4IAEA

Crystal structure of bay 60-2770 bound to nostoc h-nox domain
Total Genus 59
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
59
sequence length
182
structure length
182
Chain Sequence
MYGLVNKAIQDMISKHHGEDTWEAIKQKAGLEDIDFFVGMEAYSDDVTYHLVGAASEVLGKPAEELLIAFGEYWVTYTSEEGYGELLASAGDSLPEFMENLDNLHARVGLSFPQLRPPAFECQHTSSKSMELHYQSTRAGLAPMVLGLLHGLGKRFQTKVEVTQTAFRETGEDHDIFSIKYE
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title Insights into BAY 60-2770 Activation and S-Nitrosylation-Dependent Desensitization of Soluble Guanylyl Cyclase via Crystal Structures of Homologous Nostoc H-NOX Domain Complexes.
pubmed doi rcsb
molecule tags Lyase
source organism Nostoc sp.
molecule keywords Alr2278 protein
total genus 59
structure length 182
sequence length 182
chains with identical sequence B
ec nomenclature ec 4.6.1.2: Guanylate cyclase.
pdb deposition date 2012-12-06

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF07700 HNOB Haem-NO-binding
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.90.1520.10 Alpha Beta Alpha-Beta Complex H-NOX domain H-NOX domain 4iaeA00
3NVUA 3TFDA 5JRVA 3M0BA 4FDKA 1U55A 3LAIA 5JRUA 5JRXA 1U56A 3TFAA 4IT2A 4U9JA 4U9BA 3TF0A 4U99A 3TF1A 2O0CA 3TFEA 3SJ5A 3IQBA 3LAHA 4IAEA 1U4HA 3TFFA 2KILA 4IAMA 4U9KA 3TF8A 3TFGA 3TF9A 3EEEA 3L6JA 2KIIA 4IAHA 1XBNA 2O0GA 2O09A 3NVRA 4JQHA 4U9GA
chains in the Genus database with same CATH superfamily
3NVUA 3TFDA 5JRVA 3M0BA 4FDKA 1U55A 3LAIA 5JRUA 5JRXA 1U56A 3TFAA 4IT2A 4U9JA 4U9BA 3TF0A 4U99A 3TF1A 2O0CA 3TFEA 3SJ5A 3IQBA 3LAHA 4IAEA 1U4HA 3TFFA 2KILA 4IAMA 4U9KA 3TF8A 3TFGA 3TF9A 3EEEA 3L6JA 2KIIA 4IAHA 1XBNA 2O0GA 2O09A 3NVRA 4JQHA 4U9GA
chains in the Genus database with same CATH topology
3NVUA 3TFDA 5JRVA 3M0BA 4FDKA 1U55A 3LAIA 5JRUA 5JRXA 1U56A 3TFAA 4IT2A 4U9JA 4U9BA 3TF0A 4U99A 3TF1A 2O0CA 3TFEA 3SJ5A 3IQBA 3LAHA 4IAEA 1U4HA 3TFFA 2KILA 4IAMA 4U9KA 3TF8A 3TFGA 3TF9A 3EEEA 3L6JA 2KIIA 4IAHA 1XBNA 2O0GA 2O09A 3NVRA 4JQHA 4U9GA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 3NVU A;  3TFD A;  5JRV A;  3M0B A;  4FDK A;  1U55 A;  3LAI A;  5JRU A;  5JRX A;  1U56 A;  3TFA A;  4IT2 A;  4U9J A;  4U9B A;  3TF0 A;  4U99 A;  3TF1 A;  2O0C A;  3TFE A;  3SJ5 A;  3IQB A;  3LAH A;  4IAE A;  1U4H A;  3TFF A;  2KIL A;  4IAM A;  4U9K A;  3TF8 A;  3TFG A;  3TF9 A;  3EEE A;  3L6J A;  2KII A;  4IAH A;  1XBN A;  2O0G A;  2O09 A;  3NVR A;  4JQH A;  4U9G A; 
#chains in the Genus database with same CATH topology
 3NVU A;  3TFD A;  5JRV A;  3M0B A;  4FDK A;  1U55 A;  3LAI A;  5JRU A;  5JRX A;  1U56 A;  3TFA A;  4IT2 A;  4U9J A;  4U9B A;  3TF0 A;  4U99 A;  3TF1 A;  2O0C A;  3TFE A;  3SJ5 A;  3IQB A;  3LAH A;  4IAE A;  1U4H A;  3TFF A;  2KIL A;  4IAM A;  4U9K A;  3TF8 A;  3TFG A;  3TF9 A;  3EEE A;  3L6J A;  2KII A;  4IAH A;  1XBN A;  2O0G A;  2O09 A;  3NVR A;  4JQH A;  4U9G A; 
#chains in the Genus database with same CATH homology
 3NVU A;  3TFD A;  5JRV A;  3M0B A;  4FDK A;  1U55 A;  3LAI A;  5JRU A;  5JRX A;  1U56 A;  3TFA A;  4IT2 A;  4U9J A;  4U9B A;  3TF0 A;  4U99 A;  3TF1 A;  2O0C A;  3TFE A;  3SJ5 A;  3IQB A;  3LAH A;  4IAE A;  1U4H A;  3TFF A;  2KIL A;  4IAM A;  4U9K A;  3TF8 A;  3TFG A;  3TF9 A;  3EEE A;  3L6J A;  2KII A;  4IAH A;  1XBN A;  2O0G A;  2O09 A;  3NVR A;  4JQH A;  4U9G A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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