1N8ZC

Crystal structure of extracellular domain of human her2 complexed with herceptin fab
Total Genus 151
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
151
sequence length
607
structure length
581
Chain Sequence
TQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLSPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTATQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDSNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSIWKFPDEEGACQPCPIN
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase
source organism Mus musculus, homo sapiens
publication title Structure of the Extracellular Region of HER2 Alone and in Complex with the Herceptin Fab
pubmed doi rcsb
molecule keywords Herceptin Fab (antibody) - light chain
total genus 151
structure length 581
sequence length 607
ec nomenclature ec 2.7.10.1: Receptor protein-tyrosine kinase.
pdb deposition date 2002-11-21

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
C PF00757 Furin-like Furin-like cysteine rich region
C PF01030 Recep_L_domain Receptor L domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.220.10 Mainly Beta Ribbon Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 1n8zC02
2.10.220.10 Mainly Beta Ribbon Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 1n8zC04
3.80.20.20 Alpha Beta Alpha-Beta Horseshoe 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A Receptor L-domain 1n8zC03
3.80.20.20 Alpha Beta Alpha-Beta Horseshoe 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A Receptor L-domain 1n8zC01
3W11E 4UFRB 4LI2B 5SX5M 3MZWA 3P11A 3NJPA 4P59A 4C9AB 2A91A 3LTFA 4C8VA 3B2UA 3I2TA 4C8WI 3H3BA 1S78A 4C99B 4KRLA 1M6BA 1N8YC 4OGAE 4HRNC 4BSRC 4LEOC 1NQLA 5SX4M 3U7UA 3WSQA 1MOXA 3BE1A 4XSSE 3B2VA 2HR7A 1YY9A 1IVOA 3QWQA 3C09A 3N85A 3LTGA 1N8ZC 4XSTE 4UV7A 3WLWA 1IGRA 4C9EB 4HRMA 4HRLC 4KRMA 4KROA 4KRPA 2AHXA 4BSUC 3U2PA 4BSOA 4QXFC 4C9VB 4C9UB 4CDKE 4BSSC 4C9RB 3U9UE 3P0YA 4BSPA 4KNGM 5J3HE 4KT1E
chains in the Genus database with same CATH superfamily
3W11E 4UFRB 4LI2B 5SX5M 3MZWA 3P11A 3NJPA 4P59A 4C9AB 2A91A 3LTFA 4C8VA 3B2UA 3I2TA 4C8WI 3H3BA 1S78A 4C99B 4KRLA 1M6BA 1N8YC 4OGAE 4HRNC 4BSRC 4LEOC 1NQLA 5SX4M 3U7UA 3WSQA 1MOXA 3BE1A 4XSSE 3B2VA 2HR7A 1YY9A 1IVOA 3QWQA 3C09A 3N85A 3LTGA 1N8ZC 4XSTE 4UV7A 3WLWA 1IGRA 4C9EB 4HRMA 4HRLC 4KRMA 4KROA 4KRPA 2AHXA 4BSUC 3U2PA 4BSOA 4QXFC 4C9VB 4C9UB 4CDKE 4BSSC 4C9RB 3U9UE 3P0YA 4BSPA 4KNGM 5J3HE 4KT1E
chains in the Genus database with same CATH topology
3W11E 4UFRB 4LI2B 5SX5M 3MZWA 3P11A 3NJPA 4P59A 4C9AB 2A91A 3LTFA 4C8VA 3B2UA 3I2TA 4C8WI 3H3BA 1S78A 4C99B 4KRLA 1M6BA 1N8YC 4OGAE 4HRNC 4BSRC 4LEOC 1NQLA 5SX4M 3U7UA 3WSQA 1MOXA 3BE1A 4XSSE 3B2VA 2HR7A 1YY9A 1IVOA 3QWQA 3C09A 3N85A 3LTGA 1N8ZC 4XSTE 4UV7A 3WLWA 1IGRA 4C9EB 4HRMA 4HRLC 4KRMA 4KROA 4KRPA 2AHXA 4BSUC 3U2PA 4BSOA 4QXFC 4C9VB 4C9UB 4CDKE 4BSSC 4C9RB 3U9UE 3P0YA 4BSPA 4KNGM 5J3HE 4KT1E
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3W11 E;  4UFR B;  4LI2 B;  5SX5 M;  3MZW A;  3P11 A;  3NJP A;  4P59 A;  4C9A B;  2A91 A;  3LTF A;  4C8V A;  3B2U A;  3I2T A;  4C8W I;  3H3B A;  1S78 A;  4C99 B;  4KRL A;  1M6B A;  1N8Y C;  4OGA E;  4HRN C;  4BSR C;  4LEO C;  1NQL A;  5SX4 M;  3U7U A;  3WSQ A;  1MOX A;  3BE1 A;  4XSS E;  3B2V A;  2HR7 A;  1YY9 A;  1IVO A;  3QWQ A;  3C09 A;  3N85 A;  3LTG A;  1N8Z C;  4XST E;  4UV7 A;  3WLW A;  1IGR A;  4C9E B;  4HRM A;  4HRL C;  4KRM A;  4KRO A;  4KRP A;  2AHX A;  4BSU C;  3U2P A;  4BSO A;  4QXF C;  4C9V B;  4C9U B;  4CDK E;  4BSS C;  4C9R B;  3U9U E;  3P0Y A;  4BSP A;  4KNG M;  5J3H E;  4KT1 E; 
#chains in the Genus database with same CATH topology
 3W11 E;  4UFR B;  4LI2 B;  5SX5 M;  3MZW A;  3P11 A;  3NJP A;  4P59 A;  4C9A B;  2A91 A;  3LTF A;  4C8V A;  3B2U A;  3I2T A;  4C8W I;  3H3B A;  1S78 A;  4C99 B;  4KRL A;  1M6B A;  1N8Y C;  4OGA E;  4HRN C;  4BSR C;  4LEO C;  1NQL A;  5SX4 M;  3U7U A;  3WSQ A;  1MOX A;  3BE1 A;  4XSS E;  3B2V A;  2HR7 A;  1YY9 A;  1IVO A;  3QWQ A;  3C09 A;  3N85 A;  3LTG A;  1N8Z C;  4XST E;  4UV7 A;  3WLW A;  1IGR A;  4C9E B;  4HRM A;  4HRL C;  4KRM A;  4KRO A;  4KRP A;  2AHX A;  4BSU C;  3U2P A;  4BSO A;  4QXF C;  4C9V B;  4C9U B;  4CDK E;  4BSS C;  4C9R B;  3U9U E;  3P0Y A;  4BSP A;  4KNG M;  5J3H E;  4KT1 E; 
#chains in the Genus database with same CATH homology
 3W11 E;  4UFR B;  4LI2 B;  5SX5 M;  3MZW A;  3P11 A;  3NJP A;  4P59 A;  4C9A B;  2A91 A;  3LTF A;  4C8V A;  3B2U A;  3I2T A;  4C8W I;  3H3B A;  1S78 A;  4C99 B;  4KRL A;  1M6B A;  1N8Y C;  4OGA E;  4HRN C;  4BSR C;  4LEO C;  1NQL A;  5SX4 M;  3U7U A;  3WSQ A;  1MOX A;  3BE1 A;  4XSS E;  3B2V A;  2HR7 A;  1YY9 A;  1IVO A;  3QWQ A;  3C09 A;  3N85 A;  3LTG A;  1N8Z C;  4XST E;  4UV7 A;  3WLW A;  1IGR A;  4C9E B;  4HRM A;  4HRL C;  4KRM A;  4KRO A;  4KRP A;  2AHX A;  4BSU C;  3U2P A;  4BSO A;  4QXF C;  4C9V B;  4C9U B;  4CDK E;  4BSS C;  4C9R B;  3U9U E;  3P0Y A;  4BSP A;  4KNG M;  5J3H E;  4KT1 E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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