2A91A

Crystal structure of erbb2 domains 1-3
Total Genus 142
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
142
sequence length
510
structure length
506
Chain Sequence
STQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQKCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCAKGHCWGPGPTQCVND
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Signaling protein,transferase,membrane protein
source organism Homo sapiens
publication title The Crystal Structure of a Truncated ErbB2 Ectodomain Reveals an Active Conformation, Poised to Interact with Other ErbB Receptors
pubmed doi rcsb
molecule keywords Receptor tyrosine-protein kinase erbB-2
total genus 142
structure length 506
sequence length 510
ec nomenclature ec 2.7.10.1: Receptor protein-tyrosine kinase.
pdb deposition date 2005-07-11

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00757 Furin-like Furin-like cysteine rich region
A PF01030 Recep_L_domain Receptor L domain
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.220.10 Mainly Beta Ribbon Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 2a91A02
3.80.20.20 Alpha Beta Alpha-Beta Horseshoe 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A Receptor L-domain 2a91A03
3.80.20.20 Alpha Beta Alpha-Beta Horseshoe 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A Receptor L-domain 2a91A01
1IVOA 4HRLC 1IGRA 4HRNC 3QWQA 3WSQA 4QXFC 4BSPA 3I2TA 4LI2B 2AHXA 3P11A 4C8VA 4C99B 4C9UB 3H3BA 1YY9A 5SX4M 4C9AB 3C09A 4KRPA 3U7UA 4KRLA 3LTFA 5SX5M 3MZWA 1M6BA 1N8ZC 4OGAE 1N8YC 4BSUC 3U9UE 3BE1A 4C8WI 4KT1E 3W11E 4BSSC 4KRMA 1NQLA 3NJPA 4UV7A 5J3HE 3WLWA 4BSRC 4P59A 4C9EB 3N85A 4UFRB 3LTGA 4KNGM 4KROA 1S78A 3B2UA 4HRMA 3B2VA 3U2PA 4XSTE 4XSSE 4C9RB 4CDKE 4BSOA 2A91A 3P0YA 1MOXA 2HR7A 4LEOC 4C9VB
chains in the Genus database with same CATH superfamily
1IVOA 4HRLC 1IGRA 4HRNC 3QWQA 3WSQA 4QXFC 4BSPA 3I2TA 4LI2B 2AHXA 3P11A 4C8VA 4C99B 4C9UB 3H3BA 1YY9A 5SX4M 4C9AB 3C09A 4KRPA 3U7UA 4KRLA 3LTFA 5SX5M 3MZWA 1M6BA 1N8ZC 4OGAE 1N8YC 4BSUC 3U9UE 3BE1A 4C8WI 4KT1E 3W11E 4BSSC 4KRMA 1NQLA 3NJPA 4UV7A 5J3HE 3WLWA 4BSRC 4P59A 4C9EB 3N85A 4UFRB 3LTGA 4KNGM 4KROA 1S78A 3B2UA 4HRMA 3B2VA 3U2PA 4XSTE 4XSSE 4C9RB 4CDKE 4BSOA 2A91A 3P0YA 1MOXA 2HR7A 4LEOC 4C9VB
chains in the Genus database with same CATH topology
1IVOA 4HRLC 1IGRA 4HRNC 3QWQA 3WSQA 4QXFC 4BSPA 3I2TA 4LI2B 2AHXA 3P11A 4C8VA 4C99B 4C9UB 3H3BA 1YY9A 5SX4M 4C9AB 3C09A 4KRPA 3U7UA 4KRLA 3LTFA 5SX5M 3MZWA 1M6BA 1N8ZC 4OGAE 1N8YC 4BSUC 3U9UE 3BE1A 4C8WI 4KT1E 3W11E 4BSSC 4KRMA 1NQLA 3NJPA 4UV7A 5J3HE 3WLWA 4BSRC 4P59A 4C9EB 3N85A 4UFRB 3LTGA 4KNGM 4KROA 1S78A 3B2UA 4HRMA 3B2VA 3U2PA 4XSTE 4XSSE 4C9RB 4CDKE 4BSOA 2A91A 3P0YA 1MOXA 2HR7A 4LEOC 4C9VB
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1IVO A;  4HRL C;  1IGR A;  4HRN C;  3QWQ A;  3WSQ A;  4QXF C;  4BSP A;  3I2T A;  4LI2 B;  2AHX A;  3P11 A;  4C8V A;  4C99 B;  4C9U B;  3H3B A;  1YY9 A;  5SX4 M;  4C9A B;  3C09 A;  4KRP A;  3U7U A;  4KRL A;  3LTF A;  5SX5 M;  3MZW A;  1M6B A;  1N8Z C;  4OGA E;  1N8Y C;  4BSU C;  3U9U E;  3BE1 A;  4C8W I;  4KT1 E;  3W11 E;  4BSS C;  4KRM A;  1NQL A;  3NJP A;  4UV7 A;  5J3H E;  3WLW A;  4BSR C;  4P59 A;  4C9E B;  3N85 A;  4UFR B;  3LTG A;  4KNG M;  4KRO A;  1S78 A;  3B2U A;  4HRM A;  3B2V A;  3U2P A;  4XST E;  4XSS E;  4C9R B;  4CDK E;  4BSO A;  2A91 A;  3P0Y A;  1MOX A;  2HR7 A;  4LEO C;  4C9V B; 
#chains in the Genus database with same CATH topology
 1IVO A;  4HRL C;  1IGR A;  4HRN C;  3QWQ A;  3WSQ A;  4QXF C;  4BSP A;  3I2T A;  4LI2 B;  2AHX A;  3P11 A;  4C8V A;  4C99 B;  4C9U B;  3H3B A;  1YY9 A;  5SX4 M;  4C9A B;  3C09 A;  4KRP A;  3U7U A;  4KRL A;  3LTF A;  5SX5 M;  3MZW A;  1M6B A;  1N8Z C;  4OGA E;  1N8Y C;  4BSU C;  3U9U E;  3BE1 A;  4C8W I;  4KT1 E;  3W11 E;  4BSS C;  4KRM A;  1NQL A;  3NJP A;  4UV7 A;  5J3H E;  3WLW A;  4BSR C;  4P59 A;  4C9E B;  3N85 A;  4UFR B;  3LTG A;  4KNG M;  4KRO A;  1S78 A;  3B2U A;  4HRM A;  3B2V A;  3U2P A;  4XST E;  4XSS E;  4C9R B;  4CDK E;  4BSO A;  2A91 A;  3P0Y A;  1MOX A;  2HR7 A;  4LEO C;  4C9V B; 
#chains in the Genus database with same CATH homology
 1IVO A;  4HRL C;  1IGR A;  4HRN C;  3QWQ A;  3WSQ A;  4QXF C;  4BSP A;  3I2T A;  4LI2 B;  2AHX A;  3P11 A;  4C8V A;  4C99 B;  4C9U B;  3H3B A;  1YY9 A;  5SX4 M;  4C9A B;  3C09 A;  4KRP A;  3U7U A;  4KRL A;  3LTF A;  5SX5 M;  3MZW A;  1M6B A;  1N8Z C;  4OGA E;  1N8Y C;  4BSU C;  3U9U E;  3BE1 A;  4C8W I;  4KT1 E;  3W11 E;  4BSS C;  4KRM A;  1NQL A;  3NJP A;  4UV7 A;  5J3H E;  3WLW A;  4BSR C;  4P59 A;  4C9E B;  3N85 A;  4UFR B;  3LTG A;  4KNG M;  4KRO A;  1S78 A;  3B2U A;  4HRM A;  3B2V A;  3U2P A;  4XST E;  4XSS E;  4C9R B;  4CDK E;  4BSO A;  2A91 A;  3P0Y A;  1MOX A;  2HR7 A;  4LEO C;  4C9V B; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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