3U7UA

Crystal structure of extracellular region of human epidermal growth factor receptor 4 in complex with neuregulin-1 beta
Total Genus 162
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
162
sequence length
556
structure length
550
Chain Sequence
QSVCAGTENKLSSLSDLEQQYRALRKYYENCEVVMGNLEITSIEHNRDLSFLRSVREVTGYVLVALNQFRYLPLENLRIIRGTKLYEDRYALAIFLNYRKDGNFGLQELGLKNLTEILNGGVYVDQNKFLCYADTIHWQDIVRNPSNLTLVSSGCGRCHKSCTGRCWGPTENHCQTLTRTVCAEQCDGRCYGPYVSDCCHRECAGGCSGPKDTDCFACMNFNDSGACVTQCPQTFVYNPTTFQLEHNFNAKYTYGAFCVKKCPHNFVVDSSSCVRACPSSKMEVEENGIKMCKPCTDICPKACDGIGTGSLMSAQTVDSSNIDKFINCTKINGNLIFLVTGIHGDPYNAIEAIDPEKLNVFRTVREITGFLNIQSWPPNMTDFSVFSNLVTIGGRVLYSGLSLLILKQQGITSLQFQSLKEISAGNIYITDNSNLCYYHTINWTTLFSTINQRIVIRDNRKAENCTAEGMVCNHLCSSDGCWGPGPDQCLSCRRFSRGRICIESCNLYDGEFREFENDSICVECDPQCEKMEDGLLTCHGPGPDNCTKCS
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

molecule tags Transferase/transferase regulator
molecule keywords Receptor tyrosine-protein kinase erbB-4
publication title A single ligand is sufficient to activate EGFR dimers.
pubmed doi rcsb
source organism Homo sapiens
total genus 162
structure length 550
sequence length 556
chains with identical sequence B, C, D, E, F
ec nomenclature ec 2.7.10.1: Receptor protein-tyrosine kinase.
pdb deposition date 2011-10-14

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00757 Furin-like Furin-like cysteine rich region
A PF01030 Recep_L_domain Receptor L domain
A PF14843 GF_recep_IV Growth factor receptor domain IV
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
2.10.220.10 Mainly Beta Ribbon Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 3u7uA02
2.10.220.10 Mainly Beta Ribbon Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A domain 2 Hormone Receptor, Insulin-like Growth Factor Receptor 1; Chain A, domain 2 3u7uA04
3.80.20.20 Alpha Beta Alpha-Beta Horseshoe 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A Receptor L-domain 3u7uA03
3.80.20.20 Alpha Beta Alpha-Beta Horseshoe 24 nucleotide stem-loop, u2 snrnp hairpin iv. U2 a'; Chain A Receptor L-domain 3u7uA01
4C99B 4C9AB 4XSTE 3U2PA 3B2VA 4KRMA 2A91A 4UV7A 3WLWA 4QXFC 4KNGM 4BSRC 5SX4M 4KT1E 4BSOA 2AHXA 4KRPA 3P0YA 3H3BA 4KROA 1NQLA 4LI2B 4C9RB 4HRNC 1IGRA 4OGAE 4BSUC 4C8WI 4LEOC 3MZWA 3NJPA 3U7UA 3C09A 1S78A 4C8VA 4C9VB 3P11A 5J3HE 3U9UE 1N8YC 1N8ZC 1IVOA 1MOXA 4BSPA 1M6BA 4UFRB 2HR7A 3QWQA 4P59A 3LTGA 3W11E 3WSQA 4BSSC 4HRMA 4KRLA 3BE1A 1YY9A 4C9UB 4CDKE 3LTFA 3N85A 5SX5M 3I2TA 4HRLC 4C9EB 3B2UA 4XSSE
chains in the Genus database with same CATH superfamily
4C99B 4C9AB 4XSTE 3U2PA 3B2VA 4KRMA 2A91A 4UV7A 3WLWA 4QXFC 4KNGM 4BSRC 5SX4M 4KT1E 4BSOA 2AHXA 4KRPA 3P0YA 3H3BA 4KROA 1NQLA 4LI2B 4C9RB 4HRNC 1IGRA 4OGAE 4BSUC 4C8WI 4LEOC 3MZWA 3NJPA 3U7UA 3C09A 1S78A 4C8VA 4C9VB 3P11A 5J3HE 3U9UE 1N8YC 1N8ZC 1IVOA 1MOXA 4BSPA 1M6BA 4UFRB 2HR7A 3QWQA 4P59A 3LTGA 3W11E 3WSQA 4BSSC 4HRMA 4KRLA 3BE1A 1YY9A 4C9UB 4CDKE 3LTFA 3N85A 5SX5M 3I2TA 4HRLC 4C9EB 3B2UA 4XSSE
chains in the Genus database with same CATH topology
4C99B 4C9AB 4XSTE 3U2PA 3B2VA 4KRMA 2A91A 4UV7A 3WLWA 4QXFC 4KNGM 4BSRC 5SX4M 4KT1E 4BSOA 2AHXA 4KRPA 3P0YA 3H3BA 4KROA 1NQLA 4LI2B 4C9RB 4HRNC 1IGRA 4OGAE 4BSUC 4C8WI 4LEOC 3MZWA 3NJPA 3U7UA 3C09A 1S78A 4C8VA 4C9VB 3P11A 5J3HE 3U9UE 1N8YC 1N8ZC 1IVOA 1MOXA 4BSPA 1M6BA 4UFRB 2HR7A 3QWQA 4P59A 3LTGA 3W11E 3WSQA 4BSSC 4HRMA 4KRLA 3BE1A 1YY9A 4C9UB 4CDKE 3LTFA 3N85A 5SX5M 3I2TA 4HRLC 4C9EB 3B2UA 4XSSE
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4C99 B;  4C9A B;  4XST E;  3U2P A;  3B2V A;  4KRM A;  2A91 A;  4UV7 A;  3WLW A;  4QXF C;  4KNG M;  4BSR C;  5SX4 M;  4KT1 E;  4BSO A;  2AHX A;  4KRP A;  3P0Y A;  3H3B A;  4KRO A;  1NQL A;  4LI2 B;  4C9R B;  4HRN C;  1IGR A;  4OGA E;  4BSU C;  4C8W I;  4LEO C;  3MZW A;  3NJP A;  3U7U A;  3C09 A;  1S78 A;  4C8V A;  4C9V B;  3P11 A;  5J3H E;  3U9U E;  1N8Y C;  1N8Z C;  1IVO A;  1MOX A;  4BSP A;  1M6B A;  4UFR B;  2HR7 A;  3QWQ A;  4P59 A;  3LTG A;  3W11 E;  3WSQ A;  4BSS C;  4HRM A;  4KRL A;  3BE1 A;  1YY9 A;  4C9U B;  4CDK E;  3LTF A;  3N85 A;  5SX5 M;  3I2T A;  4HRL C;  4C9E B;  3B2U A;  4XSS E; 
#chains in the Genus database with same CATH topology
 4C99 B;  4C9A B;  4XST E;  3U2P A;  3B2V A;  4KRM A;  2A91 A;  4UV7 A;  3WLW A;  4QXF C;  4KNG M;  4BSR C;  5SX4 M;  4KT1 E;  4BSO A;  2AHX A;  4KRP A;  3P0Y A;  3H3B A;  4KRO A;  1NQL A;  4LI2 B;  4C9R B;  4HRN C;  1IGR A;  4OGA E;  4BSU C;  4C8W I;  4LEO C;  3MZW A;  3NJP A;  3U7U A;  3C09 A;  1S78 A;  4C8V A;  4C9V B;  3P11 A;  5J3H E;  3U9U E;  1N8Y C;  1N8Z C;  1IVO A;  1MOX A;  4BSP A;  1M6B A;  4UFR B;  2HR7 A;  3QWQ A;  4P59 A;  3LTG A;  3W11 E;  3WSQ A;  4BSS C;  4HRM A;  4KRL A;  3BE1 A;  1YY9 A;  4C9U B;  4CDK E;  3LTF A;  3N85 A;  5SX5 M;  3I2T A;  4HRL C;  4C9E B;  3B2U A;  4XSS E; 
#chains in the Genus database with same CATH homology
 4C99 B;  4C9A B;  4XST E;  3U2P A;  3B2V A;  4KRM A;  2A91 A;  4UV7 A;  3WLW A;  4QXF C;  4KNG M;  4BSR C;  5SX4 M;  4KT1 E;  4BSO A;  2AHX A;  4KRP A;  3P0Y A;  3H3B A;  4KRO A;  1NQL A;  4LI2 B;  4C9R B;  4HRN C;  1IGR A;  4OGA E;  4BSU C;  4C8W I;  4LEO C;  3MZW A;  3NJP A;  3U7U A;  3C09 A;  1S78 A;  4C8V A;  4C9V B;  3P11 A;  5J3H E;  3U9U E;  1N8Y C;  1N8Z C;  1IVO A;  1MOX A;  4BSP A;  1M6B A;  4UFR B;  2HR7 A;  3QWQ A;  4P59 A;  3LTG A;  3W11 E;  3WSQ A;  4BSS C;  4HRM A;  4KRL A;  3BE1 A;  1YY9 A;  4C9U B;  4CDK E;  3LTF A;  3N85 A;  5SX5 M;  3I2T A;  4HRL C;  4C9E B;  3B2U A;  4XSS E; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
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