3U7UA

Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
sequence length
556
structure length
550
Chain Sequence
QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPSNLTLVSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENDSICVECDPQCEKMEDGLLTCHGPGPDNCTKCS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase regulator
molecule keywords Receptor tyrosine-protein kinase erbB-4
publication title A single ligand is sufficient to activate EGFR dimers.
pubmed doi rcsb
source organism Homo sapiens
total genus 162
structure length 550
sequence length 556
chains with identical sequence B, C, D, E, F
ec nomenclature ec 2.7.10.1: Receptor protein-tyrosine kinase.
pdb deposition date 2011-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00757 Furin-like Furin-like cysteine rich region
A PF01030 Recep_L_domain Receptor L domain
A PF14843 GF_recep_IV Growth factor receptor domain IV
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.220.10 Mainly Beta Ribbon Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 3u7uA02
2.10.220.10 Mainly Beta Ribbon Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 3u7uA04
3.80.20.20 Alpha Beta Alpha-Beta Horseshoe 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A Receptor L-domain 3u7uA03
3.80.20.20 Alpha Beta Alpha-Beta Horseshoe 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A Receptor L-domain 3u7uA01
4BSPA 1YY9A 3P0YA 1N8YC 5SX4M 3I2TA 4UFRB 1IVOA 3C09A 4KROA 4UV7A 4KNGM 3LTGA 3U9UE 3H3BA 4OGAE 4C9AB 3U7UA 3QWQA 4BSOA 4HRLC 3LTFA 4C8WI 4KRLA 3NJPA 3P11A 3W11E 1MOXA 4LI2B 4BSUC 4XSSE 4C9UB 4CDKE 4P59A 4BSRC 4KRMA 3U2PA 4HRNC 4XSTE 1N8ZC 4QXFC 1IGRA 3WSQA 5SX5M 4HRMA 4C9EB 2A91A 3WLWA 4C99B 2AHXA 3MZWA 1M6BA 3BE1A 4KT1E 4C9VB 4KRPA 3B2VA 4BSSC 1S78A 5J3HE 4C8VA 3B2UA 4LEOC 1NQLA 3N85A 4C9RB 2HR7A
chains in the Genus database with same CATH superfamily
4BSPA 1YY9A 3P0YA 1N8YC 5SX4M 3I2TA 4UFRB 1IVOA 3C09A 4KROA 4UV7A 4KNGM 3LTGA 3U9UE 3H3BA 4OGAE 4C9AB 3U7UA 3QWQA 4BSOA 4HRLC 3LTFA 4C8WI 4KRLA 3NJPA 3P11A 3W11E 1MOXA 4LI2B 4BSUC 4XSSE 4C9UB 4CDKE 4P59A 4BSRC 4KRMA 3U2PA 4HRNC 4XSTE 1N8ZC 4QXFC 1IGRA 3WSQA 5SX5M 4HRMA 4C9EB 2A91A 3WLWA 4C99B 2AHXA 3MZWA 1M6BA 3BE1A 4KT1E 4C9VB 4KRPA 3B2VA 4BSSC 1S78A 5J3HE 4C8VA 3B2UA 4LEOC 1NQLA 3N85A 4C9RB 2HR7A
chains in the Genus database with same CATH topology
4BSPA 1YY9A 3P0YA 1N8YC 5SX4M 3I2TA 4UFRB 1IVOA 3C09A 4KROA 4UV7A 4KNGM 3LTGA 3U9UE 3H3BA 4OGAE 4C9AB 3U7UA 3QWQA 4BSOA 4HRLC 3LTFA 4C8WI 4KRLA 3NJPA 3P11A 3W11E 1MOXA 4LI2B 4BSUC 4XSSE 4C9UB 4CDKE 4P59A 4BSRC 4KRMA 3U2PA 4HRNC 4XSTE 1N8ZC 4QXFC 1IGRA 3WSQA 5SX5M 4HRMA 4C9EB 2A91A 3WLWA 4C99B 2AHXA 3MZWA 1M6BA 3BE1A 4KT1E 4C9VB 4KRPA 3B2VA 4BSSC 1S78A 5J3HE 4C8VA 3B2UA 4LEOC 1NQLA 3N85A 4C9RB 2HR7A
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4BSP A;  1YY9 A;  3P0Y A;  1N8Y C;  5SX4 M;  3I2T A;  4UFR B;  1IVO A;  3C09 A;  4KRO A;  4UV7 A;  4KNG M;  3LTG A;  3U9U E;  3H3B A;  4OGA E;  4C9A B;  3U7U A;  3QWQ A;  4BSO A;  4HRL C;  3LTF A;  4C8W I;  4KRL A;  3NJP A;  3P11 A;  3W11 E;  1MOX A;  4LI2 B;  4BSU C;  4XSS E;  4C9U B;  4CDK E;  4P59 A;  4BSR C;  4KRM A;  3U2P A;  4HRN C;  4XST E;  1N8Z C;  4QXF C;  1IGR A;  3WSQ A;  5SX5 M;  4HRM A;  4C9E B;  2A91 A;  3WLW A;  4C99 B;  2AHX A;  3MZW A;  1M6B A;  3BE1 A;  4KT1 E;  4C9V B;  4KRP A;  3B2V A;  4BSS C;  1S78 A;  5J3H E;  4C8V A;  3B2U A;  4LEO C;  1NQL A;  3N85 A;  4C9R B;  2HR7 A; 
#chains in the Genus database with same CATH topology
 4BSP A;  1YY9 A;  3P0Y A;  1N8Y C;  5SX4 M;  3I2T A;  4UFR B;  1IVO A;  3C09 A;  4KRO A;  4UV7 A;  4KNG M;  3LTG A;  3U9U E;  3H3B A;  4OGA E;  4C9A B;  3U7U A;  3QWQ A;  4BSO A;  4HRL C;  3LTF A;  4C8W I;  4KRL A;  3NJP A;  3P11 A;  3W11 E;  1MOX A;  4LI2 B;  4BSU C;  4XSS E;  4C9U B;  4CDK E;  4P59 A;  4BSR C;  4KRM A;  3U2P A;  4HRN C;  4XST E;  1N8Z C;  4QXF C;  1IGR A;  3WSQ A;  5SX5 M;  4HRM A;  4C9E B;  2A91 A;  3WLW A;  4C99 B;  2AHX A;  3MZW A;  1M6B A;  3BE1 A;  4KT1 E;  4C9V B;  4KRP A;  3B2V A;  4BSS C;  1S78 A;  5J3H E;  4C8V A;  3B2U A;  4LEO C;  1NQL A;  3N85 A;  4C9R B;  2HR7 A; 
#chains in the Genus database with same CATH homology
 4BSP A;  1YY9 A;  3P0Y A;  1N8Y C;  5SX4 M;  3I2T A;  4UFR B;  1IVO A;  3C09 A;  4KRO A;  4UV7 A;  4KNG M;  3LTG A;  3U9U E;  3H3B A;  4OGA E;  4C9A B;  3U7U A;  3QWQ A;  4BSO A;  4HRL C;  3LTF A;  4C8W I;  4KRL A;  3NJP A;  3P11 A;  3W11 E;  1MOX A;  4LI2 B;  4BSU C;  4XSS E;  4C9U B;  4CDK E;  4P59 A;  4BSR C;  4KRM A;  3U2P A;  4HRN C;  4XST E;  1N8Z C;  4QXF C;  1IGR A;  3WSQ A;  5SX5 M;  4HRM A;  4C9E B;  2A91 A;  3WLW A;  4C99 B;  2AHX A;  3MZW A;  1M6B A;  3BE1 A;  4KT1 E;  4C9V B;  4KRP A;  3B2V A;  4BSS C;  1S78 A;  5J3H E;  4C8V A;  3B2U A;  4LEO C;  1NQL A;  3N85 A;  4C9R B;  2HR7 A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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#similar chains, but unknotted
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