1IYTA

Solution structure of the alzheimer's disease amyloid beta-peptide (1-42)
Total Genus 12
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
12
sequence length
42
structure length
42
Chain Sequence
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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molecule tags Protein binding
molecule keywords Alzheimer's disease amyloid
publication title Solution structure of the Alzheimer amyloid beta-peptide (1-42) in an apolar microenvironment. Similarity with a virus fusion domain.
pubmed doi rcsb
total genus 12
structure length 42
sequence length 42
ec nomenclature
pdb deposition date 2002-09-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF03494 Beta-APP Beta-amyloid peptide (beta-APP)
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
4.10.230.10 Few Secondary Structures Irregular Amyloid A4 Amyloidogenic glycoprotein, amyloid-beta peptide 1iytA00
1AMLA 1IYTA 1BA4A 1Z0QA
chains in the Genus database with same CATH superfamily
1AMLA 1IYTA 1BA4A 1Z0QA
chains in the Genus database with same CATH topology
1AMLA 1IYTA 1BA4A 1Z0QA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1AML A;  1IYT A;  1BA4 A;  1Z0Q A; 
#chains in the Genus database with same CATH topology
 1AML A;  1IYT A;  1BA4 A;  1Z0Q A; 
#chains in the Genus database with same CATH homology
 1AML A;  1IYT A;  1BA4 A;  1Z0Q A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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