptor kinase 1
publication title Structural and functional analysis of g protein-coupled receptor kinase inhibition by paroxetine and a rationally designed analog.
pubmed doi rcsb
source organism Homo sapiens
total genus 14
structure length 59
sequence length 59
ec nomenclature
pdb deposition date 2013-09-04
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.260.10 Few Secondary Structures Irregular G Protein Gi Gamma 2 Transducin (heterotrimeric G protein), gamma chain 4mk0G00
3KRXG 3PSCG 2BCJG 2PBIA 1OMWG 4PNKG 5HE3G 3PVUG 4MK0G 3SN6G 3V5WG 1TBGE 5HE2G 1GOTG 1GG2G 3KRWG 1A0RG 1XHMB 3CIKG 1GP2G 4KFMG 3AH8G 2TRCG 5TDHG 5KDOG 5HE0G 1B9YB 5HE1G 3PVWG 1B9XB
chains in the Genus database with same CATH superfamily
3KRXG 3PSCG 2BCJG 2PBIA 1OMWG 4PNKG 5HE3G 3PVUG 1HFES 4MK0G 3SN6G 3V5WG 1TBGE 5HE2G 1GOTG 1GG2G 3KRWG 1A0RG 1XHMB 3CIKG 1GP2G 4KFMG 3AH8G 2TRCG 5TDHG 5KDOG 5HE0G 1B9YB 5HE1G 3PVWG 1B9XB 1IOJA
chains in the Genus database with same CATH topology
3KRXG 3PSCG 2BCJG 2PBIA 1OMWG 4PNKG 5HE3G 3PVUG 4MK0G 3SN6G 3V5WG 1TBGE 5HE2G 1GOTG 1GG2G 3KRWG 1A0RG 1XHMB 3CIKG 1GP2G 4KFMG 3AH8G 2TRCG 5TDHG 5KDOG 5HE0G 1B9YB 5HE1G 3PVWG 1B9XB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3KRX G;  3PSC G;  2BCJ G;  2PBI A;  1OMW G;  4PNK G;  5HE3 G;  3PVU G;  4MK0 G;  3SN6 G;  3V5W G;  1TBG E;  5HE2 G;  1GOT G;  1GG2 G;  3KRW G;  1A0R G;  1XHM B;  3CIK G;  1GP2 G;  4KFM G;  3AH8 G;  2TRC G;  5TDH G;  5KDO G;  5HE0 G;  1B9Y B;  5HE1 G;  3PVW G;  1B9X B; 
#chains in the Genus database with same CATH topology
 3KRX G;  3PSC G;  2BCJ G;  2PBI A;  1OMW G;  4PNK G;  5HE3 G;  3PVU G;  1HFE S;  4MK0 G;  3SN6 G;  3V5W G;  1TBG E;  5HE2 G;  1GOT G;  1GG2 G;  3KRW G;  1A0R G;  1XHM B;  3CIK G;  1GP2 G;  4KFM G;  3AH8 G;  2TRC G;  5TDH G;  5KDO G;  5HE0 G;  1B9Y B;  5HE1 G;  3PVW G;  1B9X B;  1IOJ A; 
#chains in the Genus database with same CATH homology
 3KRX G;  3PSC G;  2BCJ G;  2PBI A;  1OMW G;  4PNK G;  5HE3 G;  3PVU G;  4MK0 G;  3SN6 G;  3V5W G;  1TBG E;  5HE2 G;  1GOT G;  1GG2 G;  3KRW G;  1A0R G;  1XHM B;  3CIK G;  1GP2 G;  4KFM G;  3AH8 G;  2TRC G;  5TDH G;  5KDO G;  5HE0 G;  1B9Y B;  5HE1 G;  3PVW G;  1B9X B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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