3S2KC

Structural basis of wnt signaling inhibition by dickkopf binding to lrp5/6.
Total Genus 14
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
14
sequence length
85
structure length
76
Chain Sequence
KGQEGSVCLRSSDCASGLCCARHFWSKICKPVLKEGQVCTKHRRKGSHGLEIFQRCYCGEGLSCRIQKRLHTCQRH
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Signaling protein
molecule keywords Low-density lipoprotein receptor-related protein 6
publication title Structural Basis of Wnt Signaling Inhibition by Dickkopf Binding to LRP5/6.
pubmed doi rcsb
source organism Homo sapiens
total genus 14
structure length 76
sequence length 85
ec nomenclature
pdb deposition date 2011-05-16
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.80.10 Mainly Beta Ribbon Lipase, subunit A Lipase, subunit A 3s2kC00
2KRAA 3S8VX 2JTKA 1ETHB 1LPBA 3S2KC 1LPAA 5FWWC 1IMTA 1PCOA 1N8SC 2N8KA 1PCNA
chains in the Genus database with same CATH superfamily
2KRAA 3S8VX 2JTKA 1ETHB 1LPBA 3S2KC 1LPAA 5FWWC 1IMTA 3BT4A 1PCOA 1N8SC 2N8KA 1PCNA
chains in the Genus database with same CATH topology
2KRAA 3S8VX 2JTKA 1ETHB 1LPBA 3S2KC 1LPAA 5FWWC 1IMTA 3BT4A 1PCOA 1N8SC 2N8KA 1PCNA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 2KRA A;  3S8V X;  2JTK A;  1ETH B;  1LPB A;  3S2K C;  1LPA A;  5FWW C;  1IMT A;  1PCO A;  1N8S C;  2N8K A;  1PCN A; 
#chains in the Genus database with same CATH topology
 2KRA A;  3S8V X;  2JTK A;  1ETH B;  1LPB A;  3S2K C;  1LPA A;  5FWW C;  1IMT A;  3BT4 A;  1PCO A;  1N8S C;  2N8K A;  1PCN A; 
#chains in the Genus database with same CATH homology
 2KRA A;  3S8V X;  2JTK A;  1ETH B;  1LPB A;  3S2K C;  1LPA A;  5FWW C;  1IMT A;  3BT4 A;  1PCO A;  1N8S C;  2N8K A;  1PCN A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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#similar chains in the pdb database (?% sequence similarity)
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