4AV1A

Crystal structure of the human parp-1 dna binding domain in complex with dna
Total Genus 13
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The genus trace: a function that shows values of genus (vertical axis) for subchains spanned between the first residue, and all other residues (shown on horizontal axis). The number of the latter residue and the genus of a given subchain are shown interactively.

Total Genus
13
sequence length
86
structure length
86
Chain Sequence
DKLYRVEYAKSGRASCKKCSESIPKDSLRMAIMVQSPMFDGKVPHWYHFSCFWKVGHSIRHPDVEVDGFSELRWDDQQKVKKTAEA
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The genus matrix. At position (x,y) a genus value for a subchain spanned between x’th and y’th residue is shown. Values of the genus are represented by color, according to the scale given on the right.

Structure visualization

After clicking on a point (x,y) in the genus matrix above, a subchain from x to y is shown in color.

Chord Diagram
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publication title The Zinc-Finger Domains of Parp1 Cooperate to Recognise DNA Strand-Breaks
pubmed doi rcsb
molecule keywords POLY [ADP-RIBOSE] POLYMERASE 1
molecule tags Transferase
source organism Homo sapiens
total genus 13
structure length 86
sequence length 86
chains with identical sequence B, C, D
ec nomenclature ec 2.4.2.30: NAD(+) ADP-ribosyltransferase.
pdb deposition date 2012-05-23

pfam database annotations

chain Pfam Accession Code Pfam Family Identifier Pfam Description
A PF00645 zf-PARP Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region
Image from the rcsb pdb (www.rcsb.org)
cath code
ClassArchitectureTopologyHomologyDomain
3.30.1740.10 Alpha Beta 2-Layer Sandwich first zn-finger domain of poly(adp-ribose) polymerase-1 Zinc finger, PARP-type 4av1A00
4DQYA 1UW0A 2DMJA 1V9XA 4OQBA 2L30A 3OD8A 3ODEA 2CS2A 2L31A 3ODAA 4AV1A 4OPXA 3ODCA 4OQAA 2N8AA
chains in the Genus database with same CATH superfamily
1UW0A 2DMJA 3ODEA 5A2Qa 4OPXA 3ODCA 3JAMa 5LL6e 2L30A 2CS2A 3J81a 3J7A3 5IT9a 3OD8A 3ODAA 4AV1A 4DQYA 5FLXa 1V9XA 4OQBA 2L31A 4OQAA 3J80a 2N8AA
chains in the Genus database with same CATH topology
4DQYA 1UW0A 2DMJA 1V9XA 4OQBA 2L30A 3OD8A 3ODEA 2CS2A 2L31A 3ODAA 4AV1A 4OPXA 3ODCA 4OQAA 2N8AA
chains in the Genus database with same CATH homology


 
#chains in the Genus database with same CATH superfamily
 4DQY A;  1UW0 A;  2DMJ A;  1V9X A;  4OQB A;  2L30 A;  3OD8 A;  3ODE A;  2CS2 A;  2L31 A;  3ODA A;  4AV1 A;  4OPX A;  3ODC A;  4OQA A;  2N8A A; 
#chains in the Genus database with same CATH topology
 1UW0 A;  2DMJ A;  3ODE A;  5A2Q a;  4OPX A;  3ODC A;  3JAM a;  5LL6 e;  2L30 A;  2CS2 A;  3J81 a;  3J7A 3;  5IT9 a;  3OD8 A;  3ODA A;  4AV1 A;  4DQY A;  5FLX a;  1V9X A;  4OQB A;  2L31 A;  4OQA A;  3J80 a;  2N8A A; 
#chains in the Genus database with same CATH homology
 4DQY A;  1UW0 A;  2DMJ A;  1V9X A;  4OQB A;  2L30 A;  3OD8 A;  3ODE A;  2CS2 A;  2L31 A;  3ODA A;  4AV1 A;  4OPX A;  3ODC A;  4OQA A;  2N8A A; 
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similar chains in the Genus database (?% sequence similarity)
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similar chains in the pdb database (?% sequence similarity)

 
#similar chains in the Genus database (?% sequence similarity)
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#similar chains, but unknotted
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