1W88I

The crystal structure of pyruvate dehydrogenase e1(d180n,e183q) bound to the peripheral subunit binding domain of e2
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
40
structure length
40
Chain Sequence
RVIAMPSVRKYAREKGVDIRLVQGTGKNGRVLKEDIDAFL
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title A Molecular Switch and Proton-Wire Synchronize the Active Sites in Thiamine-Dependent Enzymes
pubmed doi rcsb
molecule tags Oxidoreductase
source organism Geobacillus stearothermophilus
molecule keywords PYRUVATE DEHYDROGENASE E1 COMPONENT, ALPHA SUBUNIT
total genus 12
structure length 40
sequence length 40
chains with identical sequence J
ec nomenclature ec 2.3.1.12: Dihydrolipoyllysine-residue acetyltransferase.
pdb deposition date 2004-09-16

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
I PF02817 E3_binding e3 binding domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.320.10 Few Secondary Structures Irregular Dihydrolipoamide Transferase E3-binding domain 1w88I00
2BTGA 3DV0I 2WXCA 2EQ9C 2BTHA 2F5ZK 1W4FA 1W4IA 1ZWVA 1BALA 3DVAI 1W4HA 3RNME 1W4JA 1W3DA 1W4EA 1W88I 1ZY8K 1EBDC 1W4KA 1W85I 4QOYE 2F60K 2PDEA 1W4GA 2PDDA
chains in the Genus database with same CATH superfamily
2BTGA 3DV0I 2WXCA 2EQ9C 2BTHA 2F5ZK 1W4FA 1W4IA 1ZWVA 1BALA 3DVAI 1W4HA 3RNME 1W4JA 1W3DA 1W4EA 1W88I 1ZY8K 1EBDC 1W4KA 1W85I 4QOYE 2F60K 2PDEA 1W4GA 2PDDA
chains in the Genus database with same CATH topology
2BTGA 3DV0I 2WXCA 2EQ9C 2BTHA 2F5ZK 1W4FA 1W4IA 1ZWVA 1BALA 3DVAI 1W4HA 3RNME 1W4JA 1W3DA 1W4EA 1W88I 1ZY8K 1EBDC 1W4KA 1W85I 4QOYE 2F60K 2PDEA 1W4GA 2PDDA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2BTG A;  3DV0 I;  2WXC A;  2EQ9 C;  2BTH A;  2F5Z K;  1W4F A;  1W4I A;  1ZWV A;  1BAL A;  3DVA I;  1W4H A;  3RNM E;  1W4J A;  1W3D A;  1W4E A;  1W88 I;  1ZY8 K;  1EBD C;  1W4K A;  1W85 I;  4QOY E;  2F60 K;  2PDE A;  1W4G A;  2PDD A; 
#chains in the Genus database with same CATH topology
 2BTG A;  3DV0 I;  2WXC A;  2EQ9 C;  2BTH A;  2F5Z K;  1W4F A;  1W4I A;  1ZWV A;  1BAL A;  3DVA I;  1W4H A;  3RNM E;  1W4J A;  1W3D A;  1W4E A;  1W88 I;  1ZY8 K;  1EBD C;  1W4K A;  1W85 I;  4QOY E;  2F60 K;  2PDE A;  1W4G A;  2PDD A; 
#chains in the Genus database with same CATH homology
 2BTG A;  3DV0 I;  2WXC A;  2EQ9 C;  2BTH A;  2F5Z K;  1W4F A;  1W4I A;  1ZWV A;  1BAL A;  3DVA I;  1W4H A;  3RNM E;  1W4J A;  1W3D A;  1W4E A;  1W88 I;  1ZY8 K;  1EBD C;  1W4K A;  1W85 I;  4QOY E;  2F60 K;  2PDE A;  1W4G A;  2PDD A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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