1TPXA

Ovine recombinant prp(114-234), arq variant in complex with the fab of the vrq14 antibody
Total Genus 38
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
38
sequence length
102
structure length
102
Chain Sequence
GLGGYMLGSAMSRPLIHFGNDYEDRYYRENMYRYPNQVYYRPVDQYSNQNNFVHDCVNITVKQHTVTTTTKGENFTETDIKIMERVVEQMCITQYQRESQAY
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insight into the PrPC -> PrPSc conversion from the structures of antibody-bound ovine prion scrapie-susceptibility variants.
pubmed doi rcsb
molecule tags Unknown function
source organism Ovis aries
molecule keywords major prion protein
total genus 38
structure length 102
sequence length 102
ec nomenclature
pdb deposition date 2004-06-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.790.10 Mainly Alpha Orthogonal Bundle Major Prion Protein Prion/Doppel protein, beta-ribbon domain 1tpxA00
2KFLA 2L1KA 1DWYA 2KU5A 1AG2A 2L39A 2K5OA 4DGIA 3HESA 1QM3A 1B10A 1DWZA 1TQCA 1Y2SA 1QM1A 2JOMA 2FJ3A 2L40A 2L1DA 1XYXA 1DX1A 1UW3A 1XYKA 1E1JA 3HAKA 1XU0A 2LH8A 1U5LA 2W9EA 2K56A 2L1HA 1I4MA 1XYJA 2KU6A 1QLXA 1H0LA 1XYQA 1E1GA 1TPXA 2LSBA 1FO7A 2LEJA 1LG4A 1E1UA 2KU4A 3O79A 1XYUA 2KFMA 2KUNA 2LFTA 1E1WA 1Y16A 2MV8A 1QM2A 1HJNA 3HJ5A 3HAFA 2JOHA 1DX0A 1FKCA 3HERA 1E1SA 3HJXA 2KTMA 1TQBA 1QLZA 1E1PA 3HEQA 1XYWA 2K1DA 1U3MA 2L1EA 1HJMA 1I17A 1Y15A 2KFOA 1QM0A
chains in the Genus database with same CATH superfamily
2KFLA 2L1KA 1DWYA 2KU5A 1AG2A 2L39A 2K5OA 4DGIA 3HESA 1QM3A 1B10A 1DWZA 2KZCA 1TQCA 1Y2SA 1QM1A 2JOMA 2FJ3A 2L40A 2L1DA 1XYXA 1DX1A 1UW3A 1XYKA 1E1JA 3HAKA 1XU0A 2LH8A 1U5LA 2W9EA 2K56A 2L1HA 1I4MA 1XYJA 2KU6A 1QLXA 1H0LA 1XYQA 1E1GA 1TPXA 2LSBA 1FO7A 2LEJA 1LG4A 1E1UA 2KU4A 3O79A 1XYUA 2MDZA 2KFMA 2KUNA 2LFTA 1E1WA 1Y16A 2MV8A 1QM2A 1HJNA 3HJ5A 3HAFA 2JOHA 1DX0A 1FKCA 3HERA 1E1SA 3HJXA 2KTMA 1TQBA 1QLZA 1E1PA 3HEQA 1XYWA 2K1DA 1U3MA 2L1EA 1HJMA 1I17A 1Y15A 2KFOA 2LL0A 1QM0A
chains in the Genus database with same CATH topology
2KFLA 2L1KA 1DWYA 2KU5A 1AG2A 2L39A 2K5OA 4DGIA 3HESA 1QM3A 1B10A 1DWZA 1TQCA 1Y2SA 1QM1A 2JOMA 2FJ3A 2L40A 2L1DA 1XYXA 1DX1A 1UW3A 1XYKA 1E1JA 3HAKA 1XU0A 2LH8A 1U5LA 2W9EA 2K56A 2L1HA 1I4MA 1XYJA 2KU6A 1QLXA 1H0LA 1XYQA 1E1GA 1TPXA 2LSBA 1FO7A 2LEJA 1LG4A 1E1UA 2KU4A 3O79A 1XYUA 2KFMA 2KUNA 2LFTA 1E1WA 1Y16A 2MV8A 1QM2A 1HJNA 3HJ5A 3HAFA 2JOHA 1DX0A 1FKCA 3HERA 1E1SA 3HJXA 2KTMA 1TQBA 1QLZA 1E1PA 3HEQA 1XYWA 2K1DA 1U3MA 2L1EA 1HJMA 1I17A 1Y15A 2KFOA 1QM0A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KFL A;  2L1K A;  1DWY A;  2KU5 A;  1AG2 A;  2L39 A;  2K5O A;  4DGI A;  3HES A;  1QM3 A;  1B10 A;  1DWZ A;  1TQC A;  1Y2S A;  1QM1 A;  2JOM A;  2FJ3 A;  2L40 A;  2L1D A;  1XYX A;  1DX1 A;  1UW3 A;  1XYK A;  1E1J A;  3HAK A;  1XU0 A;  2LH8 A;  1U5L A;  2W9E A;  2K56 A;  2L1H A;  1I4M A;  1XYJ A;  2KU6 A;  1QLX A;  1H0L A;  1XYQ A;  1E1G A;  1TPX A;  2LSB A;  1FO7 A;  2LEJ A;  1LG4 A;  1E1U A;  2KU4 A;  3O79 A;  1XYU A;  2KFM A;  2KUN A;  2LFT A;  1E1W A;  1Y16 A;  2MV8 A;  1QM2 A;  1HJN A;  3HJ5 A;  3HAF A;  2JOH A;  1DX0 A;  1FKC A;  3HER A;  1E1S A;  3HJX A;  2KTM A;  1TQB A;  1QLZ A;  1E1P A;  3HEQ A;  1XYW A;  2K1D A;  1U3M A;  2L1E A;  1HJM A;  1I17 A;  1Y15 A;  2KFO A;  1QM0 A; 
#chains in the Genus database with same CATH topology
 2KFL A;  2L1K A;  1DWY A;  2KU5 A;  1AG2 A;  2L39 A;  2K5O A;  4DGI A;  3HES A;  1QM3 A;  1B10 A;  1DWZ A;  2KZC A;  1TQC A;  1Y2S A;  1QM1 A;  2JOM A;  2FJ3 A;  2L40 A;  2L1D A;  1XYX A;  1DX1 A;  1UW3 A;  1XYK A;  1E1J A;  3HAK A;  1XU0 A;  2LH8 A;  1U5L A;  2W9E A;  2K56 A;  2L1H A;  1I4M A;  1XYJ A;  2KU6 A;  1QLX A;  1H0L A;  1XYQ A;  1E1G A;  1TPX A;  2LSB A;  1FO7 A;  2LEJ A;  1LG4 A;  1E1U A;  2KU4 A;  3O79 A;  1XYU A;  2MDZ A;  2KFM A;  2KUN A;  2LFT A;  1E1W A;  1Y16 A;  2MV8 A;  1QM2 A;  1HJN A;  3HJ5 A;  3HAF A;  2JOH A;  1DX0 A;  1FKC A;  3HER A;  1E1S A;  3HJX A;  2KTM A;  1TQB A;  1QLZ A;  1E1P A;  3HEQ A;  1XYW A;  2K1D A;  1U3M A;  2L1E A;  1HJM A;  1I17 A;  1Y15 A;  2KFO A;  2LL0 A;  1QM0 A; 
#chains in the Genus database with same CATH homology
 2KFL A;  2L1K A;  1DWY A;  2KU5 A;  1AG2 A;  2L39 A;  2K5O A;  4DGI A;  3HES A;  1QM3 A;  1B10 A;  1DWZ A;  1TQC A;  1Y2S A;  1QM1 A;  2JOM A;  2FJ3 A;  2L40 A;  2L1D A;  1XYX A;  1DX1 A;  1UW3 A;  1XYK A;  1E1J A;  3HAK A;  1XU0 A;  2LH8 A;  1U5L A;  2W9E A;  2K56 A;  2L1H A;  1I4M A;  1XYJ A;  2KU6 A;  1QLX A;  1H0L A;  1XYQ A;  1E1G A;  1TPX A;  2LSB A;  1FO7 A;  2LEJ A;  1LG4 A;  1E1U A;  2KU4 A;  3O79 A;  1XYU A;  2KFM A;  2KUN A;  2LFT A;  1E1W A;  1Y16 A;  2MV8 A;  1QM2 A;  1HJN A;  3HJ5 A;  3HAF A;  2JOH A;  1DX0 A;  1FKC A;  3HER A;  1E1S A;  3HJX A;  2KTM A;  1TQB A;  1QLZ A;  1E1P A;  3HEQ A;  1XYW A;  2K1D A;  1U3M A;  2L1E A;  1HJM A;  1I17 A;  1Y15 A;  2KFO A;  1QM0 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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