3L6JA

Structure of cinaciguat (bay 58-2667) bound to nostoc h-nox domain
Total Genus 53
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
53
sequence length
182
structure length
182
Chain Sequence
MYGLVNKAIQDMISKHHGEDTWEAIKQKAGLEDIDFFVGMEAYSDDVTYHLVGAASEVLGKPAEELLIAFGEYWVTYTSEEGYGELLASAGDSLPEFMENLDNLHARVGLSFPQLRPPAFECQHTSSKSMELHYQSTRCGLAPMVLGLLHGLGKRFQTKVEVTQTAFRETGEDHDIFSIKYE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Structure of cinaciguat (BAY 58-2667) bound to Nostoc H-NOX domain reveals insights into heme-mimetic activation of the soluble guanylyl cyclase.
pubmed doi rcsb
molecule tags Signaling protein
source organism Nostoc sp.
molecule keywords Alr2278 protein
total genus 53
structure length 182
sequence length 182
chains with identical sequence B
ec nomenclature
pdb deposition date 2009-12-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07700 HNOB Haem-NO-binding
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1520.10 Alpha Beta Alpha-Beta Complex H-NOX domain H-NOX domain 3l6jA00
1U55A 3NVUA 4IAHA 4U9KA 2O0CA 2O09A 4U99A 3TFDA 3TF8A 3TF0A 4IT2A 3TFGA 3NVRA 3TFFA 5JRUA 3LAIA 3EEEA 2KILA 4IAEA 3IQBA 4U9BA 4U9JA 2O0GA 4JQHA 3TFAA 3TFEA 3TF9A 3M0BA 3TF1A 5JRVA 3SJ5A 4IAMA 1U4HA 3LAHA 1U56A 2KIIA 3L6JA 4U9GA 1XBNA 4FDKA 5JRXA
chains in the Genus database with same CATH superfamily
1U55A 3NVUA 4IAHA 4U9KA 2O0CA 2O09A 4U99A 3TFDA 3TF8A 3TF0A 4IT2A 3TFGA 3NVRA 3TFFA 5JRUA 3LAIA 3EEEA 2KILA 4IAEA 3IQBA 4U9BA 4U9JA 2O0GA 4JQHA 3TFAA 3TFEA 3TF9A 3M0BA 3TF1A 5JRVA 3SJ5A 4IAMA 1U4HA 3LAHA 1U56A 2KIIA 3L6JA 4U9GA 1XBNA 4FDKA 5JRXA
chains in the Genus database with same CATH topology
1U55A 3NVUA 4IAHA 4U9KA 2O0CA 2O09A 4U99A 3TFDA 3TF8A 3TF0A 4IT2A 3TFGA 3NVRA 3TFFA 5JRUA 3LAIA 3EEEA 2KILA 4IAEA 3IQBA 4U9BA 4U9JA 2O0GA 4JQHA 3TFAA 3TFEA 3TF9A 3M0BA 3TF1A 5JRVA 3SJ5A 4IAMA 1U4HA 3LAHA 1U56A 2KIIA 3L6JA 4U9GA 1XBNA 4FDKA 5JRXA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 1U55 A;  3NVU A;  4IAH A;  4U9K A;  2O0C A;  2O09 A;  4U99 A;  3TFD A;  3TF8 A;  3TF0 A;  4IT2 A;  3TFG A;  3NVR A;  3TFF A;  5JRU A;  3LAI A;  3EEE A;  2KIL A;  4IAE A;  3IQB A;  4U9B A;  4U9J A;  2O0G A;  4JQH A;  3TFA A;  3TFE A;  3TF9 A;  3M0B A;  3TF1 A;  5JRV A;  3SJ5 A;  4IAM A;  1U4H A;  3LAH A;  1U56 A;  2KII A;  3L6J A;  4U9G A;  1XBN A;  4FDK A;  5JRX A; 
#chains in the Genus database with same CATH topology
 1U55 A;  3NVU A;  4IAH A;  4U9K A;  2O0C A;  2O09 A;  4U99 A;  3TFD A;  3TF8 A;  3TF0 A;  4IT2 A;  3TFG A;  3NVR A;  3TFF A;  5JRU A;  3LAI A;  3EEE A;  2KIL A;  4IAE A;  3IQB A;  4U9B A;  4U9J A;  2O0G A;  4JQH A;  3TFA A;  3TFE A;  3TF9 A;  3M0B A;  3TF1 A;  5JRV A;  3SJ5 A;  4IAM A;  1U4H A;  3LAH A;  1U56 A;  2KII A;  3L6J A;  4U9G A;  1XBN A;  4FDK A;  5JRX A; 
#chains in the Genus database with same CATH homology
 1U55 A;  3NVU A;  4IAH A;  4U9K A;  2O0C A;  2O09 A;  4U99 A;  3TFD A;  3TF8 A;  3TF0 A;  4IT2 A;  3TFG A;  3NVR A;  3TFF A;  5JRU A;  3LAI A;  3EEE A;  2KIL A;  4IAE A;  3IQB A;  4U9B A;  4U9J A;  2O0G A;  4JQH A;  3TFA A;  3TFE A;  3TF9 A;  3M0B A;  3TF1 A;  5JRV A;  3SJ5 A;  4IAM A;  1U4H A;  3LAH A;  1U56 A;  2KII A;  3L6J A;  4U9G A;  1XBN A;  4FDK A;  5JRX A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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