The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.
Total Genus |
135
|
sequence length |
612
|
structure length |
612
|
Chain Sequence |
EKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEVVLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALAVLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDFQNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGCTGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYVVTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFKNCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAFENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKLFGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCKLLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVMGENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPT
|
The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.
After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.
| publication title |
EGF activates its receptor by removing interactions that auto-inhibit ectodomain dimerization
pubmed doi rcsb |
| molecule tags |
Hormone/growth factor receptor
|
| source organism |
Homo sapiens
|
| molecule keywords |
epidermal growth factor receptor
|
| total genus |
135
|
| structure length |
612
|
| sequence length |
612
|
| ec nomenclature |
ec
2.7.10.1: Receptor protein-tyrosine kinase. |
| pdb deposition date | 2003-01-21 |
| chain | Pfam Accession Code | Pfam Family Identifier | Pfam Description |
|---|---|---|---|
| A | PF00757 | Furin-like | Furin-like cysteine rich region |
| A | PF01030 | Recep_L_domain | Receptor L domain |
| A | PF14843 | GF_recep_IV | Growth factor receptor domain IV |
Image from the rcsb pdb (www.rcsb.org)
cath code
| Class | Architecture | Topology | Homology | Domain |
|---|---|---|---|---|---|
| Mainly Beta | Ribbon | Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 | Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 | ||
| Mainly Beta | Ribbon | Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 | Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 | ||
| Alpha Beta | Alpha-Beta Horseshoe | 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A | Receptor L-domain | ||
| Alpha Beta | Alpha-Beta Horseshoe | 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A | Receptor L-domain |
#chains in the Genus database with same CATH superfamily 4KRM A; 4LEO C; 3U7U A; 3P0Y A; 2AHX A; 4KRO A; 3B2U A; 4BSP A; 4XSS E; 3W11 E; 4BSR C; 3P11 A; 5SX5 M; 3LTG A; 4LI2 B; 1YY9 A; 4C9E B; 2HR7 A; 3WSQ A; 3H3B A; 3QWQ A; 3U2P A; 1IVO A; 4KRL A; 2A91 A; 4KT1 E; 3BE1 A; 1NQL A; 4KRP A; 3N85 A; 4UFR B; 4UV7 A; 4OGA E; 4BSU C; 4C8W I; 1N8Y C; 4C9A B; 4CDK E; 4BSO A; 4BSS C; 1S78 A; 3I2T A; 4XST E; 3LTF A; 3MZW A; 4P59 A; 4HRN C; 3B2V A; 1MOX A; 4QXF C; 4C9V B; 4C8V A; 3C09 A; 4C9R B; 4HRM A; 1N8Z C; 1M6B A; 5SX4 M; 5J3H E; 3NJP A; 3U9U E; 4HRL C; 1IGR A; 4C9U B; 3WLW A; 4KNG M; 4C99 B; #chains in the Genus database with same CATH topology 4KRM A; 4LEO C; 3U7U A; 3P0Y A; 2AHX A; 4KRO A; 3B2U A; 4BSP A; 4XSS E; 3W11 E; 4BSR C; 3P11 A; 5SX5 M; 3LTG A; 4LI2 B; 1YY9 A; 4C9E B; 2HR7 A; 3WSQ A; 3H3B A; 3QWQ A; 3U2P A; 1IVO A; 4KRL A; 2A91 A; 4KT1 E; 3BE1 A; 1NQL A; 4KRP A; 3N85 A; 4UFR B; 4UV7 A; 4OGA E; 4BSU C; 4C8W I; 1N8Y C; 4C9A B; 4CDK E; 4BSO A; 4BSS C; 1S78 A; 3I2T A; 4XST E; 3LTF A; 3MZW A; 4P59 A; 4HRN C; 3B2V A; 1MOX A; 4QXF C; 4C9V B; 4C8V A; 3C09 A; 4C9R B; 4HRM A; 1N8Z C; 1M6B A; 5SX4 M; 5J3H E; 3NJP A; 3U9U E; 4HRL C; 1IGR A; 4C9U B; 3WLW A; 4KNG M; 4C99 B; #chains in the Genus database with same CATH homology 4KRM A; 4LEO C; 3U7U A; 3P0Y A; 2AHX A; 4KRO A; 3B2U A; 4BSP A; 4XSS E; 3W11 E; 4BSR C; 3P11 A; 5SX5 M; 3LTG A; 4LI2 B; 1YY9 A; 4C9E B; 2HR7 A; 3WSQ A; 3H3B A; 3QWQ A; 3U2P A; 1IVO A; 4KRL A; 2A91 A; 4KT1 E; 3BE1 A; 1NQL A; 4KRP A; 3N85 A; 4UFR B; 4UV7 A; 4OGA E; 4BSU C; 4C8W I; 1N8Y C; 4C9A B; 4CDK E; 4BSO A; 4BSS C; 1S78 A; 3I2T A; 4XST E; 3LTF A; 3MZW A; 4P59 A; 4HRN C; 3B2V A; 1MOX A; 4QXF C; 4C9V B; 4C8V A; 3C09 A; 4C9R B; 4HRM A; 1N8Z C; 1M6B A; 5SX4 M; 5J3H E; 3NJP A; 3U9U E; 4HRL C; 1IGR A; 4C9U B; 3WLW A; 4KNG M; 4C99 B;
#similar chains in the Genus database (?% sequence similarity) ...loading similar chains, please wait... #similar chains, but unknotted ...loading similar chains, please wait... #similar chains in the pdb database (?% sequence similarity) ...loading similar chains, please wait...
