3G6EX

Co-crystal structure of homoharringtonine bound to the large ribosomal subunit
Total Genus 21
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
21
sequence length
82
structure length
82
Chain Sequence
ERVVTIPLRDARAEPNHKRADKAMILIREHLAKHFSVDEDAVRLDPSINEAAWARGRANTPSKIRVRAARFEEEGEAIVEAE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title U2504 determines the species specificity of the A-site cleft antibiotics: the structures of tiamulin, homoharringtonine, and bruceantin bound to the ribosome.
pubmed doi rcsb
molecule keywords 23S ribosomal RNA
molecule tags Ribosome
total genus 21
structure length 82
sequence length 82
ec nomenclature
pdb deposition date 2009-02-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
X PF01198 Ribosomal_L31e Ribosomal protein L31e
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.10.440.10 Alpha Beta Roll Ribosomal Protein L31e; Chain: W; Ribosomal Protein L31e; Chain: W; 3g6eX00
3CCSX 3I56X 3CCRX 1JJ2W 1W2BW 1VQ6X 2QEXX 1VQOX 1YIJX 1VQKX 1VQ4X 1KQSW 1N8RY 3G4SX 3CD6X 1K8AY 1YHQX 1VQ9X 2OTJX 1NJIY 1VQLX 1VQMX 3CCVX 2OTLX 3CC4X 1QVFW 1M90Y 1VQ8X 1VQNX 3CCJX 1YITX 1KD1Y 3CC2X 1VQPX 3CCQX 3CCMX 1QVGW 1YI2X 1KC8Y 1S72X 1M1KY 1YJWX 1VQ7X 3CCUX 2QA4X 3CPWW 3CMEX 1Q81Y 3I55X 3CXCW 3CC7X 1Q86Y 3G71X 1VQ5X 3CCEX 1K73Y 1Q7YY 3CCLX 3CMAX 3G6EX 1YJ9X 1Q82Y 1YJNX 1K9MY 3OW2W
chains in the Genus database with same CATH superfamily
3CCSX 3I56X 3CCRX 1JJ2W 1W2BW 1VQ6X 2QEXX 1VQOX 1YIJX 1VQKX 1VQ4X 1KQSW 1N8RY 3G4SX 3CD6X 1K8AY 1YHQX 1VQ9X 2OTJX 1NJIY 1VQLX 1VQMX 3CCVX 2OTLX 3CC4X 1QVFW 1M90Y 1VQ8X 1VQNX 3CCJX 1YITX 1KD1Y 3CC2X 1VQPX 3CCQX 3CCMX 1QVGW 1YI2X 1KC8Y 1S72X 1M1KY 1YJWX 1VQ7X 3CCUX 2QA4X 3CPWW 3CMEX 1Q81Y 3I55X 3CXCW 3CC7X 1Q86Y 3G71X 1VQ5X 3CCEX 1K73Y 1Q7YY 3CCLX 3CMAX 3G6EX 1YJ9X 1Q82Y 1YJNX 1K9MY 3OW2W
chains in the Genus database with same CATH topology
3CCSX 3I56X 3CCRX 1JJ2W 1W2BW 1VQ6X 2QEXX 1VQOX 1YIJX 1VQKX 1VQ4X 1KQSW 1N8RY 3G4SX 3CD6X 1K8AY 1YHQX 1VQ9X 2OTJX 1NJIY 1VQLX 1VQMX 3CCVX 2OTLX 3CC4X 1QVFW 1M90Y 1VQ8X 1VQNX 3CCJX 1YITX 1KD1Y 3CC2X 1VQPX 3CCQX 3CCMX 1QVGW 1YI2X 1KC8Y 1S72X 1M1KY 1YJWX 1VQ7X 3CCUX 2QA4X 3CPWW 3CMEX 1Q81Y 3I55X 3CXCW 3CC7X 1Q86Y 3G71X 1VQ5X 3CCEX 1K73Y 1Q7YY 3CCLX 3CMAX 3G6EX 1YJ9X 1Q82Y 1YJNX 1K9MY 3OW2W
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3CCS X;  3I56 X;  3CCR X;  1JJ2 W;  1W2B W;  1VQ6 X;  2QEX X;  1VQO X;  1YIJ X;  1VQK X;  1VQ4 X;  1KQS W;  1N8R Y;  3G4S X;  3CD6 X;  1K8A Y;  1YHQ X;  1VQ9 X;  2OTJ X;  1NJI Y;  1VQL X;  1VQM X;  3CCV X;  2OTL X;  3CC4 X;  1QVF W;  1M90 Y;  1VQ8 X;  1VQN X;  3CCJ X;  1YIT X;  1KD1 Y;  3CC2 X;  1VQP X;  3CCQ X;  3CCM X;  1QVG W;  1YI2 X;  1KC8 Y;  1S72 X;  1M1K Y;  1YJW X;  1VQ7 X;  3CCU X;  2QA4 X;  3CPW W;  3CME X;  1Q81 Y;  3I55 X;  3CXC W;  3CC7 X;  1Q86 Y;  3G71 X;  1VQ5 X;  3CCE X;  1K73 Y;  1Q7Y Y;  3CCL X;  3CMA X;  3G6E X;  1YJ9 X;  1Q82 Y;  1YJN X;  1K9M Y;  3OW2 W; 
#chains in the Genus database with same CATH topology
 3CCS X;  3I56 X;  3CCR X;  1JJ2 W;  1W2B W;  1VQ6 X;  2QEX X;  1VQO X;  1YIJ X;  1VQK X;  1VQ4 X;  1KQS W;  1N8R Y;  3G4S X;  3CD6 X;  1K8A Y;  1YHQ X;  1VQ9 X;  2OTJ X;  1NJI Y;  1VQL X;  1VQM X;  3CCV X;  2OTL X;  3CC4 X;  1QVF W;  1M90 Y;  1VQ8 X;  1VQN X;  3CCJ X;  1YIT X;  1KD1 Y;  3CC2 X;  1VQP X;  3CCQ X;  3CCM X;  1QVG W;  1YI2 X;  1KC8 Y;  1S72 X;  1M1K Y;  1YJW X;  1VQ7 X;  3CCU X;  2QA4 X;  3CPW W;  3CME X;  1Q81 Y;  3I55 X;  3CXC W;  3CC7 X;  1Q86 Y;  3G71 X;  1VQ5 X;  3CCE X;  1K73 Y;  1Q7Y Y;  3CCL X;  3CMA X;  3G6E X;  1YJ9 X;  1Q82 Y;  1YJN X;  1K9M Y;  3OW2 W; 
#chains in the Genus database with same CATH homology
 3CCS X;  3I56 X;  3CCR X;  1JJ2 W;  1W2B W;  1VQ6 X;  2QEX X;  1VQO X;  1YIJ X;  1VQK X;  1VQ4 X;  1KQS W;  1N8R Y;  3G4S X;  3CD6 X;  1K8A Y;  1YHQ X;  1VQ9 X;  2OTJ X;  1NJI Y;  1VQL X;  1VQM X;  3CCV X;  2OTL X;  3CC4 X;  1QVF W;  1M90 Y;  1VQ8 X;  1VQN X;  3CCJ X;  1YIT X;  1KD1 Y;  3CC2 X;  1VQP X;  3CCQ X;  3CCM X;  1QVG W;  1YI2 X;  1KC8 Y;  1S72 X;  1M1K Y;  1YJW X;  1VQ7 X;  3CCU X;  2QA4 X;  3CPW W;  3CME X;  1Q81 Y;  3I55 X;  3CXC W;  3CC7 X;  1Q86 Y;  3G71 X;  1VQ5 X;  3CCE X;  1K73 Y;  1Q7Y Y;  3CCL X;  3CMA X;  3G6E X;  1YJ9 X;  1Q82 Y;  1YJN X;  1K9M Y;  3OW2 W; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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