2L1KA

Mouse prion protein (121-231) containing the substitutions y169a, y225a, and y226a
Total Genus 30
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
30
sequence length
114
structure length
114
Chain Sequence
GSVVGGLGGYMLGSAMSRPMIHFGNDWEDRYYRENMYRYPNQVYYRPVDQASNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCVTQYQKESQAAADGRRSS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

publication title Temperature-dependent conformational exchange in the cellular form of prion proteins
rcsb
molecule tags Membrane protein
source organism Mus musculus
molecule keywords Major prion protein
total genus 30
structure length 114
sequence length 114
ec nomenclature
pdb deposition date 2010-07-28
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
1.10.790.10 Mainly Alpha Orthogonal Bundle Major Prion Protein Prion/Doppel protein, beta-ribbon domain 2l1kA00
1QLXA 2LSBA 1Y16A 2FJ3A 1Y2SA 2KFMA 3HJXA 1Y15A 2KU4A 2LH8A 2L1KA 3O79A 3HJ5A 1B10A 1XYJA 2KTMA 2K1DA 1XYWA 1E1WA 1QM2A 1HJNA 2KU6A 2KUNA 1TPXA 1XYXA 1E1SA 3HEQA 1I17A 1U3MA 1DX0A 1E1JA 2K56A 1QM1A 1UW3A 1E1UA 2KU5A 1XYQA 1XYUA 2L1EA 2L1HA 1E1PA 1FKCA 1U5LA 2L40A 2K5OA 2KFLA 1DWZA 1LG4A 3HAKA 2MV8A 1QM0A 1QM3A 3HAFA 1FO7A 1TQCA 2L39A 1DX1A 3HERA 2KFOA 4DGIA 1H0LA 1HJMA 1E1GA 2LFTA 2JOHA 2W9EA 2JOMA 1XYKA 1I4MA 1XU0A 2LEJA 1DWYA 1AG2A 2L1DA 1QLZA 3HESA 1TQBA
chains in the Genus database with same CATH superfamily
1QLXA 2LSBA 1Y16A 2FJ3A 1Y2SA 2KFMA 3HJXA 1Y15A 2KU4A 2LL0A 2LH8A 2L1KA 3O79A 3HJ5A 1B10A 1XYJA 2KTMA 2K1DA 1XYWA 1E1WA 1QM2A 1HJNA 2KU6A 2KUNA 2KZCA 1TPXA 1XYXA 1E1SA 3HEQA 1I17A 1U3MA 1DX0A 1E1JA 2K56A 1QM1A 1UW3A 1E1UA 2KU5A 1XYQA 1XYUA 2L1EA 2MDZA 2L1HA 1E1PA 1FKCA 1U5LA 2L40A 2K5OA 2KFLA 1DWZA 1LG4A 3HAKA 2MV8A 1QM0A 1QM3A 3HAFA 1FO7A 1TQCA 2L39A 1DX1A 3HERA 2KFOA 4DGIA 1H0LA 1HJMA 1E1GA 2LFTA 2JOHA 2W9EA 2JOMA 1XYKA 1I4MA 1XU0A 2LEJA 1DWYA 1AG2A 2L1DA 1QLZA 3HESA 1TQBA
chains in the Genus database with same CATH topology
1QLXA 2LSBA 1Y16A 2FJ3A 1Y2SA 2KFMA 3HJXA 1Y15A 2KU4A 2LH8A 2L1KA 3O79A 3HJ5A 1B10A 1XYJA 2KTMA 2K1DA 1XYWA 1E1WA 1QM2A 1HJNA 2KU6A 2KUNA 1TPXA 1XYXA 1E1SA 3HEQA 1I17A 1U3MA 1DX0A 1E1JA 2K56A 1QM1A 1UW3A 1E1UA 2KU5A 1XYQA 1XYUA 2L1EA 2L1HA 1E1PA 1FKCA 1U5LA 2L40A 2K5OA 2KFLA 1DWZA 1LG4A 3HAKA 2MV8A 1QM0A 1QM3A 3HAFA 1FO7A 1TQCA 2L39A 1DX1A 3HERA 2KFOA 4DGIA 1H0LA 1HJMA 1E1GA 2LFTA 2JOHA 2W9EA 2JOMA 1XYKA 1I4MA 1XU0A 2LEJA 1DWYA 1AG2A 2L1DA 1QLZA 3HESA 1TQBA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1QLX A;  2LSB A;  1Y16 A;  2FJ3 A;  1Y2S A;  2KFM A;  3HJX A;  1Y15 A;  2KU4 A;  2LH8 A;  2L1K A;  3O79 A;  3HJ5 A;  1B10 A;  1XYJ A;  2KTM A;  2K1D A;  1XYW A;  1E1W A;  1QM2 A;  1HJN A;  2KU6 A;  2KUN A;  1TPX A;  1XYX A;  1E1S A;  3HEQ A;  1I17 A;  1U3M A;  1DX0 A;  1E1J A;  2K56 A;  1QM1 A;  1UW3 A;  1E1U A;  2KU5 A;  1XYQ A;  1XYU A;  2L1E A;  2L1H A;  1E1P A;  1FKC A;  1U5L A;  2L40 A;  2K5O A;  2KFL A;  1DWZ A;  1LG4 A;  3HAK A;  2MV8 A;  1QM0 A;  1QM3 A;  3HAF A;  1FO7 A;  1TQC A;  2L39 A;  1DX1 A;  3HER A;  2KFO A;  4DGI A;  1H0L A;  1HJM A;  1E1G A;  2LFT A;  2JOH A;  2W9E A;  2JOM A;  1XYK A;  1I4M A;  1XU0 A;  2LEJ A;  1DWY A;  1AG2 A;  2L1D A;  1QLZ A;  3HES A;  1TQB A; 
#chains in the Genus database with same CATH topology
 1QLX A;  2LSB A;  1Y16 A;  2FJ3 A;  1Y2S A;  2KFM A;  3HJX A;  1Y15 A;  2KU4 A;  2LL0 A;  2LH8 A;  2L1K A;  3O79 A;  3HJ5 A;  1B10 A;  1XYJ A;  2KTM A;  2K1D A;  1XYW A;  1E1W A;  1QM2 A;  1HJN A;  2KU6 A;  2KUN A;  2KZC A;  1TPX A;  1XYX A;  1E1S A;  3HEQ A;  1I17 A;  1U3M A;  1DX0 A;  1E1J A;  2K56 A;  1QM1 A;  1UW3 A;  1E1U A;  2KU5 A;  1XYQ A;  1XYU A;  2L1E A;  2MDZ A;  2L1H A;  1E1P A;  1FKC A;  1U5L A;  2L40 A;  2K5O A;  2KFL A;  1DWZ A;  1LG4 A;  3HAK A;  2MV8 A;  1QM0 A;  1QM3 A;  3HAF A;  1FO7 A;  1TQC A;  2L39 A;  1DX1 A;  3HER A;  2KFO A;  4DGI A;  1H0L A;  1HJM A;  1E1G A;  2LFT A;  2JOH A;  2W9E A;  2JOM A;  1XYK A;  1I4M A;  1XU0 A;  2LEJ A;  1DWY A;  1AG2 A;  2L1D A;  1QLZ A;  3HES A;  1TQB A; 
#chains in the Genus database with same CATH homology
 1QLX A;  2LSB A;  1Y16 A;  2FJ3 A;  1Y2S A;  2KFM A;  3HJX A;  1Y15 A;  2KU4 A;  2LH8 A;  2L1K A;  3O79 A;  3HJ5 A;  1B10 A;  1XYJ A;  2KTM A;  2K1D A;  1XYW A;  1E1W A;  1QM2 A;  1HJN A;  2KU6 A;  2KUN A;  1TPX A;  1XYX A;  1E1S A;  3HEQ A;  1I17 A;  1U3M A;  1DX0 A;  1E1J A;  2K56 A;  1QM1 A;  1UW3 A;  1E1U A;  2KU5 A;  1XYQ A;  1XYU A;  2L1E A;  2L1H A;  1E1P A;  1FKC A;  1U5L A;  2L40 A;  2K5O A;  2KFL A;  1DWZ A;  1LG4 A;  3HAK A;  2MV8 A;  1QM0 A;  1QM3 A;  3HAF A;  1FO7 A;  1TQC A;  2L39 A;  1DX1 A;  3HER A;  2KFO A;  4DGI A;  1H0L A;  1HJM A;  1E1G A;  2LFT A;  2JOH A;  2W9E A;  2JOM A;  1XYK A;  1I4M A;  1XU0 A;  2LEJ A;  1DWY A;  1AG2 A;  2L1D A;  1QLZ A;  3HES A;  1TQB A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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